Telaprevir

Zamkati

• Musanatenge telaprevir,
• Telaprevir ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi kapena zina mwazomwe zalembedwa mu gawo la CHENJEZO LOFUNIKA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:
• Zizindikiro za bongo zingaphatikizepo izi:

Telaprevir sichikupezeka ku United States pambuyo pa Okutobala 16, 2014. Ngati mukugwiritsa ntchito telaprevir, muyenera kuyimbira dokotala kuti akambirane zosinthira kuchipatala china.

Telaprevir itha kuyambitsa khungu kapena kuwononga khungu. Itanani dokotala wanu nthawi yomweyo kapena pitani kuchipatala mwadzidzidzi mukakumana ndi izi: zotupa, zotupa, kapena zilonda pakhungu; kuyabwa; malungo; nkhope yotupa; zilonda mkamwa; kapena ofiira, otupa, oyabwa, kapena amisozi. Dokotala wanu angakuuzeni kuti musiye kumwa telaprevir (mwinanso mankhwala ena) ngati khungu lanu lisintha; osasiya kumwa mankhwala anu pokhapokha adokotala atakuwuzani kuti muchite izi. Ngati dokotala akukuuzani kuti musiye kumwa telaprevir chifukwa cha kusintha kwa khungu, simuyenera kuyambiranso.

Telaprevir imagwiritsidwa ntchito limodzi ndi mankhwala ena awiri (ribavirin [Copegus, Rebetol] ndi peginterferon alfa [Pegasys]) kuchiza matenda a chiwindi a C (matenda opatsirana omwe amawononga chiwindi) mwa anthu omwe sanalandire chithandizo cha matendawa kapena omwe Matendawa sakanatha kuchiritsidwa ndi ribavirin ndi peginterferon alfa yekha. Telaprevir ali mgulu la mankhwala otchedwa protease inhibitors. Zimagwira ntchito pochepetsa kuchuluka kwa kachilombo ka hepatitis C (HCV) mthupi. Telaprevir sangalepheretse kufalikira kwa matenda a chiwindi a C kwa anthu ena.

Telaprevir imabwera ngati piritsi kuti itenge pakamwa. Nthawi zambiri amatengedwa kawiri patsiku (maola 10 kapena 14 aliwonse). Muyenera kudya chakudya kapena chotupitsa chomwe chili ndi pafupifupi magalamu 20 a mafuta mkati mwa mphindi 30 musanatenge telaprevir. Zitsanzo za zakudya (mitundu yanthawi zonse, osakhala mafuta ochepa kapena osagwiritsa ntchito mafuta) omwe atha kutengedwa ndi telaprevir ndi awa: bagel wokhala ndi kirimu tchizi, 1/2 mtedza wa chikho, supuni 3 chiponde, kapu 1 ayisikilimu, ma ola awiri aku America kapena cheddar tchizi, tchipisi tating'onoting'ono tating'onoting'ono tating'onoting'ono tating'onoting'ono tating'onoting'ono tating'onoting'ono tomwe. Funsani dokotala wanu zitsanzo zina za zakudya zomwe zili ndi magalamu 20 a mafuta omwe mungadye mukamamwa telaprevir. Musatenge telaprevir popanda chakudya. Tengani telaprevir mozungulira nthawi yofanana tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani telaprevir ndendende monga mwalamulo. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Kumeza mapiritsi lonse; osagawana, kuphwanya, kapena kutafuna. Ngati simungathe kumeza mapiritsi athunthu, uzani dokotala wanu.

Pitirizani kumwa telaprevir ngakhale mukumva bwino. Telaprevir imayenera kutengedwa limodzi ndi peginterferon alfa ndi ribavirin, makamaka kwa milungu 12. Peginterferon alfa ndi ribavirin nthawi zambiri amapitilira mukamaliza mankhwala a telaprevir. Osasiya kumwa telaprevir, peginterferon alfa, kapena ribavirin, pokhapokha akauzidwa ndi dokotala wanu.

