Mankhwala atsopano a Rheumatoid Arthritis ndi Kafukufuku: Kafukufuku Watsopano

Zamkati

• Zoletsa za JAK zimapereka mpumulo
• BTK inhibitor pakukula
• Neurostimulation ikuwonetsa lonjezo
• Omega-3 fatty acids atha kuthandiza
• Mankhwala a RA olumikizidwa ndi phindu laumoyo wamtima
• Kutenga

Matenda a nyamakazi (RA) ndi matenda osachiritsika omwe amachititsa kutupa molimba, kuuma, ndi kupweteka. Palibe mankhwala odziwika a RA - koma pali mankhwala omwe amapezeka kuti athandize kuthana ndi zofooka, kuchepetsa kuwonongeka kwamagulu, komanso kulimbikitsa thanzi labwino.

Asayansi akamapitiliza kupanga ndikusinthira chithandizo cha RA, adotolo angakulimbikitseni kuti musinthe dongosolo lanu.

Pemphani kuti muphunzire zamankhwala aposachedwa kwambiri komanso njira zamankhwala zaposachedwa kwambiri za matendawa.

Zoletsa za JAK zimapereka mpumulo

Anthu ambiri omwe ali ndi RA amagwiritsa ntchito mankhwala osokoneza bongo (DMARD) omwe amadziwika kuti methotrexate. Koma nthawi zina, chithandizo cha methotrexate chokha sichikwanira kuwongolera zizindikilo.

Ngati mwakhala mukumwa methotrexate ndipo mukukumanabe ndi zizindikiro zochepa za RA, dokotala wanu angakulimbikitseni kuwonjezera choletsa janus kinase (JAK) ku mapulani anu. Ma JAK inhibitors amathandizira kuyimitsa zomwe zimayambitsa kutupa mthupi lanu. Methotrexate imachitanso izi, koma mwanjira ina. Kwa anthu ena, ma JAK inhibitors amagwira ntchito bwino kwambiri.

Pakadali pano, Food and Drug Administration (FDA) yavomereza mitundu itatu ya ma JAK inhibitors kuti ichiritse RA:

• tofacitinib (Xeljanz), yovomerezeka mu 2012
• baricitinib (Olumiant), wovomerezeka mu 2018
• upadacitinib (Rinvoq), yovomerezeka mu 2019

Ochita kafukufuku akupitiliza kuphunzira za mankhwalawa kuti aphunzire momwe amafanirana ndi mitundu ina ya mankhwala. Mwachitsanzo, asayansi posachedwapa apeza kuti kuphatikiza kwa methotrexate ndi upadacitinib kunali kothandiza kuposa methotrexate ndi adalimumab pochepetsa kupweteka ndikuwongolera magwiridwe antchito mwa anthu omwe ali ndi RA. Oposa 1,600 omwe ali ndi RA adatenga nawo gawo phunziroli.

Mayesero azachipatala akuchitikanso kuti apange ma Jhibit inhibitors atsopano, kuphatikiza mankhwala oyeserera otchedwa filgotinib. Mu kuyesa kwaposachedwa kwa gawo lachitatu lachipatala, filgotinib idapezeka kuti ndiyothandiza kwambiri kuposa placebo yothandizira RA mwa anthu omwe adayesapo DMARD imodzi kapena zingapo. Kafukufuku wowonjezereka amafunikira kuti aphunzire za chitetezo cha nthawi yayitali ndi mphamvu ya mankhwala oyesererawa.

Kuti mudziwe zambiri pazabwino zomwe zingachitike komanso kuopsa kotenga JAK inhibitor, lankhulani ndi dokotala wanu. Amatha kukuthandizani kudziwa ngati mankhwalawa akhoza kukhala chisankho chabwino kwa inu.

BTK inhibitor pakukula

Bruton's tyrosine kinase (BTK) ndi enzyme yomwe imathandizira kukulira kutupa. Kuletsa zomwe BTK ikuchita, ofufuza akhala akupanga ndikuyesa choletsa cha BTK chotchedwa fenebrutinib.

Kafukufuku woyambirira akuwonetsa kuti fenebrutinib itha kuperekanso chithandizo china cha RA. Gulu lapadziko lonse lapansi la ofufuza posachedwapa amaliza kuyesa kwachiwiri II kuti aphunzire za chitetezo ndi mphamvu ya fenebrutinib yothandizira vutoli. Adapeza kuti fenebrutinib inali yovomerezeka motetezeka komanso modzichepetsa.

Kafukufukuyu adawona kuti kuphatikiza ndi methotrexate, fenebrutinib inali yothandiza kwambiri kuposa placebo yochiza matenda a RA. Fenebrutinib anali ndi mphamvu zofananira zofananira ndi adalimumab.

Kafukufuku wowonjezereka amafunikira kuti muphunzire za chitetezo ndi mphamvu ya fenebrutinib.

