Cinqair (reslizumab)

Zamkati

• Cinqair ndi chiyani?
• Kuchita bwino
• Cinqair generic kapena biosimilar
• Mtengo wa Cinqair
• Thandizo lazachuma komanso inshuwaransi
• Zotsatira za Cinqair
• Zotsatira zofala kwambiri
• Zotsatira zoyipa
• Zotsatira zoyipa
• Mlingo wa Cinqair
• Mitundu ya mankhwala ndi mphamvu
• Mlingo wa mphumu
• Ndingatani ngati ndaphonya mlingo?
• Kodi ndiyenera kugwiritsa ntchito mankhwalawa nthawi yayitali?
• Cinqair ya mphumu
• Kugwiritsa ntchito Cinqair ndi mankhwala ena
• Njira Zina ku Cinqair
• Cinqair vs. Nucala
• Ntchito
• Mafomu azamankhwala ndi makonzedwe
• Zotsatira zoyipa ndi zoopsa
• Kuchita bwino
• Mtengo
• Cinqair vs. Fasenra
• Ntchito
• Mafomu azamankhwala ndi makonzedwe
• Zotsatira zoyipa ndi zoopsa
• Kuchita bwino
• Mtengo
• Cinqair ndi mowa
• Zochita za Cinqair
• Momwe Cinqair amaperekedwera
• Mungapeze liti Cinqair
• Momwe Cinqair amagwirira ntchito
• Kodi Cinqair amatani?
• Zimatenga nthawi yayitali bwanji kuti zigwire ntchito?
• Cinqair ndi mimba
• Cinqair ndi kuyamwitsa
• Mafunso wamba okhudza Cinqair
• Kodi Cinqair ndi mankhwala osokoneza bongo?
• Chifukwa chiyani Cinqair samabwera ngati inhaler kapena piritsi?
• Chifukwa chiyani sindingapeze Cinqair ku pharmacy?
• Kodi ana angagwiritse ntchito Cinqair?
• Kodi ndifunikirabe kumwa corticosteroid ndi Cinqair?
• Kodi ndifunikirabe kukhala ndi inhaler yopulumutsa ndi ine?
• Zodzitetezera ku Cinqair
• Chenjezo la FDA: Anaphylaxis
• Machenjezo ena
• Zambiri zamakinala pa Cinqair
• Zisonyezero
• Njira yogwirira ntchito
• Pharmacokinetics ndi metabolism
• Zotsutsana
• Yosungirako

Cinqair ndi chiyani?

Cinqair ndi mankhwala omwe amadziwika kuti ndi mankhwala. Amagwiritsidwa ntchito pochizira mphumu yoopsa ya eosinophilic mwa akuluakulu. Ndi mphumu yamtunduwu, mumakhala ndi ma eosinophil (mtundu wamaselo oyera). Mutenga Cinqair kuwonjezera pa mankhwala ena a mphumu. Cinqair sagwiritsidwa ntchito pochizira mphumu.

Cinqair ili ndi reslizumab, womwe ndi mtundu wa mankhwala omwe amatchedwa biologic. Biologics imapangidwa kuchokera kumaselo osati kuchokera kumankhwala.

Cinqair ndi gawo limodzi la mankhwala omwe amatchedwa interleukin-5 antagonist monoclonal antibodies (IgG4 kappa). Gulu la mankhwala ndi gulu la mankhwala omwe amagwiranso ntchito chimodzimodzi.

Wothandizira zaumoyo adzakupatsani Cinqair ngati kulowetsedwa kwa intravenous (IV) muofesi ya dokotala kapena kuchipatala. Ichi ndi jakisoni mumtsempha wanu womwe umadontha pang'onopang'ono pakapita nthawi. Ma infusions a Cinqair nthawi zambiri amatenga mphindi 20 mpaka 50.

Kuchita bwino

Cinqair yapezeka kuti ndi yothandiza pochiza mphumu yayikulu ya eosinophilic.

M'maphunziro awiri azachipatala, 62% ndi 75% ya anthu omwe adalandira Cinqair chifukwa cha mphumu yayikulu ya eosinophilic analibe mphumu. Koma ndi 46% ndi 55% yokha mwa anthu omwe adatenga maloboti (popanda chithandizo) omwe sanakhale ndi vuto la mphumu. Anthu onse amathandizidwa ndi Cinqair kapena placebo kwa milungu 52. Komanso, anthu ambiri anali kumwa ma corticosteroids ndi beta-agonists panthawi yophunzira.

Cinqair generic kapena biosimilar

Cinqair imangopezeka ngati mankhwala odziwika ndi dzina. Lili ndi mankhwala yogwira reslizumab.

Cinqair sikupezeka pakadali pano mu fomu ya biosimilar.

Biosimilar ndi mankhwala omwe amafanana ndi mankhwala omwe amadziwika ndi dzina. Mankhwala achibadwa, kumbali inayo, ndi mtundu wofanana wa mankhwala omwe amadziwika ndi dzina. Biosimilars amachokera ku mankhwala a biologic, omwe amapangidwa kuchokera kuzinthu zamoyo. Zodzoladzola zimadalira mankhwala omwe amapangidwa kuchokera ku mankhwala.

Biosimilars ndi generic zonse ndizotetezeka komanso zothandiza monga mankhwala omwe amadziwika kuti ndiotengera. Komanso, amakhala otsika mtengo poyerekeza ndi mankhwala omwe amadziwika ndi dzina.

Mtengo wa Cinqair

Monga mankhwala onse, mtengo wa Cinqair umasiyana. Wothandizira zaumoyo adzakupatsani mankhwalawa ngati kulowetsedwa kwa intravenous (IV) kuofesi yanu kapena kuchipatala. Mtengo womwe mumalipira pakulowetsedwa kwanu udalira dongosolo lanu la inshuwaransi komanso komwe mumalandila chithandizo. Cinqair sikupezeka kuti mugule ku malo ogulitsa mankhwala.

Thandizo lazachuma komanso inshuwaransi

Ngati mukufuna thandizo lazachuma kuti mulipire Cinqair, kapena ngati mukufuna thandizo kuti mumvetsetse inshuwaransi yanu, thandizo lilipo.

Teva Respiratory, LLC, wopanga Cinqair, amapereka Teva Support Solutions. Kuti mumve zambiri komanso kuti mudziwe ngati mukuyenera kuthandizidwa, imbani 844-838-2211 kapena pitani patsamba lino.

Zotsatira za Cinqair

Cinqair imatha kuyambitsa zovuta zochepa kapena zoyipa. Mndandanda wotsatira uli ndi zovuta zina zomwe zingachitike mukalandira Cinqair. Mndandandawu mulibe zovuta zonse zomwe zingachitike.

Kuti mumve zambiri pazomwe zingachitike chifukwa cha Cinqair, lankhulani ndi dokotala kapena wamankhwala. Amatha kukupatsirani malangizo amomwe mungathetsere mavuto omwe angakhale ovuta.

Zotsatira zofala kwambiri

Zotsatira zoyipa kwambiri za Cinqair ndi ululu wam'mimba. Uku ndikumva kuwawa m'khosi mwako komwe kuli kuseri kwa kamwa yako. M'maphunziro azachipatala, 2.6% ya anthu omwe adatenga Cinqair anali ndi ululu wam'mimba. Izi zidafanizidwa ndi 2.2% ya anthu omwe adatenga maloboti (popanda chithandizo).

