Mayeso a Antineutrophil Cytoplasmic Antibodies (ANCA)

Zamkati

• Kodi mayeso a antineutrophil cytoplasmic antibodies (ANCA) ndi ati?
• Amagwiritsidwa ntchito yanji?
• Chifukwa chiyani ndikufuna mayeso a ANCA?
• Kodi chimachitika ndi chiyani pakuyesedwa kwa ANCA?
• Kodi ndiyenera kuchita chilichonse kukonzekera mayeso?
• Kodi pali zoopsa zilizonse pamayeso?
• Kodi zotsatirazi zikutanthauza chiyani?
• Kodi pali china chilichonse chomwe ndiyenera kudziwa pamayeso a ANCA?
• Zolemba

Kodi mayeso a antineutrophil cytoplasmic antibodies (ANCA) ndi ati?

Kuyesaku kumayang'ana ma antineutrophil cytoplasmic antibodies (ANCA) m'magazi anu. Ma antibodies ndi mapuloteni omwe chitetezo chanu chamthupi chimapanga kuti athane ndi zinthu zakunja monga mavairasi ndi mabakiteriya. Koma ma ANCA amalimbana ndi maselo athanzi omwe amadziwika kuti neutrophil (mtundu wa maselo oyera amwazi) molakwika. Izi zitha kubweretsa matenda omwe amadziwika kuti autoimmune vasculitis. Autoimmune vasculitis imayambitsa kutupa ndi kutupa kwa mitsempha yamagazi.

Mitsempha yamagazi imanyamula magazi kuchokera pamtima panu kupita ku ziwalo zanu, minofu, ndi machitidwe ena, kenako nkubwereranso. Mitundu yamitsempha yamagazi imaphatikizapo mitsempha, mitsempha, ndi ma capillaries. Kutupa m'mitsempha yamagazi kumatha kuyambitsa mavuto akulu azaumoyo. Mavuto amasiyana kutengera mitsempha yamagazi ndi machitidwe amthupi omwe amakhudzidwa.

Pali mitundu iwiri yayikulu ya ANCA. Iliyonse imalunjika mapuloteni mkati mwa maselo oyera amwazi:

• PANCA, yomwe imayang'ana mapuloteni otchedwa MPO (myeloperoxidase)
• cANCA, yomwe imayang'ana puloteni yotchedwa PR3 (proteinase 3)

Kuyezetsa kumatha kuwonetsa ngati muli ndi mitundu itatu kapena mitundu itatu ya ma antibodies. Izi zitha kuthandiza othandizira kuti azitha kuzindikira matenda anu.

Mayina ena: Ma antibodies a ANCA, cANCA pANCA, ma cytoplasmic neutrophil antibodies, seramu, anticytoplasmic autoantibodies

Amagwiritsidwa ntchito yanji?

Mayeso a ANCA amagwiritsidwa ntchito nthawi zambiri kuti mudziwe ngati muli ndi mtundu wa vasculitis. Pali mitundu yosiyanasiyana yamatendawa. Zonsezi zimayambitsa kutupa ndi kutupa kwa mitsempha yamagazi, koma mtundu uliwonse umakhudza mitsempha yamagazi yosiyana ndi ziwalo zina za thupi. Mitundu ya autoimmune vasculitis ndi monga:

• Granulomatosis ndi polyangiitis (GPA), poyamba ankatchedwa matenda a Wegener. Nthawi zambiri zimakhudza mapapu, impso, ndi sinus.
• Microscopic polyangiitis (MPA). Vutoli limatha kukhudza ziwalo zingapo mthupi, kuphatikizapo mapapu, impso, dongosolo lamanjenje, ndi khungu.
• Eosinophilic granulomatosis ndi polyangiitis (EGPA), omwe kale amatchedwa Churg-Strauss syndrome. Matendawa nthawi zambiri amakhudza khungu ndi mapapo. Nthawi zambiri imayambitsa mphumu.
• Polyarteritis nodosa (PAN). Matendawa nthawi zambiri amakhudza mtima, impso, khungu, komanso dongosolo lamanjenje.

Mayeso a ANCA atha kugwiritsidwanso ntchito kuwunika chithandizo cha zovuta izi.

Chifukwa chiyani ndikufuna mayeso a ANCA?

