Mavyret (glecaprevir / pibrentasvir)

Zamkati

• Mavyret ndi chiyani?
• Kuchita bwino
• Kuvomerezeka ndi FDA
• Mavyret generic
• Mtengo wa Mavyret
• Thandizo lazachuma komanso inshuwaransi
• Zotsatira zoyipa za Mavyret
• Zotsatira zofala kwambiri
• Zotsatira zoyipa
• Zotsatira zoyipa
• Zotsatira zoyipa mwa ana
• Mlingo wa Mavyret
• Mitundu ya mankhwala ndi mphamvu
• Mlingo wa hepatitis C
• Mlingo wa ana
• Ndingatani ngati ndaphonya mlingo?
• Kodi ndiyenera kugwiritsa ntchito mankhwalawa nthawi yayitali?
• Mavyret ndi mowa
• Njira zina zopezera Mavyret
• Mavyret vs. Harvoni
• Pafupi
• Ntchito
• Mafomu azamankhwala ndi makonzedwe
• Zotsatira zoyipa ndi zoopsa
• Kuchita bwino
• Mtengo
• Mavyret vs. Epclusa
• Pafupi
• Ntchito
• Mafomu azamankhwala ndi makonzedwe
• Zotsatira zoyipa ndi zoopsa
• Kuchita bwino
• Mtengo
• Mavyret wa hepatitis C
• Kuchita bwino
• Mavyret ya ana
• Kuyanjana kwa Mavyret
• Mavyret ndi mankhwala ena
• Mavyret ndi zitsamba ndi zowonjezera
• Mavyret ndi mimba
• Mavyret ndi kuyamwitsa
• Momwe mungatengere Mavyret
• Nthawi yoti mutenge
• Kutenga Mavyret ndi chakudya
• Kodi Mavyret ikhoza kuphwanyidwa, kugawanika, kapena kutafuna?
• Momwe Mavyret amagwirira ntchito
• Zimatenga nthawi yayitali bwanji kuti zigwire ntchito?
• Mafunso wamba okhudza Mavyret
• Kodi nditha kumwa Mavyret ngati ndili ndi HIV komanso hepatitis C?
• Kodi Mavyret akuchita bwino bwanji pochiza hepatitis C?
• Ngati ndalandira mankhwala ena a hepatitis C, nditha kugwiritsa ntchito Mavyret?
• Kodi ndifunikira mayeso aliwonse asanafike kapena akamamwa Mavyret?
• Kodi ndingagwiritse ntchito Mavyret ngati ndili ndi matenda enaake?
• Zisamaliro za Mavyret
• Chenjezo la FDA: kuyambiranso kwa kachilombo ka hepatitis B
• Machenjezo ena
• Kuledzera kwa Mavyret
• Zomwe muyenera kuchita mukamagwiritsa ntchito bongo
• Kutha kwa Mavyret, kusunga, ndi kutaya
• Yosungirako
• Kutaya
• Zambiri za Mavyret
• Zisonyezero
• Njira yogwirira ntchito
• Pharmacokinetics ndi metabolism
• Zotsutsana
• Yosungirako

Mavyret ndi chiyani?

Mavyret ndi mankhwala osokoneza bongo omwe amagwiritsidwa ntchito pochiza kachilombo koyambitsa matenda a chiwindi (HCV). Kachilomboka kamayambitsa chiwindi chanu ndipo kamayambitsa kutupa.

Mavyret itha kugwiritsidwa ntchito ndi anthu omwe ali ndi mitundu isanu ndi umodzi ya HCV omwe alibe chiwindi (kufooka kwa chiwindi) kapena omwe adalipira (chifuwa chofatsa). Mavyret itha kugwiritsidwanso ntchito kuchiza mtundu wa HCV 1 mwa anthu omwe adathandizidwapo kale (koma osachiritsidwa) ndi mtundu wina wa mankhwala.

Mavyret imavomerezedwa kuti igwiritsidwe ntchito kwa akulu. Amavomerezedwanso kuti agwiritsidwe ntchito kwa ana azaka 12 kapena kupitilira apo, kapena omwe amalemera pafupifupi 45 kilogalamu (pafupifupi mapaundi 99).

Mavyret imabwera ngati piritsi limodzi lokhala ndi mankhwala awiri othandizira: glecaprevir (100 mg) ndi pibrentasvir (40 mg). Zimatengedwa pakamwa kamodzi tsiku lililonse.

Kuchita bwino

M'mayesero azachipatala, achikulire omwe ali ndi HCV (mitundu 1, 2, 3, 4, 5, ndi 6) omwe sanalandirepo kachilomboka adapatsidwa Mavyret. Mwa anthuwa, 98% mpaka 100% adachiritsidwa atatha chithandizo cha masabata 8 mpaka 12. M'maphunzirowa, kuchiritsidwa kumatanthauza kuti kuyezetsa magazi kwa anthu, komwe kunachitika miyezi itatu atalandira chithandizo, sikunawonetse zizindikiro zilizonse za matenda a HCV mthupi lawo.

Kuti mumve zambiri zothandiza, onani gawo la "Kuchita bwino" pamutu wakuti "Mavyret for hepatitis C" pansipa.

Kuvomerezeka ndi FDA

Mavyret adavomerezedwa ndi Food and Drug Administration (FDA) mu Epulo 2017 kuti athetse kachilombo koyambitsa matenda a chiwindi a C (mitundu 1, 2, 3, 4, 5, ndi 6) mwa akulu.

Mu Epulo 2019, a FDA adakulitsa kuvomereza kwamankhwalawa kuti aphatikize kugwiritsa ntchito ana. Amavomerezedwa kuti azigwiritsidwa ntchito kwa ana azaka 12 kapena kupitilira apo, kapena omwe amalemera pafupifupi 45 kg (pafupifupi 99 lbs.).

Mavyret generic

Mavyret imangopezeka ngati mankhwala odziwika ndi dzina. Sikupezeka pakadali pano mu mawonekedwe achibadwa.

Mavyret ili ndi zinthu ziwiri zomwe zimagwira ntchito: glecaprevir ndi pibrentasvir.

Mtengo wa Mavyret

Monga mankhwala onse, mtengo wa Mavyret umatha kusiyanasiyana. Kuti mupeze mitengo yamtundu wa Mavyret mdera lanu, onani GoodRx.com.

Mtengo womwe mumapeza pa GoodRx.com ndiomwe mungalipire popanda inshuwaransi. Mtengo weniweni womwe mudzalipira umadalira dongosolo la inshuwaransi yanu, komwe mumakhala, komanso malo ogulitsira mankhwala omwe mumagwiritsa ntchito.

Thandizo lazachuma komanso inshuwaransi

Ngati mukufuna thandizo lazachuma kuti mulipire Mavyret, kapena ngati mukufuna thandizo kuti mumvetsetse inshuwaransi yanu, thandizo lilipo.

Abbvie, yemwe amapanga Mavyret, amapereka pulogalamu yotchedwa Mavyret Patient Support, yomwe ingakuthandizeni kuchepetsa mtengo wanu wa mankhwalawa. Kuti mumve zambiri komanso kuti mudziwe ngati mukuyenera kuthandizidwa, imbani 877-628-9738 kapena pitani patsamba lino.

Zotsatira zoyipa za Mavyret

Mavyret imatha kuyambitsa zovuta zochepa kapena zoyipa. Mndandanda wotsatira uli ndi zovuta zina zomwe zingachitike mukamamwa Mavyret. Mndandandawu mulibe zovuta zonse zomwe zingachitike.

Kuti mumve zambiri pazomwe zingachitike chifukwa cha Mavyret, lankhulani ndi dokotala kapena wamankhwala. Amatha kukupatsirani malangizo amomwe mungathetsere mavuto omwe angakhale ovuta.

Zotsatira zofala kwambiri

Zotsatira zofala kwambiri za Mavyret zitha kuphatikiza:

• mutu
• kumva kutopa
• nseru
• kutsegula m'mimba
• kuchuluka kwa bilirubin (kuyesa labu komwe kumayang'ana chiwindi chanu)

Zambiri mwa zotsatirazi zimatha kutha masiku angapo kapena milungu ingapo. Ngati ali ovuta kwambiri kapena osapita, lankhulani ndi dokotala kapena wamankhwala.

Zotsatira zoyipa

Zotsatira zoyipa zochokera ku Mavyret sizodziwika, koma zimatha kuchitika. Itanani dokotala wanu nthawi yomweyo ngati muli ndi zovuta zina. Itanani 911 ngati zizindikiro zanu zikuwopseza moyo kapena ngati mukuganiza kuti mukukumana ndi vuto lachipatala.