Kupweteka kwa m'mimba kumatha kutha masiku angapo kapena milungu ingapo. Ngati kupweteka kukukulira kapena sikutha, lankhulani ndi dokotala kapena wamankhwala. Amatha kunena zamankhwala kuti akuthandizeni kumva bwino.

Zotsatira zoyipa

Zotsatira zoyipa zochokera ku Cinqair sizodziwika, koma zimatha kuchitika. Itanani dokotala wanu nthawi yomweyo ngati muli ndi zovuta zina. Itanani 911 ngati zizindikiro zanu zikuwopseza moyo kapena ngati mukuganiza kuti mukukumana ndi vuto lachipatala.

Zotsatira zoyipa komanso zizindikilo zake zimatha kukhala izi:

• Anaphylaxis * (mtundu wa zovuta zomwe zimachitika). Zizindikiro zimatha kuphatikiza:
  • kuvuta kupuma, kuphatikiza kutsokomola ndi kupuma
  • vuto kumeza
  • kutupa kumaso, mkamwa, kapena mmero
  • kugunda pang'onopang'ono
  • mantha a anaphylactic (kugwa mwadzidzidzi kwa kuthamanga kwa magazi komanso kupuma movutikira)
  • zidzolo
  • khungu loyabwa
  • mawu osalankhula
  • kupweteka m'mimba (m'mimba)
  • nseru
  • chisokonezo
  • nkhawa
• Khansa. Zizindikiro zimatha kuphatikiza:
  • kusintha m'thupi lanu (mitundu yosiyana, kapangidwe kake, kutupa, kapena zotupa m'mawere anu, chikhodzodzo, matumbo, kapena khungu)
  • kupweteka mutu
  • kugwidwa
  • masomphenya kapena vuto lakumva
  • weramira mbali imodzi ya nkhope yako
  • kutuluka magazi kapena kuphwanya
  • chifuwa
  • kusintha kwa njala
  • kutopa (kusowa mphamvu)
  • malungo
  • kutupa kapena zotupa
  • kunenepa kapena kuonda

Zotsatira zoyipa

Mutha kudabwa kuti zovuta zina zimachitika kangati ndi mankhwalawa. Nazi zina mwazomwe zingayambitse mankhwalawa.

Matupi awo sagwirizana

Monga mankhwala ambiri, anthu ena amatha kusokonezeka atalandira Cinqair. Zizindikiro za kuchepa pang'ono zimatha kuphatikiza:

• zotupa pakhungu
• kuyabwa
• Kutentha (kutentha ndi kufiira pakhungu lanu)

Sizikudziwika kuti ndi anthu angati omwe anayamba kudwala atalandira Cinqair.

Zomwe zimayambitsa matendawa zimakhala zochepa koma ndizotheka. Amatchedwa anaphylaxis (onani m'munsimu).

Anaphylaxis

Pomwe akulandira Cinqair, anthu ena amatha kukhala ndi vuto lodana ndi matenda lotchedwa anaphylaxis. Izi ndizovuta ndipo zitha kupha moyo. M'maphunziro azachipatala, 0.3% ya anthu omwe adalandira Cinqair adayamba anaphylaxis.

Chitetezo chanu cha mthupi chimateteza thupi lanu ku zinthu zomwe zingayambitse matenda. Koma nthawi zina thupi lako limasokonezeka komanso kumenyana ndi zinthu zomwe sizimayambitsa matenda. Kwa anthu ena, chitetezo cha mthupi chawo chimagwiritsa ntchito Cinqair. Izi zitha kubweretsa anaphylaxis.

Zizindikiro za anaphylaxis zitha kuphatikiza:

• kutupa pansi pa khungu lanu, makamaka m'makope anu, milomo, manja, kapena mapazi
• kutupa lilime, pakamwa, kapena pakhosi
• kuvuta kupuma

Anaphylaxis imatha kuchitika mutangomaliza kumwa Cinqair, chifukwa chake ndikofunikira kuti zomwe zimayendetsedwa nthawi yomweyo.

Ichi ndichifukwa chake wothandizira zaumoyo wanu adzakuwunikirani kwa maola angapo mutalandira Cinqair. Mukakhala ndi zizindikiro za anaphylaxis, wothandizira zaumoyo wanu adzakuthandizani nthawi yomweyo. Adziwitsanso dokotala wanu.

Ngati dokotala akufuna kuti musiye kugwiritsa ntchito Cinqair, atha kukulangizani za mankhwala ena.

Anaphylactic reaction nthawi zina imatha kuyambitsa biphasic anaphylaxis. Uku ndikuukira kwachiwiri kwa anaphylaxis. Biphasic anaphylaxis imatha kuchitika patatha masiku angapo kuchokera pomwe kuukira koyamba. Ngati muli ndi anaphylactic reaction, wothandizira zaumoyo wanu angafune kukuwunikirani. Afuna kuwonetsetsa kuti simukupanga biphasic anaphylaxis.

Zizindikiro za biphasic anaphylaxis zitha kuphatikiza:

• khungu lomwe limayabwa, lofiira, kapena lili ndi ming'oma (kuyabwa kwanyengo)
• nkhope yotupa ndi lilime
• kuvuta kupuma
• kupweteka m'mimba (m'mimba)
• kusanza
• kutsegula m'mimba
• kuthamanga kwa magazi
• kutaya chidziwitso (kukomoka)
• mantha a anaphylactic (kugwa mwadzidzidzi kwa kuthamanga kwa magazi komanso kupuma movutikira)

Ngati simukukhala kuchipatala ndipo mukuganiza kuti muli ndi anaphylactic kapena biphasic reaction ku Cinqair, itanani 911 nthawi yomweyo. Mukalandira mankhwalawa, auzeni dokotala wanu. Angakulimbikitseni mankhwala osiyana siyana a mphumu.

Khansa

Mankhwala ena amatha kupangitsa kuti maselo anu azikula kukula kapena kuchuluka ndikukhala ndi khansa. Nthawi zina ma cell omwe ali ndi khansa amasunthira kumatumba osiyanasiyana mthupi lanu. Mitunduyi imatchedwa zotupa.

M'maphunziro azachipatala, 0.6% ya anthu omwe adalandira Cinqair adapanga zotupa zomwe zimapangidwa m'malo osiyanasiyana amthupi. Ambiri mwa anthuwa amapezeka kuti ali ndi zotupa pakadutsa miyezi isanu ndi umodzi kuchokera pomwe adalandira Cinqair. Izi zimafanizidwa ndi anthu 0,3% omwe adatenga placebo (palibe chithandizo).

Mukawona zizindikiro zilizonse za zotupa zomwe sizimatha, uzani dokotala wanu. (Onani gawo la "Zotsatira zoyipa" pamwambapa kuti muwone mndandanda wazizindikiro.) Mungafunike kuyesedwa kuti muthandize dokotala kudziwa zambiri za zotupa. Dokotala wanu angakulimbikitseninso mankhwala osiyanasiyana a mphumu.

Mlingo wa Cinqair

Mlingo wa Cinqair omwe dokotala wanu akukulemberani umadalira kulemera kwanu.

Chidziwitso chotsatirachi chimalongosola miyezo yomwe amagwiritsidwa ntchito kwambiri kapena amalimbikitsidwa. Komabe, wothandizira zaumoyo wanu akhoza kukupatsani ina ngati atakulangizani ndi dokotala kuti muchite izi. Dokotala wanu adzazindikira mlingo woyenera kuti ugwirizane ndi zosowa zanu.

