Biologics ndi Crohn's Disease Remission: Zomwe Muyenera Kudziwa

Zamkati

• Momwe biologics imayang'ana kutupa
• Momwe mungadziwire ngati muli okhululukidwa
• Momwe biologics imakusungirani mu chikhululukiro
• Kodi biosimilars ndi chiyani?
• Chithandizo mukakhululukidwa
• Kutenga

Chidule

Mu 1932, Dr. Burrill Crohn ndi anzawo awiri adapereka pepala ku American Medical Association lofotokoza tsatanetsatane wa zomwe timatcha kuti Crohn's disease.

Kuyambira pamenepo, njira zamankhwala zasintha ndikuphatikizira biologics, yomwe ndi mankhwala opangidwa kuchokera m'maselo amoyo omwe adapangidwa kuti azitha kutupa.

Kutupa ndiko chifukwa chachikulu cha matenda a Crohn ndi zovuta zake. Mukakhala mukukhululukidwa, kutupa kwanu kumatha. Mukakumana ndi kuyaka kwa Crohn, kutupa kwanu kumabwereranso.

Ngakhale kulibe mankhwala a Crohn's, cholinga cha chithandizo ndikuchepetsa kutupa kuti matendawa akhululukidwe, ndikuwakhalitsa pamenepo.

Momwe biologics imayang'ana kutupa

Tumor necrosis factor, kapena TNF, ndi protein yomwe imapangitsa kutupa ngati gawo la chitetezo chamthupi. Anti-TNF biologics imagwira ntchito polimbana ndi protein iyi kuti ichepetse zotupa zake.

Ngati mutenga Remicade (infliximab), Humira (adalimumab), Cimzia (certolizumab), kapena Simponi (golimumab), mukutenga anti-TNF biologic.

Ndi matenda a Crohn, chitetezo chanu cha mthupi chimatumiza maselo oyera ambiri m'magazi am'mimba (GI), omwe amayambitsa kutupa. Njira yina yomwe biologics imayeserera kutupa ndikuthana ndi vuto lakukhala ndi maselo oyera ambiri m'magulu a GI.

Entyvio (vedolizumab) ndi Tysabri (natalizumab) amagwira ntchito motere. Amaletsa maselo oyera kuti asalowe m'mimba. Kuchepetsa kumeneku kumapangitsa kuti maselo oyera azikhala kutali ndi m'matumbo, pomwe amayambitsa kutupa. Izi zimathandizanso kuti malowo azichira.

Biologics imatha kuwongolera njira zina mthupi zomwe zimayambitsa kutupa. Stelara (ustekinumab) ndi interleukin inhibitor. Amayang'ana mapuloteni awiri omwe amaganiza kuti amayambitsa kutupa. Anthu omwe ali ndi Crohn's amakhala ndi mapuloteni apamwamba mthupi lawo.

Pogwiritsa ntchito mapuloteniwa, Stelara amatseka zotupa m'matenda a GI ndikuchepetsa zizindikilo za matenda a Crohn.

Momwe mungadziwire ngati muli okhululukidwa

Ndi zachilendo kukhala ndi masiku abwino komanso masiku oyipa mukakhala ndi a Crohn, ndiye mungadziwe bwanji ngati muli mu chikhululukiro osati kungokhala ndi masiku angapo abwino?

Pali mbali ziwiri zakhululukidwe. Kukhululukidwa kwamatenda kumatanthauza kuti mulibe zizindikilo zowonekera. Kukhululuka kwamatenda kumatanthauza kuti kuyesa kumawonetsa kuti zotupa zanu zikuchira ndipo magazi anu ali ndi milingo yotupa.

Dokotala wanu amagwiritsa ntchito china chake chotchedwa Crohn's disease activity index (CDAI) kuti adziwe momwe Crohn's yanu imagwirira ntchito kapena kukhululukidwa. CDAI imaganiziranso zomwe zikuwonetsa, monga kuchuluka kwa matumbo ndi momwe mukumvera.

Zimaganiziranso zovuta za matenda a Crohn ndi zotsatira za mayeso anu.

Ngakhale mutakhala okhululukidwa, ndizofala kuti biopsy iwonetse kusintha kwakung'onoting'ono m'matumba anu komwe kumawonetsa kutukuka koyambirira. Nthawi zina, pakakhala kukhululuka kwakanthawi komanso kwakanthawi, zotsatira za biopsy sizachilendo, koma sizikhala choncho nthawi zambiri.

Momwe biologics imakusungirani mu chikhululukiro

Biologics imakupangitsani kuti mukhululukidwe poletsa chitetezo chamthupi chanu kuchitapo kanthu mopitilira muyeso. Mukachoka pamankhwala anu mukakhululukidwa, mumakhala pachiwopsezo chazomwe mungachite poyambira.

Nthawi zina zoyambitsa zimakhala zovuta kuneneratu. Zina, monga zotsatirazi, ndizosavuta kuzindikira:

• kusintha kwa zakudya
• kusuta ndudu
• mankhwala amasintha
• nkhawa
• kuipitsa mpweya

Ngati mukumwa mankhwala mukamakumana ndi zovuta, matenda anu a Crohn sangayambe kuchititsidwa.

Kodi biosimilars ndi chiyani?

Biosimilars ndi mitundu ina yamakedzana ya biologics yofanana, kapangidwe kake, chitetezo, komanso mphamvu. Sizithunzithunzi za biologics zoyambirira. M'malo mwake, iwo ndi makope a biologics oyambirira omwe mavoti awo atha ntchito.

Nthawi zambiri amawononga ndalama zochepa ndipo amathandizanso kuti pakhale chikhululukiro.

Chithandizo mukakhululukidwa

Mukakhala mukukhululukidwa, mutha kuyesedwa kuti musiye mankhwala. Mukatero, mumakhala pachiwopsezo chatsopano.

Mukasiya kumwa mankhwala anu, pali kuthekera kwakuti mwina sizingagwire ntchito nthawi ina mukadzakhala ndi moto. Izi ndichifukwa choti mukasiya kumwa biologic, thupi lanu limatha kulimbana ndi mankhwalawa, zomwe zimapangitsa kuti mtsogolo musadzagwire ntchito bwino.

Zingayambitsenso zovuta.

Biologics imapondereza chitetezo chanu chamthupi, chomwe chimayika pachiwopsezo chotenga matenda. Chifukwa cha izi, pali zina zomwe dokotala angakulimbikitseni kuti mupite kokamwa mankhwala. Izi zikuphatikiza:

• opaleshoni
• katemera
• mimba

Kupanda kutero, chizolowezi chomwe mukufuna ndikuti mukhalebe pamankhwala ngakhale mutakhululukidwa.

Kafukufuku wasonyeza kuti theka lokha la anthu omwe amasiya kugwiritsa ntchito anti-TNF biologic yawo pokhululukidwa amakhalabe okhululukidwa kwazaka zopitilira ziwiri, ndipo chiwerengerocho chimachepa pakapita nthawi.

Kutenga

Cholinga cha chithandizo chanu cha Crohn ndikupeza kukhululukidwa. Kusowa mankhwala kumatha kuyambitsa moto. Ndikofunika kugwira ntchito ndi dokotala kuti mupeze njira yabwino yopezera chikhululukiro. Izi zikuphatikiza kuwunika nthawi zonse ndikusunga mankhwala anu.