Wothandizira zaumoyo wanu akhoza kuyitanitsa mayeso a ANCA ngati muli ndi zizindikiro za autoimmune vasculitis. Zizindikiro zake ndi izi:

• Malungo
• Kutopa
• Kuchepetsa thupi
• Minofu ndi / kapena zophatikizana zamagulu

Zizindikiro zanu zingakhudzenso gawo limodzi kapena angapo mthupi lanu. Ziwalo zomwe zimakonda kukhudzidwa ndizizindikiro zomwe zimayambitsa zimaphatikizapo:

• Maso
  • Kufiira
  • Masomphenya olakwika
  • Kutaya masomphenya
• Makutu
  • Kulira m'makutu (tinnitus)
  • Kutaya kwakumva
• Zojambula
  • Sinus ululu
  • Mphuno yothamanga
  • Mphuno imatuluka magazi
• Khungu
  • Ziphuphu
  • Zilonda kapena zilonda zam'mimba, mtundu wa zilonda zakuya zomwe zimachedwa kuchira komanso / kapena zimangobwerera
• Mapapo
  • Tsokomola
  • Kuvuta kupuma
  • Kupweteka pachifuwa
• Impso
  • Magazi mkodzo
  • Mkodzo wa thovu, womwe umayambitsidwa ndi mapuloteni mumkodzo
• Mchitidwe wamanjenje
  • Dzanzi ndi kumva kulasalasa mbali zosiyanasiyana za thupi

Kodi chimachitika ndi chiyani pakuyesedwa kwa ANCA?

Katswiri wa zamankhwala adzatenga magazi kuchokera mumtsinje uli m'manja mwanu, pogwiritsa ntchito singano yaying'ono. Singanoyo italowetsedwa, magazi ang'onoang'ono amatengedwa mu chubu choyesera. Mutha kumva kuluma pang'ono singano ikamalowa kapena kutuluka. Izi nthawi zambiri zimatenga mphindi zosakwana zisanu.

Kodi ndiyenera kuchita chilichonse kukonzekera mayeso?

Simukusowa kukonzekera kulikonse kwapoyesedwa kwa ANCA.

Kodi pali zoopsa zilizonse pamayeso?

Pali chiopsezo chochepa kwambiri choyesedwa magazi. Mutha kukhala ndi ululu pang'ono kapena kuvulala pamalo pomwe singano idayikidwapo, koma zizindikiro zambiri zimatha msanga.

Kodi zotsatirazi zikutanthauza chiyani?

Ngati zotsatira zanu zinali zoipa, zikutanthauza kuti zizindikilo zanu mwina sizomwe zimachitika chifukwa cha autoimmune vasculitis.

Ngati zotsatira zanu zinali zabwino, zitha kutanthauza kuti muli ndi vasculitis. Ikhozanso kuwonetsa ngati ma canan kapena ma pANCA apezeka. Izi zitha kukuthandizani kudziwa mtundu wa vasculitis womwe muli nawo.

Ziribe kanthu mtundu wa ma antibodies omwe anapezeka, mungafunike kuyesedwa kowonjezera, kotchedwa biopsy, kuti mutsimikizire matendawa. Biopsy ndi njira yomwe imachotsa pang'ono pang'ono minofu kapena maselo kuti ayesedwe. Wothandizira zaumoyo wanu amathanso kuyitanitsa mayeso ochulukirapo kuti athe kuyeza kuchuluka kwa ANCA m'magazi anu.

Ngati mukumenyedwa chifukwa cha autoimmune vasculitis, zotsatira zanu zitha kuwonetsa ngati chithandizo chanu chikugwira ntchito.

Ngati muli ndi mafunso pazotsatira zanu, lankhulani ndi omwe amakuthandizani.

Dziwani zambiri zamayeso a labotale, magawo owerengera, ndi zotsatira zakumvetsetsa.

Kodi pali china chilichonse chomwe ndiyenera kudziwa pamayeso a ANCA?

Zotsatira zanu za ANCA zikuwonetsa kuti muli ndi vasculitis, pali njira zochizira ndikuwongolera vutoli. Mankhwalawa atha kuphatikizira mankhwala, mankhwala omwe amachotsa ma ANCA kwakanthawi m'magazi anu, ndi / kapena opaleshoni.