Mitundu ya mankhwala ndi mphamvu

Cinqair imabwera mumtsuko wa 10-mL. Mbale iliyonse imakhala ndi 100 mg ya reslizumab. Wothandizira zaumoyo wanu adzakupatsani yankho ngati kulowetsedwa m'mitsempha (IV). Ichi ndi jakisoni mumtsempha wanu womwe umadontha pang'onopang'ono pakapita nthawi. Ma infusions a Cinqair nthawi zambiri amatenga mphindi 20 mpaka 50.

Mlingo wa mphumu

Cinqair imaperekedwa muyezo wa 3 mg / kg, kamodzi pakatha milungu inayi iliyonse.

Kuchuluka kwa Cinqair komwe mudzalandire kumadalira kuchuluka kwanu. Mwachitsanzo, 150-lb. munthu amalemera pafupifupi 68 kg. Ngati dokotalayo akupatsani 3 mg / kg ya Cinqair kamodzi pakatha milungu inayi, mlingo wa Cinqair udzakhala 204 mg pomulowetsa (68 x 3 = 204).

Ndingatani ngati ndaphonya mlingo?

Ngati mwaphonya nthawi yoti mudzalandire Cinqair, itanani foni yanu posachedwa. Amatha kukonza nthawi yatsopano yodzisankhira ndikusintha nthawi yakuchezera kwina ngati kuli kofunikira.

Ndibwino kuti mulembe ndandanda yanu yamankhwala pakalendala. Muthanso kukhazikitsa chikumbutso pafoni yanu kuti musaphonye nthawi yokumana.

Kodi ndiyenera kugwiritsa ntchito mankhwalawa nthawi yayitali?

Cinqair amayenera kugwiritsidwa ntchito ngati chithandizo chanthawi yayitali cha mphumu yoopsa ya eosinophilic. Ngati inu ndi adotolo mumazindikira kuti Cinqair ndiyotetezeka komanso yothandiza kwa inu, mutha kuyigwiritsa ntchito kwa nthawi yayitali.

Cinqair ya mphumu

Food and Drug Administration (FDA) imavomereza mankhwala akuchipatala monga Cinqair kuti athetse mavuto ena. Cinqair imavomerezedwa kuti ichiritse mphumu yayikulu mwa akulu. Mankhwalawa savomerezedwa kuti athetse mitundu ina ya mphumu. Komanso, Cinqair sivomerezeka kuti athetse mphumu.

Mutenga Cinqair kuwonjezera pa chithandizo chanu cha mphumu.

Pakafukufuku wazachipatala, Cinqair idaperekedwa kwa anthu 245 omwe ali ndi mphumu yoopsa ya eosinophilic kwa milungu 52. Mu gululi, anthu 62% analibe vuto la mphumu nthawi imeneyo. Izi zikuyerekeza ndi 46% ya anthu omwe adalandira malowa (palibe chithandizo). Mwa iwo omwe anali ndi vuto la mphumu:

• Anthu omwe adalandira Cinqair anali ndi 50% yotsika pang'ono mchaka chimodzi kuposa anthu omwe adalandira malowa.
• Anthu omwe adalandira Cinqair anali ndi 55% yotsika pang'ono yomwe imafunikira kugwiritsa ntchito corticosteroids kuposa anthu omwe adalandira malowa.
• Anthu omwe adalandira Cinqair anali ndi 34% yotsika pang'ono yomwe idapangitsa kuti azikhala mchipatala kuposa anthu omwe adalandira malowa.

Pakafukufuku wina wazachipatala, Cinqair idaperekedwa kwa anthu 232 omwe ali ndi mphumu yoopsa ya eosinophilic kwa milungu 52. Mu gululi, 75% ya anthu adalibe mphumu nthawi imeneyo. Izi zikuyerekeza ndi 55% ya anthu omwe adalandira malowa (palibe chithandizo). Mwa iwo omwe anali ndi vuto la mphumu:

• Anthu omwe adalandira Cinqair anali ndi zolakwika zochepa pa 59% kuposa anthu omwe adalandira malowa.
• Anthu omwe adalandira Cinqair anali ndi 61% yotsika pang'ono ya ma flare-ups omwe amafunikira corticosteroids kuposa anthu omwe adalandira malowa.
• Anthu omwe adalandira Cinqair anali ndi 31% yotsika yamoto zomwe zidapangitsa kuti azikhala mchipatala kuposa anthu omwe adalandira malowa.

Kugwiritsa ntchito Cinqair ndi mankhwala ena

Mukuyenera kuti mugwiritse ntchito Cinqair limodzi ndi mankhwala anu a mphumu. Zitsanzo za mankhwala omwe angagwiritsidwe ntchito ndi Cinqair kuchiza mphumu yayikulu ndi awa:

• Mpweya ndi corticosteroids wamlomo. Chomwe chimagwiritsidwa ntchito kwambiri pa mphumu yoopsa ndi awa:
  • beclomethasone dipropionate (Qvar Redihaler)
  • budesonide (Pulmicort Flexhaler)
  • Ciclesonide (Alvesco)
  • fluticasone propionate (ArmonAir RespiClick, Arnuity Ellipta, Flovent Diskus, Flovent HFA)
  • mometasone furoate (Asmanex HFA, Asmanex Twisthaler)
  • prednisone (Rayos)
• Beta-adrenergic bronchodilators. Chomwe chimagwiritsidwa ntchito kwambiri pa mphumu yoopsa ndi awa:
  • salmeterol (Serevent)
  • mawonekedwe (Foradil)
  • albuterol (ProAir HFA, ProAir RespiClick, Proventil HFA, Ventolin HFA)
  • levalbuterol (Xopenex, Xopenex HFA)
• Zosintha njira za Leukotriene. Chomwe chimagwiritsidwa ntchito kwambiri pa mphumu yoopsa ndi awa:
  • montelukast (Singulair)
  • zafirlukast (Zolondola)
  • zileuton (Zyflo)
• Muscarinic blockers, mtundu wa anticholinergic. Chomwe chimagwiritsidwa ntchito kwambiri pa mphumu yoopsa ndi awa:
  • tiotropium bromide (Spiriva Kuyankha)
  • ipratropium
• Theophylline

Ambiri mwa mankhwalawa amabweranso ngati mankhwala osakanikirana. Mwachitsanzo, Symbicort (budesonide ndi formoterol) ndi Advair Diskus (fluticasone ndi salmeterol).

Mtundu wina wamankhwala womwe muyenera kupitiriza kugwiritsa ntchito ndi Cinqair ndi chida chopulumutsa. Ngakhale kuti Cinqair imagwira ntchito popewa kuwonongeka kwa mphumu, mutha kukhalabe ndi vuto la mphumu. Izi zikachitika, muyenera kugwiritsa ntchito yopulumutsa inhaler kuti muchepetse mphumu yanu nthawi yomweyo. Onetsetsani kuti mukunyamula inhaler yanu yopulumutsa nthawi zonse.

Ngati mukugwiritsa ntchito Cinqair, osasiya kumwa mankhwala ena a mphumu pokhapokha dokotala atakuwuzani. Ndipo ngati muli ndi mafunso okhudza kuchuluka kwa mankhwala omwe mumamwa, funsani dokotala wanu.

Njira Zina ku Cinqair

Mankhwala ena alipo omwe angachiritse mphumu yoopsa ya eosinophilic. Ena akhoza kukuyenererani kuposa ena. Ngati mukufuna kupeza njira ina kuposa Cinqair, lankhulani ndi dokotala wanu. Amatha kukuwuzani zamankhwala ena omwe atha kukuthandizani.

