Upangiri Wokambirana Kwa Doctor: Malangizo Okambirana PIK3CA Kusintha ndi Dokotala Wanu

Zamkati

• Kusintha kwa PIK3CA ndi chiyani?
• Kodi mumapeza bwanji kusinthaku?
• Kodi kusintha kwanga kumakhudza bwanji chithandizo changa?
• Kodi kusintha kwanga kumasintha bwanji malingaliro anga?
• Tengera kwina

Mayesero angapo amatha kuthandiza dokotala kuti adziwe khansa ya m'mawere, kudziwa momwe ichitikire, ndikupeza chithandizo chothandiza kwambiri kwa inu. Mayeso achibadwa amayang'ana kusintha kwa majini, magawo a DNA mkati mwa maselo anu omwe amayang'anira momwe thupi lanu limagwirira ntchito.

Chimodzi mwazinthu zosintha zomwe dokotala angayesere ndi PIK3CA. Werengani kuti mudziwe momwe kusinthaku kungakhudzire chithandizo chanu komanso malingaliro anu.

Kusintha kwa PIK3CA ndi chiyani?

Pulogalamu ya PIK3CA jini imakhala ndi malangizo opangira mapuloteni otchedwa p110α. Puloteni iyi ndiyofunikira pazinthu zambiri zama cell, kuphatikiza kuuza maselo anu nthawi yomwe ayenera kukula ndikugawana.

Anthu ena atha kukhala ndi masinthidwe amtunduwu. PIK3CA Kusintha kwa majini kumapangitsa kuti maselo azikula mosalamulirika, zomwe zingayambitse khansa.

PIK3CA Kusintha kwa majini kumalumikizidwa ndi khansa ya m'mawere, komanso khansa ya m'mimba, m'mapapo, m'mimba, ndi ubongo. Khansa ya m'mawere mwina imachokera pakuphatikizika kosintha kupita ku PIK3CA ndi majini ena.

PIK3CA Kusintha kumakhudza pafupifupi khansa yonse ya m'mawere, ndipo 40% ya anthu omwe ali ndi estrogen receptor (ER) -osintha, anthu epidermal kukula factor receptor 2 (HER2) -khansa yoyamwa yamawere.

ER-positive amatanthauza kuti khansa yanu ya m'mawere imakula chifukwa cha hormone estrogen. HER2-hasi amatanthauza kuti mulibe mapuloteni achilendo a HER2 pamwamba pama cell anu a khansa ya m'mawere.

Kodi mumapeza bwanji kusinthaku?

Ngati muli ndi vuto la ER, khansa ya m'mawere ya HER2, dokotala yemwe amachiza khansa yanu akhoza kukuyesani PIK3CA kusintha kwa majini. Mu 2019, a FDA adavomereza mayeso otchedwa therascreen kuti azindikire masinthidwe mu PIK3CA jini.

Mayesowa amagwiritsa ntchito magazi anu kapena minofu yanu kuchokera pachifuwa chanu. Kuyezetsa magazi kumachitika monga mayeso ena onse amwazi. Namwino kapena waluso amakoka magazi m'manja mwanu ndi singano.

Sampulo yamwaziyo kenako imapita ku labu kukafufuza. Khansa ya m'mawere imatsanulira tizigawo ting'onoting'ono ta DNA m'mwazi. Labu idzayesa mayeso a PIK3CA jini m'magazi anu.

Mukapeza zotsatira zoyipa pakuyesa magazi, muyenera kukhala ndi biopsy kuti mutsimikizire. Dokotala wanu adzachotsa minofu yanu pachifuwa chanu panthawi yochita opaleshoni yaying'ono. Zoyesazo kenako zimapita ku labu, komwe akatswiri amaziyesa ngati PIK3CA kusintha kwa majini.

Kodi kusintha kwanga kumakhudza bwanji chithandizo changa?

Kukhala ndi PIK3CA Kusintha kumatha kuletsa kuti khansa yanu isayankhidwe komanso mankhwala a mahomoni omwe amagwiritsidwa ntchito pochiza khansa ya m'mawere. Zimatanthauzanso kuti ndinu ofuna mankhwala atsopano otchedwa alpelisib (Piqray).

Piqray ndi PI3K inhibitor. Ndi mankhwala oyamba kwambiri amtunduwu. A FDA adavomereza Piqray mu Meyi 2019 kuti azichitira azimayi ndi abambo omwe atha msinkhu omwe ali ndi zotupa za m'mawere PIK3CA kusintha ndipo ali ndi HR-positive komanso HER2-negative.

Chivomerezocho chinali potengera zotsatira za kafukufuku wa SOLAR-1. Mlanduwo unaphatikiza azimayi ndi abambo 572 omwe ali ndi khansa ya m'mawere ya HR-positive komanso HER2-negative. Khansara ya omwe atenga nawo mbali idapitilira kukula ndikufalikira atalandira mankhwala a aromatase inhibitor ngati anastrozole (Arimidex) kapena letrozole (Femara).

Ofufuza apeza kuti kutenga Piqray kumathandizira kuti nthawi yomwe anthu azikhala popanda khansa ya m'mawere ikuipiraipira. Kwa anthu omwe adamwa mankhwalawa, khansa yawo sinapite patsogolo kwa miyezi 11, poyerekeza ndi pafupifupi miyezi 5.7 mwa anthu omwe sanatenge Piqray.

Piqray imaphatikizidwa ndi mankhwala a hormone fulvestrant (Faslodex). Kutenga mankhwala awiriwa limodzi kumawathandiza kuti azigwira ntchito bwino.

Kodi kusintha kwanga kumasintha bwanji malingaliro anga?

Ngati muli ndi PIK3CA Kusintha, mwina simungayankhe mankhwala omwe amagwiritsidwa ntchito pochiza khansa ya m'mawere. Komabe kuyambitsidwa kwa Piqray kumatanthauza kuti tsopano pali mankhwala omwe amayang'ana makamaka pakusintha kwanu.

Anthu omwe amatenga Piqray kuphatikiza Faslodex amakhala nthawi yayitali popanda matenda awo kupita patsogolo poyerekeza ndi omwe samamwa mankhwalawa.

Tengera kwina

Kudziwa yanu PIK3CA mkhalidwe wa majini ungakhale wothandiza ngati khansa yanu sinasinthe kapena yabwerera mutalandira chithandizo. Funsani dokotala ngati mukufuna kukayezetsa jini imeneyi. Mukayezetsa kuti muli ndi kachilombo, chithandizo chatsopano chitha kuthandiza kusintha malingaliro anu.