Kutenga Biologics ndikukhazikitsanso Matenda Anu a Psoriatic

Zamkati

• Kodi biologics ndi chiyani?
• Mitundu ya biologics
• Abatacept
• Adalimumab
• Chizindikiro cha pegol
• Etanercept
• Golimumab
• Zowonjezera
• Ustekinumab
• Mankhwala osakaniza
• Zotsatira zoyipa ndi machenjezo
• Biologics ndi gawo limodzi la mapulani a PsA

Chidule

Matenda a Psoriatic (PsA) ndi matenda osachiritsika, ndipo amafunika chithandizo chamankhwala kupitiriza kuteteza kuwonongeka kosagwirizana. Chithandizo choyenera chingathenso kuchepetsa kuchuluka kwa nyamakazi.

Biologics ndi mtundu umodzi wokha wa mankhwala omwe amagwiritsidwa ntchito pochizira PsA. Izi zimagwira ntchito popondereza chitetezo chanu chamthupi kotero chimasiya kuwononga ziwalo zathanzi ndikupweteka komanso kuwonongeka.

Kodi biologics ndi chiyani?

Biologics ndi mitundu ingapo yamatenda osokoneza bongo (DMARDs). Ma DMARD amaimitsa chitetezo chanu chamthupi kuti chisayambitse kutupa kwa PsA ndi zina zomwe zimangokhala zokha.

Kuchepetsa kutupa kuli ndi zotsatira zazikulu ziwiri:

• Pakhoza kukhala zopweteka zochepa chifukwa kutupa m'malo olumikizirana ndi komwe kumayambitsa kulumikizana.
• Zowonongeka zitha kuchepetsedwa.

Biologics imagwira ntchito poletsa chitetezo chamthupi chomwe chimatulutsa kutupa. Mosiyana ndi ma DMARD ena, biologics imayendetsedwa ndi kulowetsedwa kapena jekeseni wokha.

Biologics imaperekedwa ngati chithandizo choyamba cha anthu omwe ali ndi PsA yogwira. Ngati biologic yoyamba yomwe mungayesere sichithandiza kuti muchepetse zizindikilo zanu, adotolo amatha kukusinthani kuti mugwiritse ntchito mankhwala ena m'kalasiyi.

Mitundu ya biologics

Mitundu inayi ya biologics imagwiritsidwa ntchito pochizira PsA:

• chotupa necrosis factor-alpha (TNF-alpha) inhibitors: adalimumab (Humira), certolizumab pegol (Cimzia), etanercept (Enbrel), golimumab (Simponi Aria), infliximab (Remicade)
• interleukin 12/23 (IL-12/23) zoletsa: ustekinumab (Stelara)
• interleukin 17 (IL-17 inhibitors): ixekizumab (Taltz), secukinumab (Cosentyx)
• T cell inhibitors: abatacept (Orencia)

Mankhwalawa amalepheretsa mapuloteni ena omwe amaonetsa kuti chitetezo chamthupi chanu chitha kulimbana ndi maselo athanzi, kapena amalimbana ndi maselo amthupi omwe amatenga nawo mbali potupa. Cholinga cha mtundu uliwonse wa biologic ndikuletsa kuti zotupa zisayambike.

Ma biologics angapo amapezeka. Otsatirawa ndi omwe amafotokozedwera PsA.

Abatacept

Abatacept (Orencia) ndi T cell inhibitor. Maselo a T ndi maselo oyera a magazi. Amathandiza pa chitetezo cha mthupi, komanso poyambitsa kutupa. Orencia amayang'ana maselo a T kuti athetse kutupa.

Orencia amathandizanso nyamakazi (RA) ndi achinyamata idiopathic arthritis (JIA). Amapezeka ngati kulowetsedwa kudzera mumtsempha, kapena ngati jekeseni yomwe mumadzipatsa.

Adalimumab

Adalimumab (Humira) imagwira ntchito poletsa TNF-alpha, puloteni yomwe imalimbikitsa kutupa. Anthu omwe ali ndi PsA amapanga ma TNF-alpha ochulukirapo pakhungu lawo ndi zimfundo.

Humira ndi mankhwala ojambulidwa. Amaperekedwanso kwa matenda a Crohn ndi mitundu ina ya nyamakazi.

Chizindikiro cha pegol

Certolizumab pegol (Cimzia) ndi mankhwala ena a TNF-alpha. Zapangidwa kuti zithetse mitundu yaukali ya PsA, komanso matenda a Crohn's, RA, ndi ankylosing spondylitis (AS).

Cimzia imaperekedwa ngati jakisoni wokha.

Etanercept

Etanercept (Enbrel) ndi mankhwala a TNF-alpha. Ndili m'gulu la mankhwala ovomerezeka akale kwambiri ochizira a PsA, ndipo amagwiritsidwa ntchito pochiza matenda ena a nyamakazi.

Enbrel amadzibayitsa kamodzi kapena kawiri pa sabata.

