Matenda a Klinefelter

Klinefelter syndrome ndi chibadwa chomwe chimapezeka mwa amuna akakhala ndi X chromosome yowonjezera.

Anthu ambiri ali ndi ma chromosomes 46. Ma chromosomes ali ndi majini anu onse ndi DNA, zomangira thupi. Ma chromosomes awiri ogonana (X ndi Y) amadziwika ngati mudzakhale mnyamata kapena mtsikana. Atsikana nthawi zambiri amakhala ndi ma chromosomes awiri X. Anyamata nthawi zambiri amakhala ndi 1 X ndi 1 Y chromosome.

Matenda a Klinefelter amayamba mwana akabadwa ali ndi chromosome osachepera 1 owonjezera. Izi zalembedwa ngati XXY.

Matenda a Klinefelter amapezeka pafupifupi 1 mwa ana 500 mpaka 1,000 aamuna. Amayi omwe amatenga pakati atakwanitsa zaka 35 amakhala ndi mwayi wambiri wokhala ndi matendawa kuposa azimayi achichepere.

Kusabereka ndichizindikiro chofala kwambiri cha matenda a Klinefelter.

Zizindikiro zimatha kuphatikizira izi:

• Kukula kwa thupi (miyendo yayitali, thunthu lalifupi, phewa lofanana ndi kukula kwa m'chiuno)
• Mabere akulu modabwitsa (gynecomastia)
• Kusabereka
• Mavuto azakugonana
• Tsitsi locheperako, khwapa, ndi nkhope ndizochepera
• Machende ang'onoang'ono, olimba
• Kutalika kwambiri
• Kukula kwa mbolo yaying'ono
  
  

Matenda a Klinefelter amatha kupezeka koyamba munthu akabwera kuchipatala chifukwa cha kusabereka. Mayesero otsatirawa akhoza kuchitidwa:

• Karyotyping (amayang'ana ma chromosomes)
• Kuwerengera kwa umuna

Kuyezetsa magazi kudzachitika kuti muwone kuchuluka kwa mahomoni, kuphatikiza:

• Estradiol, mtundu wa estrogen
• Follicle yolimbikitsa mahomoni
• Mahomoni a Luteinizing
• Testosterone

Chithandizo cha testosterone chitha kuperekedwa. Izi zitha kuthandiza:

• Khalani tsitsi la thupi
• Sinthani mawonekedwe a minofu
• Sinthani chidwi
• Sinthani malingaliro ndi kudzidalira
• Lonjezerani mphamvu ndi kugonana
• Lonjezerani mphamvu

Amuna ambiri omwe ali ndi matendawa sangathe kutenga mayi pakati. Katswiri wosabereka atha kuthandiza. Kuwona dokotala wotchedwa endocrinologist kungakhalenso kothandiza.

Izi zingapereke chidziwitso chambiri pa matenda a Klinefelter:

• Msonkhano wa X ndi Y Chromosome Variations - genetic.org
• National Library of Medicine, Genetics Home Reference - medlineplus.gov/klinefelterssyndrome.html

Mano otambalala ndi malo opatulira ndiofala kwambiri mu matenda a Klinefelter. Izi zimatchedwa taurodontism. Izi zitha kuwoneka pa ma x-ray amano.

Matenda a Klinefelter amachulukitsanso chiopsezo cha:

• Kusokonezeka kwa matenda osokoneza bongo (ADHD)
• Matenda osokoneza bongo, monga lupus, nyamakazi, ndi Sjögren syndrome
• Khansa ya m'mawere mwa amuna
• Matenda okhumudwa
• Kulephera kuphunzira, kuphatikizapo kusokonezeka, komwe kumakhudza kuwerenga
• Chotupa chosowa chotchedwa extragonadal germ cell chotupa
• Matenda am'mapapo
• Kufooka kwa mafupa
• Mitsempha ya Varicose

Lumikizanani ndi omwe amakupatsani ngati mwana wanu samakula atatha msinkhu. Izi zikuphatikiza kukula kwa tsitsi lakumaso ndikukula kwa mawu.

Mlangizi wa majini atha kukupatsirani chidziwitso cha vutoli ndikukuwuzani kuti muthandizire magulu mdera lanu.

Matenda a 47 XY; Matenda a XXY; Matenda a XXY; 47, XXY / 46, XY; Matenda a mosaic; Matenda a Poly-X Klinefelter

Allan CA, McLachlan RI. Matenda a Androgen akusowa. Mu: Jameson JL, De Groot LJ, de Kretser DM, et al, olemba. Endocrinology: Akuluakulu ndi Ana. Wachisanu ndi chiwiri. Philadelphia, PA: Elsevier Saunders; 2016: chap 139.

Matsumoto AM, Anawalt BD, Matenda a testicular. Mu: Melmed S, Auchus, RJ, Goldfine AB, Koenig RJ, Rosen CJ, olemba. Buku la Williams la Endocrinology. Wolemba 14th. Philadelphia, PA: Elsevier; 2020: mutu 19.

Nussbaum RL, McInnes RR, Willard HF (Adasankhidwa) Chromosomal and genomic maziko a matenda: zovuta zama autosomes ndi ma chromosomes ogonana. Mu: Nussbaum RL, McInnes RR, Willard HF, olemba. Thompson & Thompson Genetics mu Mankhwala. 8th ed. Philadelphia, PA: Elsevier; 2016: mutu 6.