Matenda a Felty

Felty syndrome ndi matenda omwe amaphatikizapo nyamakazi ya nyamakazi, nthenda yotupa, kuchepa kwama cell oyera, komanso matenda obwerezabwereza. Ndizochepa.

Zomwe zimayambitsa matenda a Felty sizikudziwika. Ndizofala kwambiri kwa anthu omwe akhala akudwala nyamakazi (RA) kwanthawi yayitali. Anthu omwe ali ndi vutoli ali pachiwopsezo chotenga kachilombo chifukwa ali ndi kuchuluka kwama cell oyera.

Zizindikiro zake ndi izi:

• Kumva kuwawa (malaise)
• Kutopa
• Kufooka mwendo kapena mkono
• Kutaya njala
• Kuchepetsa mwangozi
• Zilonda pakhungu
• Kutupa kofanana, kuuma, kupweteka, ndi kuwonongeka
• Matenda opatsirana
• Diso lofiira ndi kutentha kapena kutulutsa

Kuyezetsa thupi kukuwonetsa:

• Kutupa nthenda
• Magulu omwe amawonetsa zizindikilo za RA
• Mwinamwake kutupa chiwindi ndi ma lymph node

Kuwerengera kwathunthu kwa magazi (CBC) kosiyanitsa kukuwonetsa kuchuluka kochepa kwa maselo oyera amtundu wotchedwa neutrophils. Pafupifupi anthu onse omwe ali ndi matenda a Felty ali ndi mayeso abwino a chifuwa chachikulu.

Mimba yam'mimba ya ultrasound imatha kutsimikizira nthenda yotupa.

Nthawi zambiri, anthu omwe ali ndi matendawa samalandira chithandizo cha RA. Angafune mankhwala ena kuti ateteze chitetezo cha m'thupi ndikuchepetsa zochitika za RA.

Methotrexate itha kusintha kuchuluka kotsika kwa neutrophil. Rituximab ya mankhwala yakhala ikuyenda bwino mwa anthu omwe samayankha methotrexate.

Chochititsa chidwi cha Granulocyte-colony factor (G-CSF) chitha kukweza kuchuluka kwa neutrophil.

Anthu ena amapindula ndi kuchotsedwa kwa ndulu (splenectomy).

Popanda chithandizo, matenda amatha kupitilirabe.

RA akhoza kukuipiraipira.

Kuchiza RA, komabe, kuyenera kukonza matenda a Felty.

Mutha kukhala ndi matenda omwe amabwereranso.

Anthu ena omwe ali ndi matenda a Felty awonjezera ma lymphocyte akuluakulu, omwe amatchedwanso LGL leukemia. Izi zidzathandizidwa ndi methotrexate nthawi zambiri.

Itanani omwe akukuthandizani mukakhala ndi zodwala.

Chithandizo cha RA mwachangu ndi mankhwala omwe akulimbikitsidwa pano amachepetsa chiopsezo chokhala ndi matenda a Felty.

Matenda a nyamakazi (RA); Matenda a Felty

• Ma antibodies

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Erickson AR, Cannella AC, Mikuls TR. Matenda a nyamakazi ya nyamakazi. Mu: Firestein GS, Budd RC, Gabriel SE, McInnes IB, O'Dell JR, olemba. Kelley ndi Firestein's Bookbook of Rheumatology. 10th ed. Philadelphia, PA: Elsevier; 2017: chap 70.

Gazitt T, Loughran TP Jr. Matenda a neutropenia mu LGL khansa ya m'magazi ndi nyamakazi ya nyamakazi. Hematology Am Soc Hematol Maphunziro Pulogalamu. 2017; 2017 (1): 181-186. PMID: 29222254 www.ncbi.nlm.nih.gov/pubmed/29222254. (Adasankhidwa)

Myasoedova E, Turesson C, Matteson EL. Zochitika zapadera za nyamakazi ya nyamakazi. Mu: Hochberg MC, Gravallese EM, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH, olemba. Zamatsenga. Wachisanu ndi chiwiri. Philadelphia, PA: Elsevier; 2019: chap 95.

Savola P, Brück O, Olson T, ndi al. Somatic STAT3 masinthidwe mu matenda a Felty: tanthauzo la tizilombo toyambitsa matenda omwe ali ndi leukemia yayikulu ya granular. Haematologica. 2018; 103 (2): 304-312. (Adasankhidwa) PMID: 29217783 www.ncbi.nlm.nih.gov/pubmed/29217783.

Wang CR, Chiu YC, Chen YC. Kuchiza bwino kwa refractory neutropenia mu Felty's syndrome ndi rituximab. Scand J Rheumatol. 2018; 47 (4): 340-341. PMID: 28753121 www.ncbi.nlm.nih.gov/pubmed/28753121.