Golimumab

Golimumab (Simponi) ndi mankhwala a TNF-alpha opangidwa kuti athandize PsA yogwira. Amaperekedwanso kwa RA wodekha, wolimba kwambiri mpaka wam'mimba (UC), komanso AS yogwira ntchito.

Mumatenga Simponi kamodzi pamwezi kudzera pa jekeseni yanu.

Zowonjezera

Infliximab (Remicade) ndi mtundu wolowetsedwa wa mankhwala a TNF-alpha. Mumalowetsedwa ku ofesi ya dokotala katatu pamasabata asanu ndi limodzi. Pambuyo pa chithandizo choyamba, infusions imaperekedwa miyezi iwiri iliyonse.

Remicade imathandizanso matenda a Crohn, UC, ndi AS. Madokotala amatha kupereka mankhwalawa kwa RA, pamodzi ndi methotrexate.

Ixekizumab

Ixekizumab (Taltz) ndi IL-17 inhibitor. Imalepheretsa IL-17, yomwe imakhudzidwa ndi kuyankha kwamthupi kotupa.

Mumalandira Taltz ngati jakisoni wambiri pakhungu milungu iwiri iliyonse, kenako milungu inayi iliyonse.

Mphotho

Secukinumab (Cosentyx) ndi IL-17 inhibitor ina. Amavomerezedwa kuchiza psoriasis ndi PsA, komanso AS.

Mumatenga ngati kuwombera pansi pa khungu lanu.

Ustekinumab

Ustekinumab (Stelara) ndi IL-12/23 inhibitor. Imalepheretsa mapuloteni IL-12 ndi IL-23, omwe amayambitsa kutupa mu PsA. Stelara amavomerezedwa kuti azitha kugwira ntchito ya PsA, plaque psoriasis, komanso matenda a Crohn's average.

Stelara amabwera ngati jakisoni. Pambuyo pa jakisoni woyamba, amaperekedwanso pambuyo pa milungu inayi, ndiyeno kamodzi pamasabata khumi ndi awiri.

Mankhwala osakaniza

Kuti mukhale ndi PsA yochepa kwambiri, biologics ndiyofunikira pakuwongolera zizindikiritso zazifupi komanso zazitali komanso zovuta. Komabe, dokotala wanu amathanso kulangiza chithandizo china.

Dokotala wanu akhoza kukupatsani mankhwala osakanikirana ndi kutupa (NSAIDs) a ululu wophatikizana. Izi zimachepetsanso kutupa. Mitundu ya pa-counter (OTC), monga ibuprofen (Advil), imapezeka kwambiri, komanso njira zamagetsi zamagetsi.

Popeza kugwiritsa ntchito nthawi yayitali kumawonjezera chiwopsezo cha kutuluka m'mimba, mavuto amtima, ndi sitiroko, ma NSAID ayenera kugwiritsidwa ntchito pang'ono komanso pamlingo wotsikitsitsa kwambiri.

Mukadakhala ndi psoriasis pamaso pa PsA, ndiye kuti mungafunenso chithandizo chothandizira kuchepetsa zotupa pakhungu ndi mavuto amisomali. Njira zochiritsira zomwe mungaphatikizepo ndi corticosteroids, mankhwala opepuka, ndi mafuta am'thupi.

Zotsatira zoyipa ndi machenjezo

Zotsatira zoyipa kwambiri za biologics ndimakhungu (monga kufiira ndi zotupa) pamalo obayira. Chifukwa biologics imayang'anira chitetezo chanu chamthupi, mutha kukhala pachiwopsezo chachikulu chotenga matenda.

Zotsatira zochepa, koma zoyipa, zimaphatikizapo:

• kukulitsa psoriasis
• matenda opuma opuma
• chifuwa chachikulu
• Zizindikiro zonga lupus (monga kupweteka kwa minofu ndi mafupa, kutentha thupi, ndi kutayika tsitsi)

Lankhulani ndi rheumatologist wanu za zotsatirazi zomwe zingachitike, ndikuyang'anirani matenda anu mosamala. Itanani nthawi yomweyo ngati mukukayikira kuti mukuvutika ndi mankhwala anu.

Komanso, amayi omwe ali ndi pakati kapena akukonzekera kutenga pakati ayenera kugwiritsa ntchito biologics mosamala.

Ngakhale zomwe zimakhudza mwana yemwe akukula sizikumveka kwenikweni, pali kuthekera kwa zovuta pathupi. Kutengera ndi kuuma kwa PsA, madokotala ena amalimbikitsa kuti asiye kugwiritsa ntchito mankhwala apakati.

Biologics ndi gawo limodzi la mapulani a PsA

Biologics imabweretsa chiyembekezo kwa ambiri ndi PsA. Sikuti ma biologics amangothandiza kuthana ndi zisonyezo za PsA, amachepetsanso kuwononga komwe kumayambitsa kutupa.

Komabe, ndikofunikira kukumbukira kuti biologics ndi gawo limodzi chabe lamaphunziro anu a nthawi yayitali a PsA. Lankhulani ndi dokotala wanu za kusintha kwa moyo wanu ndi mankhwala ena omwe angakuthandizeni.