Ivermectin: ndi chiyani komanso momwe mungagwiritsire ntchito

Zamkati

• Ndi chiyani
• Momwe mungagwiritsire ntchito
• 1. Strongyloidiasis, filariasis, nsabwe ndi nkhanambo
• 2. Onchocerciasis
• Zotsatira zoyipa
• Yemwe sayenera kutenga
• Ivermectin ndi COVID-19
• Pochiza COVID-19
• Popewa COVID-19

Ivermectin ndi mankhwala oletsa antiparasitic omwe amatha kufooka ndikulimbikitsa kuthetsedwa kwa majeremusi angapo, makamaka akuwonetsedwa ndi dokotala pochiza onchocerciasis, elephantiasis, pediculosis, ascariasis ndi nkhanambo.

Izi zikutanthauza kuti achikulire ndi ana opitilira zaka 5 ndipo amatha kupezeka m'masitolo, ndikofunikira kukaonana ndi adotolo za momwe angagwiritsire ntchito, chifukwa mlingowu umasiyana malinga ndi zomwe wothandizirayo ayenera kulandira komanso kulemera kwa munthu wokhudzidwayo. .

Ndi chiyani

Ivermectin ndi mankhwala antiparasitic akuwonetseredwa kwambiri pochiza matenda angapo, monga:

• Matumbo amphamvu;
• Filariasis, yotchedwa elephantiasis;
• Mphere, wotchedwanso mphere;
• Ascariasis, yomwe ndi matenda opatsirana ndi tiziromboti Ascaris lumbricoides;
• Pediculosis, yomwe imadzaza ndi nsabwe;
• Onchocerciasis, yotchuka kwambiri monga "khungu lakhungu".

Ndikofunikira kuti kugwiritsa ntchito ivermectin kuchitidwe molingana ndi malangizo a dokotala, chifukwa ndizotheka kupewa kuwoneka ngati zotsekula m'mimba, kutopa, kupweteka m'mimba, kuonda, kudzimbidwa ndi kusanza. Nthawi zina, chizungulire, kugona, chizungulire, kunjenjemera ndi ming'oma kumawonekeranso pakhungu.

Momwe mungagwiritsire ntchito

Ivermectin imagwiritsidwa ntchito pamlingo umodzi malinga ndi wothandizila yemwe akuyenera kuthetsedwa. Mankhwalawa ayenera kumwa mopanda kanthu, ola limodzi musanadye chakudya choyamba tsikulo. Sitiyenera kumwa mankhwala a barbiturate, benzodiazepine kapena valproic acid.

1. Strongyloidiasis, filariasis, nsabwe ndi nkhanambo

Pofuna kuchiza strongyloidiasis, filariasis, nsabwe kapena matenda amphere, mlingo woyenera uyenera kusinthidwa kulemera kwanu, motere:

2. Onchocerciasis

Pofuna kuchiza onchocerciasis, mlingo woyenera, kutengera kulemera kwake, ndi motere:

Zotsatira zoyipa

Zina mwazovuta zomwe zimachitika mukalandira chithandizo ndi ivermectin ndikutsekula m'mimba, mseru, kusanza, kufooka kwathunthu komanso kusowa kwa mphamvu, kupweteka m'mimba, kusowa kwa njala kapena kudzimbidwa. Izi zimakhala zofatsa komanso zosakhalitsa.

Kuphatikiza apo, zovuta zimathanso kupezeka, makamaka mukamamwa ivermectin ya onchocerciasis, yomwe imatha kuwonetsa ndi kupweteka m'mimba, malungo, thupi loyabwa, mawanga ofiira pakhungu, kutupa m'maso kapena zikope. Ngati zizindikirozi zikuwoneka, ndibwino kuti musiye kugwiritsa ntchito mankhwalawa ndikupempha thandizo kuchipatala mwachangu kapena kuchipatala chapafupi.

Yemwe sayenera kutenga

Mankhwalawa amatsutsana ndi amayi apakati, amayi omwe akuyamwitsa, ana osakwana zaka 5 kapena 15 makilogalamu ndi odwala meninjaitisi kapena mphumu. Kuphatikiza apo, sayenera kugwiritsidwanso ntchito kwa anthu omwe ali ndi hypersensitivity ku ivermectin kapena zina zilizonse zomwe zikupezeka mu chilinganizo.

Ivermectin ndi COVID-19

Kugwiritsa ntchito ivermectin motsutsana ndi COVID-19 kwakhala kukufotokozedwa kwambiri kwa asayansi, chifukwa antiparasitic iyi ili ndi njira yothanirana ndi kachilombo koyambitsa matenda a yellow fever, ZIKA ndi dengue ndipo, chifukwa chake, amayenera kuti ikhudzanso SARS- CoV-2.

