Jekeseni wa Tocilizumab

Zamkati

• Jekeseni wa Tocilizumab imagwiritsidwa ntchito payokha kapena kuphatikiza mankhwala ena kuti athetse zizindikiritso zamatenda amitundu ina ndi zina monga:
• Asanalandire jakisoni wa tocilizumab,
• Jakisoni wa Tocilizumab angayambitse mavuto. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa M'CHENJEZO CHOFUNIKA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:

Kugwiritsa ntchito jakisoni wa tocilizumab kumachepetsa kuthekera kwanu kothana ndi matenda kuchokera ku mabakiteriya, mavairasi, ndi bowa ndikuwonjezera chiopsezo kuti mutenga matenda owopsa kapena owopsa omwe angafalikire m'thupi. Uzani dokotala wanu ngati nthawi zambiri mumakhala ndi matenda aliwonse kapena ngati muli kapena mukuganiza kuti mutha kukhala ndi matenda aliwonse pano. Izi zimaphatikizapo matenda ang'onoang'ono (monga mabala otseguka kapena zilonda), matenda omwe amabwera ndikutha (monga zilonda zozizira), ndi matenda omwe akupitilira omwe samatha. Uzani dokotala wanu ngati mwakhalapo ndi matenda a shuga, kachilombo ka HIV, kapena vuto lililonse lomwe limakhudza chitetezo cha mthupi lanu, ndipo ngati muli ndi moyo, mudakhalako, kapena mwapita kumadera monga zigwa za Ohio ndi Mississippi ndi Kummwera chakumadzulo komwe matenda ofala a mafangasi amapezeka kwambiri. Funsani dokotala wanu ngati simukudziwa ngati matendawa amapezeka ponseponse m'dera lanu. Uzani dokotala wanu ngati mukumwa: abatacept (Orencia); adalimumab (Humira); anakinra (Kineret); certolizumab (Cimzia); etanercept (Enbrel); golimumab (Simponi); infliximab (Remicade); mankhwala omwe amaletsa chitetezo cha mthupi monga azathioprine (Azasan, Imuran), cyclosporine (Gengraf, Neoral, Sandimmune), methotrexate (Otrexup, Trexall, ena), sirolimus (Rapamune), ndi tacrolimus (Prograf); oral steroids monga dexamethasone, methylprednisolone, ndi prednisone (Rayos); kapena rituximab (Rituxan). Ngati mukumane ndi izi, uzani dokotala nthawi yomweyo: malungo; kuzizira; thukuta; kuvuta kupuma; chikhure; chifuwa; kuonda; kutsegula m'mimba; kupweteka m'mimba; magazi mu phlegm; kutopa kwambiri; kupweteka kwa minofu; khungu lofunda, lofiira, kapena lopweteka; zilonda pakhungu kapena pakamwa; kutentha mukakodza; pafupipafupi pokodza; kapena zizindikiro zina za matenda.

Mutha kukhala ndi chifuwa chachikulu (TB; mtundu wamatenda am'mapapo) kapena hepatitis B (mtundu wa matenda a chiwindi) koma mulibe zizindikiro zilizonse za matendawa. Poterepa, jakisoni wa tocilizumab akhoza kuonjezera chiopsezo kuti matenda anu adzakula kwambiri ndipo mudzakhala ndi zizindikiro. Dokotala wanu adzakuyesani khungu kuti muwone ngati muli ndi kachilombo ka TB kosagwira ntchito ndipo atha kuyitanitsa kuyesa magazi kuti muwone ngati muli ndi matenda a hepatitis B. Ngati ndi kotheka, dokotala wanu adzakupatsani mankhwala ochizira matendawa musanayambe kugwiritsa ntchito jakisoni wa tocilizumab. Uzani dokotala wanu ngati mwakhalapo ndi TB kapena hepatitis B, ngati mudapitako kudziko lililonse kumene TB imafala, kapena ngati mwakhalapo ndi munthu amene ali ndi TB. Ngati muli ndi zizindikiro zotsatirazi za chifuwa chachikulu cha TB, kapena ngati mukukhala ndi zina mwazizindikiro mukamalandira chithandizo, pitani kuchipatala nthawi yomweyo: kukhosomola, kupweteka pachifuwa, kutsokomola magazi kapena ntchofu, kufooka kapena kutopa, kuonda, kusowa njala, kuzizira, malungo, kapena thukuta usiku. Komanso itanani dokotala wanu nthawi yomweyo ngati muli ndi zina mwazizindikiro za matenda a chiwindi a B kapena ngati mungakhale ndi zina mwazizindikiro mukalandira kapena mutalandira chithandizo: kutopa kwambiri, khungu lachikaso kapena maso, kusowa chilakolako chambiri, nseru, kusanza, kupweteka kwa minofu, mkodzo wakuda, matumbo ofiira, kutentha thupi, kuzizira, kupweteka m'mimba, kapena zidzolo.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amayang'anira thanzi lanu mosamala kuti atsimikizire kuti simukukhala ndi matenda akulu. Dokotala wanu amalamula mayeso ena a labu musanachitike komanso mukamalandira chithandizo kuti muwone momwe thupi lanu lingayankhire jakisoni wa tocilizumab.

