Matenda a granulomatous

Matenda a granulomatous (CGD) ndimatenda obadwa nawo momwe maselo ena amthupi samagwira bwino ntchito. Izi zimabweretsa matenda obwereza komanso owopsa.

Mu CGD, maselo amthupi otchedwa phagocytes sangathe kupha mitundu ina ya mabakiteriya ndi bowa. Matendawa amatsogolera kumatenda a nthawi yayitali (osachiritsika) komanso obwereza (obwereza). Vutoli limapezeka nthawi yayitali kwambiri ali mwana. Mitundu yovuta kwambiri imatha kupezeka pazaka zaunyamata, kapena ngakhale atakula.

Zowopsa zimaphatikizira mbiri yakubadwa ya matenda omwe amapezeka kapena obwera.

Pafupifupi theka la milandu ya CGD imadutsa m'mabanja ngati chizolowezi chogonana. Izi zikutanthauza kuti anyamata ndi omwe amatenga matendawa kuposa atsikana. Jini lopunduka limayendetsedwa pa X chromosome. Anyamata ali ndi 1 X chromosome ndi 1 Y chromosome. Ngati mwana ali ndi X chromosome yokhala ndi cholakwika cha jini, amatha kulandira izi. Atsikana ali ndi ma X chromosomes awiri. Ngati mtsikana ali ndi 1 X chromosome yokhala ndi jini lopunduka, X yina chromosome itha kukhala ndi jini yogwira ntchito yopangira iyo. Mtsikana ayenera kulandira cholowa cha X cholakwika kuchokera kwa kholo lililonse kuti athe kudwala.

CGD imatha kuyambitsa mitundu yambiri yamatenda apakhungu omwe ndi ovuta kuchiza, kuphatikiza:

• Matuza kapena zilonda kumaso (impetigo)
• Chikanga
• Kukula kumadzaza mafinya (abscesses)
• Mitsempha yodzaza ndi mafinya pakhungu (zithupsa)

CGD ingayambitsenso:

• Kutsekula m'mimba kosalekeza
• Kutupa ma lymph node m'khosi
• Matenda am'mapapo, monga chibayo kapena chifuwa cham'mapapo

Wothandizira zaumoyo adzawunika ndipo atha kupeza:

• Kutupa chiwindi
• Kutupa kwamatenda
• Kutupa ma lymph node

Pakhoza kukhala zizindikilo za matenda a mafupa, omwe angakhudze mafupa ambiri.

Mayeso omwe angachitike ndi awa:

• Kujambula mafupa
• X-ray pachifuwa
• Kuwerengera kwathunthu kwa magazi (CBC)
• Kuyenda kwa cytometry kuyesa kutsimikizira matendawa
• Kuyezetsa magazi kuti mutsimikizire matendawa
• Kuyesedwa kwa maselo oyera a magazi
• Zolemba zamatenda

Maantibayotiki amagwiritsidwa ntchito pochiza matendawa, ndipo amathanso kugwiritsidwa ntchito popewa matenda. Mankhwala otchedwa interferon-gamma angathandizenso kuchepetsa matenda opatsirana kwambiri. Kuchita opaleshoni kungafunikire kuchiza ma abscess ena.

Chithandizo chokha cha CGD ndikumanga mafupa kapena kutsitsa maselo.

Mankhwala a nthawi yayitali amathandizira kuchepetsa matenda, koma kufa msanga kumatha kuchitika chifukwa chobwereza matenda am'mapapo.

CGD itha kubweretsa zovuta izi:

• Kuwonongeka kwa mafupa ndi matenda
• Matenda Matenda Mphuno
• Chibayo chomwe chimabwerabe ndipo chimakhala chovuta kuchiza
• Kuwonongeka kwa mapapo
• Kuwonongeka kwa khungu
• Ma lymph node otupa omwe amakhala otupa, amapezeka nthawi zambiri, kapena amapanga zotupa zomwe zimafunikira kuchitidwa kuti zithetsedwe

Ngati inu kapena mwana wanu muli ndi vutoli ndipo mukukayikira chibayo kapena matenda ena, imbani foni kwa wothandizirayo nthawi yomweyo.

Uzani wothandizira wanu ngati mapapo, khungu, kapena matenda ena samayankha mankhwala.

Upangiri wa chibadwa umalimbikitsidwa ngati mukukonzekera kukhala ndi ana ndipo muli ndi mbiri yakubadwa kwa matendawa. Kupita patsogolo pakuwunika kwa majini komanso kugwiritsidwa ntchito kowonjezera kwa chorionic villus sampling (mayeso omwe atha kuchitika pa sabata la 10 mpaka la 12 la mayi ali ndi pakati) zapangitsa kuti CGD izindikiridwe msanga. Komabe, izi sizinafalikire kapena kuvomerezedwa kwathunthu.

CGD; Kupha granulomatosis yaubwana; Matenda a granulomatous aubwana; Kupita patsogolo kwa septic granulomatosis; Kulephera kwa Phagocyte - matenda osachiritsika a granulomatous

Mavuto a Glogauer M. a phagocyte. Mu: Goldman L, Schafer AI, olemba. Mankhwala a Goldman-Cecil. Wolemba 25. Philadelphia, PA: Elsevier Saunders; 2016: chap 169.

Holland SM, kuperewera kwa Uzel G. Phagocyte. Mu: Rich RR, Fleisher TA, Shearer WT, Schroeder JR. HW, Frew AJ, Weyand CM, olemba. Clinical Immunology: Mfundo ndi Zochita. 5th ed. Philadelphia, PA: Elsevier; 2019: mutu 22.