Pancreatic islet cell chotupa

Chotupa cha pancreatic islet cell ndichotupa chosowa kwambiri cha kapamba chomwe chimayambira pamtundu wa khungu lotchedwa islet cell.

M'mapaketi athanzi, maselo otchedwa islet cell amatulutsa mahomoni omwe amayang'anira zochitika zingapo m'thupi. Izi zimaphatikizapo kuchuluka kwa shuga m'magazi komanso kupanga asidi wam'mimba.

Zotupa zomwe zimachokera ku islet cell of pancreas zitha kupanganso mahomoni osiyanasiyana, omwe amatha kubweretsa zizindikiritso zina.

Zotupa zapancreatic islet cell zimatha kukhala zopanda khansa (zotupa) kapena khansa (zoyipa).

Zilonda za Islet zimaphatikizapo:

• Gastrinoma (matenda a Zollinger-Ellison)
• Glucagonoma
• Insulinoma
• Somatostatinoma
  
• VIPoma (Verner-Morrison syndrome)

Mbiri yakubanja ya ma endocrine neoplasia angapo, amtundu wa I (MEN I) ndiwowopsa pakukula kwa zotupa zam'madzi.

Zizindikiro zimadalira kuti ndi mahomoni ati omwe amapangidwa ndi chotupacho.

Mwachitsanzo, insulin imatulutsa insulin, yomwe imachepetsa shuga m'magazi. Zizindikiro zimaphatikizapo:

• Kumva kutopa kapena kufooka
• Kugwedezeka kapena thukuta
• Mutu
• Njala
• Mantha, nkhawa, kapena kukwiya
• Maganizo osamveka bwino kapena kudzimva wosakhazikika
• Masomphenya awiri kapena osaoneka bwino
• Kuthamanga kapena kugunda kwamtima

Shuga wanu wamagazi akatsika kwambiri, mutha kukomoka, kukomoka, kapena ngakhale kukomoka.

Gastrinomas amapanga hormone gastrin, yomwe imauza thupi kupanga asidi m'mimba. Zizindikiro zimaphatikizapo:

• Kupweteka m'mimba
• Kutsekula m'mimba
• Zilonda zam'mimba ndi matumbo ang'onoang'ono
• Kusanza magazi (nthawi zina)

Glucagonomas amapanga hormone glucagon, yomwe imathandiza kuti thupi likweze shuga. Zizindikiro zimatha kuphatikiza:

• Matenda a shuga
• Kutupa kofiira, kofiyira m'mabako kapena matako
• Kuchepetsa thupi
• Kukodza pafupipafupi ndi ludzu

Somatostatinomas amapanga hormone somatostatin. Zizindikiro zimaphatikizapo:

• Shuga wamagazi ambiri
• Miyala
• Maonekedwe achikaso pakhungu, ndi maso
• Kuchepetsa thupi
• Kutsekula m'mimba ndi zimbudzi zonunkha

VIPomas amapanga hormone vasoactive intestinal peptide (VIP) yomwe imathandizira kuti pakhale mchere wambiri, sodium, potaziyamu ndi mchere wina m'galamu la GI. VIPomas atha kuyambitsa:

• Kutsekula m'mimba kwambiri komwe kumatha kubweretsa kusowa kwa madzi m'thupi
• Magazi a potaziyamu ochepa, komanso calcium yambiri
• Kupweteka m'mimba
• Kuchepetsa thupi

Wothandizira zaumoyo wanu amatenga mbiri yanu yazachipatala ndikuyesani kwakuthupi.

Mayeso amwazi amasiyana, kutengera zizindikiro, koma atha kukhala:

• Kusala kwa mulingo wa shuga
• Mulingo wa Gastrin
• Mayeso a kulolerana kwa glucose
• Kuyesa kwamphamvu kwa Secretin kwa kapamba
• Mulingo wa glucagon wamagazi
• Insulini yamagazi C-peptide
• Mulingo wama insulin
• Kusala kwa seramu somatostatin mulingo
• Mlingo wa Serum vasoactive m'matumbo peptide (VIP)

Kuyesa kuyesa kungachitike:

• M'mimba mwa CT scan
• M'mimba ultrasound
• Endoscopic ultrasound
• MRI yamimba

Muyeso wamagazi amathanso kutengedwa kuchokera mumtsempha m'mapapo kuti ayesedwe.

