Pazopanib

Zamkati

• Musanatenge pazopanib,
• Pazopanib ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa MUCHENJEZO CHENJEZO, itanani dokotala wanu mwachangu:
• Zizindikiro za bongo zingaphatikizepo:

Pazopanib imatha kuwononga chiwindi choopsa kapena chowopsa. Uzani dokotala wanu ngati mwakhalapo kapena mukudwala matenda a chiwindi. Ngati mukumane ndi izi, uzani dokotala nthawi yomweyo: khungu lachikaso kapena maso; mkodzo wamdima; kutopa kwambiri; nseru; kusanza; kusowa chilakolako; kupweteka kumtunda chakumanja kwam'mimba; kapena kutuluka mwachilendo kapena kuvulala.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena a labu musanayambe kutenga pazopanib ndipo kamodzi pamwezi kwa miyezi inayi yoyambirira yamankhwala anu kenako pafupipafupi momwe mungafunikire.

Dokotala wanu kapena wamankhwala adzakupatsani pepala lazidziwitso za wopanga (Medication Guide) mukayamba chithandizo ndi pazopanib ndipo nthawi iliyonse mukadzaza mankhwala anu. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kuyendera tsamba la Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kapena tsamba laopanga kuti mupeze Medication Guide.

Lankhulani ndi dokotala wanu za kuopsa kotenga pazopanib.

Pazopanib imagwiritsidwa ntchito pochizira renal cell carcinoma (RCC, mtundu wa khansa womwe umayamba m'maselo a impso) mwa akulu. Pazopanib ali mgulu la mankhwala otchedwa kinase inhibitors. Zimagwira ntchito pochepetsa kapena kuletsa kufalikira kwa maselo a khansa.

Pazopanib imabwera ngati piritsi kuti itenge pakamwa. Nthawi zambiri amatengedwa m'mimba yopanda kanthu kamodzi patsiku, osachepera ola limodzi musanadye kapena maola awiri mutadya. Tengani pazopanib nthawi yofananira tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani pazopanib ndendende monga momwe adauzira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Kumeza mapiritsi lonse; osagawana, kutafuna, kapena kuwaphwanya.

Dokotala wanu amatha kusintha mlingo wa pazopanib mukamalandira chithandizo kapena akhoza kusiya kumwa mankhwala. Izi zimadalira momwe mankhwalawa amakuthandizirani komanso zovuta zina zomwe mungakumane nazo. Lankhulani ndi dokotala wanu za momwe mukumvera mukamalandira chithandizo. Pitilizani kutenga pazopanib ngakhale mukumva bwino. Osasiya kumwa pazopanib osalankhula ndi adotolo.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge pazopanib,

• uzani dokotala wanu komanso wamankhwala kuti ngati muli ndi vuto la pazopanib, mankhwala ena aliwonse, kapena zosakaniza zilizonse pamapiritsi a pazopanib. Funsani wamankhwala wanu kapena onani Chithandizo cha Mankhwala kuti mupeze mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: cisapride (Propulsid) (sikupezeka ku U.S.); clarithromycin (Biaxin, mu Prevpac); dofetilide (Tikosyn); erythromycin (EES, E-Mycin, Erythrocin); ketoconazole (Nizoral); mankhwala ena osagunda pamtima monga amiodarone (Cordarone), digoxin (Digitek, Lanoxicaps, Lanoxin), diltiazem (Cardizem, Dilacor, Tiazac, ena), disopyramide (Norpace), flecainide (Tambocor), mexiletine (Mexitil), procainamide ), propafenone (Rythmol), propranolol (Inderal, Innopran XL, ku Inderide), quinidine, sotalol (Betapace, Betapace AF, Sorine), ndi verapamil (Calan, Isoptin, Verelan); moxifloxacin (Avelox); pimozide (Orap); rifampin (Rifadin, ku Rifamate, ku Rifater, Rimactane); ritonavir (Norvir, ku Kaletra); sparfloxacin (Zagam) (sikupezeka ku U.S.); ndi thioridazine (Mellaril). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi pazopanib, chifukwa chake onetsetsani kuti muwauze adotolo zamankhwala onse omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• uzani dokotala ngati mwakhosomola magazi kapena mwatuluka magazi m'mimba, m'matumbo, kapena muubongo m'miyezi 6 yapitayi kapena mwachitidwa opaleshoni m'masiku 7 apitawa. Muuzeni dokotala ngati mwadulapo kapena munagwapo m'mimba kapena m'matumbo; kulumikizana kwachilendo pakati pa magawo awiri am'mimba mwako; Matenda a Gilbert (chibadwa chomwe chimakhudza chiwindi ndipo chimatha kuyambitsa matenda a chikasu (khungu lachikopa kapena maso); kuthamanga kwa magazi; sitiroko; kugunda kwamtima kosasintha; nthawi yayitali ya QT (vuto losowa la mtima lomwe lingayambitse kugunda kwamtima, kukomoka, kapena kufa mwadzidzidzi); matenda a mtima; kupweteka pachifuwa; kapena matenda a mtima kapena chithokomiro.
• uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena mukuyamwitsa. Simuyenera kutenga pakati mukatenga pazopanib. Mukakhala ndi pakati mukatenga pazopanib, itanani dokotala wanu. Pazopanib atha kuvulaza mwana wosabadwayo.
• ngati mukuchitidwa opaleshoni, kuphatikizapo opaleshoni ya mano, uzani dokotala kapena dokotala kuti mukumwa pazopanib.

Musadye zipatso zamphesa kapena kumwa madzi amphesa mukamamwa mankhwalawa.

Tengani mlingo womwe mwaphonya mukangokumbukira. Komabe, ngati mkati mwa maola 12 a mlingo wanu wotsatira womwe mwakhala mukukonzekera, tulukani mlingo womwe mwaphonyawo ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Pazopanib ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kutsegula m'mimba
• kudzimbidwa
• kutentha pa chifuwa
• kusintha kwa kulawa chakudya
• kulumikizana kapena kupweteka kwa minofu
• kutupa kwa nkhope
• zofewa, zanjedza zofiira za manja ndi mapazi
• kutayika tsitsi
• zikhadabo zoonda, zopyapyala kapena tsitsi
• kusintha mtundu wa tsitsi
• kunyezimira kwa khungu
• zidzolo
• kufooka
• kukhumudwa
• kusowa kwachilendo pamazizira ozizira
• kuonda

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa MUCHENJEZO CHENJEZO, itanani dokotala wanu mwachangu:

• kuthamanga kapena kusakhazikika kwamtima
• kupweteka pachifuwa
• kupweteka m'manja, kumbuyo, m'khosi kapena nsagwada
• kupuma movutikira
• mutu
• mawu odekha kapena ovuta
• chizungulire kapena kukomoka
• kufooka kapena kufooka kwa mkono kapena mwendo
• mabala omwe sachira
• kupweteka m'mimba kapena kutupa
• mipando yakuda ndi yodikira
• magazi ofiira m'mipando
• masanzi amagazi
• kusanza komwe kumawoneka ngati malo a khofi
• magazi mkodzo
• mwazi wa m'mphuno
• kutsokomola magazi

Pazopanib ikhoza kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Zizindikiro za bongo zingaphatikizepo:

• kutopa kwambiri

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Odzipereka^®