Zotsatira zoyipa, zomwe zafotokozedwa pansipa mu "Zotsatira zoyipa," ndi izi:

• kuyambiranso kwa kachilombo ka hepatitis B (kuwonongeka kwa kachilomboka, ngati kuli kale m'thupi lanu) *
• kwambiri thupi lawo siligwirizana

Zotsatira zoyipa

Mutha kudabwa kuti zovuta zina zimachitika kangati ndi mankhwalawa, kapena ngati zovuta zina zake zimakhudza. Nazi zina mwazovuta zomwe mankhwalawa angapangitse kapena sangayambitse.

Matupi awo sagwirizana

Monga momwe zimakhalira ndi mankhwala ambiri, anthu ena amatha kusokonezeka atalandira Mavyret. Sidziwika motsimikiza kuti kangati anthu omwe amamwa mankhwalawa amakhala ndi vuto lawo. Zizindikiro za kuchepa pang'ono zimatha kuphatikiza:

• zotupa pakhungu
• kuyabwa
• Kutentha (kutentha ndi kufiira pakhungu lanu)

Zomwe zimayambitsa matendawa zimakhala zochepa koma ndizotheka. Zizindikiro za kuyanjana kwambiri ndi izi:

• kutupa pansi pa khungu lanu, makamaka m'makope anu, milomo, manja, kapena mapazi
• kutupa lilime, pakamwa, kapena pakhosi
• kuvuta kupuma kapena kuyankhula

Itanani dokotala wanu nthawi yomweyo ngati mukuvutika kwambiri ndi Mavyret. Itanani 911 ngati zizindikiro zanu zikuwopseza moyo kapena ngati mukuganiza kuti mukukumana ndi vuto lachipatala.

Kuyabwa

Mutha kuwona kuyabwa mukamagwiritsa ntchito Mavyret.M'mayesero azachipatala, anthu ena adamva kuyamwa akamamwa mankhwalawa. Kuyabwa kumachitika kokha mwa anthu omwe amamwa mankhwala omwe anali ndi matenda a impso komanso matenda a hepatitis C (HCV). Mu gululi, pafupifupi 17% ya anthu anena kuyabwa ngati zoyipa zina.

Kuyabwa nthawi zina kumakhala chizindikiro cha HCV. Kuyabwa kumachitika pafupifupi anthu 20% omwe ali ndi HCV. Chizindikiro ichi mwina chimakhala chifukwa cha kuchuluka kwa mankhwala otchedwa bilirubin mthupi lanu. Kuyabwa komwe kumayambitsidwa ndi HCV kumatha kukhala m'dera limodzi kapena kuthupi lanu lonse.

Ngati muli ndi nkhawa zokhala ndi khungu loyabwa mukamamwa Mavyret, lankhulani ndi dokotala wanu. Amatha kulangiza njira zokuthandizani kuchepetsa zotsatirazi mukamagwiritsa ntchito mankhwalawa.

Kutsegulanso kwa hepatitis B

Mutha kukhala ndi chiopsezo chowonjezereka cha kuyambiranso kachilombo ka hepatitis B (HBV) (flare-up) mukamatenga Mavyret.

Chithandizo cha Mavyret chimawonjezera chiwopsezo cha kuyambiranso kwa HBV mwa anthu omwe ali ndi HBV ndi HCV. Zikakhala zovuta, kuyambiranso kwa HBV kumatha kuyambitsa chiwindi kulephera kapena kufa kumene.

Zizindikiro zakubwezeretsanso kwa HBV zitha kuphatikizira:

• kupweteka kumanja kwa mimba yako
• chopondapo chowala
• kumva kutopa
• chikasu cha khungu lako kapena kuyera kwa maso ako

Musanayambe Mavyret, dokotala wanu adzakuyesani ngati muli ndi HBV. Ngati muli ndi HBV, mungafunikire kuchiritsidwa musanatenge Mavyret. Kapena dokotala wanu angakulimbikitseni kuyesedwa pa nthawi ya chithandizo cha Mavyret kuti muwone kuyambiranso kwa HBV ndikuchiza matendawa ngati kuli kofunikira.

Kulemera kumasintha (osati zotsatira zoyipa)

Kuchepetsa thupi komanso kunenepa sanafotokozedwe ngati zoyipa za Mavyret panthawi yamankhwala. Komabe, Mavyret amatha kuyambitsa nseru, zomwe zitha kudzetsa kuchepa kwa anthu ena. Ngati mukumva nseru mukamamwa mankhwalawa, mwina mumadya chakudya chochepa, chomwe chingapangitse kuti muchepetse thupi.

Ngati muli ndi nkhawa zakukula kunenepa kapena kuonda mukamamwa Mavyret, lankhulani ndi dokotala wanu. Amatha kukuthandizani kukonzekera zakudya zopatsa thanzi mukamalandira chithandizo.

Ziphuphu pakhungu (osati zotsatira zoyipa)

Kutupa pakhungu sikunanenedwe ngati zotsatira zoyipa za Mavyret panthawi yamayesero azachipatala. Komabe, HCV yokha nthawi zina imatha kuyambitsa khungu. Izi zitha kulakwitsa chifukwa chotsatira mankhwala. Kutupa komwe kumayambitsidwa ndi HCV kumatha kukhala paliponse pathupi lanu, kuphatikiza nkhope yanu, chifuwa, kapena mikono. Zingakupangitseni kuti muzimva kuyabwa.

Ngati muli ndi zotupa pakhungu mukugwiritsa ntchito Mavyret, lankhulani ndi dokotala wanu. Amatha kunena njira zochepetsera matenda anu ndikupatsirani chithandizo pakafunika kutero.

Zotsatira zoyipa mwa ana

Pakati pa maphunziro azachipatala, zoyipa zomwe zimawonedwa mwa ana (azaka 12 mpaka 17) kutenga Mavyret zinali zofanana ndi zoyipa zomwe zimawonedwa mwa akulu atamwa mankhwalawa. M'maphunzirowa, palibe mwana amene anasiya kulandira chithandizo chifukwa cha zovuta zina.

Zotsatira zoyipa zomwe zimawonedwa mwa ana ndi izi:

• kumva kutopa
• nseru
• mutu
• kuchuluka kwa bilirubin (kuyesa labu komwe kumayang'ana chiwindi chanu)

Ngati mukuda nkhawa ndi zovuta zomwe zimachitika mwa mwana yemwe amagwiritsira ntchito Mavyret, lankhulani ndi dokotala wanu. Angathe kulangiza njira zochepetsera zotsatirazi panthawi yachipatala.

Mlingo wa Mavyret

Chidziwitso chotsatirachi chimalongosola miyezo yomwe amagwiritsidwa ntchito kwambiri kapena amalimbikitsidwa. Komabe, onetsetsani kuti mwatenga mlingo womwe dokotala akukulemberani. Dokotala wanu adzazindikira mlingo woyenera kuti ugwirizane ndi zosowa zanu.

Mitundu ya mankhwala ndi mphamvu

Mavyret amabwera ngati piritsi lomwe limatengedwa pakamwa. Piritsi lililonse lili ndi 100 mg ya glecaprevir ndi 40 mg ya pibrentasvir.

Mlingo wa hepatitis C

Mlingo wa Mavyret wa matenda a chiwindi cha hepatitis C (HCV) ndi mapiritsi atatu omwe amatengedwa pakamwa kamodzi patsiku. Mankhwalawa ayenera kutengedwa ndi chakudya. Iyeneranso kumwedwa nthawi yofananira tsiku lililonse.

Dokotala wanu adzawona kutalika komwe muyenera kutenga Mavyret. Chisankhochi chimadalira chithandizo chilichonse cham'mbuyomu cha HCV chomwe mudagwiritsa ntchito.

Kutalika kwa chithandizo cha munthu aliyense kumatha kusiyanasiyana, koma anthu ambiri amatenga Mavyret kulikonse kuyambira masabata 8 mpaka masabata 16. Kutalika kwa chithandizo cha Mavyret ndi motere:

• Ngati simunalandirepo HCV, ndipo mulibe matenda enaake (kufooka kwa chiwindi), mudzalandira mankhwala kwa milungu 8.
• Ngati simunalandirepo HCV, ndipo mwalipirira matenda ofatsa (ofatsa), mwina mudzalandira mankhwala kwa milungu 12.
• Ngati mudapatsidwa chithandizo cha HCV m'mbuyomu, ndipo chithandizo chanu sichinali chothandiza (sichinachiritse matenda anu), kutalika kwa chithandizo chanu ndi Mavyret kumatha kusiyanasiyana. Itha kukhala kulikonse kuyambira milungu 8 mpaka milungu 16. Kutalika kwenikweni kwa chithandizo chanu kumadalira mtundu wa mankhwala a HCV omwe mudagwiritsa ntchito m'mbuyomu.

