Kodi Migraine Ikhoza Kukhala M'chiberekero Chanu?

Zamkati

• Kodi mutu waching'alang'ala ungakhale wachibadwa?
• Kodi kafukufukuyu akuti chiyani?
• Kusintha kwa majini komwe kumakhudzana ndi migraine
• Kusiyanasiyana kwa Gene komwe kumakhudzana ndi migraine
• Kodi mitundu ina ya mutu waching'alang'ala ili ndi cholumikizira champhamvu kuposa china?
• Kodi kukhala ndi cholowa cha migraine kungakuthandizeni bwanji?
• Nthawi yoti muwonane ndi dokotala
• Kodi njira zamankhwala zodziwika bwino kwambiri ndi ziti?
• Mankhwala azizindikiro zoyipa za migraine
• Mankhwala omwe amaletsa mutu wa migraine
• Mankhwala ophatikiza
• Mfundo yofunika

Migraine ndi matenda amitsempha omwe amakhudza anthu pafupifupi 40 miliyoni ku United States.

Migraine kuukira nthawi zambiri kumachitika mbali imodzi ya mutu. Nthawi zina amatha kutsogozedwa kapena kutsagana ndi zosokoneza zowoneka kapena zotchedwa aura.

Zizindikiro zina, monga kunyansidwa, kusanza, komanso kutengeka pang'ono, zimatha kupezeka panthawi yamavuto a migraine.

Ngakhale kuti chifukwa chenicheni cha migraine sichidziwika, amakhulupirira kuti zonse zachilengedwe komanso majini zimathandizira. Pansipa, tiwona kulumikizana kwapakati pa migraine ndi majini.

Kodi mutu waching'alang'ala ungakhale wachibadwa?

DNA yanu, yomwe imakhala ndi majini anu, ili m'magulu 23 a ma chromosomes. Mumalandira ma chromosomes kuchokera kwa amayi anu ndipo enawo kuchokera kwa abambo anu.

Jini ndi gawo la DNA lomwe limafotokoza momwe mungapangire mapuloteni osiyanasiyana mthupi lanu.

Nthawi zina majini amatha kusintha, ndipo kusintha kumeneku kumatha kuyambitsa kapena kupangitsa munthu kudwala. Kusintha kwamtunduwu kumatha kupitilizidwa kuchokera kwa kholo kupita kwa mwana.

Kusintha kwa majini kapena kusiyanasiyana kumalumikizidwa ndi migraine. M'malo mwake, akuti anthu opitilira theka omwe ali ndi mutu waching'alang'ala ali ndi wachibale wawo mmodzi yemwe ali ndi vutoli.

Kodi kafukufukuyu akuti chiyani?

Tiyeni titengeke mozama mu zomwe ofufuza akuphunzira zokhudza chibadwa ndi mutu waching'alang'ala.

Kusintha kwa majini komwe kumakhudzana ndi migraine

Mwinamwake mudamvapo za kafukufuku wina munkhani zakusintha kwamitundu yosiyanasiyana komwe kumalumikizidwa ndi migraine. Zitsanzo zina ndi izi:

• KCNK18. Jini imeneyi imayika puloteni yotchedwa TRESK, yomwe imalumikizidwa ndi njira zopweteka ndipo imapezeka m'malo amitsempha yokhudzana ndi migraine. Kusintha kwina mu KCNK18 wakhala akugwirizanitsidwa ndi migraine ndi aura.
• CKIdelta. Jini ili ndi enzyme yomwe imagwira ntchito zambiri mthupi, imodzi mwayo imalumikizidwa ndi nthawi yomwe mumagona. Malinga ndi kafukufuku wa 2013, masinthidwe ena mu CKIdelta anali okhudzana ndi migraine.

Kusiyanasiyana kwa Gene komwe kumakhudzana ndi migraine

Ndikofunika kunena kuti zambiri zomwe zimachitika ku migraine zimakhulupirira kuti ndi polygenic. Izi zikutanthauza kuti majini angapo amathandizira kutengera vutoli. Izi zikuwoneka kuti zikuchitika chifukwa cha kusiyanasiyana kwakanthawi kochepa komwe kumatchedwa single-nucleotide polymorphisms (SNPs).

Kafukufuku wa chibadwa adapeza malo opitilira 40 okhala ndi mitundu yosiyanasiyana yomwe imakhudzana ndi mitundu yodziwika ya migraine. Malo awa nthawi zambiri amalumikizidwa ndi zinthu monga ma cell ndi ma signature a mitsempha kapena ntchito yamitsempha (yotengera magazi).

Zokha, kusiyanaku kungakhale ndi zotsatira zochepa. Komabe, ambiri a iwo akadziunjikira, zimathandizira kukulitsa migraine.

