Somatostatinomas

Zamkati

• Zizindikiro za somatostatinoma
• Zomwe zimayambitsa komanso zoopsa za somatostatinomas
• Kodi zotupa zimapezeka bwanji?
• Amawachitira bwanji?
• Zochitika zogwirizana ndi zovuta
• Mtengo wa kupulumuka kwa somatostatinomas

Chidule

Somatostatinoma ndi mtundu wosowa kwambiri wa chotupa cha neuroendocrine chomwe chimamera m'mapiko ndipo nthawi zina matumbo ang'onoang'ono. Chotupa cha neuroendocrine ndi chomwe chimapangidwa ndimaselo opanga ma hormone. Maselo opanga ma hormone amatchedwa islet cell.

Somatostatinoma imayamba makamaka mu delta islet cell, yomwe imayang'anira kupanga hormone somatostatin. Chotupacho chimapangitsa kuti maselowa apange mahomoni ambiri.

Thupi lanu likatulutsa mahomoni owonjezera a somatostatin, limasiya kutulutsa mahomoni ena am'mimba. Mahomoni enawa akayamba kusowa, pamapeto pake zimayambitsa zizindikilo.

Zizindikiro za somatostatinoma

Zizindikiro za somatostatinoma nthawi zambiri zimayamba kuchepa ndikuwonjezeka mwamphamvu pang'onopang'ono. Zizindikirozi ndizofanana ndi zomwe zimayambitsa matenda ena. Pachifukwa ichi, ndikofunikira kuti mupange nthawi ndi dokotala wanu kuti mupeze matenda oyenera. Izi zikuyenera kuwonetsetsa kuti mukulandira chithandizo chilichonse chazachipatala chomwe chimayambitsa matenda anu.

Zizindikiro zomwe zimayambitsidwa ndi somatostatinoma zitha kuphatikizira izi:

• kupweteka pamimba (chizindikiro chofala kwambiri)
• matenda ashuga
• kuonda kosadziwika
• miyala yamtengo wapatali
• steatorrhea, kapena mipando yamafuta
• kutsekula matumbo
• kutsegula m'mimba
• jaundice, kapena khungu lachikasu (lofala kwambiri ngati somatostatinoma ili m'matumbo ang'onoang'ono)

Matenda ena kupatula somatostatinoma atha kuyambitsa zizindikilo zambiri. Izi zimachitika nthawi zambiri, chifukwa ma somatostatinomas ndi osowa kwambiri. Komabe, ndi dokotala wanu yekhayo amene angazindikire zomwe zikuchitika pazizindikiro zanu.

Zomwe zimayambitsa komanso zoopsa za somatostatinomas

Zomwe zimayambitsa somatostatinoma sizikudziwika pakadali pano. Komabe, pali zinthu zina zowopsa zomwe zingayambitse somatostatinoma.

Matendawa, omwe amatha kukhudza amuna ndi akazi, nthawi zambiri amapezeka atakwanitsa zaka 50. Izi ndi zina mwaziwopsezo zomwe zimayambitsa zotupa za neuroendocrine:

• mbiri yabanja yamagulu angapo a endocrine neoplasia mtundu 1 (MEN1), mtundu wosowa wa khansa womwe umachokera
• neurofibromatosis
• Matenda a von Hippel-Lindau
• chifuwa chachikulu

Kodi zotupa zimapezeka bwanji?

Matendawa ayenera kupangidwa ndi akatswiri azachipatala. Dokotala wanu nthawi zambiri amayamba kuyezetsa magazi ndikuyesa magazi mwachangu. Kuyesaku kumafufuza mulingo wapamwamba wa somatostatin. Kuyezetsa magazi nthawi zambiri kumatsatiridwa ndi chimodzi mwazinthu zotsatirazi kapena ma X-ray:

• endoscopic ultrasound
• Kujambula kwa CT
• octreoscan (yomwe ndi pulogalamu yamagetsi)
• Kujambula kwa MRI

Mayeserowa amalola dokotala wanu kuti awone chotupacho, chomwe chingakhale khansa kapena chosagwetsa khansa. Ambiri mwa somatostatinomas ali ndi khansa. Njira yokhayo yodziwira ngati chotupa chanu ndi khansa ndichopanga opaleshoni.

Amawachitira bwanji?

Somatostatinoma nthawi zambiri imachiritsidwa pochotsa chotupacho kudzera mu opaleshoni. Ngati chotupacho chili ndi khansa ndipo khansara yafalikira (matenda omwe amatchedwa metastasis), kuchitidwa opaleshoni sikungakhale kotheka. Pankhani ya metastasis, adotolo azithandizira ndikuwongolera zomwe zingayambitse somatostatinoma.

Zochitika zogwirizana ndi zovuta

Zina mwazomwe zimakhudzana ndi somatostatinomas zitha kukhala izi:

• matenda a von Hippel-Lindau
• Amuna1
• mtundu wa neurofibromatosis 1
• matenda ashuga

Somatostatinomas nthawi zambiri amapezeka mtsogolo, zomwe zimatha kusokoneza njira zamankhwala. Kumapeto kwa nthawi, zotupa za khansa zimakhala kuti zatha kale. Pambuyo pa metastasis, chithandizo chimakhala chochepa, chifukwa opaleshoni nthawi zambiri sichotheka.

Mtengo wa kupulumuka kwa somatostatinomas

Ngakhale kuti ma somatostatinomas ndi osowa, mawonekedwe ake ndiabwino pazaka zisanu zapulumuka. Ngati somatostatinoma itha kuchotsedwa opaleshoni, pamakhala pafupifupi 100% yopulumuka zaka zisanu zitachotsedwa. Kuchuluka kwa zaka zisanu kwa omwe amachiritsidwa pambuyo pa somatostatinoma kwasinthidwa ndi 60%.

Chinsinsi chake ndikupeza matendawa msanga. Ngati muli ndi zina mwazizindikiro za somatostatinoma, muyenera kupita kukakumana ndi dokotala posachedwa. Kuyezetsa matenda kudzatha kudziwa chomwe chimayambitsa matenda anu.

Ngati dokotala akutsimikizira kuti muli ndi somatostatinoma, ndiye kuti mukayamba kulandira chithandizo cham'mbuyomu, matenda anu azikhala bwino.