Kuperewera kwa Prothrombin

Kuperewera kwa Prothrombin ndi vuto lomwe limayamba chifukwa chosowa mapuloteni m'magazi otchedwa prothrombin. Zimadzetsa mavuto ndi magazi oundana (coagulation). Prothrombin imadziwikanso kuti factor II (factor 2).

Mukamatuluka magazi, zochitika zingapo zimachitika mthupi zomwe zimathandiza kuundana kwamagazi. Izi zimatchedwa coagulation cascade. Zimaphatikizapo mapuloteni apadera otchedwa coagulation, kapena clotting, factor. Mutha kukhala ndi mwayi wambiri wokhetsa magazi ngati chimodzi kapena zingapo mwazinthuzi zikusowa kapena sizikugwira ntchito momwe ziyenera kukhalira.

Prothrombin, kapena factor II, ndichimodzi mwazinthu zoterezi. Kuperewera kwa Prothrombin kumayambira m'mabanja (obadwa nawo) ndipo ndikosowa kwambiri. Makolo onse ayenera kukhala ndi jini yopatsira ana awo vutoli. Mbiri yabanja yokhudzana ndi kutaya magazi imatha kukhala pachiwopsezo.

Kuperewera kwa Prothrombin kumathanso chifukwa cha vuto lina kapena kugwiritsa ntchito mankhwala ena. Izi zimatchedwa kusowa kwa prothrombin. Itha kuyambitsidwa ndi:

• Kusowa kwa vitamini K (ana ena amabadwa ndi kuchepa kwa vitamini K)
• Matenda owopsa a chiwindi
• Kugwiritsa ntchito mankhwala omwe amateteza kuundana (maanticoagulants monga warfarin)

Zizindikiro zimatha kuphatikizira izi:

• Kutuluka magazi kosazolowereka pobereka
• Kutaya magazi kwambiri
• Magazi pambuyo opaleshoni
• Kutuluka magazi pambuyo povulala
• Kulalata mosavuta
• Kutulutsa magazi m'mphuno komwe sikumatha mosavuta
• Umbilical chingwe kutuluka magazi atabadwa

Mayeso omwe angachitike ndi awa:

• Factor II kuyesa
• Nthawi yapadera ya thromboplastin
• Nthawi ya Prothrombin (PT)
• Kusakaniza kuphunzira (kuyesa kwapadera kwa PTT kutsimikizira kuperewera kwa prothrombin)

Kutaya magazi kumatha kuyang'aniridwa ndikulowetsedwa m'mitsempha yamagazi (IV) m'madzi am'magazi kapena kuphatikiza kwa zinthu zotseka magazi. Ngati mulibe vitamini K, mutha kumwa vitaminiyo pakamwa, kudzera muma jakisoni pakhungu, kapena kudzera mumitsempha (kudzera m'mitsempha).

Ngati muli ndi vuto lotaya magazi, onetsetsani kuti:

• Uzani omwe amakupatsani chithandizo chamankhwala musanachite chilichonse, kuphatikiza opaleshoni ndi ntchito ya mano.
• Uzani achibale anu chifukwa atha kukhala ndi vuto lofananalo koma sakudziwa panobe.

Izi zitha kukupatsirani zambiri zakusowa kwa Factor VII:

• National Hemophilia Foundation: Zofooka Zina Zowonjezera - www.hemophilia.org/Bleeding-Disorders/Types-of-Beeding-Disorders/Other-Factor-Deficiencies
• NIH Genetic and Rare Diseases Information Center - rarediseases.info.nih.gov/diseases/2926/prothrombin-deficiency

Zotsatira zake ndizabwino ndi chithandizo choyenera.

Choloŵa cha prothrombin ndichikhalidwe cha moyo wonse.

Kuwona kwakusowa kwa prothrombin kumatengera chifukwa. Ngati imayambitsidwa ndi matenda a chiwindi, zotsatira zake zimadalira momwe matenda anu a chiwindi angachiritsiridwe. Kutenga zowonjezera mavitamini K kumathandiza kuchepa kwa vitamini K.

Kutaya magazi kwambiri m'ziwalo kumatha kuchitika.

Pezani chithandizo chadzidzidzi nthawi yomweyo ngati mwataya magazi mosadziwika bwino kapena kwa nthawi yayitali, kapena ngati simungathe kuwongolera magaziwo.

Palibe njira yodziwira zoperewera za prothrombin. Ngati kusowa kwa vitamini K ndiye chifukwa, kugwiritsa ntchito vitamini K kumatha kuthandizira.

Hypoprothrombinemia; Kusowa kwa Factor II; Dysprothrombinemia

• Mapangidwe a magazi
• Kuundana kwamagazi

Gailani D, Wheeler AP, Neff AT. Zofooka zambiri zomwe zimachitika nthawi zambiri. Mu: Hoffman R, Benz EJ, Silberstein LE, et al, olemba. Hematology: Mfundo Zoyambira ndi Zochita. Wachisanu ndi chiwiri. Philadelphia, PA: Elsevier; 2018: mutu 137.

Hall JE. Hemostasis ndi magazi coagulation. Mu: Hall JE, mkonzi. Guyton ndi Hall Textbook of Medical Physiology. Wolemba 13. Philadelphia, PA: Elsevier Saunders; 2016: chap 37.

Ragni MV. Matenda a hemorrhagic: coagulation factor deficience. Mu: Goldman L, Schafer AI, olemba. Mankhwala a Goldman-Cecil. Wolemba 25. Philadelphia, PA: Elsevier Saunders; 2016: chap 174.