Zitsanzo za mankhwala ena omwe angagwiritsidwe ntchito pochizira mphumu yayikulu ndi awa:

• mepolizumab (Nucala)
• benralizumab (Fasenra)
• omalizumab (Xolair)
• dupilumab (Wophunzira)

Cinqair vs. Nucala

Mutha kudabwa momwe Cinqair amafananira ndi mankhwala ena omwe amaperekedwa kuti agwiritsidwe ntchito mofananamo. Apa tikuwona momwe Cinqair ndi Nucala alili ofanana komanso osiyana.

Ntchito

Food and Drug Administration (FDA) yavomereza Cinqair ndi Nucala kuti athetse mphumu yoopsa kwa akulu. Nucala amavomerezedwanso kuti athetse mphumu yoopsa kwa ana azaka zapakati pa 12 mpaka 18. Mankhwala onsewa amagwiritsidwa ntchito limodzi ndi mankhwala ena a mphumu omwe mumamwa.

Kuphatikiza apo, Nucala amaloledwa kuchiza matenda osowa omwe amatchedwa eosinophilic granulomatosis ndi polyangiitis (EGPA). Matendawa amadziwikanso kuti Churg-Strauss syndrome, ndipo amachititsa kuti mitsempha yanu yam'mimba iyambe kutupa.

Cinqair ndi Nucala ali mgulu la mankhwala omwe amatchedwa interleukin-5 antagonist monoclonal antibody. Gulu la mankhwala ndi gulu la mankhwala omwe amagwiranso ntchito chimodzimodzi.

Mafomu azamankhwala ndi makonzedwe

Cinqair ili ndi mankhwala osokoneza bongo a reslizumab. Nucala ili ndi mankhwala osokoneza bongo mepolizumab.

Cinqair amabwera mu mbale. Wothandizira zaumoyo wanu adzakupatsani yankho ngati jakisoni mumitsempha yanu (kulowetsedwa mkati). Ma infusions a Cinqair nthawi zambiri amatenga mphindi 20 mpaka 50.

Nucala amabwera m'njira zitatu:

• Mlingo umodzi wa ufa. Wothandizira zaumoyo wanu adzasakaniza ufa ndi madzi osabereka. Kenako akupatsani yankho ngati jakisoni pansi pa khungu lanu (jakisoni wocheperako).
• Cholembera chimodzi chodzipangira cholembera. Wopereka chithandizo chazaumoyo wanu akuphunzitsani kaye momwe mungagwiritsire ntchito cholembera. Kenako mutha kudzipatsa jakisoni pakhungu lanu.
• Mlingo umodzi wokhala ndi syringe imodzi. Wopereka chithandizo chamankhwala ayamba kukuphunzitsani momwe mungagwiritsire ntchito jakisoni. Kenako mutha kudzipatsa jakisoni pakhungu lanu.

Cinqair imaperekedwa muyezo wa 3 mg / kg, kamodzi pakatha milungu inayi iliyonse. Kuchuluka kwa mankhwala omwe mumalandira kumadalira kuchuluka kwa kulemera kwanu.

Mlingo woyenera wa Nucala wa mphumu ndi 100 mg, kamodzi milungu inayi iliyonse.

Zotsatira zoyipa ndi zoopsa

Cinqair ndi Nucala onse ali mgulu limodzi la mankhwala osokoneza bongo, motero amagwira ntchito chimodzimodzi. Mankhwala awiriwa amatha kuyambitsa zovuta zina kapena zofanana. M'munsimu muli zitsanzo za zotsatirazi.

Zotsatira zofala kwambiri

Mndandandawu uli ndi zitsanzo za zovuta zomwe zimachitika ndi Cinqair kapena Nucala.

• Zitha kuchitika ndi Cinqair:
  • kupweteka kwa oropharyngeal (kupweteka kwa khosi lanu komwe kuli m'kamwa mwanu)
• Zitha kuchitika ndi Nucala:
  • mutu
  • kupweteka kwa msana
  • kutopa (kusowa mphamvu)
  • zotupa pakhungu pamalo a jakisoni, kuphatikiza kupweteka, kufiira, kutupa, kuyabwa, kumva kutentha

Zotsatira zoyipa

Mndandandawu uli ndi zitsanzo za zovuta zoyipa zomwe zingachitike ndi Cinqair, ndi Nucala, kapena mankhwala onsewa (akaperekedwa payekhapayekha).

• Zitha kuchitika ndi Cinqair:
  • zotupa
• Zitha kuchitika ndi Nucala:
  • matenda a herpes zoster (ming'alu)
• Zitha kuchitika ndi Cinqair ndi Nucala:
  • kusintha kwakukulu, kuphatikizapo anaphylaxis *

Kuchita bwino

Cinqair ndi Nucala onse amagwiritsidwa ntchito pochizira mphumu yoopsa ya eosinophilic.

Mankhwalawa sanayerekezeredwe mwachindunji m'maphunziro azachipatala, koma kuwunikanso kwa kafukufukuyu kunapeza kuti Cinqair ndi Nucala ndizothandiza pakuchepetsa ziwopsezo za mphumu.

Mtengo

Cinqair ndi Nucala onse ndi mankhwala osokoneza bongo. Pakadali pano palibe mitundu ya mankhwala osokoneza bongo.

Biosimilar ndi mankhwala omwe amafanana ndi mankhwala omwe amadziwika ndi dzina. Mankhwala achibadwa, kumbali inayo, ndi mtundu wofanana wa mankhwala omwe amadziwika ndi dzina. Biosimilars amachokera ku mankhwala a biologic, omwe amapangidwa kuchokera kuzinthu zamoyo. Zodzoladzola zimadalira mankhwala omwe amapangidwa kuchokera ku mankhwala. Biosimilars ndi generic zonse ndizotetezeka komanso zothandiza monga mankhwala omwe akuyesera kutengera. Komanso, amakhala otsika mtengo poyerekeza ndi mankhwala omwe amadziwika ndi dzina.

Malinga ndi kuyerekezera kwa WellRx.com, Cinqair nthawi zambiri amawononga ndalama zochepa kuposa Nucala. Mtengo weniweni womwe mudzalipire mankhwalawa umadalira dongosolo lanu la inshuwaransi komanso komwe muli.

Cinqair vs. Fasenra

Kuphatikiza pa Nucala (pamwambapa), Fasenra ndi mankhwala ena omwe amagwiritsanso ntchito ngati Cinqair. Apa tikuwona momwe Cinqair ndi Fasenra alili ofanana komanso osiyana.

Ntchito

Food and Drug Administration (FDA) yavomereza onse a Cinqair ndi Fasenra kuti athe kuchiza mphumu yayikulu mwa akulu. Fasenra imavomerezanso kuchiza mphumu yayikulu mu ana azaka zapakati pa 12 mpaka 18. Mankhwala onsewa amagwiritsidwa ntchito limodzi ndi mankhwala ena a mphumu omwe mumamwa.

Onse a Cinqair ndi Fasenra ali mgulu la mankhwala otchedwa interleukin-5 antagonist monoclonal antibodies. Gulu la mankhwala ndi gulu la mankhwala omwe amagwiranso ntchito chimodzimodzi.

Mafomu azamankhwala ndi makonzedwe

Cinqair ili ndi mankhwala osokoneza bongo a reslizumab. Fasenra ili ndi mankhwala osokoneza bongo a benralizumab.

Cinqair imabwera mumtsuko. Wothandizira zaumoyo wanu adzakupatsani yankho ngati jakisoni mumitsempha yanu (kulowetsedwa mkati). Ma infusions a Cinqair nthawi zambiri amatenga mphindi 20 mpaka 50.