Dokotala wanu kapena wamankhwala adzakupatsani pepala lazidziwitso za wopanga (Medication Guide) mukayamba chithandizo ndi jakisoni wa tocilizumab ndipo nthawi iliyonse yomwe mumalandira mankhwalawo. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kuyendera tsamba la Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kapena tsamba laopanga kuti mupeze Medication Guide.

Lankhulani ndi dokotala wanu za kuopsa kogwiritsa ntchito jakisoni wa tocilizumab.

Jekeseni wa Tocilizumab imagwiritsidwa ntchito payokha kapena kuphatikiza mankhwala ena kuti athetse zizindikiritso zamatenda amitundu ina ndi zina monga:

• nyamakazi ya nyamakazi (momwe thupi limagwirira mafupa ake, kupweteketsa, kutupa, ndi kutayika kwa ntchito) mwa anthu omwe sanathandizidwe ndi mankhwala ena osintha matenda (DMARDs),
• giant cell arteritis (vuto lomwe limayambitsa kutupa kwa mitsempha, makamaka pamutu ndi pamutu),
• polyarticular juvenile idiopathic arthritis (PJIA; mtundu wamatenda amwana omwe amakhudza ziwalo zisanu kapena zingapo m'miyezi isanu ndi umodzi yoyambirira ya vutoli, zomwe zimapweteka, kutupa, komanso kutha kwa ntchito) mwa ana azaka 2 kapena kupitirira.
• Matenda a ana omwe amachititsa kuti kutupa kumadera osiyanasiyana mthupi, kuyambitsa malungo, kupweteka kwa mafupa ndi kutupa, kutha kwa ntchito, komanso kuchedwa kukula ndi chitukuko) mwa ana azaka 2 kapena kupitirira,
• cytokine release syndrome (yoopsa ndipo mwina yowopseza moyo) yomwe imachitika mwa akulu ndi ana azaka 2 kapena kupitirira atalandira ma infusions ena.

Jakisoni wa Tocilizumab ali mgulu la mankhwala otchedwa interleukin-6 (IL-6) receptor inhibitors. Zimagwira ntchito poletsa ntchito ya interleukin-6, chinthu m'thupi chomwe chimayambitsa kutupa.

Jakisoni wa Tocilizumab amabwera ngati yankho (madzi) oti alowe jakisoni (mumtsempha) m'manja mwanu ndi dokotala kapena namwino kuofesi ya zamankhwala kapena kuchipatala cha odwala kuchipatala kapena ngati jakisoni woyenera kubayikira pansi pa khungu) nokha kunyumba. Pamene tocilizumab imaperekedwa kudzera m'mitsempha yochizira nyamakazi kapena polyarticular achinyamata a idiopathic arthritis, imaperekedwa kamodzi pamasabata anayi. Mankhwala a tocilizumab akapatsidwa kudzera m'mitsempha yothetsera matenda a nyamakazi a ana, nthawi zambiri amaperekedwa kamodzi pakadutsa sabata limodzi kapena awiri. Pamene tocilizumab imaperekedwa kudzera m'mitsempha kuti ithetse matenda a cytokine release, nthawi zambiri imaperekedwa kamodzi, koma mpaka milingo itatu yowonjezera imatha kuperekedwa osachepera maola 8. Zitenga pafupifupi ola limodzi kuti mulandire jakisoni wa tocilizumab kudzera m'mitsempha. Pamene tocilizumab imaperekedwa mosakondera kuchiza nyamakazi kapena chimphona cha arteritis, nthawi zambiri imaperekedwa kamodzi sabata iliyonse kapena kamodzi sabata iliyonse.

