Jekeseni wa Arsenic Trioxide

Zamkati

• Asanalandire jekeseni wa arsenic trioxide,
• Jakisoni wa Arsenic trioxide angayambitse shuga m'magazi anu. Itanani dokotala wanu nthawi yomweyo ngati muli ndi zizindikiro zotsatirazi za hyperglycemia (shuga wambiri wamagazi):
• Ngati shuga wambiri m'magazi sakuchiritsidwa, matenda owopsa omwe amatchedwa matenda ashuga ketoacidosis amatha. Pezani chithandizo chamankhwala nthawi yomweyo ngati muli ndi izi:
• Jakisoni wa Arsenic trioxide angayambitse mavuto. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa MUCHENJEZO CHENJEZO, itanani dokotala wanu mwachangu:
• Zizindikiro za bongo zingaphatikizepo:

Arsenic trioxide iyenera kuperekedwa moyang'aniridwa ndi dokotala yemwe amadziwa zambiri zochizira anthu omwe ali ndi leukemia (khansa yamagazi oyera).

Arsenic trioxide imatha kuyambitsa matenda oopsa kapena owopsa omwe amatchedwa APL kusiyanitsa matenda. Dokotala wanu amayang'anitsitsa mosamala kuti awone ngati mukukula matendawa. Dokotala wanu akhoza kukupemphani kuti muzidziyesa tsiku lililonse m'masabata angapo oyamba a chithandizo chanu chifukwa kunenepa kwambiri ndi chizindikiro cha kusiyana kwa APL. Ngati mukumane ndi izi, uzani dokotala nthawi yomweyo: malungo, kunenepa, kupuma movutikira, kupuma movutikira, kupweteka pachifuwa, kapena kutsokomola. Pachizindikiro choyamba kuti mukukula ndi matenda a APL, dokotala wanu adzakupatsani mankhwala amodzi kapena angapo kuti athetse vutoli.

Arsenic trioxide imatha kuyambitsa kutalikirana kwa QT (minofu ya mtima imatenga nthawi yayitali kuti ibwererenso pakati pa kumenyedwa chifukwa chamagetsi), zomwe zimatha kuyambitsa mavuto owopsa kapena owopsa amoyo. Musanayambe kumwa mankhwala ndi arsenic trioxide, dokotala wanu adzaitanitsa electrocardiogram (ECG; mayeso omwe amalemba zamagetsi mumtima) ndi mayeso ena kuti muwone ngati muli ndi vuto lamagetsi mumtima mwanu kapena muli pachiwopsezo chachikulu kuposa kukulitsa vutoli. Dokotala wanu adzakuwunikirani mosamala ndipo adzaitanitsa ECG ndi mayeso ena mukamalandira arsenic trioxide. Uzani dokotala wanu ngati mwakhalapo ndi kutalikilapo kwa QT, mtima wosalimba, kugunda kwamtima mosasinthasintha, kapena potaziyamu kapena magnesium m'magazi anu. Muuzeni dokotala ngati mukumwa mankhwala aliwonse awa: amiodarone (Nexterone, Pacerone), amphotericin (Abelcet, Amphotec, Fungizone), cisapride (Propulsid), disopyramide (Norpace), diuretics ('mapiritsi amadzi'), dofetilide ( Tikosyn), erythromycin (EES, E-Mycin, Erythrocin), moxifloxacin (Avelox), pimozide (Orap), procainamide (Procanbid, Pronestyl), quinidine (Quinidex), sotalol (Betapace, Betapace AF), sparfagineine (sparfagine) (Mellaril), ndi ziprasidone (Geodon). Itanani dokotala wanu nthawi yomweyo ngati muli ndi vuto losagwirizana kapena losachedwa kugunda kapena mukakomoka mukamalandira mankhwala a arsenic trioxide.

Jekeseni wa Arsenic trioxide itha kubweretsa encephalopathy (chisokonezo, zovuta zokumbukira, ndi zovuta zina zomwe zimayambitsidwa ndi magwiridwe antchito aubongo). Uzani dokotala wanu ngati mumamwa kapena mumamwa mowa wambiri, ngati muli ndi vuto la malabsorption (mavuto akumwa chakudya), kusowa kwa zakudya m'thupi, kapena ngati mukumwa furosemide (Lasix). Ngati mukumane ndi izi, uzani dokotala nthawi yomweyo: chisokonezo; kutaya chidziwitso; kugwidwa; malankhulidwe amasintha; mavuto ndi mgwirizano, kulimbitsa thupi, kapena kuyenda; kapena kusintha kwamaso monga kuchepa kwa malingaliro, zovuta zowerenga, kapena masomphenya awiri. Onetsetsani kuti achibale anu kapena omwe akukusamalirani amadziwa zomwe zitha kukhala zovuta kuti athe kupeza chithandizo chamankhwala ngati simungakwanitse kupita nokha.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena asanachitike kapena pambuyo pake kuti awone kuyankha kwa thupi lanu ku arsenic trioxide.

Lankhulani ndi dokotala wanu za kuopsa kogwiritsa ntchito arsenic trioxide.

