Kutchuka kwa lipoprotein lipase

Kutchuka kwa lipoprotein lipase kusowa ndi gulu lamavuto achilengedwe momwe munthu amasowa mapuloteni ofunikira kuti awononge ma molekyulu amafuta. Matendawa amayambitsa mafuta ochuluka m'magazi.

Kuperewera kwabwino kwa lipoprotein lipase kumayambitsidwa ndi jini losalongosoka lomwe limaperekedwa kudzera m'mabanja.

Anthu omwe ali ndi vutoli alibe enzyme yotchedwa lipoprotein lipase. Popanda enzyme iyi, thupi silingathe kuthyola mafuta kuchokera muzakudya. Tinthu tating'onoting'ono ta ma chylomicrons timakhala m'mwazi.

Zowopsa zimaphatikizaponso mbiri yakubadwa kwa lipoprotein lipase.

Matendawa amawoneka koyamba ali wakhanda kapena ali mwana.

Zizindikiro zimatha kuphatikizira izi:

• Kupweteka m'mimba (kumawoneka ngati kolic mwa makanda)
• Kutaya njala
• Nseru, kusanza
• Kupweteka kwa minofu ndi mafupa
• Kukulitsa chiwindi ndi ndulu
• Kulephera kukula bwino mwa makanda
• Mafuta amasungika pakhungu (xanthomas)
• Mulingo wambiri wa triglyceride m'magazi
• Ma retinas otuwa ndi mitsempha yamagazi yoyera m'maso
• Kutupa kosalekeza kwa kapamba
• Chikasu cha maso ndi khungu (jaundice)

Wothandizira zaumoyo amayeza thupi ndikufunsa za zizindikilozo.

Kuyezetsa magazi kudzachitika kuti muwone kuchuluka kwa cholesterol ndi triglyceride. Nthawi zina, kuyezetsa magazi mwapadera kumachitika mutapatsidwa opaka magazi kudzera mumitsempha. Kuyesaku kumayang'ana zochitika za lipoprotein lipase m'magazi anu.

Mayeso achibadwa atha kuchitidwa.

Chithandizochi chimathandizira kuwongolera zizindikilozo komanso kuchuluka kwa magazi a triglyceride wokhala ndi mafuta ochepa kwambiri. Wopezayo angakulimbikitseni kuti musadye mafuta opitilira 20 magalamu patsiku kuti zidziwitso zisabwererenso.

Mafuta magalamu makumi awiri ndi ofanana ndi awa:

• Magalasi awiri a ma ounili (240 milliliters) a mkaka wathunthu
• Supuni 4 (9.5 magalamu) a margarine
• 4 ounces (113 magalamu) operekera nyama

Chakudya chambiri ku America chimakhala ndi mafuta mpaka 45% yamafuta onse. Mavitamini osungunuka ndi mafuta A, D, E, ndi K ndi zowonjezera mavitamini zimalimbikitsidwa kwa anthu omwe amadya zakudya zopanda mafuta kwambiri. Mungafune kuti mukambirane zosowa zanu ndi omwe amakupatsirani chakudya komanso katswiri wazakudya.

Pancreatitis yomwe imakhudzana ndi kuchepa kwa lipoprotein lipase imayankha chithandizo cha vutoli.

Izi zitha kupereka chidziwitso chambiri pakuchepa kwa lipoprotein lipase:

• National Organisation for Rare Disways - rarediseases.org/rare-diseases/familial-lipoprotein-lipase-deficiency
• Buku Lofotokozera la NIH Genetics - ghr.nlm.nih.gov/condition/familial-lipoprotein-lipase-deficiency

Anthu omwe ali ndi vutoli omwe amatsata zakudya zonenepa kwambiri amatha kukhala achikulire.

Pancreatitis ndi magawo obwereza am'mimba amatha kukula.

Xanthomas samakhala opweteka nthawi zambiri pokhapokha atapukutidwa kwambiri.

Itanani omwe akukuthandizani kuti awone ngati wina m'banja mwanu ali ndi vuto la lipoprotein lipase. Upangiri wa chibadwa umalimbikitsidwa kwa aliyense amene ali ndi mbiri yakubadwa kwa matendawa.

Palibe choletsa kudziwika cha matendawa obwera chifukwa chobadwa nawo. Kudziwitsa zoopsa kumatha kuloleza kuzindikira msanga. Kutsata zakudya zonenepetsa kwambiri kumatha kusintha zizindikilo za matendawa.

Mtundu I hyperlipoproteinemia; Chylomicronemia yodziwika; Kuperewera kwabwino kwa LPL

• Mitsempha ya Coronary

Genest J, Libby P. Lipoprotein zovuta ndi matenda amtima. Mu: Zipes DP, Libby P, Bonow RO, Mann DL, Tomaselli GF, Braunwald E, olemba. Matenda a Mtima a Braunwald: Buku Lophunzitsira la Mankhwala Amtima. 11th ed. Philadelphia, PA: Elsevier; 2019: chap 48.

Semenkovich CF, Goldberg AC, Goldberg IJ. Matenda amadzimadzi amadzimadzi. Mu: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, olemba. Buku la Williams la Endocrinology. Wolemba 13. Philadelphia, PA: Elsevier; 2016: chap 37.