Mulandila jakisoni woyamba wa mankhwala a tocilizumab mu ofesi ya dokotala. Ngati mukubaya jekeseni wa tocilizumab modzidzimutsa nokha kunyumba kapena kukhala ndi mnzanu kapena wachibale akubayirani mankhwalawo, dokotala wanu akuwonetsani inu kapena munthu amene akulowetsani mankhwalawo momwe angawabayire. Inu ndi munthu amene mukubaya mankhwalawo muyeneranso kuwerenga malangizo omwe agwiritsidwe ntchito omwe amabwera ndi mankhwalawo.

Mphindi makumi atatu musanakonzekere kubaya jakisoni wa tocilizumab, muyenera kuchotsa mankhwalawo mufiriji, kuwatulutsa mukatoni ake, ndi kuwalola kuti afike kutentha. Mukamachotsa jakisoni woyambira m'bokosi, samalani kuti musakhudze zala zoyambira pa syringe. Osayesa kutenthetsa mankhwalawo powotenthetsa mu microwave, ndikuwayika m'madzi ofunda, kapena njira ina iliyonse.

Musachotse kapu m'jekeseni yoyambilira pomwe mankhwala akutentha. Muyenera kuchotsa kapu osapitirira mphindi zisanu musanafike jakisoni wamankhwala. Osachotsa kapu mutachotsa. Musagwiritse ntchito syringe mukamaigwetsa pansi.

Chongani jakisoni woyikiratu kuti mutsimikizire kuti tsiku lotha ntchito lomwe lidasindikizidwa paphukusili silinadutse, Kugwira sirinji yomwe singano yokutidwa ikuloza pansi, yang'anani mosamala madzi a mu syringe. Madziwo ayenera kukhala oyera kapena otumbululuka achikasu ndipo sayenera kukhala mitambo kapena yopaka utoto kapena kukhala ndi zotumphukira kapena tinthu tating'onoting'ono. Itanani wamankhwala wanu ngati pali vuto lililonse ndi phukusi kapena syringe ndipo musabayire mankhwala.

Mutha kubaya jakisoni wa tocilizumab patsogolo pa ntchafu kapena paliponse m'mimba kupatula mchombo wanu (batani lamimba) ndi dera mainchesi awiri mozungulira. Ngati wina akubaya jakisoni wamankhwala anu, malo akunja am'manja atha kugwiritsidwanso ntchito. Osalowetsa mankhwala pakhungu lofewa, lophwanyika, lofiira, lolimba, kapena losasunthika, kapena lomwe lili ndi zipsera, timadontho, kapena mikwingwirima. Sankhani malo osiyana nthawi iliyonse mukamamwa mankhwala, osachepera inchi imodzi kuchokera pomwe mudagwiritsapo ntchito kale. Ngati mulingo wathunthu sunabayidwe, itanani dokotala wanu kapena wamankhwala.

Musagwiritsenso ntchito majekeseni oyeserera a tocilizumab ndipo musabwerenso ma syringe mukatha kugwiritsa ntchito. Tayani majakisoni aliwonse omwe amagwiritsidwa ntchito mchidebe chosagwiritsika ntchito ndipo funsani wamankhwala wanu momwe angatayere beseniyo.

Jakisoni wa Tocilizumab amatha kuthandizira kuwongolera zizindikilo zanu, koma sizingathetse vuto lanu. Dokotala wanu amakuyang'anirani mosamala kuti muwone momwe jakisoni wa tocilizumab amakugwirirani ntchito. Dokotala wanu amatha kusintha mlingo wanu kapena kuchedwetsa chithandizo chanu ngati mutasintha zina pazakuyeza kwanu. Ndikofunika kuuza dokotala momwe mukumvera mukamalandira chithandizo.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Asanalandire jakisoni wa tocilizumab,

