Mafunso Okhudza Waldenstrom Macroglobulinemia

Zamkati

• 1. Kodi Waldenstrom macroglobulinemia imachiritsidwa?
• 2. Kodi Waldenstrom macroglobulinemia imatha kukhululukidwa?
• 3. Kodi Waldenstrom macroglobulinemia ndiyosowa motani?
• 4. Kodi Waldenstrom macroglobulinemia imayenda bwanji?
• 5. Kodi Waldenstrom macroglobulinemia imayenda m'mabanja?
• 6. Nchiyani chimayambitsa Waldenstrom macroglobulinemia?
• 7. Kodi mungakhale nthawi yayitali bwanji ndi Waldenstrom macroglobulinemia?
• 8. Kodi Waldenstrom macroglobulinemia imasokoneza?
• 9. Kodi Waldenstrom macroglobulinemia imathandizidwa motani?
• Kutenga

Waldenstrom macroglobulinemia (WM) ndi mtundu wosowa wa non-Hodgkin's lymphoma wodziwika ndi kuchuluka kwa maselo oyera amwazi wamba.

Ndi mtundu wa khansa yomwe ikukula pang'onopang'ono yomwe imakhudza anthu atatu mwa anthu 1 miliyoni ku United States chaka chilichonse, malinga ndi American Cancer Society.

WM nthawi zina amatchedwa:

• Matenda a Waldenstrom
• lymphoplasmacytic lymphoma
• chachikulu macroglobulinemia

Ngati mwapezeka ndi WM, mutha kukhala ndi mafunso ambiri okhudzana ndi matendawa. Kuphunzira momwe mungathere za khansa ndikuwunika njira zamankhwala kungakuthandizeni kuthana ndi vutoli.

Nawa mayankho amafunso asanu ndi anayi omwe angakuthandizeni kumvetsetsa WM.

1. Kodi Waldenstrom macroglobulinemia imachiritsidwa?

WM pakadali pano ilibe mankhwala odziwika. Komabe, pali mankhwala osiyanasiyana omwe angakuthandizeni kuthana ndi matenda anu.

Maganizo a anthu omwe amapezeka ndi WM asintha pazaka zambiri. Asayansi akufufuzanso katemera wothandizira kulimbikitsa chitetezo cha mthupi kukana khansa yamtunduwu ndikupanga njira zatsopano zamankhwala.

2. Kodi Waldenstrom macroglobulinemia imatha kukhululukidwa?

Pali mwayi wochepa kuti WM itha kupita kukhululukidwa, koma si zachilendo. Madokotala amangowona kuchotsedwa kwathunthu kwa matendawa mwa anthu ochepa. Chithandizo chamakono sichimalepheretsa kubwerera m'mbuyo.

Ngakhale kulibe zambiri pamitengo yakhululukidwe, kafukufuku wina wocheperako kuchokera ku 2016 adapeza kuti WM idayamba kukhululukidwa kwathunthu atalandira "R-CHOP regimen."

Malamulo a R-CHOP anaphatikizapo kugwiritsa ntchito:

• rituximab
• cyclophosphamide
• alireza
• kutuloji
• mbalambanda

Ophunzira ena 31 adakhululukidwa pang'ono.

Lankhulani ndi dokotala wanu kuti muwone ngati mankhwalawa, kapena mtundu wina wa mankhwala, ndi oyenera kwa inu.

3. Kodi Waldenstrom macroglobulinemia ndiyosowa motani?

Madokotala amatenga anthu 1,000 mpaka 1,500 ku United States omwe ali ndi WM chaka chilichonse, malinga ndi American Cancer Society. Bungwe la National Organisation of Rare Disways limawona kuti ndizosowa kwambiri.

WM imakonda kukhudza amuna owirikiza kawiri kuposa akazi. Matendawa sapezeka kwenikweni pakati pa anthu akuda kuposa azungu.

4. Kodi Waldenstrom macroglobulinemia imayenda bwanji?

WM imakonda kupita patsogolo pang'onopang'ono. Amapanga mitundu yambiri yamagazi oyera yotchedwa B lymphocyte.

Maselowa amapanga kuchuluka kwa mankhwala otchedwa immunoglobulin M (IgM), omwe amachititsa kuti magazi aziwonjezereka otchedwa hyperviscosity. Izi zimapangitsa kuti zikhale zovuta kuti ziwalo zanu ndi ziwalo zanu zizigwira bwino ntchito.

Kuchuluka kwa ma lymphocyte a B kumatha kusiya chipinda chochepa m'mafupa kuti mukhale ndi maselo amwazi wathanzi. Mutha kukhala ndi kuchepa kwa magazi m'thupi ngati kuchuluka kwanu kwama cell ofiira kutsika kwambiri.

Kuperewera kwa maselo oyera amwazi kumatha kupangitsa kuti thupi lanu likhale lolimbana ndi matenda ena. Ma platelet anu amathanso kutsika, zomwe zingayambitse magazi ndi mabala.

Anthu ena samakhala ndi zizindikiro kwa zaka zingapo atapezeka ndi matenda.

Zizindikiro zoyambirira zimaphatikizapo kutopa komanso kuchepa mphamvu chifukwa chakuchepa kwa magazi m'thupi. Mwinanso mumakhala ndikumangirira zala zanu ndi zala zanu ndikutuluka magazi m'mphuno ndi m'kamwa.

WM pamapeto pake imatha kukhudza ziwalo, zomwe zimayambitsa kutupa m'chiwindi, ndulu, ndi ma lymph node. Hyperviscosity kuchokera ku matendawa amathanso kubweretsa kusawona bwino kapena zovuta zakutuluka kwamagazi kupita ku diso.

