Glucagonoma

Zamkati

• Kodi Zizindikiro za Glucagonoma ndi Ziti?
• Kodi Zimayambitsa Glucagonoma?
• Kodi Glucagonoma Amadziwika Bwanji?
• Kodi Ndizithandizo Ziti Zomwe Zilipo pa Glucagonoma?
• Kodi zovuta za Glucagonoma ndi ziti?
• Kodi Ndingayembekezere Pati?

Kodi Glucagonoma ndi chiyani?

Glucagonoma ndi chotupa chosowa chokhudza kapamba. Glucagon ndi hormone yopangidwa ndi kapamba yomwe imagwira ntchito ndi insulin kuti ichepetse kuchuluka kwa shuga m'magazi anu. Maselo otupa a Glucagonoma amatulutsa glucagon yambiri, ndipo milingo imeneyi imapanga zizindikilo zowopsa, zopweteka komanso zowopsa. Pafupifupi 5 mpaka 10 peresenti ya zotupa za neuroendocrine zomwe zimapezeka m'mankhwala ndi glucagonomas.

Kodi Zizindikiro za Glucagonoma ndi Ziti?

Ngati muli ndi chotupa chomwe chimatulutsa glucagon yambiri, imakhudza mbali zambiri za thanzi lanu. Glucagon imayesa zotsatira za insulin poyang'anira kuchuluka kwa shuga m'magazi anu. Ngati muli ndi glucagon yochuluka, maselo anu samasunga shuga ndipo m'malo mwake shuga amakhala m'magazi anu.

Glucagonoma imayambitsa matenda ngati matenda a shuga ndi zina zowawa komanso zowopsa, kuphatikizapo:

• shuga wambiri wamagazi
• ludzu kwambiri ndi njala chifukwa cha shuga wambiri wamagazi
• nthawi zambiri amadzuka usiku kuti akodzere
• kutsegula m'mimba
• zotupa pakhungu, kapena dermatitis, pankhope, pamimba, matako, ndi mapazi omwe nthawi zambiri amakhala otupa kapena odzaza mafinya
• kuonda mwangozi
• kuundana kwamagazi m'miyendo, komwe kumatchedwanso kuti vein thrombosis

Kodi Zimayambitsa Glucagonoma?

Palibe zifukwa zenizeni zodziwika za glucagonoma. Ngati muli ndi mbiri yakubadwa kwa matenda omwe amatchedwa endocrine neoplasia type 1 (MEN1) muli pachiwopsezo chachikulu chotenga glucagonoma. Komabe, iwo omwe alibe zifukwa zina zowopsa amatha kukhala ndi zotupazi.

Glucagonomas ali ndi khansa, kapena yoyipa, pafupifupi nthawiyo. Malignant glucagonomas amafalikira m'matumba ena, nthawi zambiri chiwindi, ndikuyamba kusokoneza ntchito ya ziwalo zina.

Kodi Glucagonoma Amadziwika Bwanji?

Kungakhale kovuta kupeza glucagonoma. Nthawi zambiri, zizindikirazo zimawoneka kuti zimayambitsidwa ndi vuto lina, ndipo mwina pamatha zaka zambiri kuti apeze matenda olondola.

Matendawa amapangidwa poyesa magazi angapo. Mlingo wa glucagon wapamwamba ndizodziwika bwino za vutoli. Zizindikiro zina zimaphatikizapo shuga wambiri wamagazi, kuchuluka kwa chromogranin A, yomwe ndi protein yomwe imapezeka m'matumbo a carcinoid, komanso kuchepa kwa magazi m'thupi, zomwe ndizomwe mumakhala ndi magazi ofiira ochepa.

Dokotala wanu azitsatira mayesowa ndi CT scan pamimba kuti ayang'ane kupezeka kwa zotupa.