Nthawi zina, pamafunika opaleshoni kuti mupeze vutoli. Pochita izi, dokotalayo amafufuza kapamba ndi dzanja komanso ndi ultrasound.

Chithandizo chimadalira mtundu wa chotupa komanso ngati chili ndi khansa.

Zotupa za khansa zimatha kukula msanga ndikufalikira ku ziwalo zina. Atha kukhala osachiritsika. Nthawi zambiri zotupa zimachotsedwa ndikuchita opaleshoni, ngati zingatheke.

Ngati maselo a khansa amafalikira pachiwindi, gawo lina la chiwindi limatha kuchotsedwa, ngati zingatheke. Ngati khansara ili ponseponse, chemotherapy itha kugwiritsidwa ntchito poyesa kuchepetsa zotupazo.

Ngati kupanga modabwitsa kwa mahomoni kukuyambitsa zizindikilo, mutha kulandira mankhwala kuti athane ndi zovuta zawo. Mwachitsanzo, ndi gastrinomas, kuchulukitsa kwa gastrin kumabweretsa asidi wambiri m'mimba. Mankhwala omwe amaletsa kutuluka kwa asidi m'mimba amatha kuchepetsa zizindikilo.

Mutha kuchepetsa nkhawa zamankhwala ndikulowa nawo gulu lothandizira khansa. Kugawana ndi ena omwe akumana ndi mavuto omwe akukumana nawo kungakuthandizeni kuti musamve nokha.

Mutha kuchiritsidwa ngati zotupazo zimachotsedwa opaleshoni zisanafalikire ku ziwalo zina. Ngati zotupa zili ndi khansa, chemotherapy itha kugwiritsidwa ntchito, koma nthawi zambiri siyichiritsa anthu.

Mavuto owopsa (monga shuga wotsika kwambiri wamagazi) amatha kuchitika chifukwa cha kuchuluka kwa mahomoni, kapena ngati khansa imafalikira mthupi lonse.

Zovuta za zotupazi ndi monga:

• Matenda a shuga
• Mavuto a mahomoni (ngati chotupacho chimatulutsa mitundu ina ya mahomoni)
• Shuga wambiri wamagazi (kuchokera ku insulinomas)
• Zilonda zam'mimba ndi m'matumbo ang'ono (kuchokera ku gastrinomas)
• Kufalikira kwa chotupacho mpaka pachiwindi

Itanani omwe akukuthandizani ngati mukukhala ndi zotupa, makamaka ngati muli ndi mbiri yabanja ya MEN I.

Palibe njira yodziwika yotetezera zotupazi.

Khansa - kapamba; Khansa - kapamba; Khansa yapancreatic; Zotupa za Islet; Islet wa chotupa cha Langerhans; Zotupa za neuroendocrine; Chilonda chachikulu - chotupa cha khungu; Hypoglycemia - chotupa cha khungu; Matenda a Zollinger-Ellison; Matenda a Verner-Morrison; Gastrinoma; Insulinoma; VIPoma; Somatostatinoma; Glucagonoma

• Matenda a Endocrine
• Miphalaphala

Foster DS, Norton JA. Kuwongolera zotupa zapancreatic islet cell kupatula gastrinoma. Mu: Cameron AM, Cameron JL, olemba., Eds. Chithandizo Chamakono Cha Opaleshoni. Wolemba 13. Philadelphia, PA: Elsevier; 2020: 581-584.

Tsamba la National Cancer Institute. Chithandizo cha khansa ya Pancreatic (PDQ) - mtundu wa akatswiri azaumoyo. www.cancer.gov/types/pancreatic/hp/pnet-kuchiza-pdq. Idasinthidwa pa Januware 2, 2020. Idapezeka pa February 25, 2020.

Tsamba la National Comprehensive Cancer Network. Maupangiri azachipatala a NCCN mu oncology (malangizo a NCCN). Matenda a neuroendocrine ndi adrenal. Mtundu 1.2019. www.nccn.org/professionals/physician_gls/pdf/neuroendocrine.pdf. Idasinthidwa pa Marichi 5, 2019. Idapezeka pa February 25, 2020.

Tsamba la National Comprehensive Cancer Network. Malangizo a NCCN kwa odwala. Zotupa za Neuroendocrine. 2018. www.nccn.org/patients/guidelines/content/PDF/neuroendocrine-patient.pdf.