Dziwani tanthauzo la mahomoni a ACTH otsika kapena otsika

Zamkati

• Zotheka kusintha ku ACTH
• Mkulu ACTH
• Low ACTH
• Malangizo pakuyesa

Hormone ya adrenocorticotropic, yomwe imadziwikanso kuti corticotrophin ndi dzina loti ACTH, imapangidwa ndimatenda a pituitary ndipo imathandizira makamaka kuyesa zovuta zokhudzana ndi zotupa za pituitary ndi adrenal. Chifukwa chake, kuyeza kwa ACTH ndikofunikira kuzindikira zinthu monga Cushing's syndrome, matenda a Addison, ectopic secretion syndrome, khansa yamapapo ndi chithokomiro komanso kulephera kwa adrenal gland, mwachitsanzo.

Mayeso a ACTH nthawi zambiri amafunsidwa ndi dokotala limodzi ndi muyeso wa cortisol kuti ubale wapakati pa mahomoni awiriwa athe kuwunikiridwa, popeza ACTH imalimbikitsa kupanga kwa cortisol. Mtengo wabwinobwino wa ACTH m'magazi umafika pa 46 pg / mL, zomwe zimatha kusiyanasiyana kutengera labotale momwe mayeso amachitidwira komanso nthawi yosonkhanitsira, popeza kuchuluka kwa timadzi timeneti kumasiyana tsiku lonse, ndipo zosonkhetsa zimalimbikitsidwa pofika m'mawa.

Mtengo wa mayeso a ACTH umasiyanasiyana pakati pa R $ 38 ndi R $ 50.00 kutengera labotale, komabe, imaperekedwa ndi SUS.

Zotheka kusintha ku ACTH

ACTH imabisidwa pang'onopang'ono masana, imakhala yokwera nthawi ya 6 ndi 8 m'mawa ndikutsika nthawi ya 9 pm ndi 10 pm. Kupanga kwa hormone iyi kumawonjezeka makamaka munthawi zovuta, zomwe zimapangitsa kuti cortisol imasulidwe, yomwe imayang'anira kuthana ndi nkhawa, nkhawa komanso kutupa. Dziwani zambiri za cortisol ndi zomwe zimapangidwira.

Zosintha zomwe zingakhalepo ku ACTH zitha kukhala:

Mkulu ACTH

• Matenda a Cushing, omwe angapangitse kuchuluka kwa ACTH ndimatenda a pituitary;
• Kulephera kwapadera kwa adrenal;
• Matenda a Adrenogenital ndi kuchepa kwa kupanga kwa cortisol;
• Kugwiritsa ntchito amphetamines, insulin, levodopa, metoclopramide ndi mifepristone.

Kuchuluka kwambiri kwa ACTH m'magazi kumatha kukulitsa kuwonongeka kwa lipids, kukulitsa kuchuluka kwa mafuta acid ndi glycerol m'magazi, kuchititsa kutulutsa kwa insulin ndikuwonjezera kutulutsa kwa hormone yakukula, GH. Mvetsetsani kuti GH ndi chiyani komanso kuti ndi chiyani.

Low ACTH

• Hypopituitarism;
• Matenda osakwanira a ACTH - sekondale adrenal;
• Kugwiritsa ntchito corticosteroids, estrogens, spironolactone, amphetamines, mowa, lithiamu, mimba, msambo, masewera olimbitsa thupi.

Mayesowa amalamulidwa ndi adotolo munthuyo akakhala ndi zizindikiro zokhudzana ndi kuchuluka kapena kuchepa kwa cortisol m'magazi. Zizindikiro zomwe zingawonetse kuti cortisol yayikulu ndiyonenepa kwambiri, khungu lopyapyala komanso lofooka, zipsera zofiira pamimba, ziphuphu, kuwonjezeka kwa tsitsi la thupi ndi zizindikilo zomwe zitha kuwonetsa kuti cortisol yotsika ndi kufooka, kutopa, kuwonda, kuda khungu komanso kusowa kwa njala.

Malangizo pakuyesa

Kuti muchite mayeso, tikulimbikitsidwa kuti munthuyo azisala kudya kwa maola osachepera 8 kapena malinga ndi upangiri wa zamankhwala ndikuti zosonkhanitsazo zipangidwe m'mawa, makamaka maola awiri munthuyo atadzuka.

Kuphatikiza apo, ndikofunikanso kuti musachite masewera olimbitsa thupi patsiku la mayeso kapena dzulo ndikuchepetsa kumwa zakumwa monga mkate, mpunga, mbatata ndi pasitala kutatsala maola 48 kuti ayesedwe, popeza hormone iyi imagwira malamulo a mapuloteni, shuga ndi lipid metabolism.