Khansa ya m'mawere ya HER2-Positive vs. HER2-Hative: Kodi Zikunditanthauzanji?

Zamkati

• Kodi HER2 ndi chiyani?
• Kodi HER2-positive ikutanthauzanji?
• Kodi HER2-negative imatanthauza chiyani?
• Kuyesa HER2
• Kuchiza khansa ya m'mawere ya HER2
• Chiwonetsero

Chidule

Ngati inu kapena wokondedwa wanu mwadwala khansa ya m'mawere, mwina mudamvapo mawu oti "HER2." Mutha kukhala mukuganiza kuti kumatanthauza chiyani kukhala ndi khansa ya m'mawere ya HER2 kapena HER2.

Udindo wanu wa HER2, komanso kuchuluka kwa mahomoni a khansa yanu, zimathandizira kudziwa momwe khansa yanu yapadera imafalira. Udindo wanu wa HER2 ungathandizenso kudziwa kuti khansara ndi yankhanza bwanji. Dokotala wanu adzagwiritsa ntchito mfundoyi kuti awone zomwe mungasankhe.

M'zaka zaposachedwa, pakhala zochitika zazikulu pochiza khansa ya m'mawere ya HER2. Izi zadzetsa chiyembekezo chabwino kwa anthu omwe ali ndi matenda amtunduwu.

Kodi HER2 ndi chiyani?

HER2 imayimira kukula kwa epidermal factor factor receptor 2. Mapuloteni a HER2 amapezeka pamwamba pama cell am'mabere. Amakhudzidwa ndikukula kwamaselo koma amatha "kupitirira patsogolo." Izi zikutanthauza kuti milingo ya protein ndiyokwera kuposa yachibadwa.

HER2 idapezeka mzaka za m'ma 1980. Ofufuzawo adazindikira kuti kupezeka kwa mapuloteni ambiri a HER2 kumatha kupangitsa kuti khansa ikule ndikufalikira mwachangu. Kupeza kumeneku kunayambitsa kafukufuku wamomwe angachedwetse kapena kusintha kukula kwa mitundu iyi yamaselo a khansa.

Kodi HER2-positive ikutanthauzanji?

Khansa ya m'mawere ya HER2 imakhala ndi mapuloteni ambiri a HER2 modabwitsa. Izi zitha kupangitsa kuti maselo achulukane mwachangu. Kubereka kwambiri kungapangitse khansa ya m'mawere yomwe ikukula mwachangu yomwe imafalikira.

Pafupifupi 25 peresenti ya khansa ya m'mawere ndi HER2-positive.

M'zaka 20 zapitazi, kupita patsogolo kwakukulu kwachitika pazithandizo zamankhwala a khansa ya m'mawere ya HER2.

Kodi HER2-negative imatanthauza chiyani?

Ngati maselo a khansa ya m'mawere alibe milingo yachilendo ya mapuloteni a HER2, ndiye kuti khansa ya m'mawere imadziwika kuti HER2-negative. Ngati khansa yanu ili ndi HER2-negative, itha kukhalabe ndi estrogen- kapena progesterone-positive. Kaya zimakhudza momwe mungasamalire kapena ayi.

Kuyesa HER2

Mayeso omwe angadziwitse momwe HER2 alili ndi awa:

• mayeso a immunohistochemistry (IHC)
• kuyesa kwa hybridization (ISH)

Pali mayeso osiyanasiyana a IHC ndi ISH ovomerezedwa ndi Food and Drug Administration. Ndikofunika kuyesa kufotokozera mopitirira muyeso kwa HER2 chifukwa zotsatira zake zidzatsimikizira ngati mungapindule ndi mankhwala ena.

Kuchiza khansa ya m'mawere ya HER2

Kwa zaka zoposa 30, ofufuza akhala akuphunzira za khansa ya m'mawere ya HER2 ndi njira zochiritsira. Mankhwala omwe akuyembekezeredwa tsopano asintha malingaliro a khansa ya m'mawere 1 kupita ku 3 kuchoka pa osauka kukhala abwino.

Mankhwala osokoneza bongo trastuzumab (Herceptin), akagwiritsidwa ntchito limodzi ndi chemotherapy, asintha malingaliro a iwo omwe ali ndi khansa ya m'mawere ya HER2.

Woyamba adawonetsa kuti mankhwalawa adachepetsa kukula kwa khansa ya m'mawere ya HER2 kuposa chemotherapy yokha. Kwa ena, kugwiritsa ntchito Herceptin ndi chemotherapy kwadzetsa mpumulo wokhalitsa.

Kafukufuku waposachedwa apitiliza kuwonetsa kuti chithandizo ndi Herceptin kuphatikiza chemotherapy chasintha malingaliro onse a iwo omwe ali ndi khansa ya m'mawere ya HER2. Nthawi zambiri ndimachiritso oyambira khansa ya m'mawere ya HER2.

Nthawi zina, pertuzumab (Perjeta) ikhoza kuwonjezeredwa molumikizana ndi Herceptin. Izi zitha kulimbikitsidwa chifukwa cha khansa ya m'mawere ya HER2 yomwe ili pachiwopsezo chachikulu chobwereranso, monga gawo lachiwiri ndi kupitilira apo, kapena khansa yomwe yafalikira kumatenda am'mimba.

Neratinib (Nerlynx) ndi mankhwala ena omwe angalimbikitsidwe mukalandira chithandizo ndi Herceptin ngati ali ndi chiopsezo chachikulu chobwereranso.

Kwa khansa ya m'mawere ya HER2 yomwe imakhalanso ndi estrogen- komanso progesterone-positive, chithandizo chamankhwala am'magazi chingalimbikitsidwenso. Mankhwala ena okhudzana ndi HER2 amapezeka kwa iwo omwe ali ndi khansa yapakati kapena yamatenda owopsa.

Chiwonetsero

Ngati mwalandira matenda opatsirana a khansa ya m'mawere, dokotala wanu adzakuyesani ngati muli ndi khansa ya HER2. Zotsatira za mayeso zidzakusankhirani njira zabwino zochizira khansa yanu.

Zomwe zachitika posachedwa pochiza khansa ya m'mawere ya HER2 zakulitsa malingaliro kwa anthu omwe ali ndi vutoli. Kafukufuku akuchitika pazithandizo zatsopano, ndipo malingaliro a anthu omwe ali ndi khansa ya m'mawere akusintha.

Mukalandira matenda a khansa ya m'mawere YAKE, phunzirani zonse zomwe mungathe ndikulankhula momasuka za mafunso anu ndi dokotala wanu.