Kafukufuku wa 2018 wamabanja 1,589 omwe ali ndi migraine adapeza "katundu" wowonjezera wamitundu iyi poyerekeza ndi anthu ambiri.

Zamoyo zosiyanasiyana zimawonekeranso kuti zimayambitsa migraine. Kukhala ndi mbiri yolimba ya migraine kumachulukitsa chiopsezo chanu chokhala ndi:

• migraine ndi aura
• migraine nthawi zambiri
• msinkhu woyambirira wa migraine
• masiku ambiri mukayenera kugwiritsa ntchito mankhwala a migraine

Kodi mitundu ina ya mutu waching'alang'ala ili ndi cholumikizira champhamvu kuposa china?

Mitundu ina ya migraine imakhala ndi chibadwa chodziwika bwino. Chitsanzo cha izi ndi banja la hemiplegic migraine (FHM). Chifukwa cha mgwirizanowu, FHM yaphunziridwa mozama pokhudzana ndi chibadwa cha migraine.

FHM ndi mtundu wa migraine wokhala ndi aura womwe umakhala ndi zaka zoyambirira kuposa mitundu ina ya migraine. Pamodzi ndi zizindikilo zina za aura, anthu omwe ali ndi FHM amakhalanso ndi dzanzi kapena kufooka mbali imodzi ya thupi.

Pali majini atatu osiyanasiyana omwe amadziwika kuti amalumikizidwa ndi FHM. Ali:

• CACNA1A
• ATP1A2
• SCN1A

Kusintha kwa chimodzi mwazinthu izi kumatha kukhudza ma cell amitsempha, omwe angayambitse migraine.

FHM idalandiridwa mwanjira yodziyimira payokha. Izi zikutanthauza kuti mumangofunikira mtundu umodzi wa jini losinthidwa kuti mukhale ndi vutoli.

Kodi kukhala ndi cholowa cha migraine kungakuthandizeni bwanji?

Zingamveke ngati zosagwirizana, koma kukhala ndi chibadwa cha migraine kungakhale kopindulitsa. Izi ndichifukwa choti mutha kulandira chidziwitso chofunikira komanso chithandizo kuchokera kwa abale anu omwe akumvetsetsa vutoli.

Zambiri kuchokera kwa abale anu zomwe zingakhale zothandiza pazochitika zanu za migraine ndi izi:

• zomwe zimayambitsa migraine
• zizindikiro zenizeni zomwe amakumana nazo
• mankhwala kapena mankhwala omwe amathandiza kuthana ndi matenda awo a migraine
• kaya matenda awo a migraine asintha pafupipafupi, mwamphamvu, kapena m'njira zina m'moyo wawo wonse
• msinkhu womwe adakumana ndi mutu waching'alang'ala

Nthawi yoti muwonane ndi dokotala

Ngati muli ndi zizindikiro zomwe zikugwirizana ndi mutu waching'alang'ala, pitani kukaonana ndi dokotala wanu. Zizindikiro za kuukira kwa migraine ndi monga:

• kupweteka kopweteka kapena kupweteka, nthawi zambiri mbali imodzi ya mutu wanu
• nseru ndi kusanza
• kuzindikira kwa kuwala
• kumvetsetsa kwa mawu
• Zizindikiro za aura, zomwe zimayambitsa matenda a migraine ndipo zingaphatikizepo:
  • powona kuwala kowala
  • kuvuta kuyankhula
  • kumverera kufooka kapena dzanzi mbali imodzi ya nkhope yanu kapena mwendo

Nthawi zina kupweteka kwa mutu kumatha kukhala chizindikiro chachipatala. Pitani kuchipatala msanga pamutu womwe:

• amabwera mwadzidzidzi ndipo ndiwowopsa
• zimachitika kutsatira kuvulala pamutu panu
• imachitika ndi zizindikilo monga khosi lolimba, chisokonezo, kapena dzanzi
• sichitha ndipo chimaipiraipira mukadzipereka

Kodi njira zamankhwala zodziwika bwino kwambiri ndi ziti?

Migraine nthawi zambiri imachiritsidwa ndi mankhwala. Pali mitundu iwiri ya mankhwala a migraine:

• omwe amachepetsa zizindikiro zoyipa za migraine
• zomwe zimathandiza kupewa migraine kuchitika

Palinso njira zina zophatikizira zomwe zingakhale zothandiza. Tidzafufuza mtundu uliwonse wamankhwala mwatsatanetsatane pansipa.

