Kaposi sarcoma

Kaposi sarcoma (KS) ndi chotupa cha khansa cha minofu yolumikizana.

KS ndi zotsatira za matenda a gamma herpesvirus yotchedwa Kaposi sarcoma-associated herpesvirus (KSHV), kapena herpesvirus 8 (HHV8). Ali m'banja lomwelo ngati kachilombo ka Epstein-Barr, kamene kamayambitsa mononucleosis.

KSHV imafalikira makamaka kudzera m'malovu. Ikhozanso kufalikira kudzera mukugonana, kuthiridwa magazi, kapena kuziika. Akalowa m'thupi, kachilomboka kamatha kupatsira ma cell amitundu yosiyanasiyana, makamaka ma cell omwe amayendetsa mitsempha yamagazi ndi mitsempha yama lymphatic. Monga ma herpesviruses onse, KSHV imakhalabe mthupi lanu moyo wanu wonse. Ngati chitetezo chamthupi chanu chidzafooka mtsogolo, kachilomboka kangakhale ndi mwayi woti kayambiranso, ndikupangitsa zizindikilo.

Pali mitundu inayi ya KS yochokera m'magulu a anthu omwe ali ndi kachilomboka:

• Classic KS: Amakhudza kwambiri amuna achikulire aku Eastern Europe, Middle East, ndi Mediterranean. Matendawa amakula pang'onopang'ono.
• Mliri (wokhudzana ndi Edzi) KS: Umapezeka nthawi zambiri mwa anthu omwe ali ndi kachirombo ka HIV ndipo adwala Edzi.
• Odwala (Afirika) KS: Amakhudza kwambiri anthu azaka zonse ku Africa.
• Matenda a Immunosuppression, kapena K kumuika, KS: Amapezeka mwa anthu omwe adalowapo ndipo ndi mankhwala omwe amaletsa chitetezo cha mthupi lawo.

Zotupa (zotupa) nthawi zambiri zimawoneka ngati zotupa pabuluu kapena zofiirira pakhungu. Iwo ndi ofiira-ofiirira chifukwa ali ndi mitsempha yambiri.

Zilondazo zimatha kuwonekera mbali iliyonse ya thupi. Amatha kuwonekera mkati mwa thupi. Zilonda zamkati mwathupi zimatha kutuluka magazi. Zilonda m'mapapo zimatha kupangitsa kuti sputum yamagazi ikhalepo kapena kupuma pang'ono.

Wothandizira zaumoyo adzayesa thupi, kuyang'ana zilonda.

Mayesero otsatirawa akhoza kuchitidwa kuti apeze KS:

• Bronchoscopy
• Kujambula kwa CT
• Endoscopy
• Khungu lakhungu

Momwe KS amathandizidwira zimadalira:

• Momwe chitetezo cha mthupi chimaponderezedwa (immunosuppression)
• Chiwerengero ndi malo am'mimbawo
• Zizindikiro

Mankhwalawa ndi awa:

• Mankhwala ochepetsa mphamvu ya kachilombo ka HIV, chifukwa palibe mankhwala enieni a HHV-8
• Kuphatikiza chemotherapy
• Kuzizira zilondazo
• Thandizo la radiation

Zilonda zimatha kubwerera atalandira chithandizo.

Kuchiza KS sikuthandiza kuti munthu akhale ndi kachilombo ka HIV / Edzi. Kaonedwe kake kamadalira momwe munthu alili mthupi mwake komanso kuchuluka kwa kachilombo ka HIV kamakhala m'magazi ake (kuchuluka kwa ma virus). Ngati kachilombo ka HIV kamayang'aniridwa ndi mankhwala, zilondazo nthawi zambiri zimatha zokha.

Zovuta zitha kukhala:

• Chifuwa (mwina wamagazi) ndi kupuma movutikira ngati matenda ali m'mapapu
• Kutupa kwamiyendo komwe kumatha kupweteka kapena kuyambitsa matenda ngati matendawa ali munthawi yamiyendo

Zotupazo zimatha kubwerera ngakhale atalandira chithandizo. KS itha kupha munthu amene ali ndi Edzi.

Mtundu wankhanza wa KS wokhazikika ukhoza kufalikira msanga m'mafupa. Mawonekedwe ena omwe amapezeka mwa ana aku Africa samakhudza khungu. M'malo mwake, imafalikira kudzera mu ma lymph node ndi ziwalo zofunika, ndipo imatha kupha msanga.

Kugonana motetezeka kumateteza kachirombo ka HIV. Izi zimapewa HIV / AIDS ndi zovuta zake, kuphatikiza KS.

KS pafupifupi sichimapezeka mwa anthu omwe ali ndi HIV / Edzi omwe matenda awo amayendetsedwa bwino.

Sarcoma ya Kaposi; HIV - Kaposi; Edzi - Kaposi

• Kaposi sarcoma - chotupa pamapazi
• Kaposi sarcoma kumbuyo
• Kaposi sarcoma - kutseka
• Sarcoma ya Kaposi pa ntchafu
• Kaposi sarcoma - perianal
• Kaposi sarcoma wapansi

Kaye KM. Kaposi sarcoma yokhudzana ndi herpesvirus (herpesvirus yaumunthu 8). Mu: Bennett JE, Dolin R, Blaser MJ, olemba., Eds. Mandell, Douglas, ndi Bennett's Principles and Practice of Infectious Diseases. 9th ed. Philadelphia, PA: Elsevier; 2020: chap 140.

Merrick ST, Jones S, Glesby MJ. Mawonekedwe machitidwe a HIV / AIDS. Mu: Goldman L, Schafer AI, olemba. Mankhwala a Goldman-Cecil. 26 wa. Philadelphia, PA: Elsevier; 2020: chap 366.

Tsamba la National Cancer Institute. Chithandizo cha Kaposi sarcoma (PDQ) - mtundu wa akatswiri azaumoyo. www.cancer.gov/types/soft-tissue-sarcoma/hp/kaposi-kuchiritsa-pdq. Idasinthidwa pa Julayi 27, 2018. Idapezeka pa February 18, 2021.