Mlembi: Clyde Lopez
Tsiku La Chilengedwe: 20 Kulayi 2021
Sinthani Tsiku: 15 Novembala 2024
Anonim
Leflunomide (DMARD) pharmacology - mechanism of action, adverse effects and cholestyramine
Kanema: Leflunomide (DMARD) pharmacology - mechanism of action, adverse effects and cholestyramine

Zamkati

Musatenge leflunomide ngati muli ndi pakati kapena mukufuna kutenga pakati. Leflunomide atha kuvulaza mwana wosabadwayo. Simuyenera kuyamba kumwa leflunomide mpaka mutayezetsa mimba ndi zotsatira zoyipa ndipo dokotala akukuuzani kuti mulibe pakati. Muyenera kugwiritsa ntchito njira yolerera musanayambe kumwa leflunomide, mukamachiritsidwa ndi leflunomide, komanso kwa zaka 2 mutalandira chithandizo. Ngati kusamba kwanu kwachedwa kapena mwaphonya nthawi yakumwa ndi leflunomide, pitani kuchipatala nthawi yomweyo. Lankhulani ndi dokotala ngati mukufuna kukhala ndi pakati pazaka ziwiri mutasiya mankhwala ndi leflunomide. Dokotala wanu akhoza kukupatsani mankhwala omwe angakuthandizeni kuchotsa mankhwalawa mwachangu mthupi lanu.

Leflunomide imatha kuwononga chiwindi chomwe chitha kupha moyo komanso kupha. Chiwopsezo chowononga chiwindi chimakhala chachikulu mwa anthu omwe amamwa mankhwala ena omwe amadziwika kuti amawononga chiwindi, komanso mwa anthu omwe ali ndi matenda a chiwindi. Uzani dokotala wanu ngati mwakhalapo ndi matenda a chiwindi kapena mtundu wina uliwonse wa matenda a chiwindi komanso ngati mumamwa kapena mumamwa mowa wambiri. Uzani dokotala wanu komanso wamankhwala ngati mukumwa acetaminophen (Tylenol, m'zinthu zina zotsatsa), aspirin ndi mankhwala ena osagwiritsa ntchito zotupa (NSAID monga ibuprofen [Advil, Motrin] ndi naproxen [Aleve, Naprosyn], cholesterol -kuchepetsa mankhwala (ma statins), hydroxychloroquine, zinthu zachitsulo, isoniazid (Laniazid, ku Rifamate, ku Rifater), methotrexate (Trexall), niacin (nicotinic acid), kapena rifampin (Rifadin, Rimactane, ku Rifamate, ku Rifater). Mukakumana ndi zizindikiro izi, itanani dokotala wanu msanga: nseru, kutopa kwambiri, magazi osazolowereka kapena kuvulala, kusowa mphamvu, kusowa chilakolako, kupweteka kumtunda chakumanja kwa m'mimba, chikaso cha khungu kapena maso, akuda mkodzo, kapena zizindikiro ngati chimfine.


Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena kuti aone momwe thupi lanu likuyankhira ku leflunomide.

Lankhulani ndi dokotala wanu za kuopsa kotenga leflunomide.

Leflunomide imagwiritsidwa ntchito payokha kapena kuphatikiza mankhwala ena kuchiza nyamakazi (vuto lomwe thupi limagunda mafupa ake, limayambitsa kupweteka, kutupa, komanso kutayika kwa ntchito). Leflunomide ali mgulu la mankhwala otchedwa matenda-modifying antirheumatic drug (DMARDs). Zimagwira ntchito pochepetsa kutupa ndikuchepetsa kukula kwa vutoli, zomwe zingathandize kukonza zolimbitsa thupi za anthu omwe ali ndi nyamakazi.

Leflunomide amabwera ngati piritsi kuti atenge pakamwa. Nthawi zambiri amatengedwa kamodzi patsiku. Dokotala wanu akhoza kukuwuzani kuti mutenge mlingo waukulu wa leflunomide m'masiku atatu oyamba azachipatala. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani leflunomide ndendende monga momwe adauzira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.


Dokotala wanu angafunike kuchepetsa mlingo wanu kapena kusiya mankhwala mukakumana ndi zovuta zina. Onetsetsani kuti muuze dokotala momwe mukumvera mukamalandira chithandizo.

Leflunomide itha kuthandizira kuchepetsa zizindikilo za nyamakazi koma sichiza. Pitirizani kutenga leflunomide ngakhale mukumva bwino. Osasiya kumwa leflunomide osalankhula ndi dokotala.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge leflunomide,

