Jekeseni wa Ibritumomab

Zamkati

• Asanalandire jakisoni wa ibritumomab,
• Kubayira kwa Ibritumomab kumatha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi zizindikilo zilizonse zomwe zatchulidwa mgulu la CHENJEZO LA CHENJEZO kapena zina mwazizindikiro izi, pitani kuchipatala nthawi yomweyo:
• Zizindikiro za bongo zingaphatikizepo izi:

Maola angapo mlingo uliwonse wa jakisoni wa ibritumomab, mankhwala otchedwa rituximab (Rituxan) amaperekedwa. Odwala ena adakumana ndi zoopsa kapena zoopsa pamoyo wawo pomwe amalandira rituximab kapena atangolandira rituximab. Izi zimachitika kawirikawiri ndimlingo woyamba wa rituximab. Odwala ena amwalira pasanathe maola 24 atalandira rituximab. Uzani dokotala wanu ngati muli ndi vuto la rituximab kapena mankhwala opangidwa ndi mapuloteni a murine (mbewa), kapena ngati simukudziwa ngati mankhwala omwe simukugwirizana nawo amapangidwa ndi mapuloteni a murine. Uzaninso dokotala wanu ngati munapatsidwapo mankhwala ochokera ku mapuloteni am'mkodzo. Ngati ndi choncho, mutha kukhala ndi vuto la rituximab. Dokotala wanu adzayitanitsa mayeso kuti awone ngati mungakhale ndi vuto la rituximab.

Dokotala wanu adzakupatsani mankhwala musanalandire rituximab kuti muteteze zomwe zimachitika ku rituximab. Ngati mukumva rituximab, dokotala akhoza kusiya kukupatsani mankhwala kwakanthawi kapena akhoza kukupatsani pang'onopang'ono. Ngati vutoli ndi lalikulu, dokotala atseka kulowetsedwa kwa rituximab ndipo sangapitilize chithandizo chanu ndi jakisoni wa ibritumomab. Uzani dokotala wanu nthawi yomweyo ngati mukumane ndi izi kapena mutangomaliza kulandira chithandizo ndi rituximab: chifuwa; kuvuta kupuma kapena kumeza; kumangitsa pakhosi; ming'oma; kuyabwa; kutupa kwa maso, nkhope, milomo, lilime, pakamwa, kapena pakhosi; kupweteka pachifuwa, nsagwada, mkono, kumbuyo, kapena khosi; chisokonezo; kutaya chidziwitso; kugunda kwamtima; thukuta; khungu lotumbululuka; kupuma mofulumira; kuchepa pokodza; kapena manja ozizira ndi mapazi.

Chithandizo cha jekeseni ya rituximab ndi ibritumomab chingayambitse kuchepa kwamaselo amwazi mthupi lanu. Kutsika uku kumatha kuchitika milungu 7 mpaka 9 mutalandira chithandizo chanu ndipo kumatha milungu 12 kapena kupitilira apo. Kutsika uku kumatha kuyambitsa matenda owopsa kapena owopsa kapena kutaya magazi. Dokotala wanu sangakupatseni jakisoni wa ibritumomab ngati maselo anu am'magazi adakhudzidwa kwambiri ndi khansa, ngati mudalowetsedwa m'mafupa, ngati simunathe kupanga maselo okwanira (maselo omwe amapezeka m'mafupa omwe amatha kukula kuti apange mtundu uliwonse wama cell am'magazi) kuti mutengeke mafuta m'mafupa, kapena ngati muli kale ndi ma cell ochepa. Uzani dokotala ngati mukumwa mankhwala aliwonse awa: maanticoagulants ('opopera magazi') monga warfarin (Coumadin, Jantoven); aspirin ndi mankhwala ena osagwiritsa ntchito kutupa (NSAIDs) monga ibuprofen (Advil, Motrin) ndi naproxen (Aleve); ndi clopidogrel (Plavix). Ngati muli ndi zizindikiro izi, pitani kuchipatala nthawi yomweyo: khungu loyera; kufooka; kuvulaza kapena kutuluka mwachilendo; mawanga ofiira kapena zigamba pakhungu; chimbudzi chakuda kapena chamagazi; masanzi omwe ali amwazi kapena owoneka ngati malo a khofi; kutsegula m'mimba; kapena zilonda zapakhosi, malungo, kuzizira, chifuwa, kapena zizindikilo zina za matenda.