Ngati muli ndi mafunso okhudza nthawi yayitali bwanji kuti mutenge Mavyret, lankhulani ndi dokotala wanu. Angakulimbikitseni njira yabwino kwambiri yothandizira.

Mlingo wa ana

Mlingo wa ana wa Mavyret ndi wofanana ndi wa akulu: mapiritsi atatu omwe amatengedwa pakamwa (ndi chakudya) kamodzi patsiku. Dosing ya ana imagwira ntchito kwa ana:

• a zaka 12 mpaka 17, kapena
• iwo omwe amalemera pafupifupi 45 kg (pafupifupi mapaundi 99)

Mavyret sivomerezedwa pano kuti igwiritsidwe ntchito kwa ana ochepera zaka 12 kapena mwa iwo omwe amalemera makilogalamu 45.

Ndingatani ngati ndaphonya mlingo?

Ngati mwaphonya Mavyret, nazi zomwe muyenera kuchita:

• Ngati pasanathe maola 18 kuchokera pomwe muyenera kutenga Mavyret, pitirizani kumwa mankhwala anu mukamakumbukira. Kenako, tengani mlingo wanu wotsatira nthawi yanthawi zonse.
• Ngati ndi maola opitilira 18 kuchokera pomwe muyenera kutenga Mavyret, ingodumpha mulingo umenewo. Mutha kutenga mlingo wanu wotsatira nthawi yanthawi zonse.

Pofuna kuthandizira kuti musaphonye mlingo, yesani kukhazikitsa chikumbutso pafoni yanu. Timer ya mankhwala ingakhale yothandiza, nayenso.

Kodi ndiyenera kugwiritsa ntchito mankhwalawa nthawi yayitali?

Kutalika kwa nthawi yomwe muyenera kutenga Mavyret kumadalira zinthu zingapo. Izi zimaphatikizapo ngati mudalandirapo HCV kale, komanso ngati muli ndi vuto la chiwindi (cirrhosis).

Nthawi zambiri, chithandizo cha Mavyret chimatha kulikonse kuyambira milungu 8 mpaka 16. Nthawi zambiri sizikhala motalika kuposa masabata 16.

Mavyret ndi mowa

Mavyret alibe machitidwe omwe amadziwika ndi mowa. Komabe, simuyenera kumwa mowa ngati muli ndi kachilombo ka hepatitis C (HCV). Mowa umapangitsa HCV kukhala yoyipa kwambiri, yomwe imatha kubweretsa kuwonongeka koopsa (chiwindi) m'chiwindi.

Ngati mumamwa mowa, ndipo mukuda nkhawa ndi momwe mungamamwe mowa, lankhulani ndi dokotala wanu.

Njira zina zopezera Mavyret

Mankhwala ena alipo omwe angachiritse matenda a chiwindi a hepatitis C (HCV). Ena akhoza kukuyenererani kuposa ena. Ngati mukufuna kupeza njira ina m'malo mwa Mavyret, lankhulani ndi dokotala wanu. Amatha kukuwuzani zamankhwala ena omwe atha kukuthandizani.

Mankhwala ena, omwe ali ndi mankhwala osakaniza mavairasi ochizira HCV, ndi awa:

• ledipasvir ndi sofosbuvir (Harvoni)
• sofosbuvir ndi velpatasvir (Epclusa)
• velpatasvir, sofosbuvir, ndi voxilaprevir (Vosevi)
• elbasvir ndi grazoprevir (Zepatier)
• simeprevir (Olysio) ndi sofosbuvir (Sovaldi)

Ngakhale samabwera ngati mankhwala osakanikirana, Simeprevir (Olysio) ndi sofosbuvir (Sovaldi) amathanso kutengedwa limodzi kuti akachiritse HCV.

Mavyret vs. Harvoni

Mutha kudabwa momwe Mavyret amafananira ndi mankhwala ena omwe amapatsidwa ntchito zofananira. Apa tikuwona momwe Mavyret ndi Harvoni alili ofanana komanso osiyana.

Pafupi

Mavyret muli mankhwala glecaprevir ndi pibrentasvir. Harvoni muli mankhwala ledipasvir ndi sofosbuvir. Onse Mavyret ndi Harvoni ali ndi mankhwala ophatikizira, ndipo ali mgulu lomwelo la mankhwala.

Ntchito

Mavyret amavomerezedwa kuti athetse kachilombo koyambitsa matenda a hepatitis C (HCV) akuluakulu. Amavomerezedwanso kuti agwiritsidwe ntchito kwa ana azaka 12 kapena kupitilira apo, kapena omwe amalemera makilogalamu osachepera 45, omwe ali pafupifupi 99 lbs.

Mavyret imagwiritsidwa ntchito pochizira mitundu yonse (1, 2, 3, 4, 5, ndi 6) ya HCV mwa anthu:

• wopanda kufooka kwa chiwindi (cirrhosis), kapena kwa iwo omwe ali ndi matenda enaake opanda zizindikiritso za vutoli
• omwe alandila chiwindi kapena impso
• omwe ali ndi HIV

Mavyret itha kugwiritsidwanso ntchito kuchiza mtundu wa HCV 1 mwa anthu omwe adathandizidwapo kale (koma osachiritsidwa) ndi mtundu wina wa mankhwala.

Harvoni imavomerezedwa kuchiza HCV mwa akulu. Ikhoza kugwiritsidwa ntchito pochiza mitundu yotsatirayi ya HCV:

• mitundu 1, 2, 5, kapena 6 mwa anthu omwe alibe chiwindi cha chiwindi (cirrhosis), kapena mwa iwo omwe ali ndi matenda enaake opanda zizindikiritso za vutoli
• lembani 1 mwa anthu omwe ali ndi matenda enaake omwe ali ndi zizindikiro za vutoli (mwa anthuwa, Harvoni iyenera kuphatikizidwa ndi ribavirin)
• lembani 1 kapena 4 mwa anthu omwe alandila chiwindi, ndipo mwina alibe mabala a chiwindi, kapena alibe chilonda cha chiwindi popanda zisonyezo (mwa anthuwa, Harvoni iyeneranso kuphatikizidwa ndi ribavirin)

Harvoni imavomerezedwanso kuti igwiritsidwe ntchito kwa ana azaka 12 kapena kupitilira apo, kapena omwe amalemera 35 kg, yomwe ili pafupifupi 77 lbs. Itha kugwiritsidwa ntchito mwa ana otsatirawa:

• omwe ali ndi mitundu ya HCV 1, 4, 5, kapena 6
• ana opanda chilonda cha chiwindi (cirrhosis), kapena iwo omwe ali ndi matenda owuma koma omwe alibe zisonyezo

Mafomu azamankhwala ndi makonzedwe

Mavyret imabwera ngati mapiritsi, omwe amatengedwa pakamwa (ndi chakudya) kamodzi patsiku. Kawirikawiri amaperekedwa kwa nthawi ya masabata 8, 12, kapena 16 malingana ndi mbiri ya chithandizo chanu komanso momwe matenda anu a chiwindi aliri oopsa.

Harvoni imabweranso ngati mapiritsi, omwe amatengedwa pakamwa (popanda kapena chakudya) kamodzi patsiku. Kawirikawiri amaperekedwa kwa nthawi ya masabata 8, 12, kapena 24 kutengera mbiri ya chithandizo chanu komanso momwe chiwindi chanu chilili.

Zotsatira zoyipa ndi zoopsa

Mavyret ndi Harvoni mulibe mankhwala omwewo, koma ali m'gulu limodzi la mankhwala. Mankhwalawa amatha kuyambitsa mavuto ena ofanana ndi ena. M'munsimu muli zitsanzo za zotsatirazi.

Zotsatira zofala kwambiri

Mndandandawu muli zitsanzo za zovuta zoyipa zomwe zimatha kuchitika ndi Mavyret, ndi Harvoni, kapena ndi mankhwala onsewa (akatengedwa payekhapayekha).