Fasenra amabwera mu syringe yoyikidwa kale. Wopereka chithandizo chamankhwala amakupatsani mankhwalawa ngati jakisoni pansi pa khungu lanu (jakisoni wocheperako).

Cinqair imaperekedwa muyezo wa 3 mg / kg, kamodzi pakatha milungu inayi iliyonse. Kuchuluka kwa mankhwala omwe mumalandira kumadalira kuchuluka kwa kulemera kwanu.

Pazigawo zitatu zoyambirira za Fasenra, mudzalandira 30 mg kamodzi pakatha milungu inayi. Pambuyo pake, mudzalandira 30 mg ya Fasenra kamodzi pamasabata asanu ndi atatu.

Zotsatira zoyipa ndi zoopsa

Cinqair ndi Fasenra onse ali mgulu limodzi la mankhwala, chifukwa chake amagwiranso ntchito chimodzimodzi. Mankhwala awiriwa amatha kuyambitsa zovuta zina kapena zofanana. M'munsimu muli zitsanzo za zotsatirazi.

Zotsatira zofala kwambiri

Mndandandawu muli zitsanzo za zovuta zoyipa zomwe zingachitike ndi Cinqair kapena Fasenra.

• Zitha kuchitika ndi Cinqair:
  • kupweteka kwa oropharyngeal (kupweteka kwa khosi lanu komwe kuli m'kamwa mwanu)
• Zitha kuchitika ndi Fasenra:
  • mutu
  • chikhure

Zotsatira zoyipa

Mndandandawu muli zitsanzo za zovuta zoyipa zomwe zingachitike ndi Cinqair, ndi Fasenra, kapena ndi mankhwala onsewa (akaperekedwa payekhapayekha).

• Zitha kuchitika ndi Cinqair:
  • zotupa
• Zitha kuchitika ndi Fasenra:
  • zotsatira zochepa wamba wamba
• Zitha kuchitika ndi Cinqair ndi Fasenra:
  • kusintha kwakukulu, kuphatikizapo anaphylaxis *

Kuchita bwino

Cinqair ndi Fasenra onse amagwiritsidwa ntchito pochizira mphumu yoopsa ya eosinophilic.

Mankhwalawa sanafanane mwachindunji m'maphunziro azachipatala. Koma kuwunikanso kwa kafukufuku yemwe adapeza kuti Cinqair ndi yothandiza kwambiri popewa kuwuka kwa mphumu kuposa Fasenra.

Mtengo

Cinqair ndi Fasenra onse ndi mankhwala osokoneza bongo. Pakadali pano palibe mitundu ya mankhwala osokoneza bongo.

Biosimilar ndi mankhwala omwe amafanana ndi mankhwala omwe amadziwika ndi dzina. Mankhwala achibadwa, kumbali inayo, ndi mtundu wofanana wa mankhwala omwe amadziwika ndi dzina. Biosimilars amachokera ku mankhwala a biologic, omwe amapangidwa kuchokera kuzinthu zamoyo. Zodzoladzola zimadalira mankhwala omwe amapangidwa kuchokera ku mankhwala. Biosimilars ndi generic zonse ndizotetezeka komanso zothandiza monga mankhwala omwe akuyesera kutengera. Komanso, amakhala otsika mtengo poyerekeza ndi mankhwala omwe amadziwika ndi dzina.

Malinga ndi kuyerekezera kwa WellRx.com, Cinqair nthawi zambiri imakhala yotsika mtengo kuposa Fasenra. Mtengo weniweni womwe mudzalipire mankhwalawa umadalira dongosolo lanu la inshuwaransi komanso komwe muli.

Cinqair ndi mowa

Palibe zochitika zilizonse zodziwika pakati pa Cinqair ndi mowa panthawiyi. Koma anthu ena omwe ali ndi mphumu amatha kuyamba kuyamwa akamamwa mowa kapena atamwa kale. Vinyo, cider, ndi mowa ndizomwe zimayambitsa izi kuposa zakumwa zina zoledzeretsa.

Ngati muli ndi vuto la mphumu mukumwa mowa, siyani kumwa mowa nthawi yomweyo. Adziwitseni dokotala za zomwe zingachitike mukadzabweranso.

Komanso, kambiranani ndi dokotala wanu za kuchuluka kwa zakumwa zoledzeretsa zomwe mumamwa. Amatha kukuwuzani kuchuluka kwa zomwe muyenera kumwa mukamamwa mankhwala.

Zochita za Cinqair

Palibe kulumikizana kulikonse komwe kumadziwika pakati pa Cinqair ndi mankhwala ena, zitsamba, zowonjezera, kapena zakudya. Koma zina mwazi zingakulitse mwayi wanu wokhala ndi mphumu. Mwachitsanzo, zakudya zina kapena mankhwala osokoneza bongo amatha kuyambitsa mphumu.

Ngati muli ndi vuto lililonse la chakudya kapena mankhwala osokoneza bongo, uzani dokotala wanu. Tchulaninso mankhwala aliwonse, zitsamba, kapena zowonjezera zomwe mumamwa. Dokotala wanu angakulimbikitseni kusintha kwa zakudya zanu, mankhwala, kapena moyo wanu ngati mukufunikira.

Momwe Cinqair amaperekedwera

Wothandizira zaumoyo adzakupatsani Cinqair ngati kulowetsedwa kwa intravenous (IV) muofesi ya dokotala kapena kuchipatala. Ichi ndi jakisoni mumtsempha wanu womwe umadontha pang'onopang'ono pakapita nthawi.

Choyamba, wothandizira zaumoyo wanu adzaika singano mumodzi mwamitsempha yanu. Kenako amalumikiza thumba lomwe lili ndi Cinqair ku singano. Mankhwalawa amatuluka mchikwama kupita mthupi lanu. Izi zimatenga pafupifupi mphindi 20 mpaka 50.

Mukalandira mulingo wanu, wothandizira zaumoyo wanu akhoza kukuyang'anirani kuti muwone ngati mukudwala anaphylaxis. * Ichi ndi mtundu wa zovuta zomwe zimachitika. (Pazizindikiro zotheka, onani gawo la "zotsatira za Cinqair" pamwambapa). Anaphylaxis imatha kuchitika pambuyo pa mlingo uliwonse wa Cinqair. Chifukwa chake wothandizira zaumoyo wanu amatha kukuwunikirani ngakhale mutalandira Cinqair kale.

Mungapeze liti Cinqair

Cinqair nthawi zambiri imaperekedwa kamodzi pakatha milungu inayi iliyonse. Inu ndi dokotala wanu mutha kukambirana nthawi yabwino kwambiri patsiku kuti mulowetsedwe.

Ndibwino kuti mulembe ndandanda yanu yamankhwala pakalendala. Muthanso kukhazikitsa chikumbutso pafoni yanu kuti musaphonye nthawi yokumana.

Momwe Cinqair amagwirira ntchito

Mphumu ndi momwe mpweya wopita kumapapu anu umatupa (kutupa). Minofu yomwe imazungulira mayendedwe ampweya imafinya, zomwe zimalepheretsa kuti mpweya uzidutsamo. Zotsatira zake, mpweya sungafikire magazi anu.

Ndi mphumu yayikulu, zizindikilozo zitha kukhala zoyipa kuposa kukhala ndi mphumu wamba. Ndipo nthawi zina mankhwala omwe amathandiza kuchiza mphumu sagwira ntchito ya mphumu yoopsa. Chifukwa chake ngati muli ndi mphumu yayikulu, mungafunike mankhwala ena.