• uzani dokotala ndi wamankhwala ngati muli ndi vuto la tocilizumab, mankhwala ena aliwonse, kapena zina zilizonse mu jakisoni wa tocilizumab. Funsani wamankhwala wanu kapena onani Chithandizo cha Mankhwala kuti mupeze mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchula mankhwala omwe atchulidwa mgawo la CHENJEZO LACHENJEZO ndi zina mwa izi: anticoagulants ('magazi ochepetsa magazi') monga warfarin (Coumadin, Jantoven); aspirin ndi mankhwala ena osakanikirana ndi kutupa (NSAIDs) monga ibuprofen (Advil, Motrin, ena) ndi naproxen (Aleve, Naprosyn, ena); mankhwala ochepetsa mafuta m'thupi (ma statins) monga atorvastatin (Lipitor, ku Caduet), lovastatin (Altoprev, mu Advicor), ndi simvastatin (Zocor, ku Vytorin); njira zakulera zam'kamwa (mapiritsi olera); kapena theophylline (Elixophyllin, Theo-24, ena). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi jakisoni wa tocilizumab, chifukwa chake onetsetsani kuti muwauze adotolo za mankhwala omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• uzani dokotala wanu ngati mwakhalapo ndi khansa kapena mwakhalapo; diverticulitis (timatumba tating'onoting'ono tamkati mwa matumbo akulu omwe amatha kutentha); zilonda zam'mimba kapena m'matumbo; cholesterol ndi triglycerides; Matenda aliwonse omwe amakhudza dongosolo lamanjenje monga multiple sclerosis (MS; matenda omwe misempha sagwira ntchito moyenera ndipo anthu amatha kufooka, kufooka, kutayika kwa kulumikizana kwa minofu ndi mavuto a masomphenya, kulankhula, ndi chikhodzodzo) demyelinating polyneuropathy (CIDP; vuto lama chitetezo chamthupi ndi manjenje); kapena matenda a chiwindi.
• Uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena mukuyamwitsa. Mukakhala ndi pakati mukalandira jakisoni wa tocilizumab, itanani dokotala wanu.
• ngati mukuchitidwa opaleshoni, kuphatikizapo opaleshoni ya mano, uzani dokotala kapena dokotala kuti mukulandira jakisoni wa tocilizumab.
• Funsani dokotala ngati mukufuna kulandira katemera musanayambe mankhwala anu ndi jakisoni wa tocilizumab. Ngati kuli kotheka, katemera aliyense wa ana ayenera kukonzedwa bwino asanayambe kulandira chithandizo. Musakhale ndi katemera uliwonse mukamalandira chithandizo popanda kulankhula ndi dokotala.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Ngati mwaphonya nthawi yoti mulandire kulowetsedwa kwa tocilizumab, itanani dokotala wanu.

Mukaiwala kubaya jakisoni wa tocilizumab, pezani jakisoni mukangokumbukira. Komabe, ngati ili pafupi nthawi ya mlingo wotsatira, dumpha mlingo womwe umasowa ndikupitiliza dongosolo lanu lokhazikika. Osabaya jakisoni kawiri kuti mupange yomwe mwaphonya. Itanani dokotala wanu kapena wamankhwala ngati simukudziwa nthawi yoyenera jekeseni wa tocilizumab.

Jakisoni wa Tocilizumab angayambitse mavuto. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• mutu
• kutuluka mphuno kapena kuyetsemula
• kufiira, kuyabwa, kupweteka, kapena kutupa pamalo pomwe tocilizumab idalowetsedwa

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa M'CHENJEZO CHOFUNIKA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:

• zidzolo
• kuchapa
• ming'oma
• kuyabwa
• kutupa kwa maso, nkhope, milomo, lilime, mmero, mikono, manja, mapazi, akakolo, kapena miyendo yakumunsi
• kuvuta kupuma kapena kumeza
• kupweteka pachifuwa
• chizungulire kapena kukomoka
• malungo, kupweteka kwam'mimba kosalekeza, kapena kusintha kwa matumbo
• maso achikaso kapena khungu; ululu wakum'mimba chapamwamba; kuvulala kapena kutuluka magazi mosadziwika; kusowa chilakolako; chisokonezo; mkodzo wachikaso kapena wabulauni; kapena chimbudzi chotumbululuka

Tocilizumab imatha kuwonjezera chiopsezo chokhala ndi mitundu ina ya khansa. Lankhulani ndi dokotala wanu za kuopsa kolandira mankhwalawa.

Jakisoni wa Tocilizumab amatha kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukalandira mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwalawa mu phukusi lomwe adalowamo, kutali ndi kuwala, kutsekedwa mwamphamvu, komanso komwe ana sangakwanitse. Sungani jekeseni wa tocilizumab mufiriji, koma musayimitse. Sungani ma syringe oyikirapo kale. Tayani mankhwala aliwonse akale kapena osafunikanso. Lankhulani ndi wamankhwala wanu za momwe mungagwiritsire ntchito mankhwala anu.

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudza jekeseni wa tocilizumab.

Musalole kuti wina aliyense agwiritse ntchito mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Actemra^®