Neurostimulation ikuwonetsa lonjezo

Anthu ena amayesa mankhwala angapo kuti athetse RA, osapambana.

Monga njira ina m'malo mwa mankhwala, ofufuza akuphunzira zaubwino ndi zoopsa zomwe zingakhudze mitsempha ya vagus pochiza RA. Mwanjira iyi yothandizira, zikoka zamagetsi zimagwiritsidwa ntchito kutulutsa mitsempha ya vagus. Minyewa imeneyi imathandizira kuwongolera kutupa m'thupi lanu.

Asayansi posachedwapa apanga kafukufuku woyendetsa ndege wamunthu pakukweza kwamitsempha ya vagus pochiza RA. Adakhazikitsa neurostimulator yaying'ono kapena chida chachinyengo mwa anthu 14 omwe ali ndi RA. Asanu ndi m'modzi mwa anthuwa amathandizidwa ndi chidwi cha vagus kamodzi patsiku kwa milungu 12.

Mwa otenga nawo gawo omwe amalandira kukondoweza kwamitsempha ya vagus tsiku ndi tsiku, anayi mwa asanu ndi m'modzi mwa omwe akutenga nawo mbali adakumana ndi kusintha kwa RA. Ophunzira ochepa adakumana ndi zovuta panthawi yamankhwala, koma palibe zomwe zidachitikazo zinali zazikulu kapena zosatha.

Omega-3 fatty acids atha kuthandiza

Kuphatikiza pa kumwa mankhwala omwe mwalandira, kafukufuku akuwonetsa kuti kuwonjezera omega-3 chowonjezera pazomwe mumachita tsiku ndi tsiku kungathandize kuchepetsa zizindikilo za RA.

Omega-3 fatty acid mowa adalumikizidwa ndikuchepetsa kutupa m'thupi. Ofufuza ochokera ku Yunivesite ya Houston atasanthula kafukufuku wowonjezera wa omega-3, adapeza mayesero 20 azachipatala omwe amayang'ana kwambiri RA. M'mayesero 16 mwa 20, omega-3 supplementation idalumikizidwa ndikusintha kwakukulu kwa zizindikilo za RA.

Kafukufuku waposachedwa wapezanso kulumikizana pakati pa omega-3 supplementation ndikuchepetsa zochitika zamatenda mwa anthu omwe ali ndi RA. Pamsonkhano wapachaka wa 2019 ACR / ARP, ofufuza adalemba zotsatira za kafukufuku wautali wa anthu 1,557 omwe ali ndi RA. Ophunzira omwe akuti amatenga omega-3 zowonjezerapo anali ndi zocheperako pamatenda, kuchepa kwa malo olumikizirana mafupa, komanso kulumikizana kosapweteka pang'ono kuposa omwe sanatenge omega-3 zowonjezera.

Mankhwala a RA olumikizidwa ndi phindu laumoyo wamtima

Mankhwala ena a RA atha kukhala ndi phindu pamtima wanu, komanso zimfundo zanu. Malinga ndi kafukufuku watsopano awiri woperekedwa ku Msonkhano Wapachaka wa 2019 ACR / ARP, mankhwalawa akuphatikizapo methotrexate ndi hydroxychloroquine.

Pakafukufuku wina, ofufuza adatsata omenyera 2,168 omwe ali ndi RA kuyambira 2005 mpaka 2015. Adapeza kuti omwe adalandira chithandizo ndi methotrexate samakonda kukumana ndi zochitika zamtima, monga matenda amtima kapena sitiroko. Ophunzira omwe adalandira methotrexate analinso ochepa kuchipatala chifukwa cha kulephera kwa mtima.

Pakafukufuku wina, ofufuza aku Canada adasanthula zomwe zalembedwa kuchokera m'magulu atatu: anthu omwe ali ndi RA, anthu omwe ali ndi systemic lupus erythematosus (SLE), ndikuwongolera athanzi opanda vuto lililonse. Anthu omwe ali ndi RA kapena SLE omwe amathandizidwa ndi hydroxychloroquine anali ndi chiopsezo chochepa cha zochitika zamtima, monga matenda amtima kapena sitiroko.

Kutenga

Kusintha kwa sayansi yamankhwala kungathandizenso ofufuza kukonza chithandizo chomwe chilipo ndikupanga njira zatsopano zothandizira RA.

Kuti mudziwe zambiri zamankhwala posankha RA, lankhulani ndi dokotala wanu. Amatha kukuthandizani kuti mumvetsetse zabwino zomwe zingachitike komanso zoopsa zosintha mapulani anu. Akhozanso kulangiza kusintha kwa moyo, monga kusasuta kapena kutulutsa mpweya, kukuthandizani kuti mukhale ndi thanzi labwino komanso moyo wabwino ndi matendawa.