• Zitha kuchitika ndi Mavyret:
  • kutsegula m'mimba
  • kuchuluka kwa bilirubin (kuyesa labu komwe kumayang'ana chiwindi chanu)
• Zitha kuchitika ndi Harvoni:
  • kumva kufooka
  • kusowa tulo (kuvuta kugona)
  • chifuwa
  • kumva kupsa mtima
• Zitha kuchitika ndi Mavyret ndi Harvoni:
  • mutu
  • kumva kutopa
  • nseru

Zotsatira zoyipa

Zotsatira zoyipa zomwe zimatha kuchitika ndi Mavyret ndi Harvoni (akatengedwa payekha) ndi izi:

• kuyambiranso kwa kachilombo ka hepatitis B (kuwonongeka kwa kachilomboka, ngati kuli kale m'thupi lanu) *
• kwambiri thupi lawo siligwirizana

Kuchita bwino

Mavyret ndi Harvoni amavomerezedwa kuti athetse kachilombo koyambitsa matenda a chiwindi a HCV (HCV). Komabe, mankhwala amodzi atha kukhala othandiza kwa inu kuposa enawo, kutengera mtundu wa HCV womwe muli nawo komanso ngati muli ndi vuto la chiwindi (cirrhosis).

Mankhwalawa sanafanane mwachindunji m'maphunziro azachipatala. Koma kafukufuku wosiyana apeza kuti Mavyret ndi Harvoni ndi othandiza pochiza HCV.

Mtengo

Mavyret ndi Harvoni onse ndi mankhwala osokoneza bongo. Pakadali pano palibe mitundu yabwinobwino ya mankhwalawa. Mankhwala omwe ali ndi dzina nthawi zambiri amawononga ndalama zambiri kuposa ma generic.

Malinga ndi kuyerekezera kwa GoodRx.com, Mavyret ndi Harvoni nthawi zambiri amawononga chimodzimodzi. Mtengo weniweni womwe mudzalipire mankhwalawa umadalira dongosolo lanu la inshuwaransi, komwe mumakhala, komanso mankhwala omwe mumagwiritsa ntchito.

Mavyret vs. Epclusa

Mutha kudabwa momwe Mavyret amafananira ndi mankhwala ena omwe amapatsidwa ntchito zofananira. Apa tikuwona momwe Mavyret ndi Epclusa alili ofanana komanso osiyana.

Pafupi

Mavyret muli mankhwala glecaprevir ndi pibrentasvir. Epclusa ili ndi mankhwala velpatasvir ndi sofosbuvir. Onse Mavyret ndi Epclusa ali ndi mankhwala ophatikiza ma virus, ndipo ali mgulu lomwelo la mankhwala.

Ntchito

Mavyret amavomerezedwa kuti athetse kachilombo koyambitsa matenda a hepatitis C (HCV) akuluakulu. Amavomerezedwanso kuti agwiritsidwe ntchito kwa ana azaka 12 kapena kupitilira apo, kapena omwe amalemera makilogalamu osachepera 45, omwe ali pafupifupi 99 lbs.

Mavyret imagwiritsidwa ntchito pochizira mitundu yonse (1, 2, 3, 4, 5, ndi 6) ya HCV mwa anthu:

• wopanda kufooka kwa chiwindi (cirrhosis), kapena kwa iwo omwe ali ndi matenda enaake opanda zizindikiritso za vutoli
• omwe alandila chiwindi kapena impso
• omwe ali ndi HIV

Mavyret itha kugwiritsidwanso ntchito kuchiza mtundu wa HCV 1 mwa anthu omwe adathandizidwapo kale (koma osachiritsidwa) ndi mtundu wina wa mankhwala.

Mofanana ndi Mavyret, Epclusa imavomerezanso kuchiza HCV yosagwirizana ndi mitundu yonse ya kachilombo (mitundu 1, 2, 3, 4, 5, ndi 6). Amagwiritsidwa ntchito kwa achikulire omwe alibe zotupa za chiwindi (cirrhosis), kapena mwa iwo omwe ali ndi zotupa za chiwindi omwe alibe zisonyezo za vutoli.

Epclusa itha kugwiritsidwanso ntchito kwa akulu omwe ali ndi matenda enaake omwe ali ndi zizindikilo za vutoli.

Epclusa sivomerezeka kuti igwiritsidwe ntchito kwa ana.

Mafomu azamankhwala ndi makonzedwe

Mavyret imabwera ngati mapiritsi, omwe amatengedwa pakamwa (ndi chakudya) kamodzi patsiku. Kawirikawiri amaperekedwa kwa nthawi ya masabata 8, 12, kapena 16 malingana ndi mbiri ya chithandizo chanu komanso momwe matenda anu a chiwindi aliri oopsa.

Epclusa imabweranso ngati mapiritsi, omwe amatengedwa pakamwa kamodzi patsiku. Epclusa itha kumwedwa kapena wopanda chakudya. Nthawi zambiri amaperekedwa kwakanthawi kwamasabata khumi ndi awiri.

Zotsatira zoyipa ndi zoopsa

Mavyret ndi Epclusa alibe mankhwala omwewo mwa iwo. Komabe, ali mgulu lomwelo la mankhwala. Chifukwa chake, mankhwala onsewa amatha kuyambitsa zovuta zina. M'munsimu muli zitsanzo za zotsatirazi.

Zotsatira zofala kwambiri

Mndandandandawu muli zitsanzo za zovuta zoyipa zomwe zimatha kuchitika ndi Mavyret, ndi Epclusa, kapena ndi mankhwala onsewa (akamwedwa payekhapayekha).

• Zitha kuchitika ndi Mavyret:
  • kutsegula m'mimba
  • kuchuluka kwa bilirubin (kuyesa labu komwe kumayang'ana chiwindi chanu)
• Zitha kuchitika ndi Epclusa:
  • kumva kufooka
  • kusowa tulo (kuvuta kugona)
• Zitha kuchitika ndi Mavyret ndi Epclusa:
  • mutu
  • kumva kutopa
  • nseru

Zotsatira zoyipa

Zotsatira zoyipa zomwe zimatha kuchitika ndi Mavyret ndi Epclusa (akatengedwa payekha) ndi izi:

• kuyambiranso kwa kachilombo ka hepatitis B (kuwonongeka kwa kachilomboka, ngati kuli kale m'thupi lanu) *
• kwambiri thupi lawo siligwirizana

Kuchita bwino

Mavyret ndi Epclusa amagwiritsidwa ntchito pochiza mitundu yonse isanu ndi umodzi ya HCV yosachiritsika. Dokotala wanu angakulimbikitseni kuti mutenge Epclusa kapena Mavyret kutengera mtundu wa HCV womwe muli nawo komanso momwe chiwindi chanu chilili.

Mankhwalawa sanafanane mwachindunji m'maphunziro azachipatala. Koma kafukufuku wosiyana apeza kuti Mavyret ndi Epclusa ndi othandiza pochiza HCV.

Mtengo

Mavyret ndi Epclusa onse ndi mankhwala osokoneza bongo. Pakadali pano palibe mitundu yabwinobwino ya mankhwalawa. Mankhwala omwe ali ndi dzina nthawi zambiri amawononga ndalama zambiri kuposa ma generic.

Malinga ndi kuyerekezera kwa GoodRx.com, Mavyret ndi Epclusa nthawi zambiri amawononga chimodzimodzi. Mtengo weniweni womwe mudzalipire mankhwalawa umadalira dongosolo lanu la inshuwaransi, komwe mumakhala, komanso mankhwala omwe mumagwiritsa ntchito.

Mavyret wa hepatitis C

Food and Drug Administration (FDA) imavomereza mankhwala akuchipatala monga Mavyret kuti athetse mavuto ena.

Mavyret amavomerezedwa ndi FDA kuti athetse matenda opatsirana omwe amayamba chifukwa cha kachilombo ka hepatitis C (HCV). Tizilombo toyambitsa matendawa timayambitsa chiwindi chanu ndipo chimayambitsa kutupa, komwe nthawi zina kumatha kubweretsa chiwindi (chotchedwa cirrhosis). HCV ingayambitse zizindikiro monga:

• chikasu cha khungu lako ndi oyera m'maso mwako
• madzi mumimba mwanu
• malungo
• mavuto a nthawi yayitali, monga kulephera kwa chiwindi

HCV imafalikira kudzera m'magazi omwe ali ndi kachilomboka. Kufala (kufalikira) kumachitika makamaka kudzera mwa anthu kugawana masingano omwe agwiritsidwa ntchito wina ndi mnzake. Malinga ndi Centers for Disease Control and Prevention (CDC), mu 2016 pafupifupi anthu 2.4 miliyoni ku United States adadwala matenda otupa chiwindi a mtundu wa C.

