Thrombotic thrombocytopenic purpura

Thrombotic thrombocytopenic purpura (TTP) ndimatenda amwazi omwe ma platelet amaphatika m'mitsempha yaying'ono yamagazi. Izi zimabweretsa kuchuluka kwamagazi ochepa (thrombocytopenia).

Matendawa amayamba chifukwa cha mavitamini (mtundu wa zomanga thupi) womwe umakhudza magazi. Enzyme iyi imatchedwa ADAMTS13. Kupezeka kwa mavitaminiwa kumapangitsa kuti magazi aziundana. Ma Platelet ndi gawo la magazi omwe amathandiza pakumanga magazi.

Ma platelets akamalumikizana, ma platelet ochepa amapezeka m'magazi m'malo ena amthupi kuti athandizire kuundana. Izi zitha kubweretsa kutuluka magazi pakhungu.

Nthawi zina, vutoli limaperekedwa kudzera m'mabanja (obadwa nawo). Zikatero, anthu amabadwa ndi michere yotsika mwachilengedwe.

Vutoli lingayambitsenso:

• Khansa
• Chemotherapy
• Kuika hematopoietic stem cell
• Matenda a HIV
• Thandizo m'malo mwa mahomoni ndi ma estrogens
• Mankhwala (kuphatikizapo ticlopidine, clopidogrel, quinine, ndi cyclosporine A)

Zizindikiro zimatha kuphatikizira izi:

• Kuthira magazi pakhungu kapena ntchofu
• Kusokonezeka
• Kutopa, kufooka
• Malungo
• Mutu
• Mtundu wofiirira kapena khungu lachikaso
• Kupuma pang'ono
• Kuthamanga kwamtima (kupitilira 100 pamphindi)

Mayeso omwe atha kulamulidwa ndi awa:

• Mulingo wa zochitika za ADAMTS 13
• Bilirubin
• Kupaka magazi
• Kuwerengera kwathunthu kwa magazi (CBC)
• Mulingo wa Creatinine
• Mulingo wa Lactate dehydrogenase (LDH)
• Kuwerengera kwa Platelet
• Kupenda kwamadzi
• Haptoglobin
• Mayeso a Coombs

Mutha kukhala ndi chithandizo chotchedwa plasma. Amachotsa plasma yanu yachilendo ndikuyiyika ndi plasma yabwinobwino kuchokera kwa wopereka wathanzi. Plasma ndi gawo lamadzi lomwe lili ndimaselo amwazi ndi ma platelet. Kusinthana kwa plasma kumalowanso ma enzyme omwe akusowa.

Njirayi yachitika motere:

• Choyamba, mwatulutsa magazi anu ngati kuti mukupereka magazi.
• Magazi akamadutsa pamakina omwe amagawa magazi m'magulu ake osiyanasiyana, plasma yachilendo imachotsedwa ndipo ma cell anu amwazi amasungidwa.
• Maselo anu amwazi amaphatikizidwa ndi plasma yabwinobwino kuchokera kwa woperekayo, kenako nkubwezeretsedwanso kwa inu.

Mankhwalawa amabwerezedwa tsiku lililonse mpaka kuyezetsa magazi kukuwonetsa kusintha.

Anthu omwe samvera mankhwalawa kapena omwe amabwereranso amafunikira:

• Chitani opaleshoni kuti muchotse nthenda yawo
• Pezani mankhwala omwe amaletsa chitetezo cha mthupi, monga ma steroids kapena rituximab

Anthu ambiri omwe amasinthana ndi plasma amachira kwathunthu. Koma anthu ena amafa ndi matendawa, makamaka ngati sakupezeka nthawi yomweyo. Mwa anthu omwe sachira, vutoli limatha kukhala lalitali (kwanthawi yayitali).

Zovuta zingaphatikizepo:

• Impso kulephera
• Kuwerengera kwaplatelet (thrombocytopenia)
• Kuchuluka kwa maselo ofiira ofiira (amayamba chifukwa cha kuwonongeka kwa maselo ofiira asanakwane)
• Mavuto amanjenje amanjenje
• Kutaya magazi kwambiri (kukha magazi)
• Sitiroko

Itanani wanu wothandizira zaumoyo ngati muli ndi magazi osadziwika.

Chifukwa chifukwa chake sichikudziwika, palibe njira yodziwika yopewera vutoli.

TTP

• Maselo amwazi

Abrams CS. Thrombocytopenia. Mu: Goldman L, Schafer AI, olemba. Mankhwala a Goldman-Cecil. Wolemba 25. Philadelphia, PA: Elsevier Saunders; 2016: chap 172.

Webusaiti ya National Heart, Lung, ndi Blood Institute. Thrombotic thrombocytopenic purpura. www.nhlbi.nih.gov/health-topics/thrombotic-thrombocytopenic-purpura. Idapezeka pa Marichi 1, 2019.

(Adasankhidwa) Schneidewend R, Epperla N, Friedman KD. Thrombotic thrombocytopenic purpura ndi hemolytic uremic syndrome. Mu: Hoffman R, Benz EJ, Silberstein LE, et al, olemba. Hematology: Mfundo Zoyambira ndi Zochita. Wachisanu ndi chiwiri. Philadelphia, PA: Elsevier; 2018: mutu 134.