Kodi Malignant Hyperthermia ndi chithandizo chiti?

Zamkati

• Zomwe zingayambitse
• Zizindikiro zake ndi ziti
• Momwe mankhwalawa amachitikira

Malignant hyperthermia amakhala ndi kuwonjezeka kosalamulirika kwa kutentha kwa thupi, komwe kumapitilira kuthekera kwa thupi kutaya kutentha, osasintha kusintha kwa malo opatsirana a hypothalamic thermoregulatory, zomwe nthawi zambiri zimachitika pakakhala malungo.

Hyperthermia yoyipa imatha kupezeka mwa anthu omwe ali ndi cholowa chobadwa m'mafupa a mafupa komanso omwe amapezeka ndi mankhwala osokoneza bongo, monga halothane kapena enflurane, mwachitsanzo komanso atakhala ndi minofu yopumula yotchedwa succinylcholine.

Chithandizochi chimakhala ndi kuziziritsa thupi ndikupereka mankhwala mumitsempha, zomwe ziyenera kuchitika posachedwa, chifukwa hyperthermia yoyipa imatha kupha.

Zomwe zingayambitse

Matenda oopsa otchedwa hyperthermia amayamba chifukwa cha cholowa chobadwa chomwe chimapezeka mu sarcoplasmic reticulum ya mafupa am'mafupa, omwe amachititsa kuchuluka kwakanthawi kashiamu m'maselo, poyankha kuperekera mankhwala opha ululu, monga halothane kapena enflurane, mwachitsanzo, kapena chifukwa chodziwitsidwa ndi succinylcholine minofu yotsitsimula.

Pezani momwe anesthesia amagwirira ntchito komanso kuopsa kwake.

Kukwera kwa calcium iyi m'mitsempha yamafupa kumabweretsa mapangidwe a kukokomeza kwa mgwirizano waminyewa, ndikupangitsa kuwonjezeka kwadzidzidzi kwa kutentha.

Zizindikiro zake ndi ziti

Zizindikiro za hyperthermia yoyipa nthawi zambiri zimachitika mukamakumana ndi anesthesia ndipo mumakhala kutentha kwambiri, kuwonjezeka kwa mtima ndi kuchepa kwa minofu, kuuma kwa minofu ndi kuvulala, acidosis komanso kusakhazikika kwa minofu.

Momwe mankhwalawa amachitikira

Matenda oopsa a hyperthermia ayenera kuthandizidwa nthawi yomweyo mwa kusokoneza anesthesia ndi kayendedwe ka dantrolene sodium vein, kwa maola 24 mpaka 48, mpaka munthuyo atha kugwiritsa ntchito mankhwalawa pakamwa, ngati kungafunikirebe.

Kuphatikiza pa kuperekera mankhwalawa, thupi la munthu limatha kuzirala ndi masiponji achinyezi, mafani kapena malo osambira oundana ndipo, ngati zoziziritsa kunjazi sizikwanira, thupi limatha kuzilitsidwa mkati ndikutsuka kwa m'mimba ndi seramu.

Pazovuta kwambiri, momwe kutentha sikungachepetsedwe mokwanira, hemodialysis kapena cardiopulmonary yodutsa ndikuzizira kwa magazi kungakhale kofunikira.