Mavyret amaloledwa kuchiza HCV mwa akulu. Amavomerezedwanso kuti agwiritsidwe ntchito kwa ana azaka 12 kapena kupitilira apo, kapena omwe amalemera makilogalamu osachepera 45, omwe ali pafupifupi 99 lbs. Amagwiritsidwa ntchito pochizira mitundu yonse ya HCV (1, 2, 3, 4, 5, ndi 6) mwa anthu:

• wopanda kufooka kwa chiwindi (cirrhosis), kapena kwa iwo omwe ali ndi matenda enaake opanda zizindikiritso za vutoli (lotchedwa kulipidwa ndi matenda enaake)
• omwe alandila chiwindi kapena impso
• omwe ali ndi HIV

Mavyret itha kugwiritsidwanso ntchito kuchiza mtundu wa HCV 1 mwa anthu omwe adathandizidwapo kale (koma osachiritsidwa) ndi mtundu wina wa mankhwala.

Kuchita bwino

M'mayesero azachipatala, achikulire omwe ali ndi HCV (mitundu 1, 2, 3, 4, 5, ndi 6) omwe sanalandirepo kachilomboka adapatsidwa Mavyret. Mwa anthuwa, 98% mpaka 100% adachiritsidwa mkati mwa milungu 8 mpaka 12 yothandizidwa. M'maphunzirowa, kuchiritsidwa kumatanthauza kuti kuyezetsa magazi kwa anthu, komwe kunachitika miyezi itatu atalandira chithandizo, sikunawonetse zizindikiro zilizonse za matenda a HCV mthupi lawo.

Mwa anthu onse omwe anali m'maphunziro (onse omwe adalandira chithandizo cha HCV ndi omwe anali asanakhalepo), pakati pa 92% mpaka 100% adachiritsidwa ndi HCV. Zotsatirazo zimasiyanasiyana kutengera ngati anthu anali atathandizidwapo kale ndi mtundu wa HCV womwe anali nawo.

Mayesero azachipatala amayerekezeranso Mavyret ndi kuphatikiza mankhwala ena awiri omwe amatchedwa sofosbuvir (Sovaldi) ndi daclatasvir (Daklinza). Kafukufuku wina adayang'ana anthu omwe ali ndi mtundu wa 3 wa HCV, omwe sanalandirepo chithandizo kale. Anthuwa analibe chiwindi chilichonse (cirrhosis).

Pambuyo pa masabata 12, anthu 95.3% omwe amatenga Mavyret adawonedwa kuti adachiritsidwa (adalibe kachilombo ka HCV poyesa magazi). Mwa iwo omwe amatenga sofosbuvir ndi daclatasvir, 96.5% adakhala ndi zotsatira zofananira.

Mavyret ya ana

Mavyret amaloledwa kuchiza HCV mwa ana azaka 12 kapena kupitilira apo, kapena mwa iwo omwe amalemera 45 kg, omwe ali pafupifupi 99 lbs.

Kuyanjana kwa Mavyret

Mavyret amatha kulumikizana ndi mankhwala ena angapo. Itha kulumikizananso ndi zowonjezera zina.

Kuyanjana kosiyanasiyana kumatha kubweretsa zovuta zosiyanasiyana. Mwachitsanzo, kulumikizana kwina kumatha kusokoneza momwe mankhwala amagwirira ntchito. Kuyanjana kwina kumatha kukulitsa zovuta zina kapena kuwapangitsa kukhala owopsa.

Mavyret ndi mankhwala ena

M'munsimu muli mndandanda wa mankhwala omwe angagwirizane ndi Mavyret. Mndandandawu mulibe mankhwala onse omwe atha kulumikizana ndi Mavyret.

Musanatenge Mavyret, lankhulani ndi dokotala komanso wamankhwala. Auzeni zamankhwala onse omwe mumalandira, pa-pakauntala, ndi mankhwala ena omwe mumamwa. Auzeni za mavitamini, zitsamba, ndi zowonjezera zilizonse zomwe mumagwiritsa ntchito. Kugawana izi kungakuthandizeni kupewa kuyanjana komwe kungachitike.

Ngati muli ndi mafunso okhudzana ndi mankhwala omwe angakukhudzeni, funsani dokotala kapena wamankhwala.

Mavyret ndi carbamazepine (Tegretol)

Kutenga carbamazepine ndi Mavyret kumatha kuchepetsa kuchuluka kwa Mavyret mthupi lanu. Izi zitha kuchititsa kuti mankhwalawa asagwire ntchito, zomwe zingayambitse matenda anu a hepatitis C (HCV) osachiritsidwa. Ndikofunika kupewa kutenga carbamazepine ndi Mavyret limodzi.

Mavyret ndi warfarin (Coumadin)

Kutenga warfarin ndi Mavyret kumatha kusintha mtundu wa warfarin mthupi lanu. Izi zitha kubweretsa kusintha kwa makulidwe amwazi wanu, kuwapangitsa kuti akhale owonda kwambiri kapena wandiweyani. Izi zikachitika, mutha kukhala pachiwopsezo cha zovuta zina, monga kutuluka magazi kapena kukhala ndi magazi oundana.

Ngati mukumwa Mavyret ndi warfarin, ndikofunikira kuti mumayesedwe magazi nthawi zambiri kuti muwone kukula kwa magazi anu. Ngati mukufuna kumwa mankhwalawa palimodzi, adokotala amalimbikitsa njira zokuthandizani kuti mukhale otetezeka mukamalandira chithandizo.

Mavyret ndi digoxin (Lanoxin)

Kutenga Mavyret ndi digoxin kumatha kukulitsa digoxin mthupi lanu. Izi zitha kuyambitsa zizindikilo monga:

• nseru
• kusanza
• kutsegula m'mimba
• nyimbo yosasinthasintha

Ngati mukumwa digoxin mukamagwiritsa ntchito Mavyret, dokotala wanu angafunike kuti achepetse digoxin yanu. Izi zidzakuthandizani kuti milingo yanu ya digoxin isakwere kwambiri ndikupangitsa zotsatirapo. Dokotala wanu angayang'ane milingo yanu ya digoxin pakuyezetsa magazi pafupipafupi kuposa nthawi zonse mukamamwa Mavyret.

Mavyret ndi dabigatran (Pradaxa)

Kutenga Mavyret ndi dabigatran kumakulitsa milingo ya dabigatran mthupi lanu. Ngati msinkhu uwu ukukwera kwambiri, mudzakhala ndi chiopsezo chowonjezeka cha kutuluka magazi kapena kuvulala. Mwinanso mungakhale ofooka. Zizindikirozi nthawi zina zimakhala zovuta.

Ngati mukumwa dabigatran mukamagwiritsa ntchito Mavyret, dokotala wanu angafunike kuchepetsa mlingo wanu wa dabigatran. Izi zithandizira kupewa izi kuti zisachitike.

Mavyret ndi rifampin (Rifadin)

Kutenga Mavyret ndi rifampin kumachepetsa Mavyret mthupi lanu. Ngati mulingo wa Mavyret m'thupi lanu watsika, mankhwalawa sangagwire ntchito pochiza HCV. Muyenera kupewa kutenga Mavyret ndi Rifampin nthawi yomweyo.

Mavyret ndi mankhwala ena oletsa kubereka

Mankhwala ena oletsa kubereka ali ndi mankhwala otchedwa ethinyl estradiol. Kutenga mankhwalawa kuphatikiza ndi Mavyret kumatha kukulitsa kuchuluka kwa michere ya chiwindi yotchedwa alanine aminotransferase (ALT). Kuchulukitsa kwa ALT kumatha kukulitsa matenda anu a chiwindi.

Ndikulimbikitsidwa kuti musagwiritse ntchito njira zakulera zomwe zili ndi ethinyl estradiol mukamatenga Mavyret.

Zitsanzo za mapiritsi oletsa kubereka omwe ali ndi ethinyl estradiol ndi awa:

• levonorgestrel ndi ethinyl estradiol (Lessina, Levora, Seasonique)
• desogestrel ndi ethinyl estradiol (Apri, Kariva)
• norethindrone ndi ethinyl estradiol (Balziva, Junel, Loestrin / Loestrin Fe, Microgestin / Microgestin Fe)
• norgestrel ndi ethinyl estradiol (Cryselle, Lo / Ovral)
• drospirenone ndi ethinyl estradiol (Loryna, Yaz)
• norgestimate ndi ethinyl estradiol (Ortho Tri-Cyclen / Ortho Tri-Cyclen Lo, Sprintec, Tri-Sprintec, TriNessa)

Ili si mndandanda wathunthu wamapiritsi oletsa kubereka omwe ali ndi ethinyl estradiol. Ngati simukudziwa ngati njira yanu yoberekera ili ndi ethinyl estradiol, onetsetsani kuti mwafunsa dokotala kapena wamankhwala.