  • uzani dokotala wanu komanso wamankhwala kuti ngati muli ndi vuto la leflunomide, teriflunomide (Aubagio), mankhwala ena aliwonse, kapena chilichonse chopezeka m'mapiritsi a leflunomide. Funsani wamankhwala wanu kuti awonetse mndandanda wazosakaniza.
  • auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchula mankhwala omwe atchulidwa mgawo la CHENJEZO LOFUNIKA ndi zina mwa izi: maanticoagulants ('owonda magazi') monga warfarin (Coumadin Jantoven); cholestyramine (Prevalite); mankhwala agolide monga auranofin (Ridaura); mankhwala ochizira khansa; mankhwala ena omwe amapondereza chitetezo cha mthupi monga azathioprine (Azasan, Imuran), cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), ndi tacrolimus (Astagraf, Prograf); penicillamine (Cuprimine, Depen), ndi tolbutamide. Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
  • auzeni adotolo ngati mwadwalapo kapena mwakhala mukudwala matenda a kansa, khansa kapena zinthu zina zomwe zimakhudza mafupa kapena chitetezo cha mthupi (kuphatikizapo kachilombo ka HIV / kachilombo ka HIV ndi matenda opatsirana mthupi [Edzi]), matenda ashuga, kapena matenda a impso.
  • Uzani dokotala wanu ngati mukuyamwitsa. Musamwe mkaka pamene mukumwa leflunomide.
  • ngati mukukonzekera kukhala ndi mwana, muyenera kulankhula ndi dokotala wanu za kusiya leflunomide ndi kulandira chithandizo chothandizira kuchotsa mankhwalawa mthupi lanu mwachangu.
  • Funsani dokotala wanu za zakumwa zoledzeretsa pamene mukumwa leflunomide.
  • Kutenga leflunomide kumachepetsa kuthekera kwanu kothana ndi matenda. Uzani dokotala wanu ngati muli ndi kachilombo tsopano kapena ngati muli ndi zizindikiro zilizonse za matenda monga malungo, chifuwa, kapena zizindikiro ngati chimfine. Ngati mukumane ndi izi pazithandizo izi ndi leflunomide, itanani dokotala wanu: malungo; chikhure; chifuwa; zizindikiro ngati chimfine; dera la khungu lofunda, lofiira, lotupa, kapena lopweteka; kupweteka kovuta, kovuta, kapena pafupipafupi; kapena zizindikiro zina za matenda. Chithandizo chanu ndi leflunomide chingafunike kusokonezedwa ngati muli ndi matenda.
  • Mutha kukhala kuti mwadwala kale chifuwa chachikulu (TB; matenda akulu am'mapapo) koma mulibe zizindikiro zilizonse za matendawa. Poterepa, leflunomide imatha kupangitsa kuti matenda anu akhale ovuta kwambiri ndikupangitsani kukhala ndi zizindikilo. Uzani dokotala wanu ngati munakhalapo ndi TB kapena munakhalapo ndi TB, ngati munakhalako kapena munapitako kudziko kumene TB imafala, kapena ngati mwakhalapo ndi munthu amene ali ndi TB. Musanayambe kumwa mankhwala ndi leflunomide, dokotala wanu adzakuyesani khungu kuti muwone ngati muli ndi TB. Ngati muli ndi TB, dokotala wanu amachiza matendawa ndi maantibayotiki musanayambe kumwa leflunomide.
  • mulibe katemera popanda kulankhula ndi dokotala.
  • Muyenera kudziwa kuti leflunomide imatha kuyambitsa kuthamanga kwa magazi. Muyenera kuyezetsa magazi anu musanayambe kumwa mankhwala komanso nthawi zonse mukamamwa mankhwalawa.

Tengani mlingo womwe mwaphonya mukangokumbukira. Komabe, ngati ili pafupi nthawi ya mlingo wanu wotsatira, dumpha mlingo womwe umasowa ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.


Leflunomide ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

  • kutsegula m'mimba
  • kusanza
  • kutentha pa chifuwa
  • mutu
  • chizungulire
  • kuonda
  • kupweteka kwa msana
  • kupweteka kwa minofu kapena kufooka
  • kupweteka, kuwotcha, kuchita dzanzi, kapena kumva kupweteka m'manja kapena m'mapazi
  • kutayika tsitsi
  • kukokana kwamiyendo
  • khungu lowuma

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa mu CHENJEZO CHENJEZO kapena ZOCHITIKA ZABWINO, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:

  • kufulumira ndi kutentha thupi kapena wopanda malungo
  • ming'oma
  • matuza kapena khungu
  • zilonda mkamwa
  • kuyabwa
  • kuvuta kupuma
  • chifuwa chatsopano kapena chowonjezeka
  • kupweteka pachifuwa
  • khungu lotumbululuka

Kulandira mankhwala omwe amaletsa chitetezo cha mthupi kumatha kuonjezera chiopsezo chotenga mitundu ina ya khansa. Kuwonjezeka kwa khansa sikunatchulidwe m'maphunziro azachipatala ndi leflunomide mpaka pano. Lankhulani ndi dokotala wanu za kuopsa kolandila leflunomide.

Leflunomide ikhoza kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Sungani pa firiji komanso kutali ndi kutentha ndi chinyezi (osati kubafa) ndi kuwala.

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Zizindikiro za bongo zingaphatikizepo izi:

  • kutsegula m'mimba
  • kupweteka m'mimba
  • kutopa kwambiri
  • kufooka
  • khungu lotumbululuka
  • kugunda kwamtima mwachangu
  • kupuma movutikira

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

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