DAO ndi chiyani? Zowonjezera za Diamine Oxidase

Zamkati

• Kodi DAO ndi chiyani?
• Kuperewera kwa DAO ndi Kusamvana Kwakale
• Ubwino Wopindulitsa Wa Zowonjezera za DAO
• Zizindikiro Zakudya
• Migraine Akumenyedwa ndi Kumva Mutu
• Khungu Kutupa
• Osati Chithandizo
• Njira Zabwino Zothandizira Kulephera kwa DAO
• Kupititsa patsogolo Ntchito ya DAO
• Zakudya Zomwe Muyenera Kupewa
• Kusamala ndi Malangizo a Mlingo
• Mfundo Yofunika Kwambiri

Diamine oxidase (DAO) ndi enzyme komanso chowonjezera cha zakudya chomwe chimagwiritsidwa ntchito nthawi zambiri kuchiza matenda osagwirizana ndi histamine.

Kuphatikiza ndi DAO kumatha kukhala ndi maubwino ena, koma kafukufuku amakhala ndi malire.

Nkhaniyi ikufotokoza zowonjezera za DAO, kuphatikiza maubwino ake, kuchuluka kwake, ndi chitetezo.

Kodi DAO ndi chiyani?

Diamine oxidase (DAO) ndi michere yomwe imadyetsa impso, thymus, komanso matumbo am'mimba.

Ntchito yake yayikulu ndikuwononga kuchuluka kwa histamine mthupi lanu (1).

Histamine ndimapangidwe achilengedwe omwe amathandizira kuwongolera ntchito zina zam'magazi, manjenje, komanso chitetezo chamthupi.

Ngati munakhalapo ndi vuto linalake, mwina mumadziwika ndi zizolowezi zomwe zimakhudzana ndi milingo yayikulu ya histamine, monga kuchulukana kwa m'mphuno, khungu loyabwa, mutu, ndi kuyetsemula.

Muthanso kugwiritsa ntchito histamine kudzera pazakudya zanu. Nthawi zambiri zimapezeka mu zakudya zina - makamaka zomwe zakalamba, zakuchiritsidwa, kapena zofufumitsa monga tchizi, vinyo, nkhaka, ndi nyama zosuta (1).

DAO imasunga milingo ya histamine munthawi yabwino kupewa zodetsa nkhawa zomwe zimayambitsa histamine.

Diamine oxidase (DAO) ndi enzyme yomwe imathandizira kuphwanya histamine yochulukirapo m'thupi lanu, motero kumachepetsa zizindikilo zosasangalatsa, monga kuchulukana kwa m'mphuno, khungu loyabwa, kupweteka mutu, ndi kuyetsemula.

Kuperewera kwa DAO ndi Kusamvana Kwakale

Kusalolera kwa mbiri yakale ndichachipatala chomwe chimachitika chifukwa cha milingo yayikulu ya histamine.

Chimodzi mwazomwe zikukayikiridwa zakusavomerezeka kwa histamine ndikusowa kwa DAO ().

Mlingo wa DAO wanu ukakhala wocheperako, ndizovuta kuti thupi lanu lizitha kugwiritsira ntchito bwino histamine. Zotsatira zake, kuchuluka kwa histamine kumakwera, kumabweretsa zizindikilo zingapo zakuthupi.

Zizindikiro za kusagwirizana kwa histamine nthawi zambiri zimafanana ndi zomwe zimachitika chifukwa cha kusagwirizana. Zitha kuyambira poyambira mpaka zovuta ndikuphatikizira ():

• Kuchuluka kwa mphuno
• kupweteka mutu
• khungu loyabwa, zotupa, ndi ming'oma
• kuyetsemula
• mphumu komanso kupuma movutikira
• kugunda kwamtima kosafunikira (arrhythmia)
• kutsekula m'mimba, kupweteka m'mimba, komanso kuvutika m'mimba
• nseru ndi kusanza
• kuthamanga kwa magazi (hypotension)

Zinthu zingapo zimathandizira kuchepa kwa ntchito ya DAO kapena kuchulukitsa kwa histamine, kuphatikiza kusintha kwa majini, kumwa mowa, mankhwala ena, kuchuluka kwa bakiteriya m'matumbo, komanso kudya zakudya zambiri zopangidwa ndi histamine ().

Kusalolera kwa mbiri yakale kumakhala kovuta kuzindikira, chifukwa zizindikilo zake ndizazovuta ndipo zimafanana ndi zamatenda ena (1,).

Chifukwa chake, ngati mukuganiza kuti mukukumana ndi vuto la histamine, funsani wothandizira zaumoyo woyenera kuti afufuze bwino zomwe zimayambitsa matenda anu musanayese kudzipenda kapena kudzichiritsa.

Kusalolera kwa mbiriyakale kumatha kukula chifukwa chakuchepa kwa DAO ndipo kumabweretsa zizindikilo zingapo zomwe sizimakhala bwino zomwe nthawi zambiri zimafanana ndi zomwe zimachitika.

