Minocycline for Rheumatoid Arthritis: Kodi Imagwira?

Zamkati

• Zokhudza kugwiritsa ntchito mankhwala osokoneza bongo
• Kodi kafukufukuyu akuti chiyani?
• Mbiri yoyambirira yofufuza
• Zowunikira zamaphunziro ndi minocycline
• Kodi minocycline imagwira ntchito bwanji pochizira RA?
• Ndani angapindule ndi minocycline ya RA?
• Kodi protocol ndi chiyani?
• Zotsatira zake ndi ziti?
• Kutenga

Chidule

Minocycline ndi mankhwala opha tizilombo mu banja la tetracycline. Zakhala zikugwiritsidwa ntchito kuposa kulimbana ndi matenda osiyanasiyana.

, ofufuza awonetsa mphamvu zake zotsutsana ndi zotupa, zoteteza m'thupi, komanso zoteteza ku matenda.

Kuyambira, akatswiri ena am'magazi agwiritsa ntchito tetracyclines poyerekeza nyamakazi (RA). Izi zikuphatikizapo minocycline. Mitundu yatsopano ya mankhwala ikayamba kupezeka, kugwiritsa ntchito minocycline kunachepa. Nthawi yomweyo, adawonetsa kuti minocycline inali yopindulitsa kwa RA.

Minocycline sivomerezedwa mwachindunji ndi US Food and Drug Administration (FDA) kuti igwiritsidwe ntchito ndi RA. Nthawi zina amalembedwa kuti "achotseka."

Ngakhale zotsatira zake zabwino pamayesero, minocycline nthawi zambiri sagwiritsidwa ntchito pochizira RA lero.

Zokhudza kugwiritsa ntchito mankhwala osokoneza bongo

Kugwiritsa ntchito mankhwala osokoneza bongo kumatanthauza kuti mankhwala omwe avomerezedwa ndi FDA pacholinga chimodzi amagwiritsidwa ntchito pazinthu zina zomwe sizinavomerezedwe. Komabe, dokotala amatha kugwiritsabe ntchito mankhwalawa pazifukwa izi. Izi ndichifukwa choti a FDA amayang'anira kuyesa ndi kuvomereza mankhwala, koma osati momwe madotolo amagwiritsira ntchito mankhwala pochizira odwala awo.Chifukwa chake dokotala akhoza kukupatsani mankhwala ngakhale akuganiza kuti ndi bwino kuti musamalire. Phunzirani zambiri zakugwiritsa ntchito mankhwala osokoneza bongo.

Kodi kafukufukuyu akuti chiyani?

kuyambira kumapeto kwa ma 1930 kuti mabakiteriya akutenga nawo gawo poyambitsa RA.

Kafukufuku wazachipatala komanso wowongoleredwa wogwiritsa ntchito minocycline kwa RA ambiri akuti minocycline ndiyothandiza komanso yotetezeka kwa anthu omwe ali ndi RA.

Maantibayotiki ena amaphatikizapo mankhwala a sulfa, ma tetracyclines ena, ndi rifampicin. Koma minocycline yakhala ikufunsidwa mozama kafukufuku wakhungu ndi zoyeserera zamankhwala chifukwa chazambiri.

Mbiri yoyambirira yofufuza

Mu 1939, a rheumatologist waku America a Thomas McPherson-Brown ndi anzawo adatulutsa bakiteriya wofanana ndi kachilombo ka RA. Amayitcha mycoplasma.

Pambuyo pake McPherson-Brown adayamba kuyesa kuyesera RA ndi maantibayotiki. Anthu ena poyamba anaipiraipira. A McPherson-Brown akuti izi zidachitika chifukwa cha Herxheimer, kapena "kufa": Mabakiteriya akagwidwa, amatulutsa poizoni yemwe poyamba amayambitsa matenda. Izi zikuwonetsa kuti mankhwalawa akugwira ntchito.

M'kupita kwanthawi, odwala adachira. Ambiri adapeza chikhululukiro atamwa mankhwalawa kwa zaka zitatu.

Zowunikira zamaphunziro ndi minocycline

Kafukufuku 10 adafanizira maantibayotiki a tetracycline ndi mankhwala ochiritsira kapena placebo ndi RA. Kafukufukuyu adatsimikiza kuti chithandizo cha tetracycline (makamaka minocycline) chimalumikizidwa ndi kusintha komwe kunali kofunikira pachipatala.

Kafukufuku woyendetsedwa ndi 1994 wa minocycline ndi omwe anali nawo pa 65 adanenanso kuti minocycline inali yopindulitsa kwa iwo omwe ali ndi RA yogwira ntchito. Ambiri mwa anthu omwe anali mu kafukufukuyu anali ndi RA.

A mwa anthu 219 omwe ali ndi RA poyerekeza chithandizo ndi minocycline ndi placebo. Ofufuzawo adazindikira kuti minocycline inali yothandiza komanso yotetezeka munthawi zochepa za RA.