Dokotala wanu kapena wamankhwala adzakupatsani pepala lazidziwitso za wopanga (Medication Guide) mukayamba mankhwala ndi telaprevir ndipo nthawi iliyonse mukamadzaza mankhwala anu. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kuyendera tsamba la Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kapena tsamba laopanga kuti mupeze Medication Guide.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge telaprevir,

• uzani dokotala wanu komanso wamankhwala ngati simukugwirizana ndi telaprevir, ribavirin (Copegus, Rebetol), peginterferon alfa (Pegasys), mankhwala ena aliwonse, kapena zosakaniza zilizonse m'mapiritsi a telaprevir. Funsani wamankhwala wanu kapena onani Chithandizo cha Mankhwala kuti mupeze mndandanda wazosakaniza.
• Uzani dokotala ngati mukumwa mankhwala aliwonse otsatirawa kapena mankhwala azitsamba: alfuzosin (Uroxatral); carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril); cisapride (Propulsid) (sichikupezeka ku United States); mankhwala a ergot monga dihydroergotamine (DHE 45, Migranal), ergotamine (Ergomar, ku Cafergot, ku Migergot), ergonovine, ndi methylergonovine (Methergine); lovastatin (Altoprev, Mevacor, mu Advicor); midazolam yotengedwa pakamwa; phenobarbital, phenytoin (Dilantin, Phenytek); pimozide (Orap); rifampin (Rifadin, Rimactane, ku Rifamate, ku Rifater); sildenafil (mtundu wa Revatio wokha womwe umagwiritsidwa ntchito matenda am'mapapo); simvastatin (Zocor, ku Simcor, ku Vytorin); Chingwe cha St. katatu (Halcion); ndi tadalafil (mtundu wa Adcirca wokha womwe umagwiritsidwa ntchito matenda am'mapapo). Dokotala wanu angakuuzeni kuti musamwe telaprevir ngati mukumwa mankhwala amodzi kapena angapo.
• Uzani dokotala wanu komanso wamankhwala mankhwala ena omwe simukupatsidwa, mavitamini, ndi zowonjezera zakudya zomwe mukumwa kapena mukukonzekera. Onetsetsani kuti mwatchulapo izi: alprazolam (Niravam, Xanax); maanticoagulants ('oonda magazi') monga warfarin (Coumadin, Jantoven); mankhwala oletsa mafungal monga itraconazole (Onmel, Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), kapena voriconazole (Vfend); chifuwa (Tracleer); budesonide (Pulmicort, Rhinocort, ku Symbicort); zotchinga calcium monga amlodipine (Norvasc, ku Amturnide, ku Tekamlo), diltiazem (Cardizem, Cartia XT, Dilacor, Diltzac, Dilt-CD, Tiazac, Taztia XT, ena), felodipine (Plendil), nicardipine (Cardene), nifedipine (Afeditab CR, Adalat, Procardia), nisoldipine (Sular), ndi verapamil (Calan, Covera, Verelan, ku Tarka); mankhwala ochepetsa mafuta m'thupi monga atorvastatin (Lipitor, ku Caduet, ku Liptruzet), fluvastatin (Lescol), pitavastatin (Livalo), pravastatin (Pravachol), ndi rosuvastatin (Crestor); clarithromycin (Biaxin, mu Prevpac); colchicine (Colcrys, mu Col-probenecid); digoxin (Lanoxin); efavirenz (Sustiva, ku Atripla); erythromycin (EES, E-Mycin, ena); escitalopram (Lexapro); fentanyl (Abstral, Actiq, Duragesic, Fentora, Lazanda, Subsys); fluticasone (ku Advair, Flonase, Flovent); mankhwala othandizira mahomoni (HRT); ma immunosuppressants monga cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), kapena tacrolimus (Prograf); mankhwala a erectile dysfunction (ED) monga sildenafil (Viagra), tadalafil (Cialis), kapena vardenafil (Levitra, Staxyn); mankhwala a kugunda kwamtima mosasinthasintha monga amiodarone (Cordarone, Pacerone), flecainide, lidocaine (Lidoderm, Lidopen, Xylocaine), propafenone (Rhythmol), kapena quinidine; methadone (Dolophine, Methadose); jekeseni wa midazolam; njira zakulera zakumwa ('mapiritsi oletsa kubereka'); oral steroids monga dexamethasone, methylprednisolone (Depo-Medrol, Medrol, Solu-Medrol), ndi prednisone (Rayos); repaglinide (Prandin, ku Prandimet); rifabutin (Mycobutin); ritonavir (Norvir, ku Kaletra) amagwiritsidwa ntchito limodzi ndi HIV protease inhibitors monga atazanavir (Reyataz), darunavir (Prezista), fosamprenavir (Lexiva), ndi lopinavir (ku Kaletra); salmeterol (Serevent, ku Advair); telithromycin (Ketek); tenofovir (Viread, ku Atripla, ku Stribild, ku Truvada); trazodone (Oleptro); ndi zolpidem (Ambien, Edluar, Intermezzo, Zolpmist). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi telaprevir, chifukwa chake onetsetsani kuti muwauze adotolo za mankhwala omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• Uzani dokotala wanu ngati mwakhala ndikuika thupi. Komanso muuzeni dokotala ngati mwakhalapo ndi kuchepa kwa magazi (osakhala ndi magazi ofiira okwanira m'magazi kuti anyamule mpweya mthupi lonse), gout (kuwukira kwa mafupa olumikizana chifukwa cha kuchuluka kwa uric acid m'magazi), kachilombo ka HIV (HIV), mavuto amthupi lanu, hepatitis B (HBV) kapena matenda a chiwindi kupatula hepatitis C ..
• ngati mukuchitidwa opaleshoni, kuphatikizapo opaleshoni ya mano, uzani dokotala kapena dokotala kuti mukumwa telaprevir.
• Uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena mutha kutenga pakati. Ngati ndinu wamwamuna, auzeni dokotala ngati mnzanu ali ndi pakati, akukonzekera kutenga pakati, kapena atha kutenga pakati. Telaprevir iyenera kutengedwa ndi ribavirin, yomwe imatha kuvulaza mwana wosabadwayo. Muyenera kugwiritsa ntchito njira ziwiri zakulera kuti muchepetse mimba mwa inu kapena mnzanu mukamalandira mankhwalawa komanso kwa miyezi 6 mutalandira chithandizo. Lankhulani ndi dokotala wanu za njira zomwe muyenera kugwiritsa ntchito; Njira zolerera za mahomoni (mapiritsi oletsa kubereka, zigamba, ma implant, mphete, kapena jakisoni) sizingagwire bwino ntchito kwa azimayi omwe amamwa mankhwalawa komanso kwa milungu iwiri atalandira chithandizo. Inu kapena mnzanu muyenera kuyesedwa ngati muli ndi pakati mwezi uliwonse mukamalandira chithandizo komanso kwa miyezi 6 mutalandira chithandizo. Ngati inu kapena mnzanu mumakhala ndi pakati mukamamwa mankhwalawa, itanani dokotala wanu mwachangu.
• Uzani dokotala wanu ngati mukuyamwitsa.