Ubwino Wopindulitsa Wa Zowonjezera za DAO

Kuperewera kwa DAO komanso kusalolera kwa histamine kumatha kuchiritsidwa m'njira zosiyanasiyana, kuphatikiza powonjezera ndi DAO.

Kafukufuku woyambirira akuwonetsa kuti zowonjezera za DAO zitha kuchepetsa zizindikilo zina zakusamvana kwa histamine, kuphatikiza kupweteka mutu, zotupa pakhungu, komanso kugaya kwam'mimba.

Zizindikiro Zakudya

Pakafukufuku wamasabata awiri mwa anthu 14 omwe ali ndi vuto losagwirizana ndi histamine komanso zomwe zimaphatikizapo kupweteka m'mimba, kuphulika, kapena kutsekula m'mimba, 93% ya omwe atenga nawo mbali adanenanso za chizindikiro chimodzi chokhudzana ndi kugaya chakudya atatenga 4.2 mg wa DAO kawiri patsiku ().

Migraine Akumenyedwa ndi Kumva Mutu

Kafukufuku wamwezi wa 1 mwa anthu 100 omwe adapezeka kuti ali ndi vuto la DAO adawona kuti omwe amathandizira tsiku lililonse ndi DAO adachepetsedwa ndi 23% panthawi yakukumana ndi migraine, poyerekeza ndi gulu la placebo ().

Khungu Kutupa

Kafukufuku wamasiku 30 mwa anthu 20 omwe ali ndi urticaria yanthawi zonse (zotupa pakhungu) komanso kusowa kwa DAO adazindikira kuti omwe adalandira zowonjezerazo kawiri tsiku lililonse adapeza mpumulo wazizindikiro ndipo amafunikira mankhwala ochepa a antihistamine ().

Ngakhale maphunzirowa akuwonetsa kuti kuwonjezera ndi DAO kumatha kuthetsa kapena kusintha zizindikilo zakusowa, palibe chitsimikizo kuti ndizothandiza kwa aliyense.

Pomaliza, kafukufuku wina amafunika kuti tipeze mayankho omveka.

Kafukufuku woyambirira akuwonetsa kuti ma DAO othandizira amatha kusintha zina mwazomwe zimakhudzana ndi kuchepa kwa DAO komanso kusalolera kwa histamine, kuphatikiza migraine, zotupa pakhungu, komanso vuto lakugaya chakudya. Komabe, maphunziro ena amafunikira.

Osati Chithandizo

Kumvetsetsa kwasayansi kwakusalolera kwa histamine ndi kuchepa kwa DAO kudakali koyambirira.

Zinthu zingapo zimatha kukhudza kupanga kwa DAO ndi histamine m'malo osiyanasiyana mthupi lanu. Kuyankha zomwe zimayambitsa mavutowa sikophweka ngati kuchotsa DAO ndikuwonjezera (1,).

DAO amathandizira kuti athetse histamine yomwe imalowa mthupi lanu kunja, monga chakudya kapena zakumwa.

Kutenga chowonjezera ichi sikungakhudze kuchuluka kwa histamine yopangidwa mkati, chifukwa mtundu uwu wa histamine udasweka ndi enzyme ina yotchedwa N-methyltransferase ().

Ngakhale DAO zowonjezerako zitha kuchepetsa zizindikilo pochepetsa kuwonekera kwakunja kwa histamine, kafukufuku wosonyeza kuti amatha kuchiza kusamvana kwa histamine kapena kusowa kwa DAO kukusowa.

Ngati mwapezeka kuti muli ndi vuto losagwirizana ndi histamine kapena mukukayikira kuti mwina muli nawo, funsani wothandizira zaumoyo woyenera kuti apange mapulani anu malinga ndi zosowa zanu komanso zolinga zanu.

Pakadali pano, palibe kafukufuku wasayansi yemwe akuwonetsa kuti zowonjezera za DAO zitha kuchiritsa kusowa kwa DAO kapena tsankho la histamine.

Njira Zabwino Zothandizira Kulephera kwa DAO

Kusagwirizana kwa mbiri yakale komanso kuchepa kwa DAO ndizovuta zovuta zomwe zimakhala ndi zinthu zingapo zomwe zimakhudza kuopsa kwa zizindikilo zomwe zimagwirizana.

Pakadali pano, njira imodzi yothanirana ndi mavutowa ndi kudzera pazakudya.

Chifukwa zakudya zina zimadziwika kuti zimakhala ndi histamine yosiyanasiyana, kusinthidwa kwakadongosolo kumatha kusintha zizindikiritso za histamine pochepetsa kuchepa kwa zakudya zama histamine komanso kudya zakudya zomwe zingalepheretse ntchito ya DAO.

Kupititsa patsogolo Ntchito ya DAO

Thandizo lazakudya zopangira kusintha kulekerera kwa histamine ndi ntchito ya DAO ikufuna kuwonetsetsa kuti pali zakudya zokwanira zomwe zimathandizira kuphwanya histamine, kuphatikiza mkuwa ndi mavitamini B6 ndi C ().

Kafukufuku wina akuwonetsanso kuti kudya mokwanira mafuta athanzi ndi zakudya zina - monga phosphorous, zinc, magnesium, iron, ndi vitamini B12 - zitha kuthandizira kukulitsa ntchito ya DAO ().