Mtundu umodzi wa mphumu yoopsa ndi mphumu yoopsa. Ndi mphumu yamtunduwu, mumakhala ndi ma eosinophil ambiri m'magazi anu. Eosinophils ndi mtundu weniweni wa khungu loyera la magazi. (Maselo oyera amwazi ndi maselo ochokera m'thupi lanu, omwe amakuthandizani kukutetezani ku matenda.) Kuchulukitsa kwama eosinophil kumabweretsa kutupa m'mapweya ndi m'mapapu anu. Izi zimayambitsa matenda anu a mphumu.

Kodi Cinqair amatani?

Chiwerengero cha ma eosinophil m'magazi anu chimadalira pazinthu zambiri. Chofunika kwambiri ndichokhudza puloteni yotchedwa interleukin-5 (IL-5). IL-5 imalola ma eosinophil kuti akule ndikupita kumwazi wanu.

Cinqair amamangirira IL-5. Mwa kulumikizana nalo, Cinqair imayimitsa IL-5 kuti isagwire ntchito. Cinqair imathandiza kuteteza IL-5 kuti isalole kuti ma eosinophil akule ndikusunthira magazi anu. Ngati ma eosinophil sangathe kufikira magazi anu, sangathe kufikira m'mapapu anu. Chifukwa chake ma eosinophil satha kuyambitsa kutupa mumayendedwe anu am'mapapo ndi m'mapapu.

Zimatenga nthawi yayitali bwanji kuti zigwire ntchito?

Pambuyo pa mlingo wanu woyamba wa Cinqair, zimatha kutenga milungu inayi kuti matenda anu a mphumu athe.

Cinqair imafikiradi magazi anu panthawi yomwe yakupatsani. Mankhwalawa amayenda m'magazi anu kupita kumaselo anu nthawi yomweyo. Cinqair ikafika m'maselo anu, imadziphatika ku IL-5 ndikuyimitsa kuti isagwire ntchito nthawi yomweyo.

Koma IL-5 ikasiya kugwira ntchito, padzakhalabe ma eosinophil ambiri m'magazi anu. Cinqair athandizira kuti ndalamazi zisakwere. Mankhwalawa athandizanso kuchepetsa kuchuluka kwa ma eosinophil, koma izi sizingachitike nthawi yomweyo.

Zitha kutenga milungu inayi kuti muchepetse kuchuluka kwama eosinophil m'magazi anu. Chifukwa chake zizindikiro zanu za mphumu zimatha kutenga milungu inayi kuti ziwonongeke mutatha kumwa Cinqair. Zizindikiro zanu zikafika, mwina sangabwerere bola mukapitiliza kulandira Cinqair.

Cinqair ndi mimba

Palibe maphunziro azachipatala okwanira omwe adachitidwa mwa anthu kuti atsimikizire ngati Cinqair ndiyabwino kugwiritsa ntchito panthawi yapakati. Koma ndizodziwika kuti Cinqair amayenda kudzera pa nsengwa ndikufikira mwanayo. Placenta ndi chiwalo chomwe chimakula m'mimba mwanu mukakhala ndi pakati.

Kafukufuku wazinyama akuwonetsa kuti palibe zoyipa zomwe zingachitike kwa mwanayo. Koma maphunziro a nyama samawonetsa nthawi zonse zomwe zimachitika mwa anthu.

Ngati mukumwa Cinqair ndikukhala ndi pakati kapena mukufuna kukhala ndi pakati, lankhulani ndi dokotala wanu. Amatha kukuthandizani kusankha ngati Cinqair kapena mankhwala ena a mphumu ndiabwino kwa inu.

Cinqair ndi kuyamwitsa

Palibe maphunziro azachipatala mwa anthu omwe amatsimikizira ngati kuli koyenera kuyamwitsa mukamamwa Cinqair. Koma kafukufuku waumunthu akuwonetsa kuti mapuloteni ofanana ndi omwe ali ku Cinqair amapezeka mumkaka wa m'mawere. Komanso, m'maphunziro a nyama, Cinqair adapezeka mumkaka wa m'mawere wa amayi. Kotero zikuyembekezeredwa kuti Cinqair atha kupezeka mkaka wa m'mawere wa anthu, nawonso. Sizikudziwika kuti izi zingakhudze bwanji mwanayo.

Ngati mukufuna kuyamwa mukalandira Cinqair, uzani adotolo. Amatha kukambirana zabwino ndi zoyipa nanu.

Mafunso wamba okhudza Cinqair

Nawa mayankho pamafunso omwe amafunsidwa kawirikawiri za Cinqair.

Kodi Cinqair ndi mankhwala osokoneza bongo?

Inde. Cinqair ndi mtundu wa mankhwala otchedwa biologic, omwe amapangidwa kuchokera kuzinthu zamoyo. Mankhwala okhazikika, mbali inayo, amapangidwa kuchokera ku mankhwala.

Cinqair imakhalanso ndi antioclonal antibody. Ichi ndi mtundu wa biologic womwe umagwirizana ndi chitetezo chamthupi chanu. (Chitetezo cha mthupi lanu ndi chomwe chimathandiza kuteteza thupi lanu ku matenda.) Ma antibodies a monoclonal ngati Cinqair amalumikizana ndi mapuloteni omwe ali mthupi lanu. Cinqair akaphatikana ndi mapuloteniwa, amawasiya kuti asayambitse kutupa (kutupa) ndi zizindikiritso zina za mphumu.

Chifukwa chiyani Cinqair samabwera ngati inhaler kapena piritsi?

Thupi lanu silingagwiritse ntchito Cinqair mu mawonekedwe a inhaler kapena mapiritsi, kotero mankhwalawa sangathandize kuthandizira mphumu.

Cinqair ndi mtundu wa mankhwala a biologic omwe amadziwika kuti antioclonal antibody. (Kuti mumve zambiri za biologics, onani "Kodi Cinqair ndi mankhwala a biologic?" Pamwambapa.) Ma antibodies a monoclonal ndi mapuloteni akulu. Mukamwa mankhwalawa ngati mapiritsi, amatha kupita kumimba ndi m'matumbo mwanu. Kumeneko, zidulo ndi mapuloteni ena ang'onoang'ono amawononga ma monoclonal antibodies. Chifukwa ma antibodies a monoclonal adagawika mzidutswa tating'ono, sangathenso kuchiza mphumu. Kotero mu mawonekedwe a mapiritsi, mtundu uwu wa mankhwala sungagwire bwino ntchito.

Simungapume ma antibodies ambiri amtundu umodzi mwina. Mukadatero, mapuloteni m'mapapu anu amatha kugwetsa mankhwalawo nthawi yomweyo. Mankhwala ochepa kwambiri angawapangitse magazi ndi maselo anu. Izi zitha kuchepetsa momwe mankhwalawo amagwirira ntchito mthupi lanu.

Njira yabwino kwambiri yogwiritsira ntchito ma antibodies a monoclonal, kuphatikiza Cinqair, ndikulowetsedwa kudzera mu intravenous (IV). (Ichi ndi jakisoni mumtsempha wanu womwe umadontha pang'onopang'ono pakapita nthawi.) Mwa mawonekedwe awa, mankhwalawa amapita mwachindunji m'magazi anu. Palibe zidulo kapena mapuloteni omwe amawononga mankhwalawo kwa milungu ingapo. Chifukwa chake mankhwalawa amatha kuyenda m'magazi anu ndikugwira ntchito m'malo amthupi lanu omwe amafunikira.

