Zosankha za Chithandizo cha CML Pachigawo: Gawo Lopitilira, Lofulumira, ndi Kuphulika

Zamkati

• Matenda a CML
• Gawo lofulumira la CML
• Kuphulika gawo CML
• Mankhwala ena
• Kuwunika chithandizo chanu
• Kutenga

Matenda a myeloid leukemia (CML) amadziwikanso kuti khansa ya m'magazi yayikulu. Mu khansa yamtunduwu, mafupa amatulutsa maselo oyera oyera ambiri.

Ngati matendawa sakuchiritsidwa bwino, amangokulira pang'onopang'ono. Itha kupita patsogolo kuchoka nthawi yayitali, mpaka gawo lofulumira, mpaka gawo lophulika.

Ngati muli ndi CML, dongosolo lanu la mankhwala lidzadalira gawo limodzi la matendawa.

Werengani kuti mudziwe zambiri zamankhwala omwe mungasankhe gawo lililonse.

Matenda a CML

CML imakonda kuchiritsidwa kwambiri ikapezeka msanga, munthawi yayitali.

Pofuna kuchiza matenda a CML, dokotala wanu angakupatseni mtundu wa mankhwala otchedwa tyrosine kinase inhibitor (TKI).

Pali mitundu ingapo ya TKI yothandizira CML, kuphatikiza:

• imatinib (Gleevec)
• alirezatalischi (Tasigna)
• dasatinib (Spryrcel)
• bosutinib (Bosulif)
• ponatinib (Iclusig)

Gleevec nthawi zambiri amakhala mtundu woyamba wa TKI woyenera CML. Komabe, Tasigna kapena Spryrcel amathanso kupatsidwa mankhwala oyamba.

Ngati mitundu ija ya TKI sikukuthandizani, siyani kugwira ntchito, kapena kuyambitsa zovuta zina, dokotala wanu akhoza kukupatsani Bosulif.

Dokotala wanu amangokupatsani Iclusig ngati khansara singayankhe bwino ndi mitundu ina ya TKIs kapena ikayamba mtundu wamtundu wa jini, wotchedwa T315I mutation.

Ngati thupi lanu silikugwirizana ndi ma TKIs, dokotala wanu akhoza kukupatsani mankhwala a chemotherapy kapena mtundu wina wa mankhwala omwe amadziwika kuti interferon kuti athetse gawo la CML losachiritsika.

Nthawi zambiri, amalangiza kuti apange selo. Komabe, mankhwalawa amagwiritsidwa ntchito kwambiri pochizira gawo la CML.

Gawo lofulumira la CML

Mu gawo lolimbikitsidwa la CML, maselo a leukemia amayamba kuchulukirachulukira mwachangu. Maselo nthawi zambiri amakhala ndi kusintha kwa majini komwe kumawonjezera kukula ndikuchepetsa mphamvu ya chithandizo.

Ngati mwafulumizitsa gawo la CML, dongosolo lanu lothandizidwa lidzadalira chithandizo chomwe mudalandira m'mbuyomu.

Ngati simunalandirepo chithandizo chilichonse cha CML, dokotala wanu atha kusankha kuti TKI iyambe.

Ngati mwakhala mukutenga TKI kale, dokotala wanu akhoza kukulitsa mlingo wanu kapena kukusinthani ku mtundu wina wa TKI. Ngati maselo anu a khansa asintha T315I, atha kukupatsani Iclusig.

Ngati ma TKI sakukuyenderani bwino, dokotala wanu akhoza kukupatsani chithandizo ndi interferon.

Nthawi zina, dokotala wanu amatha kuwonjezera chemotherapy pa dongosolo lanu. Mankhwala a chemotherapy angathandize kubweretsa khansa kukhululukidwa, koma nthawi zambiri amasiya kugwira ntchito pakapita nthawi.

Ngati ndinu wachichepere komanso wathanzi, dokotala akhoza kukulangizani kuti mupange ma cell a stem mukamalandira mankhwala ena. Izi zidzakuthandizani kubwezeretsanso maselo omwe amapanga magazi.

Pogwiritsa ntchito makina osungira thupi, dokotala wanu amatenga maselo anu amtundu musanalandire chithandizo. Mukalandira chithandizo, amalowetsa maselowo mthupi lanu.