Kudya makamaka zakudya zochepa za histamine kumatha kuchepetsa kuchepa kwa histamine ndikuchepetsa kuchepa kwake mthupi lanu. Zakudya zochepa za histamine zimaphatikizapo:

• nyama yatsopano ndi nsomba
• mazira
• masamba ambiri - kupatula sipinachi, tomato, peyala, ndi biringanya
• zipatso zatsopano - kupatula zipatso za zipatso ndi zipatso zina
• mafuta ngati kokonati ndi maolivi
• mbewu, kuphatikizapo mpunga, quinoa, chimanga, teff, ndi mapira

Zakudya Zomwe Muyenera Kupewa

Kuchepetsa kapena kuchotsa zakudya zamtundu wa histamine kapena zomwe zimayambitsa kupanga histamine ndi njira ina yothetsera zizindikiritso za histamine komanso kupanga pang'ono kwa DAO.

Zakudya zina zomwe zimakhala ndi histamine yambiri ndipo zimatha kuyambitsa kutulutsa kwa histamine zimaphatikizapo ():

• zakumwa zoledzeretsa, monga mowa, vinyo, ndi mowa
• zakudya zofufumitsa, monga sauerkraut, pickles, yogurt, ndi kimchi
• nkhono
• mkaka
• zakudya zakale, monga tchizi komanso kusuta komanso kuchiritsa nyama
• tirigu
• mtedza, monga mtedza ndi makoko
• zipatso zina, kuphatikizapo zipatso za zipatso, nthochi, papaya, ndi strawberries
• masamba ena, kuphatikiza tomato, sipinachi, biringanya, ndi peyala
• zina zowonjezera zakudya, mitundu, ndi zotetezera

Chifukwa kusankha zakudya zomwe zimaloledwa pa chakudya chochepa kwambiri cha histamine kumatha kuchepa, mutha kukhala pachiwopsezo chazakudya choperewera komanso kuchepa kwa moyo (1,).

Chifukwa chake, chakudya chotsika kwambiri cha histamine chiyenera kugwiritsidwa ntchito kwakanthawi pongoyesa kukhudzidwa ndi zakudya zinazake.

Anthu ena omwe ali ndi tsankho la histamine amatha kulekerera zakudya zazing'ono kwambiri za histamine.

Zakudya zakuchotsa zingakuthandizeni kuzindikira kuti ndi zakudya ziti zomwe zimayambitsa zizindikilo zambiri ndipo ziyenera kupewedwa kwamuyaya komanso zomwe mungadye mopitirira muyeso.

Momwemo, njirayi imamalizidwa motsogozedwa ndi omwe amapereka chithandizo chamankhwala kuti athetse zovuta.

Mankhwala othandizira kuthandizira ntchito ya DAO ndikuchepetsa kuchepa kwa histamine amaphatikizanso njira zopewera kudya komanso kudya mokwanira michere yodziwika bwino yolimbikitsira ntchito ya DAO.

Kusamala ndi Malangizo a Mlingo

Palibe zovuta zoyipa zomwe zanenedwa m'maphunziro a zowonjezera za DAO.

Komabe, kafukufuku akadali wochepa, kotero mgwirizano wowoneka bwino wokhudzana ndi dosing ya zowonjezerazi uyenera kukhazikitsidwa.

Kafukufuku wambiri adagwiritsa ntchito Mlingo wa 4.2 mg wa DAO panthawi mpaka nthawi 2-3 tsiku lililonse asanadye (,,).

Chifukwa chake, miyezo yofananira ndiyotheka kukhala yotetezeka kwa anthu ambiri - koma sizitanthauza kuti ilibe chiopsezo 100%.

Mayiko ena monga United States sawongolera zowonjezerapo zakudya. Chifukwa chake, ndibwino kuti muwonetsetse kuti zomwe mwasankha zasankhidwa kuti ziyesedwe kuti ndi zoyera komanso zabwino ndi munthu wina, monga U.S. Pharmacopeia Convention (USP).

Nthawi zonse muzifunsa wothandizira zaumoyo wanu musanapereke zowonjezera zowonjezera muzakudya zanu.

Mlingo wa 4.2 mg wa DAO 2-3 nthawi tsiku lililonse musanadye kafukufuku asanafotokozedwe zakusokonekera. Komabe, mgwirizano womveka bwino wokhudzana ndi DAO sunakhazikitsidwe.

Mfundo Yofunika Kwambiri

Zowonjezera za DAO sizingathetse kusamvana kwa histamine kapena kuperewera kwa DAO koma zitha kuchepetsa zizindikilo powononga magwero akunja a histamine ngati omwe amachokera pazakumwa ndi zakumwa.

Kafukufuku wowonjezereka amafunikira kuti athe kukhazikitsa bwino, chitetezo, ndi kuchuluka kwake, ngakhale kafukufuku wapano sanena zovuta.

Onetsetsani kuti mufunsane ndi wothandizira zaumoyo musanawonjezere zowonjezera kapena mankhwala pazomwe mumachita.