Zolemba

1. Allina Health [Intaneti]. Minneapolis: Allina Thanzi; Kuyeza kwa C-ANCA; [yotchulidwa 2019 Meyi 3]; [pafupifupi zowonetsera 3]. Ipezeka kuchokera: https://account.allinahealth.org/library/content/49/150100
2. Allina Health [Intaneti]. Minneapolis: Allina Thanzi; Kuyeza kwa P-ANCA; [yotchulidwa 2019 Meyi 3]; [pafupifupi zowonetsera 3]. Ipezeka kuchokera: https://account.allinahealth.org/library/content/49/150470
3. Chipatala cha Cleveland [Intaneti]. Cleveland (OH): Chipatala cha Cleveland; c2019. Zilonda Zamiyendo ndi Mapazi; [yotchulidwa 2019 Meyi 3]; [pafupifupi zowonetsera 3]. Ipezeka kuchokera: https://my.clevelandclinic.org/health/diseases/17169-leg-and-foot-ulcers
4. Kuyesa kwa Labu Paintaneti [Intaneti]. Washington DC: American Association for Clinical Chemistry; c2001–2019. Ma antibodies a ANCA / MPO / PR3; [yasinthidwa 2019 Apr 29; yatchulidwa 2019 Meyi 3]; [pafupifupi zowonetsera 2]. Ipezeka kuchokera: https://labtestsonline.org/tests/ancampopr3-antibodies
5. Kuyesa kwa Labu Paintaneti [Intaneti]. Washington DC: American Association for Clinical Chemistry; c2001–2019. Chisokonezo; [yasinthidwa 2017 Jul 10; yatchulidwa 2019 Meyi 3]; [pafupifupi zowonetsera 2]. Ipezeka kuchokera: https://labtestsonline.org/glossary/biopsy
6. Kuyesa kwa Labu Paintaneti [Intaneti]. Washington DC: American Association for Clinical Chemistry; c2001–2019. Vasculitis; [yasinthidwa 2017 Sep 8; yatchulidwa 2019 Meyi 3]; [pafupifupi zowonetsera 2]. Ipezeka kuchokera: https://labtestsonline.org/conditions/vasculitis
7. Mansi IA, Opran A, Rosner F. ANCA-Associated Small-Vessel Vasculitis. Ndi Sing'anga Wodziwika [Internet]. 2002 Apr 15 [yotchulidwa 2019 Meyi 3]; 65 (8): 1615-1621. Ipezeka kuchokera: https://www.aafp.org/afp/2002/0415/p1615.html
8. Mayo Clinic Laboratories [Intaneti]. Mayo Foundation for Medical Education and Research; c1995–2019. Chidziwitso Cha Mayeso: ANCA: Ma Cytoplasmic Neutrophil Antibodies, Serum: Clinical and Interpretive; [yotchulidwa 2019 Meyi 3]; [pafupifupi zowonetsera 4]. Ipezeka kuchokera: https://www.mayocliniclabs.com/test-catalog/Clinical+and+Interpretive/9441
9. National Heart, Lung, ndi Blood Institute [Internet]. Bethesda (MD): Dipatimenti ya Zaumoyo ndi Zantchito ku U.S. Kuyesa Magazi; [yotchulidwa 2019 Meyi 3]; [pafupifupi zowonetsera 3]. Ipezeka kuchokera: https://www.nhlbi.nih.gov/health-topics/blood-tests
10. National Heart, Lung, ndi Blood Institute [Internet]. Bethesda (MD): Dipatimenti ya Zaumoyo ndi Zantchito ku U.S. Vasculitis; [yotchulidwa 2019 Meyi 3]; [pafupifupi zowonetsera 2]. Ipezeka kuchokera: https://www.nhlbi.nih.gov/health-topics/vasculitis
11. Radice A, Sinico RA. Antineutrophil Cytoplasmic Antibodies (ANCA). Kudzitchinjiriza [Internet]. 2005 Feb [yotchulidwa 2019 Meyi 3]; 38 (1): 93-103. Ipezeka kuchokera: https://www.ncbi.nlm.nih.gov/pubmed/15804710
12. UNC Impso Center [Internet]. Chapel Hill (NC): UNC Impso Center; c2019. ANCA Vasculitis; [yasinthidwa 2018 Sep; yatchulidwa 2019 Meyi 3]; [pafupifupi zowonetsera 3]. Ipezeka kuchokera: https://unckidneycenter.org/kidneyhealthlibrary/glomerular-disease/anca-vasculitis

Zomwe zili patsamba lino siziyenera kugwiritsidwa ntchito m'malo mwa chithandizo chamankhwala kapena upangiri. Lumikizanani ndi othandizira azaumoyo ngati muli ndi mafunso okhudzana ndi thanzi lanu.