Chifukwa chiyani sindingapeze Cinqair ku pharmacy?

Njira yokhayo yopezera Cinqair ndi kudzera mwa dokotala wanu. Wothandizira zaumoyo adzakupatsani Cinqair ngati kulowetsedwa kwa intravenous (IV) muofesi ya dokotala kapena kuchipatala. Ichi ndi jakisoni mumtsempha wanu womwe umadontha pang'onopang'ono pakapita nthawi. Chifukwa chake simungagule Cinqair ku pharmacy ndikudzitengera nokha.

Kodi ana angagwiritse ntchito Cinqair?

Ayi. A Food and Drug Administration (FDA) adangovomereza Cinqair kuti azichitira akuluakulu. Kafukufuku wamankhwala adayesa kugwiritsa ntchito Cinqair kwa ana azaka zapakati pa 12 mpaka 18. Koma zotsatira zake sizinasonyeze ngati mankhwalawa adagwira bwino ntchito komanso anali otetezeka mokwanira kuti agwiritse ntchito ana.

Ngati mwana wanu ali ndi mphumu yoopsa, lankhulani ndi dokotala. Atha kulangiza mankhwala ena kupatula Cinqair omwe angathandize kumuthandiza mwana wanu.

Kodi ndifunikirabe kumwa corticosteroid ndi Cinqair?

Osalephera. Simukuyenera kutenga Cinqair palokha. Muyenera kugwiritsa ntchito mankhwalawa limodzi ndi mankhwala anu a mphumu, omwe atha kuphatikizira corticosteroid.

Cinqair imangothandiza kuchepetsa mphumu yoopsa ya eosinophilic. Ichi ndi mtundu wa mphumu yomwe imayambitsidwa ndi kuchuluka kwa ma eosinophil (mtundu wa khungu loyera lamagazi) m'magazi anu.

Monga Cinqair, corticosteroids imagwira ntchito pochepetsa kutupa (kutupa) m'mapapu anu. Komabe, corticosteroids imachepetsa kutupa m'njira zosiyanasiyana. Anthu ambiri omwe ali ndi mphumu yoopsa amafunika Cinqair ndi corticosteroid kuti athetse mphumu yawo. Chifukwa chake, adokotala angakupatseni mankhwala onsewa. Osasiya kumwa corticosteroid pokhapokha dokotala atakuwuzani.

Kodi ndifunikirabe kukhala ndi inhaler yopulumutsa ndi ine?

Inde.Mudzafunikabe kunyamula inhaler yopulumutsa mukalandira Cinqair.

Ngakhale kuti Cinqair imathandizira kuthana ndi mphumu yayikulu nthawi yayitali, mutha kukhalabe ndi zovuta. Ndipo Cinqair sagwira ntchito mwachangu mokwanira kuti athe kuchiza matenda a mphumu mwadzidzidzi.

Ngati simungathe kusamalira matenda a mphumu nthawi yomweyo, amatha kukulirakulira. Chifukwa chake njira yabwino yowapezera chogwiritsira ntchito ndikugwiritsa ntchito yopulumutsa inhaler. Chida ichi chimakuthandizani kuti muchepetse matenda anu a mphumu.

Kumbukirani kuti mufunikirabe kumwa mankhwala anu ena a mphumu, kuphatikizapo Cinqair.

Zodzitetezera ku Cinqair

Mankhwalawa amabwera ndi machenjezo angapo.

Chenjezo la FDA: Anaphylaxis

Mankhwalawa ali ndi chenjezo la nkhonya. Ili ndiye chenjezo lalikulu kwambiri kuchokera ku Food and Drug Administration (FDA). Chenjezo la bokosi limachenjeza madokotala ndi anthu za zotsatira za mankhwala zomwe zingakhale zoopsa.

Zomwe zimayambitsa matenda otchedwa anaphylaxis zimatha kuchitika atalandira Cinqair. Mankhwalawa amaperekedwa ndi othandizira azaumoyo, chifukwa chake adzawunika momwe thupi lanu limachitira ndi Cinqair. Angathenso kuchiza anaphylaxis mwachangu mukayamba.

Machenjezo ena

Musanatenge Cinqair, kambiranani ndi dokotala za mbiri yanu. Cinqair mwina siyabwino kwa inu ngati mukudwala. Izi zikuphatikiza:

Matenda a Helminth

Cinqair mwina sangakhale yoyenera kwa inu ngati muli ndi kachilombo ka helminth (kachilombo koyambitsa matenda kamene kamayambitsa mphutsi). Dokotala wanu adzafunika kuchiza matendawa musanayambe kugwiritsa ntchito Cinqair.

Mukalandira matenda a helminth mukamagwiritsa ntchito Cinqair, dokotala wanu akhoza kuyimitsa chithandizo chanu. Angaperekenso mankhwala ochizira matendawa. Matendawa akangotha, dokotala wanu akhoza kuti muyambirenso kulandira Cinqair.

Kumbukirani zizindikiro za matenda a helminth kuti mudziwe zomwe muyenera kuyang'ana. Zizindikiro zake ndi monga kutsegula m'mimba, kupweteka m'mimba, kusowa zakudya m'thupi, ndi zofooka.

Mimba

Palibe maphunziro azachipatala okwanira omwe adachitidwa mwa anthu kuti atsimikizire ngati Cinqair ndiyabwino kugwiritsa ntchito panthawi yapakati. Kuti mudziwe zambiri, onani gawo la "Cinqair ndi pakati" pamwambapa.

Zindikirani: Kuti mumve zambiri paza zotsatira zoyipa za Cinqair, onani gawo la "Zotsatira za Cinqair" pamwambapa.

Zambiri zamakinala pa Cinqair

Zotsatirazi zimaperekedwa kwa azachipatala ndi ena othandizira azaumoyo.

Zisonyezero

Cinqair imawonetsedwa ngati chithandizo cha mphumu yayikulu. Kuvomerezeka kwa mankhwalawa kumakonzedwa kuti agwiritsidwe ntchito ngati zowonjezera zowonjezera chithandizo cha mphumu yoopsa. Cinqair sayenera m'malo mwa njira zamankhwala zomwe zimafotokozedwera kwa odwala, kuphatikiza kugwiritsa ntchito corticosteroids.

Kuvomerezeka kwa Cinqair ndichithandizo cha anthu omwe ali ndi eosinophilic phenotype. Mankhwalawa sayenera kuperekedwa kwa anthu omwe ali ndi phenotypes osiyanasiyana. Sichiyenera kuperekedwanso pochiza matenda ena okhudzana ndi eosinophilic.

Komanso, Cinqair sichiwonetsedwa kuti ichiritse bronchospasms yovuta kapena asthmaticus. Kugwiritsa ntchito mankhwala osokoneza bongo kuti athetse zizindikiro sizinawunikiridwe panthawi yamaphunziro azachipatala.

Kugwiritsa ntchito Cinqair kuyenera kusungidwa kwa anthu azaka zopitilira 18 zokha. Ilibe chilolezo cha Food and Drug Administration (FDA) kwa anthu ochepera zaka zimenezo.

Njira yogwirira ntchito

Njira yeniyeni yogwiritsira ntchito Cinqair siinafotokozeredwe konse. Koma amakhulupirira kuti imagwira ntchito kudzera pa njira ya interleukin-5 (IL-5).