Njira zina zolerera kupatula mapiritsi amakhalanso ndi ethinyl estradiol. Njirazi zimaphatikizapo chigamba cholera (Ortho Evra) ndi mphete ya nyini (NuvaRing).

Ngati mukugwiritsa ntchito njira zakulera zomwe zili ndi ethinyl estradiol, lankhulani ndi dokotala wanu za njira zina zomwe mungapewere kutenga mimba mukamamwa Mavyret.

Mavyret ndi mankhwala ena a HIV

Mankhwala ena a kachilombo ka HIV (otchedwa antivirals) angakhudze kuchuluka kwa Mavyret mthupi lanu. Zitsanzo za mankhwala ochepetsa ma virus omwe angasinthe kuchuluka kwa Mavyret mthupi lanu ndi awa:

• atazanavir (Reyataz)
• darunavir (Prezista)
• lopinavir ndi ritonavir (Kaletra)
• mwambo (Norvir)
• efavirenz (Sustiva)

Atazanavir sayenera kutengedwa ndi Mavyret. Kugwiritsa ntchito mankhwalawa pamodzi kumawonjezera thupi lanu enzyme inayake ya chiwindi yotchedwa alanine aminotransferase (ALT). Kuchulukitsa kwa ALT kumatha kukulitsa matenda anu a chiwindi.

Kutenga Mavyret ndi darunavir, lopinavir, kapena ritonavir sikuvomerezedwanso. Izi ndichifukwa choti mankhwala ochepetsa ma virus amatha kukulitsa kuchuluka kwa Mavyret mthupi lanu. Izi zitha kubweretsa zovuta kuchokera ku Mavyret.

Kutenga Mavyret ndi efavirenz kumachepetsa milingo ya Mavyret mthupi lanu. Izi zitha kupangitsa kuti Mavyret asagwire ntchito. Muyenera kupewa kugwiritsa ntchito efavirenz mukamamwa Mavyret.

Mavyret ndi mankhwala ena a cholesterol

Kutenga Mavyret limodzi ndi mankhwala ena a cholesterol omwe amatchedwa statins atha kukulitsa kuchuluka kwa statin mthupi lanu. Kukhala ndi ma statins owonjezera kumawonjezera chiopsezo chanu chazovuta (monga kupweteka kwa minofu) kuchokera ku statin.

Zitsanzo za ma statins ndi awa:

• atorvastatin (Lipitor)
• lovastatin (Mevacor)
• simvastatin (Zocor)
• pravastatin (Pravachol)
• rosuvastatin (Crestor)
• fluvastatin (Lescol)
• pitavastatin (Livalo)

Ndikulimbikitsidwa kuti musatenge Mavyret kuphatikiza ndi atorvastatin, lovastatin, kapena simvastatin. Ma statin awa ali pachiwopsezo chachikulu chowonjezeka pamene atengedwa ndi Mavyret.

Pravastatin itha kutengedwa ndi Mavyret ngati dokotala akuuzani kuti mufunika mankhwala a cholesterol. Mlingo wa pravastatin uyenera kutsitsidwa musanayambe kumwa Mavyret. Izi zidzakuthandizani kuchepetsa chiopsezo cha zotsatirapo kuchokera ku statin.

Ngati fluvastatin ndi pitavastatin atengedwa ndi Mavyret, ayenera kupatsidwa mlingo wotsika kwambiri. Izi zimathandiza kuchepetsa chiopsezo chanu chokhala ndi zovuta zina kuchokera kuma statins.

Mavyret ndi cyclosporine (Sandimmune)

Mavyret siyikulimbikitsidwa kuti igwiritsidwe ntchito kwa anthu omwe akutenga zoposa 100 mg patsiku la cyclosporine. Mankhwalawa amachulukitsa milingo ya Mavyret mthupi lanu, zomwe zimatha kuwonjezera chiopsezo chanu chotsatira cha Mavyret.

Ngati mukumwa cyclosporine, lankhulani ndi dokotala wanu za kuchuluka kwa cyclosporine kotetezeka kwambiri kwa inu.

Mavyret ndi omeprazole (osati kuyanjana)

Palibe kuyanjana kulikonse komwe kumadziwika pakati pa omeprazole ndi Mavyret. Omeprazole nthawi zina amapatsidwa kwa anthu omwe amamwa Mavyret ngati akusuta panthawi yachipatala. Nthawi zina, kunyansidwa kumayambitsidwa ndi kuchuluka kwa asidi m'mimba mwako. Kutenga omeprazole kumathandizira kuchepetsa kuchuluka kwa asidi m'mimba mwanu, zomwe zingathandize kuchepetsa izi.

Mavyret ndi ibuprofen (osati kuyanjana)

Palibe kulumikizana kulikonse komwe kumadziwika pakati pa ibuprofen ndi Mavyret. Ibuprofen itha kugwiritsidwa ntchito pochiza mutu mwa anthu omwe akutenga Mavyret. Kupweteka kwa mutu ndizovuta zomwe zimachitika mukamamwa Mavyret. Ibuprofen imatha kuthandiza kuchepetsa kupweteka komanso kupweteka kwa mutu.

Mavyret ndi zitsamba ndi zowonjezera

Mavyret amatha kulumikizana ndi zitsamba ndi zowonjezera, kuphatikizapo wort ya St. John (yomwe ili pansipa). Kuyanjana uku kungakhudze momwe Mavyret amagwirira ntchito m'thupi lanu.

Muyenera kuwunika mankhwala onse omwe mumamwa (kuphatikiza zitsamba zilizonse ndi zowonjezera) ndi dokotala kapena wamankhwala musanayambe kumwa Mavyret.

Mavyret ndi St. John's wort

Kutenga wort ya St. John ndi Mavyret kumatha kuchepetsa kwambiri milingo ya Mavyret mthupi lanu. Izi zitha kupangitsa kuti Mavyret asagwire bwino ntchito pochiza matenda anu a hepatitis C. Ndikulimbikitsidwa kuti musatenge wort ya St. John pomwe mukugwiritsa ntchito Mavyret.

Mavyret ndi mimba

Sipanakhalepo maphunziro aliwonse mwa anthu omwe amayang'ana ngati Mavyret ndiwotheka kutenga nthawi yapakati.

M'maphunziro azinyama, palibe vuto linawonedwa m'matumba omwe amayi awo adapatsidwa Mavyret panthawi yapakati. Komabe, zotsatira za maphunziro a nyama sizimaneneratu nthawi zonse zomwe zidzachitike mwa anthu.

Ngati muli ndi pakati kapena mutha kutenga pakati mukamagwiritsa ntchito Mavyret, lankhulani ndi dokotala wanu. Amatha kukambirana nanu za kuopsa ndi zabwino zogwiritsa ntchito mankhwalawa panthawi yapakati.

Mavyret ndi kuyamwitsa

Sipanakhale maphunziro aliwonse mwa anthu kuti adziwe ngati Mavyret amadutsa mkaka wa m'mawere, kapena ngati ungakhudze mwana woyamwitsa.

M'maphunziro azinyama, Mavyret adadutsa mkaka wa makoswe oyamwa. Komabe, mkaka uwu sunavulaze nyama zomwe zimawudya. Kumbukirani kuti zotsatirazi zitha kukhala zosiyana kwa anthu.

Ngati mukuyamwitsa, kapena mukukonzekera kuyamwitsa mukamamwa Mavyret, lankhulani ndi dokotala wanu ngati iyi ndi njira yabwino. Angakulimbikitseni njira zina zabwino zodyetsera mwana wanu.

Momwe mungatengere Mavyret

Muyenera kutenga Mavyret malinga ndi malangizo a dokotala kapena wothandizira zaumoyo.

Nthawi yoti mutenge

Zilibe kanthu kuti mwasankha kutenga Mavyret nthawi yanji, koma muyenera kuyitenga nthawi yofananira tsiku lililonse. Izi zimathandiza kuti mankhwala azigwira ntchito moyenera mthupi lanu.

Pofuna kuthandizira kuti musaphonye mlingo, yesani kukhazikitsa chikumbutso pafoni yanu. Timer ya mankhwala ingakhale yothandiza, nayenso.

