Odwala dysbetalipoproteinemia

Odwala dysbetalipoproteinemia ndi matenda omwe amapyola m'mabanja. Amayambitsa cholesterol yambiri ndi triglycerides m'magazi.

Kulephera kwa chibadwa kumayambitsa vutoli. Vutoli limabweretsa kuchuluka kwa ma lipoprotein tinthu tomwe timakhala ndi cholesterol komanso mtundu wamafuta wotchedwa triglycerides. Matendawa amalumikizidwa ndi zolakwika mu jini la apolipoprotein E.

Hypothyroidism, kunenepa kwambiri, kapena matenda ashuga atha kukulitsa vutoli. Zowopsa za mabanja a dysbetalipoproteinemia zimaphatikizapo mbiri ya banja yamatenda kapena mtsempha wamagazi.

Zizindikiro sizimawoneka mpaka zaka 20 kapena kupitilira apo.

Mafuta achikopa pakhungu lotchedwa xanthomas amatha kuwonekera pazikope, zikhatho za manja, mapazi, kapena pamiyendo yamaondo ndi zigongono.

Zizindikiro zina zitha kuphatikiza:

• Kupweteka pachifuwa (angina) kapena zizindikiro zina zamatenda amitsempha zimatha kupezeka mudakali aang'ono
• Kuponda mwana mmodzi kapena onse awiri poyenda
• Zilonda zakumapazi zomwe sizichira
• Zizindikiro zadzidzidzi monga kupweteka kuyankhula, kutsamira mbali imodzi ya nkhope, kufooka kwa mkono kapena mwendo, komanso kuchepa

Kuyesa komwe kungachitike kuti mupeze vutoli ndi monga:

• Kuyesa kwachibadwa kwa apolipoprotein E (apoE)
• Kuyesa magazi kwa lipid
• Mulingo wa Triglyceride
• Kuyesa kotsika kwambiri kwa lipoprotein (VLDL)

Cholinga cha chithandizo ndikuwongolera zinthu monga kunenepa kwambiri, hypothyroidism, ndi matenda ashuga.

Kupanga kusintha kwa zakudya kuti muchepetse mafuta, mafuta, komanso mafuta m'thupi kungathandize kuchepetsa mafuta m'thupi.

Ngati cholesterol ndi triglyceride milingo ikadali yochulukirapo mutasintha zakudya, wothandizira zaumoyo wanu atha kukupatsaninso mankhwala. Mankhwala ochepetsa magazi triglyceride ndi cholesterol amaphatikizapo:

• Mabotolo osakaniza asidi.
• Amapanga (gemfibrozil, fenofibrate).
• Nicotinic asidi.
• Zolemba.
• PCSK9 inhibitors, monga alirocumab (Praluent) ndi evolocumab (Repatha). Izi zikuyimira gulu latsopano la mankhwala ochizira cholesterol.

Anthu omwe ali ndi vutoli ali pachiwopsezo chowonjezeka cha matenda amitsempha yamagazi ndi zotumphukira zamatenda.

Ndi chithandizo, anthu ambiri amatha kuchepetsa kwambiri kuchuluka kwa cholesterol ndi triglycerides.

Zovuta zingaphatikizepo:

• Matenda amtima
• Sitiroko
• Matenda a m'mitsempha
• Kulongosola kwapakatikati
• Gangrene ya kumapeto kwenikweni

Itanani omwe akukuthandizani ngati mwapezeka kuti muli ndi vutoli ndipo:

• Zizindikiro zatsopano zimayamba.
• Zizindikiro sizisintha ndi chithandizo chamankhwala.
• Zizindikiro zimaipiraipira.

Kuwunika achibale a anthu omwe ali ndi vutoli kumatha kubweretsa kuzindikira ndi kuchiritsidwa msanga.

Kuchiritsidwa msanga komanso kuchepetsa zina zomwe zingayambitse chiopsezo monga kusuta kumatha kuthandiza kupewa mtima, zilonda, komanso kutseka mitsempha yamagazi.

Mtundu wachitatu wa hyperlipoproteinemia; Apolipoprotein yoperewera kapena yolakwika E

• Mitsempha ya Coronary

Genest J, Libby P. Lipoprotein zovuta ndi matenda amtima. Mu: Zipes DP, Libby P, Bonow RO, Mann DL, Tomaselli GF, Braunwald E, olemba. Matenda a Mtima a Braunwald: Buku Lophunzitsira la Mankhwala Amtima. 11th ed. Philadelphia, PA: Elsevier; 2019: chap 48.

Robinson JG. Matenda amadzimadzi amadzimadzi. Mu: Goldman L, Schafer AI, olemba. Mankhwala a Goldman-Cecil. 26 wa. Philadelphia, PA: Elsevier; 2020: chap 195.