Cinqair ndi anti-humanized IgG4-kappa monoclonal anti yomwe imamangiriza ku IL-5. Kumangiriza kumakhala ndi dissociation pafupipafupi ya 81 picomolar (pM). Pogwirizana ndi IL-5, Cinqair amatsutsana ndi IL-5 ndikuletsa zochitika zake. Izi zimachitika chifukwa Cinqair imalepheretsa IL-5 kuti isamangidwe ndi IL-5 receptor yomwe imapezeka pama cell a eosinophil.

IL-5 ndiye cytokine yofunikira kwambiri pakukula, kusiyanitsa, kupeza anthu ntchito, kuyambitsa, komanso kupulumutsa ma eosinophil. Kupanda kuyanjana pakati pa IL-5 ndi eosinophil kumalepheretsa IL-5 kukhala ndi ma cell awa mu ma eosinophil. Chifukwa chake mayendedwe am'manja a eosinophil ndi zochitika zachilengedwe zimasokonekera. Eosinophils asiye kugwira ntchito moyenera ndikufa.

Mwa anthu omwe ali ndi chifuwa chachikulu cha mphumu, ma eosinophil ndi omwe amachititsa matendawa kukhala ofunika. Eosinophils amachititsa kutupa nthawi zonse m'mapapu, zomwe zimayambitsa matenda a mphumu. Pochepetsa kuchuluka kwa magwiridwe antchito, Cinqair amachepetsa kutupa m'mapapo. Mphumu yayikulu imayendetsedwa kwakanthawi.

Maselo akuluakulu, macrophages, neutrophils, ndi ma lymphocyte amathanso kuyambitsa mapapu. Kuphatikiza apo, eicosanoids, histamine, cytokines, ndi leukotrienes zitha kuyambitsa kutupa. Sizikudziwika ngati Cinqair imagwira ntchito pama cell awa ndi oyimira pakati kuti athetse kutupa m'mapapu.

Pharmacokinetics ndi metabolism

Cinqair imakwaniritsa kuchuluka kwake kumapeto kwa nthawi yolowetsedwa. Maulamuliro angapo a Cinqair amatsogolera kukusungunuka kwake mu seramu ya 1.5- mpaka 1.9. Kuchuluka kwa ma seramu kumachepa pamapindikira a biphasic. Maguluwa sasintha ndikupezeka kwa ma anti-Cinqair antibodies.

Ikangoyang'aniridwa, Cinqair imakhala ndi gawo lokwanira la malita 5. Izi zikutanthauza kuti kuchuluka kwa Cinqair mwina sikungafike pamatenda owonjezera.

Monga ma antibodies ambiri amtundu umodzi, Cinqair amavutika ndi kuwonongeka kwa enzymatic. Mavitamini a proteinolytic amasintha kukhala ma peptide ang'onoang'ono ndi ma amino acid. Kutulutsa kwathunthu kwa Cinqair kumatenga nthawi. Hafu ya moyo wake ndi masiku pafupifupi 24. Komanso, kuchuluka kwake kumakhala pafupifupi mamililita 7 pa ola (mL / hr). Chilolezo chokhazikitsidwa ndi Cinqair sichingachitike. Izi ndichifukwa choti zimamanga ndi interleukin-5 (IL-5), yomwe ndi cytokine yosungunuka.

Kafukufuku wa Pharmacokinetics a Cinqair ndi ofanana kwambiri pakati pa anthu azaka zosiyana, jenda, kapena mtundu. Kusiyanasiyana pakati pa anthu kuli pakati pa 20% mpaka 30% pachimake pakuwonekera komanso kuwonekera kwathunthu.

Kafukufuku wa Pharmacokinetics sakusonyeza kusiyana kulikonse pakati pa anthu omwe ali ndi mayeso abwinobwino komanso owonjezera a chiwindi. Ntchito yabwinobwino imaphatikizapo milingo ya bilirubin ndi aspirate aminotransferase yochepera kapena yofanana ndi malire apamwamba wamba (ULN). Kuyesa kofatsa kwa ntchito kumakhudza milingo ya bilirubin pamwamba pa ULN komanso yochepera kapena yofanana ndi 1.5-ullen ULN. Zitha kuphatikizanso kuchuluka kwa aspartate aminotransferase kuposa UlN.

Komanso, maphunziro a pharmacokinetics sakusonyeza kusiyana kulikonse pakati pa anthu omwe ali ndi vuto labwino la impso. Ntchito yabwinobwino ya impso imatanthawuza kuchuluka kwa kusefera kwama glomerular (eGFR) kwakukulu kuposa kapena kofanana 90 mL pamphindi pa mita imodzi ya 1.73. (mL / mphindi / 1.73 m²). Ntchito zofewa zamkati mwachangu zimatanthauza kuchuluka kwa eGFR pakati pa 60 mpaka 89 mL / min / 1.73 m² ndi 30 mpaka 59 mL / min / 1.73 m², motsatana.

Zotsutsana

Cinqair imatsutsana ndi anthu omwe adayamba kudwala matenda opatsirana pogwiritsira ntchito Cinqair.

Hypersensitivity itha kuchitika pambuyo pokhazikitsa Cinqair. Koma nthawi zina, zimatha kuchitika patatha maola angapo kutsatira mankhwalawa. Kuwunika kwa odwala pambuyo pa kayendetsedwe ka Cinqair ndikofunikira kuwona momwe zimakhalira ndi hypersensitivity reaction.

Hypersensitivity ndimatenda amitundu yambiri omwe amatha kuyambitsa anaphylaxis ndi kufa ndi mantha a anaphylactic. Odwala onse omwe ali ndi hypersensitivity ku Cinqair ayenera kusokoneza chithandizo mwachangu. Poterepa, zizindikiro za hypersensitivity ziyenera kuthandizidwa. Odwalawa sayenera kulandiranso chithandizo cha Cinqair.

Lankhulani ndi odwala anu pazizindikiro za hypersensitivity ndi anaphylaxis. Auzeni ayimbire foni 911 nthawi yomweyo ngati akuganiza kuti ali ndi izi. Komanso, auzeni kuti adziwitse omwe amawapatsa chithandizo chamankhwala ngati atakumana ndi hypersensitivity kapena anaphylaxis kuti asinthe njira yothandizira.

Yosungirako

Cinqair iyenera kukhala mufiriji pakati pa 36 ° F mpaka 46 ° F (2 ° C mpaka 8 ° C). Ndikofunika kuti mankhwalawa asazizidwe kapena kugwedezeka. Ndikofunikanso kusunga Cinqair mu phukusi lake loyambirira mpaka pomwe adzagwiritse ntchito. Izi zidzateteza mankhwalawa ku kuwonongeka pang'ono.

Chodzikanira: Medical News Today yachita kuyesetsa konse kuti zitsimikizidwe kuti zowona zonse ndizolondola, zonse, komanso zaposachedwa. Komabe, nkhaniyi sikuyenera kugwiritsidwa ntchito m'malo mwa chidziwitso ndi ukadaulo wa akatswiri pazachipatala. Muyenera kufunsa adotolo kapena akatswiri azaumoyo musanamwe mankhwala aliwonse. Zambiri zamankhwala zomwe zili pano zitha kusintha ndipo sizingapangidwe kuti zigwiritse ntchito, mayendedwe, zodzitetezera, machenjezo, kulumikizana ndi mankhwala, kusokonezeka, kapena zovuta zina. Kusapezeka kwa machenjezo kapena zidziwitso za mankhwala omwe apatsidwa sikuwonetsa kuti kuphatikiza mankhwala kapena mankhwalawa ndiwotetezeka, ogwira ntchito, komanso oyenera kwa odwala onse kapena ntchito zina zilizonse.