Pochiza COVID-19

Ivermectin adayesedwa ndi ofufuza aku Australia pachikhalidwe cha cell mu m'galasi, yomwe idawonetsa kuti mankhwalawa ndi othandiza kuthana ndi kachilombo ka SARS-CoV-2 m'maola 48 okha ^[1] . Komabe, zotsatirazi sizinali zokwanira kutsimikizira kuti ndi zothandiza mwa anthu, ndipo mayesero azachipatala amafunikira kuti atsimikizire kuti ndi othandiza. mu vivo, ndikuwonetsanso ngati mankhwalawa ndi otetezeka mwa anthu.

Kafukufuku wa odwala omwe ali mchipatala ku Bangladesh^[2] Cholinga chake ndikutsimikizira ngati kugwiritsa ntchito ivermectin kungakhale kotetezeka kwa odwalawa komanso kuti padzakhala vuto lililonse motsutsana ndi SARS-CoV-2. Chifukwa chake, odwalawa adatumizidwa kuchipatala cha masiku asanu ndi ivermectin (12 mg) kapena mlingo umodzi wa ivermectin (12 mg) kuphatikiza mankhwala ena kwa masiku 4, ndipo zotsatira zake zidafanizidwa ndi gulu la placebo lomwe Odwala 72. Zotsatira zake, ofufuzawo adapeza kuti kugwiritsa ntchito ivermectin kokha kunali kotetezeka ndipo kunali kothandiza pochiza COVID-19 mwa odwala akulu, komabe maphunziro ena angafunike kuti atsimikizire zotsatirazi.

Kafukufuku wina yemwe adachitika ku India adatsimikiza kuti kugwiritsa ntchito ivermectin mwa kupuma kungakhale ndi mphamvu yotsutsana ndi COVID-19 ^[3], popeza mankhwalawa amatha kusokoneza mayendedwe a SARS-CoV-2 kupita pamutu wamaselo amunthu, zomwe zimapangitsa zotsatira za ma virus. Komabe, zotsatirazi zitha kuchitika ndi kuchuluka kwambiri kwa ivermectin (kuposa kuchuluka kwa mankhwala ochizira majeremusi), zomwe zingayambitse chiwopsezo cha chiwindi. Chifukwa chake, m'malo mwa kuchuluka kwa ivermectin, ofufuzawo adati kugwiritsa ntchito mankhwalawa mwa kupuma, zomwe zitha kuchitapo kanthu motsutsana ndi SARS-CoV-2, komabe njira yoyendetsera ntchitoyi ikuyenera kuphunziridwa bwino.

Dziwani zambiri za njira zochizira matendawa ndi coronavirus yatsopano.

Popewa COVID-19

Kuphatikiza pa ivermectin yowerengedwa ngati njira yothandizira COVID-19, kafukufuku wina adachitika ndi cholinga chotsimikizira ngati kugwiritsa ntchito mankhwalawa kungathandize kupewa matenda.

Kafukufuku wofufuza ku United States adafuna kuti afufuze chifukwa chake COVID-19 ili ndi zochitika zosiyanasiyana m'maiko angapo ^[5]. Chifukwa cha kafukufukuyu, apeza kuti mayiko aku Africa ali ndi vuto locheperako chifukwa chogwiritsa ntchito mankhwala osokoneza bongo, makamaka mankhwala opatsirana pogonana, kuphatikiza ivermectin, chifukwa chowopsa chowopsa cha tiziromboti m'mayikowa.

Chifukwa chake, ofufuzawo amakhulupirira kuti kugwiritsa ntchito ivermectin kumatha kuchepetsa kuchepa kwa kachilomboka ndikuletsa kukula kwa matendawa, komabe zotsatirazi zimangotengera kulumikizana, ndipo palibe mayesero azachipatala omwe adachitidwa.

Kafukufuku wina adanenanso kuti kugwiritsa ntchito nanoparticles yokhudzana ndi ivermectin kumatha kuchepetsa kufotokozera kwa ma receptors omwe amapezeka m'maselo amunthu, ACE2, omwe amalumikizana ndi kachilomboka, komanso zomanga thupi zomwe zili pamwamba pa kachilomboka, zomwe zimachepetsa chiopsezo chotenga matenda ^[6]. Komabe, maphunziro ena a vivo amafunikira kuti atsimikizire zotsatira zake, komanso maphunziro owopsa kuti atsimikizire kuti kugwiritsa ntchito ivermectin nanoparticles ndikotetezeka.

Ponena za kugwiritsidwa ntchito kwa ivermectin podziteteza, palibe maphunziro omaliza panobe. Komabe, kuti ivermectin igwire ntchito popewa kapena kuchepetsa kulowa kwa ma virus m'maselo, ndikofunikira kuti pakhale kuchuluka kwa ma virus, chifukwa chifukwa chake ndizotheka kukhala ndi ma antivirical mankhwala.