Awiri mwa magawo atatu a glucagonomas onse ndi owopsa. Zotupazi zimatha kufalikira m'thupi lonse ndikulowerera ziwalo zina. Zotupa nthawi zambiri zimakhala zazikulu ndipo zimatha kukhala mainchesi 4 mpaka 6 mulitali zikapezeka. Khansara nthawi zambiri sichipezeka mpaka itafalikira pachiwindi.

Kodi Ndizithandizo Ziti Zomwe Zilipo pa Glucagonoma?

Kuchiza glucagonoma kumaphatikizapo kuchotsa ma cell a chotupa ndikuchiza zotsatira za glucagon yochuluka mthupi lanu.

Ndibwino kuyamba mankhwalawa pokhazikitsa zotsatira za glucagon yochulukirapo. Izi nthawi zambiri zimaphatikizapo kumwa mankhwala a somatostatin analog, monga jakisoni wa octreotide (Sandostatin). Octreotide imathandiza kuthana ndi zotsatira za glucagon pakhungu lanu ndikusintha khungu.

Ngati mwataya thupi kwambiri, mungafunike IV kuti muthandizire kubwezeretsa thupi lanu. Shuga wamagazi amatha kuchiritsidwa ndi insulini komanso kuyang'anitsitsa magazi anu m'magazi.

Muthanso kupatsidwa mankhwala ochepetsa magazi, kapena ochepera magazi. Izi zimalepheretsa kupangika kwa magazi m'miyendo mwanu, amatchedwanso deep vein thrombosis. Kwa anthu omwe ali pachiwopsezo cha mitsempha yayikulu, fyuluta imatha kuyikidwa mu umodzi mwamitsempha yanu yayikulu, vena cava yotsika, kuti muteteze kuundana kuti kufikire m'mapapu anu.

Mukakhala ndi thanzi lokwanira, chotupacho chimachotsedwa opaleshoni. Chotupachi sichimayankhidwa bwino ndi chemotherapy. Opaleshoni imayenda bwino kwambiri ngati chotupacho chitagwiridwa chikadali chaching'ono.

Opaleshoni yofufuzira pamimba itha kuchitidwa laparoscopically, ndikucheka pang'ono kuti makamera, magetsi, ndi zida, kapena popanga cheke chokulirapo.

Ma glucagonomas ambiri amapezeka kumanzere kapena mchira wa kapamba. Kuchotsa gawo lino kumatchedwa distal pancreatectomy. Kwa anthu ena, ndulu imachotsedwanso. Pamene chotupacho chikuyang'aniridwa ndi microscope, zimakhala zovuta kudziwa ngati zili ndi khansa. Ngati ali ndi khansa, dokotalayo akuchotsani chotupacho momwe angathere kuti chisapitirirebe. Izi zingaphatikizepo gawo la kapamba, ma lymph node, ngakhale gawo la chiwindi.

Kodi zovuta za Glucagonoma ndi ziti?

Kuchulukitsa kwa glucagon kumabweretsa zizindikilo zonga matenda ashuga. Shuga wamagazi amatha kuyambitsa:

• kuwonongeka kwa mitsempha
• khungu
• mavuto amadzimadzi
• kuwonongeka kwa ubongo

Vuto lalikulu la mitsempha ingayambitse magazi kuundana m'mapapu, ndipo imatha kupha.

Chotupacho chikalowa m'chiwindi, chimatha kuyambitsa chiwindi kulephera.

Kodi Ndingayembekezere Pati?

Nthawi zambiri, nthawi yomwe glucagonoma imapezeka, khansara imafalikira ku ziwalo zina, monga chiwindi. Nthawi zambiri, opareshoni siyothandiza chifukwa zimakhala zovuta kuzizindikira msanga.

Chotupa chikachotsedwa, mphamvu ya glucagon yochulukirapo imachepa nthawi yomweyo. Ngati chotupacho chimangokhala paziphuphu zokha, kuchuluka kwa zaka zisanu ndiko, kutanthauza kuti 55% ya anthu amakhala zaka zisanu atachitidwa opaleshoni.Pali zaka zisanu zopulumuka ngati zotupazo sizingathe kuchotsedwa mwa opaleshoni.