Arsenic trioxide imagwiritsidwa ntchito limodzi ndi tretinoin pochiza leukemia yovuta kwambiri ya promyelocytic (APL; mtundu wa khansa momwe muli maselo amwazi ambiri m'magazi ndi m'mafupa) mwa anthu ena ngati chithandizo choyamba. Amagwiritsidwanso ntchito pochizira APL kwa anthu ena omwe sanathandizidwe ndi mitundu ina ya chemotherapy kapena omwe zinthu zawo zasintha koma kenako zimaipiraipira kutsatira mankhwala ndi retinoid ndi mitundu ina ya mankhwala a chemotherapy. Arsenic trioxide ili mgulu la mankhwala otchedwa anti-neoplastics. Zimagwira pochepetsa kapena kuletsa kukula kwa maselo a khansa.

Arsenic trioxide imabwera ngati yankho (madzi) yolowetsedwa mumtsinje ndi dokotala kapena namwino kuofesi yazachipatala kapena kuchipatala. Arsenic trioxide nthawi zambiri imabayidwa kupitilira 1 mpaka 2 maola, koma imatha kubayidwa nthawi yayitali ngati maola 4 ngati zovuta zimachitika pakulowetsedwa. Nthawi zambiri amaperekedwa kamodzi patsiku kwakanthawi kanthawi.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Asanalandire jekeseni wa arsenic trioxide,

• uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la arsenic trioxide, mankhwala ena aliwonse, kapena zina zilizonse zopangira jekeseni wa arsenic trioxide. Funsani wamankhwala wanu kuti awonetse mndandanda wazosakaniza.
• Uzani dokotala wanu komanso wamankhwala mankhwala ndi mankhwala osapatsirana, mavitamini, zowonjezera zakudya, ndi mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo mankhwala omwe atchulidwa mgulu la CHENJEZO LOFUNIKA. Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
• auzeni adotolo ngati mwadwalapo chiwindi kapena impso.
• uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena ngati mukufuna kukhala ndi mwana. Ngati ndinu wamkazi, muyenera kuyezetsa asanayambe kulandira chithandizo ndikugwiritsa ntchito njira zakulera kuti muchepetse mimba mukamalandira chithandizo komanso kwa miyezi isanu ndi umodzi mutatha kumwa. Ngati ndinu wamwamuna, inu ndi mnzanuyo muyenera kugwiritsa ntchito njira yolerera pamene mukulandira jekeseni wa arsenic trioxide komanso miyezi itatu mutalandira mankhwala omaliza. Ngati inu kapena mnzanu mumakhala ndi pakati mukamamwa mankhwalawa, itanani dokotala wanu. Lankhulani ndi dokotala wanu za momwe mungagwiritsire ntchito njira zakulera kuti muchepetse mimba mukamamwa mankhwala a arsenic trioxide. Arsenic trioxide itha kuvulaza mwana wosabadwayo.
• Uzani dokotala wanu ngati mukuyamwitsa.Dokotala wanu angakuuzeni kuti musamamwe mkaka mukamamwa mankhwala komanso kwa milungu iwiri mutatha kumwa.
• Muyenera kudziwa kuti mankhwalawa amachepetsa kubereka mwa amuna. Lankhulani ndi dokotala wanu za kuopsa kolandira arsenic trioxide.
• ngati mukuchitidwa opaleshoni, kuphatikizapo opaleshoni ya mano, uzani dokotala kapena dokotala kuti mukulandira arsenic trioxide.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Jakisoni wa Arsenic trioxide angayambitse shuga m'magazi anu. Itanani dokotala wanu nthawi yomweyo ngati muli ndi zizindikiro zotsatirazi za hyperglycemia (shuga wambiri wamagazi):

• ludzu lokwanira
• kukodza pafupipafupi
• njala yayikulu
• kufooka
• kusawona bwino

Ngati shuga wambiri m'magazi sakuchiritsidwa, matenda owopsa omwe amatchedwa matenda ashuga ketoacidosis amatha. Pezani chithandizo chamankhwala nthawi yomweyo ngati muli ndi izi:

• pakamwa pouma
• nseru ndi kusanza
• kupuma movutikira
• mpweya womwe umanunkhira zipatso
• kuchepa chikumbumtima

Jakisoni wa Arsenic trioxide angayambitse mavuto. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kutopa kwambiri
• chizungulire
• mutu
• kutsegula m'mimba
• kutupa kwa mikono, manja, mapazi, akakolo, kapena miyendo yakumunsi
• zidzolo
• kuyabwa

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa MUCHENJEZO CHENJEZO, itanani dokotala wanu mwachangu:

• kuvulaza kapena kutuluka mwachilendo
• masanzi omwe ali ndimwazi kapena omwe amawoneka ngati malo a khofi
• chopondapo chakuda ndikuchedwa kapena chokhala ndi magazi ofiira owala
• kuchepa pokodza
• ming'oma

Jekeseni wa Arsenic trioxide ungayambitse zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukalandira mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Zizindikiro za bongo zingaphatikizepo:

• kugwidwa
• kufooka kwa minofu
• chisokonezo

Funsani dokotala wanu kapena wamankhwala ngati muli ndi mafunso okhudza jekeseni wa arsenic trioxide.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Zamgululi^®