Pogwiritsa ntchito allogenic stem cell, dokotala wanu adzakupatsani maselo am'madzi kuchokera kwa wopereka woyenera. Atha kutsatira kutsalako ndikulowetsedwa kwa maselo oyera amwazi kuchokera kwa woperekayo.

Dokotala wanu angayesere kubweretsa khansa kuti ikhululukidwe ndi mankhwala asanakulimbikitseni kuti apange khungu.

Kuphulika gawo CML

Mu blast phase CML, ma cell a khansa amachulukana mwachangu ndikupangitsa zizindikilo zowonekera kwambiri.

Mankhwala samakhala othandiza panthawi yophulika, poyerekeza ndi magawo am'mbuyomu a matendawa. Zotsatira zake, anthu ambiri omwe ali ndi gawo lophulika la CML sangachiritsidwe khansa.

Mukayamba kuphulika CML, dokotala wanu adzawona mbiri yanu yamankhwala.

Ngati simunalandire mankhwala am'mbuyomu a CML, atha kukupatsani mankhwala apamwamba a TKI.

Ngati mwakhala mukutenga TKI kale, atha kukulitsa kuchuluka kwanu kapena kukulangizani kuti musinthe mtundu wina wa TKI. Ngati ma cell anu a khansa atha kusintha T315I, atha kupatsa Iclusig.

Dokotala wanu amathanso kukupatsani chemotherapy kuti muthandizire kuchepetsa khansa kapena kuchepetsa zisonyezo. Komabe, chemotherapy imakhala yosagwira ntchito kwambiri kuphulika kuposa magawo am'mbuyomu.

Ngati matenda anu akuyankha bwino ndi mankhwala, dokotala wanu angakulimbikitseni kuti muike ma cell a stem. Komabe, mankhwalawa amathandizanso kuti asakhale othandiza pakaphulika.

Mankhwala ena

Kuphatikiza pa mankhwala omwe afotokozedwa pamwambapa, dokotala wanu akhoza kukupatsani chithandizo chothandizira kuthana ndi matenda kapena kuthana ndi zovuta za CML.

Mwachitsanzo, atha kupereka:

• njira yotchedwa leukapheresis yochotsa maselo oyera m'magazi anu
• Kukula kumalimbikitsa kupuma kwa mafupa, ngati mutadwala chemotherapy
• opaleshoni kuti muchotse nthenda yanu, ikakulirakulira
• mankhwala a radiation, ngati mukukula nthenda kapena kupweteka kwa mafupa
• antibiotic, antiviral, kapena antifungal mankhwala, mukakhala ndi matenda aliwonse
• kuthiridwa magazi kapena plasma

Angathenso kulangiza uphungu kapena chithandizo china chamankhwala amisala, ngati zikukuvutani kuthana ndi zovuta zomwe mumakumana nazo pagulu kapena m'maganizo.

Nthawi zina, angakulimbikitseni kuti mulowe kuchipatala kuti mulandire chithandizo cha CML. Njira zatsopano zamankhwala zikupangidwa ndikuyesedwa ku matendawa.

Kuwunika chithandizo chanu

Mukamalandira chithandizo cha CML, dokotala wanu amatha kuyitanitsa kuyezetsa magazi pafupipafupi kuti muwone momwe thupi lanu likuyankhira.

Ngati dongosolo lanu lamankhwala likuwoneka kuti likugwira ntchito bwino, dokotala wanu angakulimbikitseni kuti mupitilize ndondomekoyi.

Ngati chithandizo chanu pakali pano sichikuwoneka ngati chikugwira ntchito bwino kapena chayamba kuchepa pakapita nthawi, dokotala wanu akhoza kukupatsani mankhwala osiyanasiyana kapena mankhwala ena.

Anthu ambiri omwe ali ndi CML amafunika kutenga TKI kwa zaka zingapo kapena kwamuyaya.

Kutenga

Ngati muli ndi CML, dongosolo lomwe dokotala akukulangizani lidzadalira gawo la matendawa, komanso zaka zanu, thanzi lanu, komanso mbiri yazachipatala zam'mbuyomu.

Pali mankhwala angapo othandiza kuchepetsa kukula kwa khansa, kuchepetsa zotupa, ndikuchepetsa zizindikilo zake. Chithandizo chimayamba kuchepa pamene matendawa akupita.

Lankhulani ndi dokotala wanu kuti mudziwe zambiri zamankhwala omwe mungasankhe, kuphatikiza phindu ndi kuwopsa kwa njira zosiyanasiyana zamankhwala.