Kutenga Mavyret ndi chakudya

Mavyret ayenera kutengedwa ndi chakudya. Izi zimathandiza thupi lanu kuyamwa bwino mankhwalawo.

Kodi Mavyret ikhoza kuphwanyidwa, kugawanika, kapena kutafuna?

Ayi, Mavyret sayenera kugawanika, kuphwanyika, kapena kutafuna. Mapiritsi amayenera kuti amezeke kwathunthu. Kuwaza, kuwaphwanya, kapena kuwatafuna kumatha kuchepetsa kuchuluka kwa mankhwala omwe amalowa mthupi lanu. Izi zitha kupangitsa kuti Mavyret asagwire bwino ntchito pochiza matenda anu a hepatitis C.

Momwe Mavyret amagwirira ntchito

Mavyret amavomerezedwa kuti athetse kachilombo koyambitsa matenda a chiwindi a H (HCV). Vutoli limayambitsa matenda mthupi lanu lomwe limakhudza chiwindi. HCV imatha kubweretsa chiwindi chowopsa ngati sichichiritsidwa moyenera.

Mavyret ili ndi mankhwala awiri: glecaprevir ndi pibrentasvir. Zimagwira ntchito poletsa kachilombo ka hepatitis C kuchulukitsa (kupanga ma virus ambiri) mkati mwa thupi lanu. Chifukwa chakuti kachilomboko sikangachuluke, pamapeto pake kamatha.

Kachilomboka kakangomwalira, ndipo sikulinso m'thupi lanu, chiwindi chanu chitha kuyamba kuchira. Mavyret imagwira ntchito yochiza mitundu yonse isanu ndi umodzi (1, 2, 3, 4, 5, ndi 6) ya HCV.

Zimatenga nthawi yayitali bwanji kuti zigwire ntchito?

Pakati pa maphunziro azachipatala, anthu 92% mpaka 100% omwe ali ndi HCV adachiritsidwa atatenga Mavyret kwa nthawi yayitali. Kutalika kwa nthawi iyi kunayamba kuyambira masabata 8 mpaka 16.

M'maphunzirowa, kuchiritsidwa kumatanthauza kuti kuyezetsa magazi kwa anthu, komwe kunachitika miyezi itatu atalandira chithandizo, sikunawonetse zizindikiro zilizonse za matenda a HCV mthupi lawo.

Mafunso wamba okhudza Mavyret

Nawa mayankho pamafunso omwe amafunsidwa okhudza Mavyret.

Kodi nditha kumwa Mavyret ngati ndili ndi HIV komanso hepatitis C?

Inde, mutha kumwa Mavyret ngati muli ndi kachilombo ka HIV komanso hepatitis C (HCV). Kukhala ndi HIV sikusintha momwe Mavyret amagwirira ntchito mthupi lanu pochiza HCV.

Kodi Mavyret akuchita bwino bwanji pochiza hepatitis C?

Mavyret yasonyezedwa kuti ndi othandiza kwambiri pochiza matenda a hepatitis C virus (HCV). M'mayesero azachipatala, pakati pa 98% ndi 100% ya anthu omwe amatenga Mavyret adachiritsidwa ndi HCV.

M'maphunzirowa, kuchiritsidwa kumatanthauza kuti kuyezetsa magazi kwa anthu, komwe kunachitika miyezi itatu chitatha chithandizo, sikuwonetsa zisonyezo za matenda a HCV. Kuchuluka kwa anthu omwe adachiritsidwa kumadalira mtundu wa HCV omwe adali nawo, ndi mtundu wanji wamankhwala omwe adagwiritsa ntchito m'mbuyomu.

Ngati ndalandira mankhwala ena a hepatitis C, nditha kugwiritsa ntchito Mavyret?

Ngati mwayesapo mankhwala ena a hepatitis C anu omwe sanagwire ntchito (kuchiza matenda anu), mutha kugwiritsabe ntchito Mavyret. Kutengera ndi mankhwala omwe mudagwiritsa ntchito m'mbuyomu, kutalika kwa chithandizo chanu ndi Mavyret kumatha kukhala kulikonse kuyambira masabata 8 mpaka 16.

Ngati muli ndi mafunso okhudza ngati mungagwiritse ntchito Mavyret, lankhulani ndi dokotala wanu.

Kodi ndifunikira mayeso aliwonse asanafike kapena akamamwa Mavyret?

Musanayambe kumwa mankhwala ndi Mavyret, dokotala wanu adzakuyesani magazi anu ngati ali ndi kachilombo ka hepatitis B (HBV). Ngati muli ndi HBV, imatha kuyambiranso (kuyaka) panthawi yamankhwala a Mavyret. Kutsegulanso HBV kumatha kuyambitsa mavuto akulu a chiwindi, kuphatikiza kulephera kwa chiwindi ndi kufa.

Ngati muli ndi HBV, dokotala wanu amalimbikitsa kuyesa magazi mukamamwa mankhwala a Mavyret kuti muwone ngati HBV ingayambitsenso. Mungafunike kulandira chithandizo cha HBV musanayambe kumwa Mavyret.

Kodi ndingagwiritse ntchito Mavyret ngati ndili ndi matenda enaake?

Mutha kutero, koma zimadalira momwe chiwindi chanu chilili chovulaza kwambiri.

Mavyret itha kugwiritsidwa ntchito ngati mwalipira (cirrhosis) yofatsa. Ndi vutoli, chiwindi chako chimakhala ndi zipsera, koma ulibe zisonyezo za matendawa ndipo chiwindi chako chikugwirabe ntchito mwachizolowezi.

Mavyret sanalandiridwebe kuti agwiritsidwe ntchito kwa anthu omwe ali ndi vuto la chiwindi. Ndi vutoli, chiwindi chanu chimakhala ndi zipsera ndipo mumakhala ndi zisonyezo. Zizindikiro zimatha kuphatikiza:

• chikasu cha khungu lako kapena kuyera kwa maso ako
• madzi owonjezera m'mimba mwanu
• kukulitsa mitsempha yamagazi pakhosi panu, yomwe imatha kuyambitsa magazi

Ngati mukudwala matenda a chiwindi koma simukudziwa mtundu wake, kambiranani ndi dokotala wanu.

Zisamaliro za Mavyret

Mankhwalawa amabwera ndi zodzitetezera zingapo.

Chenjezo la FDA: kuyambiranso kwa kachilombo ka hepatitis B

Mankhwalawa ali ndi chenjezo la nkhonya. Ili ndiye chenjezo lalikulu kwambiri kuchokera ku Food and Drug Administration (FDA). Chenjezo la nkhonya limachenjeza madokotala ndi odwala za zovuta zamankhwala zomwe zitha kukhala zowopsa.

Mankhwala a Mavyret amachulukitsa chiopsezo chotenga kachilombo ka hepatitis B (HBV) mwa anthu omwe ali ndi kachilombo ka HBV ndi hepatitis C (HCV). Zikakhala zovuta, kuyambiranso kwa HBV kumatha kuyambitsa chiwindi kulephera kapena kufa kumene.

Musanayambe Mavyret, dokotala wanu adzakuyesani ngati muli ndi HBV. Ngati muli ndi HBV, mungafunikire kuchiritsidwa musanatenge Mavyret. Kapena dokotala wanu angakulimbikitseni kuyesedwa mukamamwa mankhwala a Mavyret kuti muwone kuyambiranso kwa HBV.

Machenjezo ena

Musanatenge Mavyret, lankhulani ndi dokotala za mbiri yanu. Mavyret sangakhale oyenera kwa inu ngati mukudwala. Izi zikuphatikiza:

• Kulephera kwa chiwindi. Ngati muli ndi vuto la chiwindi, kutenga Mavyret kumatha kukulitsa vuto lanu. Lankhulani ndi dokotala wanu ngati muli ndi mbiri ya matenda a chiwindi kapena kulephera kwa chiwindi musanayambe chithandizo ndi Mavyret.
• Kugwiritsa ntchito kwa atazanavir kapena rifampin. Mavyret sayenera kugwiritsidwa ntchito mwa anthu omwe atenga atazanavir kapena rifampin. Kutenga Mavyret ndi rifampin limodzi kumachepetsa milingo ya Mavyret mthupi lanu. Izi zitha kupangitsa kuti Mavyret ikhale yopanda ntchito kwa inu. Kutenga atazanavir ndi Mavyret kumatha kukulitsa Mavyret mthupi lanu. Izi zitha kuwonjezera michere ya chiwindi (yotchedwa alanine aminotransferase), yomwe imatha kukhala yowopsa. Onani gawo la "Kuyanjana kwa Mavyret" kuti mumve zambiri. Nthawi zonse lankhulani ndi dokotala wanu za mankhwala aliwonse omwe mumamwa musanayambe Mavyret.
• Mimba. Sidziwika ngati Mavyret angakhudze mimba yomwe ikukula. M'maphunziro azinyama, Mavyret sanapweteke akagwiritsidwa ntchito panthawi yapakati. Komabe zotsatirazi zitha kukhala zosiyana ndi anthu. Kuti mumve zambiri, onani gawo la "Mavyret ndi pakati" pamwambapa.
• Kuyamwitsa. Sikudziwika ngati Mavyret amadutsa mkaka wa m'mawere, kapena ngati umavulaza mwana woyamwitsa. M'maphunziro azinyama, Mavyret adadutsa mkaka wa m'mawere, koma sizinapweteke nyama zomwe zimadya mkaka wa m'mawere. Komabe, zotsatirazi zitha kukhala zosiyana ndi anthu. Kuti mumve zambiri, onani gawo la "Mavyret ndi kuyamwitsa" pamwambapa.