Khansara pamapeto pake imatha kuyambitsa zizindikilo zonga sitiroko chifukwa cha kusayenda bwino kwa magazi kubongo, komanso mavuto amtima ndi impso.

5. Kodi Waldenstrom macroglobulinemia imayenda m'mabanja?

Asayansi akuphunzirabe za WM, koma amakhulupirira kuti majini obadwa nawo atha kukulitsa mwayi wa anthu ena kukhala ndi matendawa.

Pafupifupi 20 peresenti ya anthu omwe ali ndi khansa yamtunduwu ali pafupi kwambiri ndi munthu yemwe ali ndi WM kapena matenda ena omwe amayambitsa ma B osazolowereka.

Anthu ambiri omwe amapezeka ndi WM alibe mbiri yabanja yokhudzana ndi vutoli. Nthawi zambiri zimachitika chifukwa chakusintha kwamaselo, komwe sikulandiridwa, m'moyo wamunthu wonse.

6. Nchiyani chimayambitsa Waldenstrom macroglobulinemia?

Asayansi sanadziwebe chomwe chimayambitsa WM. Umboni ukusonyeza kuti kusakanikirana kwa majini, zachilengedwe, komanso ma virus nthawi zonse pamoyo wamunthu zitha kuyambitsa matendawa.

Kusintha kwa majini a MYD88 kumachitika pafupifupi 90 peresenti ya anthu omwe ali ndi Waldenstrom macroglobulinemiaemia, malinga ndi International Waldenstrom's Macroglobulinemia Foundation (IWMF).

Kafukufuku wina wapeza kulumikizana pakati pa matenda a hepatitis C osachiritsika ndi WM mwa anthu ena (koma osati onse) omwe ali ndi matendawa.

Kuwonetsedwa kwa zinthu zachikopa, labala, zosungunulira, utoto, ndi utoto zitha kukhalanso vuto lina la WM. Kafukufuku wazomwe zimayambitsa WM akupitilira.

7. Kodi mungakhale nthawi yayitali bwanji ndi Waldenstrom macroglobulinemia?

Kafukufuku waposachedwa akuwonetsa kuti theka la anthu omwe ali ndi WM akuyembekezeka kukhala ndi moyo zaka 14 mpaka 16 atapezeka, malinga ndi IWMF.

Maganizo anu amatha kusiyanasiyana kutengera:

• zaka zanu
• thanzi lathunthu
• Matendawa amapita mwachangu

Mosiyana ndi mitundu ina ya khansa, WM sichipezeka pang'onopang'ono. M'malo mwake, madokotala amagwiritsa ntchito International Prognostic Scoring System ya Waldenstrom Macroglobulinemia (ISSWM) kuti awone momwe mumaonera.

Njirayi imaganizira zinthu zosiyanasiyana, kuphatikiza zanu:

• zaka
• mulingo wa hemoglobin wamagazi
• kuchuluka kwa mapiritsi
• mulingo wa beta-2 microglobulin
• mulingo wamtundu wa IgM

Kutengera zomwe mwapeza pazifukwa zowopsa izi, dokotala wanu akhoza kukuikani pagulu lotsika, lapakatikati, kapena loopsa, lomwe lingakuthandizeni kumvetsetsa malingaliro anu.

Kuchuluka kwa zaka 5 za anthu omwe ali pachiwopsezo chachikulu ndi 87%, gulu lomwe lili pachiwopsezo chapakati ndi 68 peresenti, ndipo gulu lomwe lili pachiwopsezo chachikulu ndi 36%, malinga ndi American Cancer Society.

Ziwerengerozi ndizotengera za anthu 600 omwe adapezeka ndi WM ndipo adalandira chithandizo chisanafike Januware 2002.

Chithandizo chatsopano chitha kukupatsani chiyembekezo.

8. Kodi Waldenstrom macroglobulinemia imasokoneza?

Inde. WM imakhudza minofu yama lymphatic, yomwe imapezeka m'malo ambiri amthupi. Pomwe munthu amapezeka kuti ali ndi matendawa, amakhala atayamba kupezeka m'magazi ndi m'mafupa.

Itha kufalikira kumatenda am'mimba, chiwindi, ndi ndulu. Nthawi zambiri, WM imathanso kusokoneza m'mimba, chithokomiro, khungu, mapapo, ndi matumbo.

9. Kodi Waldenstrom macroglobulinemia imathandizidwa motani?

Chithandizo cha WM chimasiyanasiyana malinga ndi munthu ndipo sichimayamba pokhapokha mutakumana ndi matenda. Anthu ena sangasowe chithandizo mpaka zaka zochepa atazindikira.

Dokotala wanu angakulimbikitseni kuyamba chithandizo pakakhala zovuta zina za khansa, kuphatikiza:

• Matenda a hyperviscosity
• kuchepa kwa magazi m'thupi
• kuwonongeka kwa mitsempha
• mavuto am'thupi
• amyloidosis
• cryoglobulins

Pali mankhwala osiyanasiyana omwe angakuthandizeni kuthana ndi matendawa. Mankhwala ochiritsira a WM ndi awa:

• anayankha
• chemotherapy
• chithandizo chothandizira
• chithandizo chamankhwala

Nthawi zambiri, dokotala angakulimbikitseni chithandizo chofala, monga:

• kuchotsedwa kwa ndulu
• tsinde lothandizira
• mankhwala a radiation

Kutenga

Kupezeka ndi khansa yosawerengeka ngati WM kumatha kukhala kovuta kwambiri.

Komabe, kupeza zambiri zokuthandizani kumvetsetsa momwe matenda anu aliri komanso njira zomwe mungasamalire, kungakuthandizeni kukhala ndi chidaliro pamalingaliro anu.