Mankhwala atsopano ndi Mankhwala a Ulcerative Colitis

Zamkati

• Mankhwala apano
• Aminosalicylates
• Corticosteroids
• Ma Immunomodulators
• Oseketsa a TNF
• Opaleshoni
• Mankhwala atsopano
• Tofacitinib (Xeljanz)
• Zolemba
• Mankhwala omwe amafufuzidwa
• Kuika chimbudzi
• Thandizo la cell cell
• Mayesero azachipatala
• Tengera kwina

Chidule

Mukakhala ndi ulcerative colitis (UC), cholinga cha chithandizo ndikuletsa chitetezo chamthupi chanu kuti chisalimbane ndi matumbo anu. Izi zitsitsa kutupa komwe kumayambitsa matenda anu, ndikupatsani mwayi wokhululukidwa. Dokotala wanu amatha kusankha mitundu ingapo yamankhwala kuti akuthandizeni kukwaniritsa izi.

M'zaka zingapo zapitazi, kuchuluka kwa mankhwala omwe amagwiritsidwa ntchito pochizira UC kwawonjezeka. Ofufuzawa akuphunzira mankhwala ena atsopano komanso atha kukhala othandiza m'mayesero azachipatala.

Mankhwala apano

Mitundu ingapo yamankhwala ilipo yothandizira UC. Dokotala wanu adzakuthandizani kusankha imodzi mwanjira zochiritsira motengera:

• kuopsa kwa matenda anu (ofatsa, ochepa, kapena owopsa)
• mankhwala omwe mwamwa kale
• momwe munayankhira mankhwala amenewo
• thanzi lanu lonse

Aminosalicylates

Gulu la mankhwalawa lili ndi zopangira 5-aminosalicylic acid (5-ASA). Zikuphatikizapo:

• sulfasalazine (Azulfidine)
• mesalamine (Canasa)
• olsalazine (Dipentum)
• balsalazide (Colazal, Giazo)

Mukamwa mankhwalawa pakamwa kapena ngati enema, amathandizira kutsitsa kutupa m'matumbo mwanu. Aminosalicylates amagwira ntchito bwino kwa UC wofatsa, ndipo amathandizira kupewa kuyatsa.

Corticosteroids

Corticosteroids (mankhwala osokoneza bongo a steroid) amapondereza chitetezo cha mthupi kuti chichepetse kutupa. Zitsanzo ndi izi:

• mbalambanda
• chibadul
• methylprednisolone
• mphukira

Dokotala wanu akhoza kukupatsani mankhwalawa kwa kanthawi kochepa kuti muchepetse chizindikiro. Si bwino kukhala pa steroid nthawi yayitali, chifukwa zimatha kuyambitsa mavuto monga shuga wambiri wamagazi, kunenepa, matenda, komanso kutaya mafupa.

Ma Immunomodulators

Mankhwalawa amapondereza chitetezo cha mthupi lanu kuti chisapangitse kutupa. Mutha kuyamba kumwa imodzi mwa mankhwalawa ngati aminosalicylates sanathandize zizindikiro zanu. Zitsanzo za ma immunomodulators ndi awa:

• azathioprine (Azasan)
• 6-mercaptopurine (6MP) (Purinethol)
• cyclosporine (Sandimmune, Neoral, ena)

Oseketsa a TNF

Ma blocker a TNF ndi mtundu wa mankhwala a biologic. Biologics amapangidwa kuchokera ku mapuloteni obadwa nawo kapena zinthu zina zachilengedwe. Amachita mbali zina za chitetezo chanu cha mthupi zomwe zimayendetsa kutupa.

Mankhwala a anti-TNF amaletsa chitetezo cha mthupi chotchedwa tumor necrosis factor (TNF) chomwe chimayambitsa kutupa. Amatha kuthandiza anthu omwe ali ndi UC osapitirira malire omwe zizindikiro zawo sizinasinthe pamene ali ndi mankhwala ena.

Oletsa TNF ndi awa:

• adalimumab (Humira)
• golimumab (Simponi)
• infliximab (Kutulutsa)
• vedolizumab (Entyvio)

Opaleshoni

Ngati mankhwala omwe mwayesa sanawongolere zizindikiro zanu kapena kusiya kugwira ntchito, mungafunike kuchitidwa opaleshoni. Njira yotchedwa proctocolectomy imachotsa colon yonse ndi zotsekemera kuti zisawonongeke.

Pambuyo pa opaleshoni, simudzakhala ndi colon yosungira zinyalala. Dokotala wanu amapanga thumba kunja kwa thupi lanu lotchedwa ileostomy, kapena mkati mwathupi lanu kuchokera mbali ya m'mimba mwanu (ileum).

