Adrenocortical carcinoma

Adrenocortical carcinoma (ACC) ndi khansa yamatenda a adrenal. Zotupitsa za adrenal ndizithunzithunzi ziwiri zooneka ngati makona atatu. Gland imodzi ili pamwamba pa impso iliyonse.

ACC imafala kwambiri kwa ana ochepera zaka 5 komanso akulu azaka zapakati pa 40 ndi 50.

Vutoli limatha kulumikizidwa ndi matenda a khansa omwe amapitilira kudzera m'mabanja (obadwa nawo). Amuna ndi akazi atha kukhala ndi chotupacho.

ACC imatha kupanga mahomoni cortisol, aldosterone, estrogen, kapena testosterone, komanso mahomoni ena. Kwa amayi chotupacho nthawi zambiri chimatulutsa mahomoniwa, omwe amatha kubweretsa mikhalidwe yamwamuna.

ACC ndiyosowa kwambiri. Choyambitsa sichikudziwika.

Zizindikiro za kuchuluka kwa cortisol kapena mahomoni ena adrenal gland atha kukhala:

• Kunenepa kwambiri, kunenepa kumbuyo kumbuyo kwenikweni kwa khosi (njati)
• Nkhope yokhathamira, yozungulira yokhala ndi masaya oyipa (nkhope ya mwezi)
• Kunenepa kwambiri
• Kukula pang'ono (kutalika pang'ono)
• Virilization - mawonekedwe azimuna, kuphatikiza kuchuluka kwa tsitsi (makamaka pamaso), ubweya wamkati, ziphuphu, kuzama kwa mawu, ndi clitoris wokulitsa (akazi)

Zizindikiro za kuchuluka kwa aldosterone ndizofanana ndi kuchepa kwa potaziyamu, ndipo zimaphatikizapo:

• Kupweteka kwa minofu
• Kufooka
• Ululu m'mimba

Wothandizira zaumoyo adzakuyesani ndikufunsani za matenda anu.

Kuyezetsa magazi kudzachitika kuti muwone kuchuluka kwa mahomoni:

• Mulingo wa ACTH ukhala wotsika.
• Mulingo wa Aldosterone udzakhala wapamwamba.
• Mulingo wa Cortisol ukhala wokwera.
• Potaziyamu imakhala yotsika.
• Mahomoni amuna kapena akazi akhoza kukhala okwera kwambiri.

Kujambula mayeso pamimba atha kuphatikizira:

• Ultrasound
• Kujambula kwa CT
• MRI
• Kujambula PET

Chithandizo choyambirira ndi opaleshoni yochotsa chotupacho. ACC mwina singasinthe ndi chemotherapy. Mankhwala atha kuperekedwa kuti achepetse kupanga kwa cortisol, komwe kumayambitsa zizindikilo zambiri.

Zotsatira zake zimadalira momwe matendawa amapangidwira msanga komanso ngati chotupacho chafalikira (metastasized). Zotupa zomwe zafalikira nthawi zambiri zimabweretsa imfa pasanathe chaka chimodzi kapena zitatu.

Chotupacho chimatha kufalikira ku chiwindi, fupa, mapapo, kapena madera ena.

Itanani omwe akukuthandizani ngati inu kapena mwana wanu muli ndi matenda a ACC, Cushing syndrome, kapena akulephera kukula.

Chotupa - adrenal; ACC - adrenal

• Matenda a Endocrine
• Adrenal metastases - CT scan
• Chotupa cha Adrenal - CT

Allolio B, Fassnacht M. Adrenocortical carcinoma. Mu: Jameson JL, De Groot LJ, de Kretser DM, et al, olemba. Endocrinology: Akuluakulu ndi Ana. Wachisanu ndi chiwiri. Philadelphia, PA: Elsevier Saunders; 2016: mutu 107.

Tsamba la National Cancer Institute. Chithandizo cha Adrenocortical carcinoma (Wamkulu) (PDQ) - mtundu wa akatswiri azaumoyo. www.cancer.gov/types/adrenocortical/hp/adrenocortical-kuchiritsa-pdq. Idasinthidwa Novembala 13, 2019. Idapezeka pa Okutobala 14, 2020.