Zindikirani: Kuti mumve zambiri za zovuta zomwe zingachitike chifukwa cha Mavyret, onani gawo la "zoyipa za Mavyret" pamwambapa.

Kuledzera kwa Mavyret

Kugwiritsa ntchito mopitilira muyeso wa Mavyret kumatha kubweretsa zovuta zoyipa. Musatenge zochuluka kuposa momwe dokotala amakupatsirani.

Zomwe muyenera kuchita mukamagwiritsa ntchito bongo

Ngati mukuganiza kuti mwamwa kwambiri mankhwalawa, itanani dokotala wanu. Muthanso kuyitanitsa American Association of Poison Control Center ku 800-222-1222 kapena kugwiritsa ntchito chida chawo pa intaneti. Koma ngati matenda anu akukulira, itanani 911 kapena pitani kuchipatala chapafupi pomwepo.

Kutha kwa Mavyret, kusunga, ndi kutaya

Mukapeza Mavyret ku pharmacy, wamankhwala adzawonjezera tsiku lotha ntchito pazolemba pa botolo. Tsikuli limakhala chaka chimodzi kuchokera tsiku lomwe adapereka mankhwalawo.

Tsiku lothera ntchito limathandizira kutsimikizira kuti mankhwalawa ndi othandiza panthawiyi. Maganizo apano a Food and Drug Administration (FDA) ndikupewa kugwiritsa ntchito mankhwala omwe atha ntchito. Ngati mwagwiritsa ntchito mankhwala omwe sanadutse tsiku lomaliza, lankhulani ndi wamankhwala wanu ngati mungakwanitse kuugwiritsabe ntchito.

Yosungirako

Kutalika kwa nthawi yayitali kumadalira mankhwala, kuphatikiza momwe mungasungire mankhwalawo.

Mapiritsi a Mavyret amayenera kusungidwa kutentha kutentha (pansi pa 86 ° F / 30 ° C) mumtsuko womata mwamphamvu, kutali ndi kuwala. Pewani kusunga mankhwalawa m'malo omwe amatha kunyowa kapena kunyowa, monga zimbudzi.

Kutaya

Ngati simufunikiranso kumwa Mavyret ndikukhala ndi mankhwala otsala, ndikofunikira kuwataya mosamala. Izi zimathandiza kupewa ena, kuphatikiza ana ndi ziweto, kuti amwe mankhwalawo mwangozi. Zimathandizanso kuti mankhwalawa asawononge chilengedwe.

Tsamba la FDA limapereka malangizo angapo othandiza pakutha mankhwala. Muthanso kufunsa wamankhwala wanu kuti mumve momwe mungathere mankhwala anu.

Zambiri za Mavyret

Zotsatirazi zimaperekedwa kwa azachipatala ndi ena othandizira azaumoyo.

Zisonyezero

Mavyret imawonetsedwa ngati chithandizo cha matenda opatsirana a hepatitis C (HCV) a 1, 2, 3, 4, 5, ndi 6. Mavyret imavomerezedwa kuti igwiritsidwe ntchito kwa akulu ndi ana azaka 12 kapena kupitilira apo, kapena omwe amalemera pafupifupi 45 kg.

Iyenera kugwiritsidwa ntchito kwa odwala omwe alibe cirrhosis, kapena omwe ali ndi ziphuphu.

Mavyret amawonetsedwanso kuti amachiza matenda a genotype 1 a hepatitis C mwa anthu omwe mankhwala ake akale sanachite bwino. Mankhwalawa asanakhalepo ayenera kuphatikizapo HCV NS5A inhibitor kapena NS3 / 4A protease inhibitor.

Mavyret sichiwonetsedwa kuti ingagwiritsidwe ntchito kwa odwala omwe chithandizo chawo choyambirira chinalephera kugwiritsa ntchito HCV NS5A inhibitor komanso NS3 / 4A protease inhibitor.

Njira yogwirira ntchito

Mavyret ili ndi glecaprevir ndi pibrentasvir. Mankhwalawa ndi mankhwala omwe amathana ndi HCV.

Glecaprevir ndi NS3 / 4A protease inhibitor. Zimagwira ntchito polimbana ndi NS3 / 4A protease, yomwe ndiyofunikira pakukula kwa kachilombo ka hepatitis C.

Pibrentasvir ndi NS5A inhibitor. Poletsa NS5A, pibrentasvir imayimitsa kuyambiranso kwa ma hepatitis C.

Mavyret imagwira ntchito polimbana ndi matenda amtundu wa hepatitis C 1, 2, 3, 4, 5, ndi 6.

Pharmacokinetics ndi metabolism

Pa kafukufuku wokhudza anthu omwe si a HCV omwe amawoneka kuti ali ndi thanzi labwino, kuyamwa kwa Mavyret kunakhudzidwa kwambiri ndi kupezeka kwa chakudya. Mukamwedwa ndi chakudya, mayamwidwe a glecaprevir adakwera ndi 83% mpaka 163%. Kuyamwa kwa pibrentasvir kudakulitsidwa ndi 40% mpaka 53%. Chifukwa chake, Mavyret tikulimbikitsidwa kuti titenge ndi chakudya kuti chikuthandizeni kuyamwa.

Kuchuluka kwa plasma Mavyret kumachitika pafupifupi maola 5 pambuyo pa mlingo. Hafu ya moyo wa glecaprevir ndi maola 6, pomwe theka la pibrentasvir ndi maola 13.

Mavyret imachotsedwa makamaka kudzera pa njira ya biliary-fecal. Ambiri mwa glecaprevir ndi pibrentasvir amakhala ndi mapuloteni am'magazi.

Zotsutsana

Mavyret imatsutsana ndi odwala omwe ali ndi matenda owopsa a chiwindi, otchedwa kuti Child-Pugh C.

Mavyret imatsutsidwanso mwa odwala omwe akutenga atazanavir kapena rifampin. Kuchuluka kwa Mavyret kumachepa kwambiri ndi rifampin, yomwe imatha kuchepetsa kapena kulepheretsa chithandizo cha Mavyret. Mavyret sayenera kutengedwa ndi atazanavir chifukwa kuphatikiza kwa mankhwala kumatha kuwonjezera milingo ya alanine aminotransferase (ALT), zomwe zimawonjezera chiwopsezo cha chiwindi kulephera.

Yosungirako

Mavyret iyenera kusungidwa pansi kapena pansi pa 86 ° F (30 ° C) mu chidebe chosindikizidwa, chowuma.

Chodzikanira: Medical News Today yachita kuyesetsa konse kuti zitsimikizidwe kuti zowona zonse ndizolondola, zonse, komanso zaposachedwa. Komabe, nkhaniyi sikuyenera kugwiritsidwa ntchito m'malo mwa chidziwitso ndi ukadaulo wa akatswiri pazachipatala. Muyenera kufunsa adotolo kapena akatswiri azaumoyo musanamwe mankhwala aliwonse. Zambiri zamankhwala zomwe zili pano zitha kusintha ndipo sizingapangidwe kuti zigwiritse ntchito, mayendedwe, zodzitetezera, machenjezo, kulumikizana ndi mankhwala, kusokonezeka, kapena zovuta zina. Kusapezeka kwa machenjezo kapena zidziwitso za mankhwala omwe apatsidwa sikuwonetsa kuti kuphatikiza mankhwala kapena mankhwalawa ndiwotetezeka, ogwira ntchito, komanso oyenera kwa odwala onse kapena ntchito zina zilizonse.