Kupitilira patsogolo kwa leukoencephalopathy

Progressive multifocal leukoencephalopathy (PML) ndimatenda achilendo omwe amawononga zinthuzo (myelin) zomwe zimaphimba ndikuteteza mitsempha mu nkhani yoyera yaubongo.

Vuto la John Cunningham, kapena JC virus (JCV) limayambitsa PML. Vuto la JC limadziwikanso kuti polyomavirus ya anthu 2. Pofika zaka 10, anthu ambiri amakhala kuti ali ndi kachilomboka ngakhale kuti sizimayambitsa matendawa. Koma anthu omwe ali ndi chitetezo chamthupi chofooka ali pachiwopsezo chotenga PML. Zomwe zimayambitsa chitetezo chamthupi chofooka ndi izi:

• HIV / AIDS (zomwe sizofala kwambiri ku PML tsopano chifukwa cha kasamalidwe kabwino ka HIV / AIDS).
• Mankhwala ena omwe amapondereza chitetezo cha mthupi chotchedwa ma monoclonal antibodies. Mankhwalawa atha kugwiritsidwa ntchito kupewetsa kukana kwa ziwalo kapena kuchiza matenda ofoola ziwalo, nyamakazi ndi zovuta zina za autoimmune, ndi zovuta zina.
• Khansa, monga khansa ya m'magazi ndi Hodgkin lymphoma.

Zizindikiro zimatha kuphatikizira izi:

• Kutayika kwa mgwirizano, kusokonekera
• Kutaya luso lolankhula (aphasia)
• Kutaya kukumbukira
• Mavuto masomphenya
• Kufooka kwa miyendo ndi mikono zomwe zimaipiraipira
• Umunthu umasintha

Wothandizira zaumoyo adzayesa thupi ndikufunsa za zizindikiro.

Mayeso atha kuphatikiza:

• Ubongo wamaubongo (nthawi zambiri)
• Kuyesa kwamadzimadzi kwa JCV
• Kujambula kwa CT kwa ubongo
• Electroencephalogram (EEG)
• MRI yaubongo

Kwa anthu omwe ali ndi HIV / AIDS, chithandizo cholimbitsa chitetezo cha mthupi chitha kupangitsa kuti ayambe kuchira kuzizindikiro za PML. Palibe mankhwala ena omwe athandiza PML.

PML ndiwopseza moyo. Kutengera momwe matendawa aliri oopsa, theka la anthu omwe amapezeka ndi PML amamwalira miyezi ingapo yoyambirira.

PML; Vuto la John Cunningham; JCV; Polyomavirus ya anthu 2; JC kachilombo

• Nkhani yakuda ndi yoyera yaubongo
• Leukoencephalopathy

Berger JR, Nath A. Cytomegalovirus, Epstein-Barr virus, komanso matenda opatsirana pang'onopang'ono a dongosolo lamanjenje. Mu: Goldman L, Schafer AI, olemba. Mankhwala a Goldman-Cecil. 26 wa. Philadelphia, PA: Elsevier; 2020: chap 346.

Tan CS, Koralnik IJ. JC, BK, ndi ma polyomaviruses ena: pang'onopang'ono leukencephalopathy (PML). Mu: Bennett JE, Dolin R, Blaser MJ, olemba., Eds. Mandell, Douglas, ndi Bennett's Principles and Practice of Infectious Diseases. 9th ed. Philadelphia, PA: Elsevier; 2020: chap 144.