Kafukufuku wa 2001 wa anthu 60 omwe ali ndi RA adafanizira chithandizo ndi minocycline ndi hydroxychloroquine. Hydroxychloroquine ndi mankhwala osinthira matenda (DMARD) omwe amagwiritsidwa ntchito kwambiri pochizira RA. Ofufuzawo ananena kuti minocycline inali yothandiza kwambiri kuposa ma DMARD a RA yoyambirira yopanda mphamvu.

Kutsata kwazaka zinayi kudayang'ana odwala 46 mu kafukufuku wakhungu kawiri yemwe amayerekezera chithandizo ndi minocycline ndi placebo. Ananenanso kuti minocycline inali njira yothandizira RA. Anthu omwe amathandizidwa ndi minocycline adachotsedwa zochepa ndipo amafunikira chithandizo chamankhwala ochepa. Zinali choncho ngakhale kuti minocycline inali miyezi itatu kapena isanu ndi umodzi yokha.

Ndikofunika kuzindikira kuti ambiri mwa maphunzirowa anali kugwiritsa ntchito minocycline kwakanthawi kochepa. McPherson-Brown adatsimikiza kuti njira yothandizira kuti athe kukhululukidwa kapena kusintha kwakukulu itha kutenga zaka zitatu.

Kodi minocycline imagwira ntchito bwanji pochizira RA?

Makina enieni a minocycline monga chithandizo cha RA samamveka bwino. Kuphatikiza pa mankhwala opha tizilombo, minocycline ili ndi zotsutsana ndi zotupa. Makamaka, minocycline ku:

• zimakhudza nitric oxide synthase, yomwe imakhudzidwa ndi kuwonongeka kwa collagen
• kusintha interleukin-10, yomwe imaletsa cytokine yotupa yotupa m'minyewa yama synovial (minofu yolumikizana mozungulira mafupa)
• kupondereza B ndi T cell kugwira ntchito kwa chitetezo chamthupi

Minocycline itha kukhala ndi. Izi zikutanthauza kuti zitha kupititsa patsogolo chithandizo cha RA akaphatikizidwa ndi mankhwala osagwiritsa ntchito ma antisteroidal kapena mankhwala ena.

Ndani angapindule ndi minocycline ya RA?

Amanenedwa kuti omwe akufuna kusankha bwino ndi omwe ali kumayambiriro kwa RA. Koma kafukufuku wina akuwonetsa kuti anthu omwe ali ndi RA wapamwamba kwambiri atha kupindulanso.

Kodi protocol ndi chiyani?

Njira yodziwika bwino yazamankhwala m'maphunziro ofufuza ndi mamiligalamu 100 (mg) kawiri patsiku.

Koma aliyense ndi wosiyana, ndipo minocycline protocol imatha kusiyanasiyana. Anthu ena angafunike kuyamba ndi mlingo wochepa ndikugwira ntchito mpaka 100 mg kapena kawiri patsiku. Ena angafunikire kutsatira dongosolo lotayidwa, kumwa minocycline masiku atatu pa sabata kapena kusiyanasiyana ndi mankhwala ena.

Monga mankhwala opha tizilombo a matenda a Lyme, palibe njira imodzi yofananira. Komanso, zimatha kutenga zaka zitatu kuti muwone zotsatira za RA.

Zotsatira zake ndi ziti?

Minocycline nthawi zambiri imaloledwa bwino. Zotsatira zake zimakhala zochepa komanso zofanana ndi maantibayotiki ena. Zikuphatikizapo:

• mavuto am'mimba
• chizungulire
• kupweteka mutu
• zotupa pakhungu
• kuchuluka kudziwa dzuwa
• ukazi yisiti matenda
• kusakanikirana

Kutenga

Minocycline, makamaka yogwiritsidwa ntchito nthawi yayitali, yawonetsedwa kuti ikuthandizira kusintha kwa RA ndikuthandizira kuti anthu athe kukhululukidwa. Sigwiritsidwe ntchito masiku ano, ngakhale ili ndi mbiri yotsimikizika.

Zokambirana zomwe zimaperekedwa motsutsana ndi kugwiritsa ntchito minocycline pa RA ndi izi:

• Palibe maphunziro okwanira.
• Maantibayotiki amakhala ndi zovuta zina.
• Mankhwala ena amagwira ntchito bwino.

Ofufuza ena ndi rheumatologists sagwirizana ndi mfundo izi ndikuwonetsa zotsatira zamaphunziro omwe alipo.

Ndikofunika kutenga nawo mbali pokonzekera chithandizo chanu ndikufufuza njira zina. Kambiranani ndi dokotala zomwe zingakhale zabwino pazochitika zanu.

Ngati mukufuna kuyesa minocycline ndipo dokotala wanu walephera, funsani chifukwa. Onetsani mbiri yakale yolemba minocycline. Lankhulani ndi adotolo za zovuta zoyipa zotenga ma steroid nthawi yayitali poyerekeza ndi zovuta zoyipa za minocycline. Mungafunefune malo ofufuzira omwe agwirapo ntchito ndi minocycline ndi RA.