Mankhwala azizindikiro zoyipa za migraine

Nthawi zambiri mumamwa mankhwalawa mukangoyamba kumva zizindikiro za aura kapena migraine. Zitsanzo ndi izi:

• Mankhwala opweteka kwambiri. Izi zikuphatikiza ma NSAID monga ibuprofen (Advil, Motrin), naproxen (Aleve), ndi aspirin. Acetaminophen (Tylenol) itha kugwiritsidwanso ntchito.
• Zolemba. Pali mitundu yambiri ya ma triptan. Mankhwalawa amathandiza kutchinga ndi kutsekeka kwa mitsempha ya magazi, kuchepetsa ululu. Zitsanzo zina ndi sumatriptan (Imitrex), eletriptan (Relpax), ndi rizatriptan (Maxalt).
• Ma alkaloid opunduka. Mankhwalawa amagwira ntchito mofananamo ndi ma triptan. Angaperekedwe ngati mankhwala okhala ndi triptan sakuthandiza. Chitsanzo chimodzi ndi dihydroergotamine (Migranal).
• Achinyamata. Mtundu watsopanowu wa mankhwala a migraine umatseka peptide yomwe imathandizira kutupa.
• Ndirangu Banja lachilendo la mankhwala opulumutsa, maenje ndi ofanana ndi ma triptan koma atha kugwiritsidwa ntchito kwa anthu omwe ali ndi mbiri yakukhala ndi vuto la mtima komanso kupwetekedwa mtima, chifukwa ma triptan amatha kuonjezera mavuto amtima.

Mankhwala omwe amaletsa mutu wa migraine

Dokotala wanu akhoza kukupatsani mankhwala awa ngati mwayamba kukumana ndi mutu waching'alang'ala. Zitsanzo zina ndi izi:

• Ma anticonvulsants. Mankhwalawa adapangidwa koyambirira kuti athandizire kukomoka. Zitsanzo ndi topiramate (Topamax) ndi valproate.
• Mankhwala a magazi. Izi zitha kuphatikizira beta-blockers kapena calcium channel blockers.
• Mankhwala opatsirana pogonana. Amitriptyline, tricyclic antidepressant, itha kugwiritsidwa ntchito.
• CGRP zoletsa. Awa ndi mtundu watsopano wa mankhwala operekedwa ndi jakisoni. Ndi ma antibodies omwe amamangirira cholandirira muubongo chomwe chimalimbikitsa kupuma kwa magazi (kukulira kwa mitsempha yamagazi).
• Botox jakisoni. Kulandila jakisoni wa Botox pakatha milungu 12 ingathandize kupewa matenda a migraine mwa anthu ena achikulire.

Mankhwala ophatikiza

Palinso mankhwala osiyanasiyana ophatikizika omwe atha kukhala othandiza kwa migraine, monga:

• Njira zopumulira. Kupsinjika ndi komwe kumayambitsa migraine. Njira zopumulira zingakuthandizeni kuti muchepetse nkhawa zanu. Zitsanzo zake ndi yoga, kusinkhasinkha, kupumira, komanso kupumula kwa minofu.
• Kutema mphini. Kutema mphini kumaphatikizira kuyika singano zoonda paziwopsezo pakhungu. Izi zimaganiziridwa kuti zithandizira kubwezeretsa mphamvu m'thupi. Zingakhale zothandiza kuthetsa ululu wa migraine.
• Zitsamba, mavitamini, ndi mchere. Zitsamba zina ndi zowonjezera zimatha kuthandizira zizindikiritso za migraine. Zitsanzo zochepa ndi monga butterbur, magnesium, ndi vitamini B-2.

Mfundo yofunika

Ngakhale ofufuza adazindikira zomwe zingayambitse migraine, pakadalibe zambiri zomwe sizikudziwika.

Komabe, kuchokera ku kafukufuku yemwe wachitika, zikuwoneka kuti ndizovuta kuphatikiza zachilengedwe ndi majini zimayambitsa vutoli.

Kusintha kwa majini amtundu wina kumalumikizidwa ndi mitundu ina ya migraine, monga momwe zimakhalira ndi achibale a hemiplegic migraine. Komabe, mitundu yambiri ya migraine ndiyotheka kukhala polygenic, kutanthauza kuti kusiyanasiyana kwamitundu yambiri kumayambitsa.

Kukhala ndi mbiri yakubadwa kwa mutu waching'alang'ala kungakhale kopindulitsa chifukwa mutha kupeza chidziwitso chofunikira kuchokera kwa abale omwe akukumana ndi vuto lomweli. Mwinanso mungayankhe mankhwala omwewo.

Ngati muli ndi zizindikiro za migraine zomwe zimapangitsa kuti musavutike tsiku lonse, pitani kuchipatala kuti akambirane zomwe mungachite.