Rilpivirine

Zamkati

• Musanatenge rilpivirine,
• Rilpivirine amatha kuyambitsa mavuto. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, kapena zomwe zalembedwa mu gawo LAPadera, itanani dokotala wanu mwachangu:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi chimodzi mwazizindikirozi siyani kumwa rilpivirine ndipo itanani dokotala nthawi yomweyo kapena mupeze chithandizo chadzidzidzi:

Rilpivirine imagwiritsidwa ntchito limodzi ndi mankhwala ena kuchiza kachilombo koyambitsa matenda a chitetezo cha mthupi (1-HIV-1) mwa anthu ena achikulire ndi ana azaka 12 kapena kupitilira apo omwe amalemera 77 lb (35 kg) ndipo sanalandirepo mankhwala ochepetsa mphamvu ya kachilombo ka HIV m'mbuyomu. Amagwiritsidwanso ntchito limodzi ndi cabotegravir (Vocabria) ngati chithandizo chakanthawi kochepa cha kachilombo ka HIV-1 mwa achikulire ena. Rilpivirine ali mgulu la mankhwala otchedwa non-nucleoside reverse transcriptase inhibitors (NNRTIs). Zimagwira ntchito pochepetsa kuchuluka kwa kachilombo ka HIV m'magazi. Ngakhale rilpivirine sichitha kachilombo ka HIV, imatha kuchepetsa mwayi wanu wopeza matenda a immunodeficiency (AIDS) ndi matenda okhudzana ndi HIV monga matenda akulu kapena khansa. Kumwa mankhwalawa pamodzi ndi kugonana mosatekeseka ndikusintha zina pamoyo wanu kumachepetsa chiopsezo chotenga (kufalitsa) kachirombo ka HIV kwa anthu ena.

Rilpivirine imabwera ngati piritsi kuti itenge pakamwa. Nthawi zambiri amatengedwa ndi chakudya (osati chakumwa chokha cha mapuloteni) kamodzi patsiku. Rilpivirine akatengedwa limodzi ndi cabotegravir, nthawi zambiri amatengedwa kamodzi tsiku lililonse ndikudya. Tengani rilpivirine nokha kapena pamodzi ndi cabotegravir mozungulira nthawi yomweyo tsiku lililonse. Rilpivirine amatengedwa limodzi ndi cabotegravir kwa mwezi umodzi (masiku osachepera 28) asanayambe kulandira mankhwala ndi mitundu yayitali ya mankhwalawa kapena kwa miyezi iwiri ngati ndondomekoyi siyikupezeka kwa masiku opitilira 7. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani rilpivirine ndendende monga momwe akuuzira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Rilpivirine amalamulira kachilombo ka HIV koma samachiritsa. Pitirizani kumwa rilpivirine ngakhale mukumva bwino. Osasiya kumwa rilpivirine osalankhula ndi dokotala. Rilpivirine yanu ikayamba kuchepa, pezani zambiri kuchokera kwa dokotala kapena wamankhwala. Mukaphonya Mlingo kapena kusiya kumwa rilpivirine, vuto lanu limatha kukhala lovuta kuchiza.

Funsani wamankhwala kapena dokotala wanu kuti mumupatseko zidziwitso za wopanga kwa wodwalayo.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge rilpivirine,

• uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la rilpivirine, mankhwala ena aliwonse, kapena chilichonse mwazomwe zimaphatikizidwa pamapiritsi a rilpivirine. Funsani wamankhwala wanu kuti awonetse mndandanda wazosakaniza.
• Uzani dokotala wanu ngati mukumwa dexamethasone (Decadron); mankhwala a khunyu kuphatikizapo carbamazepine (Carbatrol, Epitol, Euetro, Tegretol, Teril), oxcarbazepine (Trileptal), phenobarbital (Luminal), kapena phenytoin (Dilantin, Phenytek); proton pump inhibitors kuphatikizapo dexlansoprazole (Dexilant), esomeprazole (Nexium, Vimovo), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), kapena rabeprazole (Aciphex); rifampin (Rifater, Rifamate, Rimactane, Rifadin); rifapentine (Priftin); ndi wort wa St. Dokotala wanu angakuuzeni kuti musamwe rilpivirine ngati mukumwa mankhwala amodzi kapena angapo.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: mankhwala oletsa mafungal, kuphatikiza fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), ndi voriconazole (Vfend); amiodarone (Nexterone, Pacerone); anagrelide (Agrylin); chloroquine; mankhwala enaake; chilonda; ciprofloxacin (Cipro); citalopram (Celexa); clarithromycin (Biaxin); disopyramide (Norpace); dofetilide (Tikosyn); donepezil (Aricept); erythromycin (E-Mycin, Eryc, Ery-Tab, PCE, Pediazole); zachilengedwe (Tambocor); haloperidol (Haldol); ibutilide (Corvert); levofloxacin; methadone (Dolophine); moxifloxacin (Velox); nelfinavir (Viracept); ondansetron (Zuplenz, Zofran); Mankhwala ena a NNRTI ochiza HIV / AIDS; pentamidine (NebuPent, Pentam); pimozide (Orap); kupeza; quinidine (mu Nuedexta); rifabutin (Mycobutin); sotalol (Betapace, Sorine, Sotylize); telithromycin (Ketek); ndi thioridazine. Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi rilpivirine, chifukwa chake onetsetsani kuti muwauze adotolo za mankhwala omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• ngati mukumwa maantacid okhala ndi calcium, magnesium, kapena aluminium (Maalox, Mylanta, Tums, ena), amwe nawo osachepera maola 2 isanathe kapena maola 4 kuchokera rilpivirine.
• ngati mukumwa mankhwala a kudzimbidwa, kutentha pa chifuwa, kapena zilonda monga cimetidine (Tagamet), famotidine (Pepcid), nizatidine (Axid), kapena ranitidine (Zantac), imwani osachepera maola 12 isanakwane kapena osachepera maola 4 pambuyo pa rilpivirine .
• ngati mukumwa didanosine (Videx), imwani osachepera maola 2 kale kapena osachepera maola 4 kuchokera rilpivirine.
• auzeni adotolo ngati mwakhalapo ndi vuto lokhumudwa kapena matenda amisala, matenda a chiwindi, kuphatikiza hepatitis B kapena C, kapena matenda a impso.
• Uzani dokotala wanu ngati muli ndi pakati kapena mukufuna kukhala ndi pakati. Mukakhala ndi pakati mukamamwa rilpivirine, itanani dokotala wanu. Uzani dokotala wanu ngati mukuyamwitsa. Simuyenera kuyamwa ngati muli ndi kachilombo ka HIV kapena ngati mukumwa rilpivirine.
• muyenera kudziwa kuti mafuta amthupi lanu amatha kuchuluka kapena kusunthira mbali zosiyanasiyana za thupi lanu monga mabere, kumtunda ndi khosi, kapena kuzungulira pakati pa thupi lanu. Kutaya mafuta kuchokera kumiyendo, mikono, ndi nkhope kumatha kuchitika.
• muyenera kudziwa kuti rilpivirine imatha kusintha malingaliro anu, machitidwe anu, kapena thanzi lanu. Itanani dokotala wanu nthawi yomweyo ngati mungakhale ndi zizindikiro izi mukamamwa rilpivirine: kukhumudwa kwatsopano kapena kukulira; kumva chisoni, kutaya chiyembekezo, kuda nkhawa, kapena kusakhazikika; kapena kuganiza zodzipha kapena kukonzekera kapena kuyesa kutero. Onetsetsani kuti banja lanu likudziwa zomwe zingakhale zovuta kuti athe kuyimbira dokotala ngati simungathe kupeza chithandizo chanokha.
• muyenera kudziwa kuti pamene mukumwa mankhwala ochizira kachilombo ka HIV, chitetezo chanu cha mthupi chingakhale champhamvu ndikuyamba kulimbana ndi matenda ena omwe anali kale mthupi lanu kapena amayambitsa zina. Izi zitha kukupangitsani kukhala ndi zizindikilo za matendawa kapena mikhalidwe. Ngati muli ndi zizindikiro zatsopano kapena zowonjezereka mutayamba kumwa mankhwala ndi rilpivirine, onetsetsani kuti mwauza dokotala.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Tengani mlingo womwe mwaphonya mukangokumbukira, ndi chakudya. Komabe, ngati patha maola opitilira 12 kuchokera pomwe mumaliza kumwa, tulukani mlingo womwe mwaphonya ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Rilpivirine amatha kuyambitsa mavuto. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kuvuta kugona kapena kugona
• mutu
• nseru
• kusanza
• chizungulire
• kupweteka m'mimba
• Kusinza

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, kapena zomwe zalembedwa mu gawo LAPadera, itanani dokotala wanu mwachangu:

• zidzolo
• chikasu cha khungu kapena maso, kupweteka kumanja kwa m'mimba, nseru, kusanza, ndowe zowala, mkodzo wakuda

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi chimodzi mwazizindikirozi siyani kumwa rilpivirine ndipo itanani dokotala nthawi yomweyo kapena mupeze chithandizo chadzidzidzi:

• zidzolo pamodzi ndi malungo, kutupa kwa nkhope, milomo, pakamwa, lilime, kapena pakhosi, zotupa, kupuma movutikira kapena kumeza, zilonda mkamwa, kufiira kapena kutupa kwa maso (conjunctivitis), kupweteka kumanja kwa m'mimba (m'mimba), kapena mkodzo wachikuda

Rilpivirine amatha kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisunge kutentha komanso kutali ndi kuwala, kutentha kwambiri ndi chinyezi (osati kubafa).

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena a labu kuti muwone momwe thupi lanu limayankhira rilpivirine.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Sungani rilpivirine m'manja. Musayembekezere mpaka mutatsala pang'ono kumwa mankhwala kuti mudzaze mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Edurant^®
• Juluca^® (monga chinthu chophatikizira chomwe chili ndi dolutegravir, rilpivirine)