Kuchita opaleshoni ndi gawo lalikulu, koma kuthana ndi zizindikilo za UC.

Mankhwala atsopano

M'zaka zingapo zapitazi, mankhwala angapo atsopano a UC apezeka.

Tofacitinib (Xeljanz)

Xeljanz ndi m'gulu la mankhwala otchedwa Janus kinase (JAK) inhibitors. Mankhwalawa amalepheretsa enzyme JAK, yomwe imayendetsa maselo amthupi kuti apange kutupa.

Xeljanz yavomerezedwa kuyambira 2012 kuti ichiritse nyamakazi (RA), ndipo kuyambira 2017 yochiza nyamakazi ya psoriatic (PsA). Mu 2018, a FDA adavomerezanso kuti ichiritse anthu omwe ali ndi UC yolimbitsa thupi omwe sanayankhe ku blockers a TNF.

Mankhwalawa ndi mankhwala oyamba amkamwa a nthawi yayitali a UC. Mankhwala ena amafuna kulowetsedwa kapena jekeseni. Zotsatira zoyipa zochokera ku Xeljanz zimaphatikizapo cholesterol, mutu, kutsekula m'mimba, chimfine, zotupa, ndi ma shongo.

Zolemba

Biosimilars ndi gulu latsopano la mankhwala omwe adapangidwa kuti azitsanzira zomwe biologics imachita. Monga biologics, mankhwalawa amalimbana ndi chitetezo cha mthupi chomwe chimathandizira kutupa.

Ma biosimilars amagwira ntchito chimodzimodzi ndi biologics, koma atha kukhala otsika mtengo kwambiri. Makalata anayi awonjezedwa kumapeto kwa dzinalo kuti athandizire kusiyanitsa mankhwala osokoneza bongo kuchokera ku biologic yoyambirira.

A FDA adavomereza ma biosimilars angapo a UC mzaka zingapo zapitazi, kuphatikiza:

• infliximab-abda (Renflexis)
• infliximab-dyyb (Chofunika)
• infliximab-qbtx (Ixifi)
• adalimumab-adbm (Cyltezo)
• adalimumab-atto (Amjevita)

Mankhwala omwe amafufuzidwa

Ofufuzawa nthawi zonse amafufuza njira zabwino zoyendetsera UC. Nawa mankhwala atsopano angapo omwe akufufuzidwa.

Kuika chimbudzi

Kuika chimbudzi, kapena kupondapo chopondapo, ndi njira yoyeserera yomwe imayika mabakiteriya athanzi kuchokera kuchopangira chopereka kulowa m'khola la wina yemwe ali ndi UC.Lingaliro lingamveke losakopa, koma mabakiteriya abwino amathandiza kuthana ndi kuwonongeka kwa UC ndikubwezeretsanso majeremusi oyenera m'matumbo.

Thandizo la cell cell

Maselo otchedwa stem cells ndi timaselo ting'onoting'ono timene timakulira m'maselo ndi minyewa yonse yathupi. Amatha kuthana ndi zovuta zonse ngati titawagwiritsa ntchito moyenera. Mu UC, maselo amtundu amatha kusintha chitetezo cha mthupi m'njira yothandizira kutsitsa kutupa ndikuchiritsa kuwonongeka.

Mayesero azachipatala

Madokotala ali ndi njira zingapo zochiritsira za UC kuposa kale. Ngakhale atakhala ndi mankhwala ochuluka chotere, anthu ena amavutika kupeza omwe angawathandize.

Ochita kafukufuku nthawi zonse amafufuza njira zatsopano zamankhwala m'mayesero azachipatala. Kulowa nawo m'modzi mwa maphunzirowa kumakupatsani mwayi wogwiritsa ntchito mankhwala osokoneza bongo asanapezeke pagulu. Funsani dokotala yemwe amakuchitirani UC ngati mayeso azachipatala mdera lanu atha kukhala abwino kwa inu.

Tengera kwina

Maganizo a anthu omwe ali ndi UC ndiabwino kwambiri masiku ano, chifukwa cha mankhwala atsopano omwe amatha kuchepetsa kutupa m'mimba. Ngati mwayesapo mankhwala ndipo sizinakuthandizeni, dziwani kuti zosankha zina zitha kukonza zizindikilo zanu. Khalani olimbikira, ndipo gwirani ntchito limodzi ndi dokotala wanu kuti mupeze mankhwala omwe amakuthandizirani.