Samalani kwambiri kuti muzimwa madzi okwanira mukamalandira mankhwalawa.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Ngati mukukumbukira mlingo womwe mwaphonya pasanathe maola 6 kuchokera nthawi yomwe mudayenera kumwa, tengani mlingo womwe mudasowa ndi chotupitsa kapena chakudya (chomwe chili ndi pafupifupi magalamu 20 a mafuta) nthawi yomweyo. Komabe, ngati papitilira maola 6 kuyambira pomwe mudamwa, tulukani mlingo womwe mwaphonyawo ndikupitilizabe ndi dosing yanu. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Telaprevir ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• nseru
• kusanza
• kutsegula m'mimba
• sinthani kuti mulawe
• kuyabwa
• zotupa m'mimba
• kusapeza bwino, kuwotcha, kapena kuyabwa mozungulira anus

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi kapena zina mwazomwe zalembedwa mu gawo la CHENJEZO LOFUNIKA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:

• khungu lotumbululuka
• chizungulire
• kupuma movutikira
• kutopa
• kufooka
• ludzu lowonjezeka
• mkodzo wachikuda
• pakamwa pouma
• amachepetsa kukodza pafupipafupi kapena kuchuluka
• amavutika kudya kapena amasanza kwambiri kapena kutsekula m'mimba.

Telaprevir ikhoza kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Zizindikiro za bongo zingaphatikizepo izi:

• nseru
• kutsegula m'mimba
• kusanza
• mutu
• kusowa chilakolako
• kusintha kwa kukoma

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena a labu kuti muwone momwe thupi lanu likuyankhira telaprevir.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Zosokoneza^®