Chithandizo cha jekeseni wa rituximab ndi ibritumomab chingayambitse khungu kapena kupha. Izi zimatha kuchitika patangopita masiku ochepa mutalandira chithandizo kapena miyezi 4 itatha mutalandira chithandizo. Uzani dokotala wanu nthawi yomweyo ngati muli ndi zotupa pakhungu lanu kapena mkamwa kapena mphuno, zotupa, kapena khungu. Dokotala wanu sangakupatseni jakisoni wina wa ibritumomab mukakhala ndi zizindikilozi.

Mukalandira jakisoni woyamba wa jakisoni wa ibritumomab, dokotala wanu amalamula zojambula (zoyesa zomwe zikuwonetsa chithunzi cha zonse kapena gawo lamkati mwa thupi) kuti muwone momwe mankhwala afalikira mthupi lanu. Ngati mankhwalawa sanafalikire m'thupi lanu monga mukuyembekezera, simulandiranso jekeseni wanu wa ibritumomab.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu adzaitanitsa mayeso ena mukamalandira chithandizo komanso kwa miyezi itatu mutalandira chithandizo kuti muwone momwe thupi lanu likuyankhira jakisoni wa ibritumomab.

Lankhulani ndi dokotala wanu za kuopsa kolandila jakisoni wa ibritumomab.

Jakisoni wa Ibritumomab amagwiritsidwa ntchito ndi rituximab (Rituxan) kuchiza mitundu ina ya non-Hodgkin's lymphoma (NHL; khansa yomwe imayamba m'maselo amthupi) yomwe sinasinthe kapena yomwe yaipiraipira pambuyo pochiritsidwa ndi mankhwala ena. Amagwiritsidwanso ntchito pochiza mitundu ina ya NHL mwa anthu omwe apindula atalandira chithandizo ndi mankhwala ena a chemotherapy. Jakisoni wa Ibritumomab ali mgulu la mankhwala otchedwa monoclonal antibodies okhala ndi ma radioisotopes. Imagwira ndikulumikiza ma cell a khansa ndikutulutsa radiation kuti iwononge ma cell a khansa.

Jakisoni wa Ibritumomab amabwera ngati madzi olowetsedwa mumtsinje kwa mphindi 10 ndi dokotala yemwe adaphunzitsidwa kuchiza odwala ndi mankhwala a radioactive. Amapatsidwa ngati gawo la mtundu wina wa khansa. Pa tsiku loyamba la mankhwalawa, mlingo wa rituximab umaperekedwa ndipo mlingo woyamba wa jakisoni wa ibritumomab umaperekedwa osapitirira maola 4 pambuyo pake. Kujambula zojambula kuti muwone momwe jakisoni wa ibritumomab wafalikira mthupi lonse amachitidwa maola 48 mpaka 72 mutapatsidwa jekeseni wa ibritumomab. Zithunzi zina zitha kuchitidwa ngati zingafunike masiku angapo otsatira. Ngati zotsatira za sikani (s) zikuwonetsa kuti jakisoni wa ibritumomab wafalikira kudzera mthupi monga momwe amayembekezera, mlingo wachiwiri wa rituximab ndi jekeseni lachiwiri la jakisoni wa ibritumomab adzapatsidwa masiku 7 mpaka 9 pambuyo poti mankhwala oyamba apatsidwa.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Asanalandire jakisoni wa ibritumomab,

• uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la ibritumomab, mankhwala aliwonse omwe atchulidwa mu gawo la CHENJEZO CHENJEZO, mankhwala ena aliwonse, kapena china chilichonse mu jakisoni wa ibritumomab. Funsani dokotala wanu kapena wamankhwala mndandanda wa zosakaniza.
• Uzani dokotala wanu komanso wamankhwala mankhwala ndi mankhwala osapatsirana, mavitamini, zowonjezera zakudya, ndi mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo mankhwala omwe atchulidwa mgulu la CHENJEZO LOFUNIKA. Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
• uzani dokotala wanu ngati mwakhalapo kapena mudakhalapo ndi matenda aliwonse.
• Uzani dokotala wanu ngati muli ndi pakati kapena mukufuna kukhala ndi pakati. Simuyenera kutenga pakati mukalandira ibritumomab. Ngati ndinu wamkazi, muyenera kuyezetsa asanayambe kulandira chithandizo ndikugwiritsa ntchito njira zakulera kuti muchepetse mimba mukamalandira chithandizo komanso kwa miyezi 12 mutalandira mankhwala omaliza. Ngati ndinu wamwamuna wokhala ndi bwenzi lachikazi, gwiritsani ntchito njira zakulera kuti muchepetse mimba mukamalandira chithandizo komanso kwa miyezi 12 mutalandira mankhwala omaliza. Ngati inu kapena mnzanu muli ndi pakati mukalandira jakisoni wa ibritumomab, itanani dokotala wanu mwachangu. Jakisoni wa Ibritumomab akhoza kuvulaza mwana wosabadwayo.
• auzeni dokotala ngati mukuyamwitsa kapena mukufuna kuyamwitsa. Simuyenera kuyamwa mukalandira ibritumomab komanso kwa miyezi 6 mutapatsidwa mankhwala omaliza.
• Muyenera kudziwa kuti mankhwalawa amachepetsa kubereka kwa abambo ndi amai. Lankhulani ndi dokotala wanu za kuopsa kolandira ibritumomab.
• ngati mukuchitidwa opaleshoni, kuphatikizapo opaleshoni ya mano, uzani dokotala kapena dokotala kuti mwalandira jakisoni wa ibritumomab.
• mulibe katemera uliwonse mukamalandira chithandizo komanso kwa miyezi 12 mutatha kumwa mankhwala musanalankhule ndi dokotala.
• muyenera kudziwa kuti radioactivity mu mlingo wachiwiri wa jakisoni wa ibritumomab imatha kupezeka m'madzi amthupi mwanu mpaka sabata mutalandira mankhwalawo. Pofuna kupewa kufalikira kwa ma radioactivity kwa anthu omwe ali pafupi nanu, muyenera kutsuka m'manja mukatha kusamba, gwiritsani ntchito kondomu nthawi zonse mukamagonana, ndipo pewani kupsompsonana kwambiri. Tsatirani izi popereka chithandizo komanso kwa masiku 7 mutalandira jekeseni ya ibritumomab.
• muyenera kudziwa kuti jakisoni wa ibritumomab uli ndi albin (chinthu chomwe chimapangidwa kuchokera m'magazi opereka amoyo). Ngakhale pali mwayi wochepa kwambiri kuti ma virus atha kufalikira kudzera m'magazi, palibe matenda amtundu wa mankhwala omwe adalembedwapo.
• muyenera kudziwa kuti ngati mulandira jakisoni wa ibritumomab, thupi lanu limatha kupanga ma antibodies (zinthu zamagazi zomwe zimathandiza chitetezo cha mthupi kuzindikira ndikuukira zinthu zakunja) kuti mumve mapuloteni. Ngati mupanga ma antibodies awa, mutha kukhala ndi vuto lanu mukamamwa mankhwala opangidwa ndi mapuloteni a murine, kapena mankhwalawa sangakugwireni bwino. amathandizidwa ndi jakisoni wa ibritumomab.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Itanani dokotala wanu nthawi yomweyo ngati simungakwanitse kusungitsa nthawi kuti mulandire jakisoni wa ibritumomab.

Kubayira kwa Ibritumomab kumatha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• nseru
• kusanza
• kupweteka m'mimba kapena kutupa
• kudzimbidwa
• kutentha pa chifuwa
• kusowa chilakolako
• mutu
• nkhawa
• chizungulire
• kuvuta kugona kapena kugona
• msana, kulumikizana, kapena kupweteka kwa minofu
• kuchapa

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi zizindikilo zilizonse zomwe zatchulidwa mgulu la CHENJEZO LA CHENJEZO kapena zina mwazizindikiro izi, pitani kuchipatala nthawi yomweyo:

• kufiira, kukoma mtima, kapena bala lotseguka mdera lomwe mankhwala adalowetsedwa

Anthu ena omwe adalandira jakisoni wa ibritumomab adapanga mitundu ina ya khansa monga khansa ya m'magazi (khansa yomwe imayamba m'maselo oyera a magazi) ndi myelodysplastic syndrome (momwe maselo amwazi samakhalira bwino) mzaka zingapo zoyambirira atalandira mankhwala. Lankhulani ndi dokotala wanu za kuopsa kolandira mankhwalawa.

Jakisoni wa Ibritumomab angayambitse zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukalandira mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Zizindikiro za bongo zingaphatikizepo izi:

• khungu lotumbululuka
• kufooka
• kupuma movutikira
• kutopa kwambiri
• kuvulaza kapena kutuluka mwachilendo
• mawanga ofiira kapena zigamba pakhungu
• zilonda zapakhosi, malungo, kuzizira, chifuwa, ndi zizindikilo zina za matenda

Funsani dokotala wanu kapena wamankhwala mafunso aliwonse omwe muli nawo okhudza jekeseni wa ibritumomab.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Zevalin^®