Kodi Vogt-Koyanagi-Harada syndrome ndi chiyani?

Zamkati

• Zomwe zimayambitsa
• Zizindikiro zotheka
• Momwe mankhwalawa amachitikira

Vogt-Koyanagi-Harada Syndrome ndi matenda osowa omwe amakhudza minofu yomwe imakhala ndi ma melanocyte, monga maso, dongosolo lamanjenje, khutu ndi khungu, zomwe zimayambitsa kutupa mu diso la diso, komwe kumakhudzana ndimatenda a khungu komanso kumva.

Matendawa amapezeka makamaka kwa achinyamata azaka zapakati pa 20 ndi 40, pomwe azimayi ndiwo amakhudzidwa kwambiri. Kuchiza kumaphatikizapo kuyang'anira ma corticosteroids ndi ma immunomodulators.

Zomwe zimayambitsa

Zomwe zimayambitsa matendawa sizikudziwika, koma amakhulupirira kuti ndi matenda omwe amadzimadzimadzimadzimodzi, pomwe pali zovuta pamatope a melanocyte, zomwe zimapangitsa kuti pakhale zotupa zambiri za ma lymphocyte a T.

Zizindikiro zotheka

Zizindikiro za matendawa zimadalira gawo lomwe muli:

Gawo lolowerera

Pakadali pano, mawonekedwe amachitidwe ofanana ndi mawonekedwe ngati chimfine amawoneka, limodzi ndi zidziwitso zamitsempha zomwe zimangokhala masiku ochepa. Zizindikiro zofala kwambiri ndi malungo, kupweteka mutu, kupweteka kwa msana, mseru, chizungulire, kupweteka kuzungulira maso, matumbo, kufooka kwa minofu, kufooka pang'ono mbali imodzi ya thupi, kuvuta kufotokoza mawu molondola kapena kuzindikira chilankhulo, photophobia, kung'amba, khungu ndi khungu hypersensitivity.

Uveitis siteji

Pakadali pano, mawonetseredwe amaso amakula, monga kutupa kwa diso, kutsika kwa masomphenya ndikumapeto kwa diso. Anthu ena amathanso kumva zizindikiro zakumva monga tinnitus, kupweteka komanso kusamva bwino m'makutu.

Gawo losatha

Munthawi imeneyi, mawonekedwe a ocular ndi dermatological amawonetsedwa, monga vitiligo, kupindika kwa nsidze, nsidze, zomwe zimatha miyezi mpaka zaka. Vitiligo imagawidwa mozungulira pamutu, nkhope ndi thunthu, ndipo imatha kukhala yokhazikika.

Gawo lobwereza

Pakadali pano anthu amatha kukhala ndi kutupa kwa diso, khungu, khungu, choroidal neovascularization ndi subretinal fibrosis.

Momwe mankhwalawa amachitikira

Chithandizochi chimakhala ndi kuperekera kwa milingo yayikulu ya corticosteroids monga prednisone kapena prednisolone, makamaka gawo lalikulu la matendawa, kwa miyezi 6. Chithandizochi chimatha kuyambitsa kukana komanso kuwonongeka kwa chiwindi ndipo munthawi imeneyi ndizotheka kusankha kugwiritsa ntchito betamethasone kapena dexamethasone.

Mwa anthu omwe zotsatira zake zoyipa za corticosteroids zimapangitsa kuti azigwiritsa ntchito muyezo wocheperako wosadalirika, ma immunomodulators monga cyclosporine A, methotrexate, azathioprine, tacrolimus kapena adalimumab angagwiritsidwe ntchito, omwe agwiritsidwa ntchito ndi zotsatira zabwino.

Pakakhala kukana kwa corticosteroids komanso mwa anthu omwe samayankhiranso mankhwala opatsirana mthupi, ma immunoglobulin angagwiritsidwe ntchito.