Jekeseni wa Brentuximab Vedotin

Zamkati

• Brentuximab vedotin jekeseni amagwiritsidwa ntchito
• Asanalandire jakisoni wa brentuximab vedotin,
• Jekeseni wa Brentuximab vedotin imatha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa M'CHENJEZO CHOFUNIKA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:
• Zizindikiro za bongo zingaphatikizepo izi:

Kulandila jakisoni wa brentuximab vedotin kungapangitse kuti mukhale ndi chiopsezo chokhala ndi leukoencephalopathy (PML); matenda opatsirana aubongo omwe sangachiritsidwe, kupewedwa, kapena kuchiritsidwa ndipo nthawi zambiri amayambitsa imfa kapena kulemala kwambiri). Uzani dokotala wanu ngati mwakhalapo kapena munakhalapo ndi vuto lomwe limakhudza chitetezo chanu chamthupi. Uzani dokotala ndi wamankhwala ngati mukumwa mankhwala aliwonse omwe amalepheretsa chitetezo cha mthupi. Ngati mukumane ndi izi, siyani kulandira jakisoni wa brentuximab vedotin ndipo itanani dokotala nthawi yomweyo: kuchepa mphamvu kapena kufooka mbali imodzi ya thupi; kuyenda movutikira; kutayika kwa mgwirizano; mutu; chisokonezo; kuvuta kuganiza bwino; kukumbukira kukumbukira; kusintha kwamakhalidwe kapena machitidwe wamba; kuvuta kuyankhula; kapena masomphenya amasintha.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu akhoza kuyitanitsa mayeso ena kuti aone momwe thupi lanu likuyankhira jekeseni wa brentuximab vedotin.

Lankhulani ndi dokotala wanu za kuopsa kolandila jakisoni wa brentuximab vedotin.

Brentuximab vedotin jekeseni amagwiritsidwa ntchito

• kuphatikiza ndi mankhwala ena a chemotherapy ochizira Hodgkin's lymphoma (matenda a Hodgkin) mwa iwo omwe sanalandire chithandizo m'mbuyomu,
• kuchiza Hodgkin's lymphoma mwa iwo omwe ali pachiwopsezo kuti matenda awo adzawonjezeke kapena kubweranso pambuyo pokhazikitsidwa ndi tsinde (njira yomwe imalowetsa m'mafupa odwala ndi mafupa athanzi),
• kuchiza Hodgkin's lymphoma mwa iwo omwe sanayankhe pakhungu lothandizira (njira yomwe imalowetsa m'mafupa odwala ndi mafupa abwino) kapena nthawi ziwiri zamankhwala,
• Kuphatikizana ndi mankhwala ena a chemotherapy ochizira anaplastic large cell lymphoma (sALCL; mtundu wa non-Hodgkin lymphoma) ndi mitundu ina ya zotumphukira T-cell lymphomas (PTCL; mtundu wa omwe si a Hodgkin lymphoma) mwa iwo omwe sanakhalepo kale analandira chithandizo,
• kuchiza systemic sALCL mwa iwo omwe sanayankhe nthawi ina ya mankhwala a chemotherapy,
• kuchiza mtundu wina wa zotupa zoyambirira zopangidwa ndi pullastic lalikulu cell lymphoma (pcALCL; mtundu wa non-Hodgkin's lymphoma) mwa anthu omwe adalandirapo chithandizo china.

Jakisoni wa Brentuximab vedotin ali mgulu la mankhwala otchedwa anti-drug conjugates. Zimagwira ntchito popha ma cell a khansa.

Jakisoni wa Brentuximab vedotin amabwera ngati ufa woti azisakanizidwa ndi madzi ndikubayidwa mphindi 30 mkati mwa minyewa (mumtsempha) ndi dokotala kapena namwino kuofesi yazachipatala kapena kuchipatala. Brentuximab vedotin ikaperekedwa kuti ichiritse Hodgkin's lymphoma, sALCL, kapena PTCL, nthawi zambiri imabayidwa kamodzi pamasabata atatu bola dokotala atakulimbikitsani kuti mulandire chithandizo. Pamene brentuximab vedotin imagwiritsidwa ntchito limodzi ndi chemotherapy yochizira Hodgkin lymphoma ngati mankhwala oyamba, nthawi zambiri amabayidwa kamodzi pamasabata awiri bola dokotala atakulimbikitsani kuti mulandire chithandizo.

Jekeseni wa Brentuximab vedotin imatha kuyambitsa mavuto ena, omwe nthawi zambiri amachitika pakulowetsedwa kwa mankhwalawo kapena mkati mwa maola 24 mulandila mlingo. Mutha kulandira mankhwala ena musanalowetsedwe kuti muchepetse zovuta ngati mungayesedwe ndi mankhwala am'mbuyomu. Dokotala wanu amakuyang'anirani mosamala mukalandira brentuximab vedotin. Ngati mukumane ndi izi, uzani dokotala nthawi yomweyo: malungo, kuzizira, zotupa, ming'oma, kuyabwa, kapena kupuma movutikira.

Dokotala wanu angafunikire kuchedwetsa chithandizo chanu, kusintha mlingo wanu, kapena kuyimitsa chithandizo chanu mukakumana ndi zovuta zina. Onetsetsani kuti muuze dokotala momwe mukumvera mukamalandira chithandizo cha jakisoni wa brentuximab vedotin.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Asanalandire jakisoni wa brentuximab vedotin,

• uzani dokotala wanu komanso wamankhwala ngati simukugwirizana ndi brentuximab vedotin, mankhwala ena aliwonse, kapena zosakaniza zilizonse mu jakisoni wa brentuximab vedotin. Funsani wamankhwala wanu kuti awonetse mndandanda wazosakaniza.
• uzani dokotala wanu ngati mukulandira bleomycin. Dokotala wanu angakuuzeni kuti musagwiritse ntchito jakisoni wa brentuximab vedotin ngati mukulandira mankhwalawa.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: clarithromycin (Biaxin, ku PrevPac), indinavir (Crixivan), itraconazole (Sporanox), ketoconazole, nefazodone, nelfinavir (Viracept), rifampin (Rifadin, Rimactane, ku Rifamate, and Rifater) ritonavir (Norvir, ku Kaletra). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
• auzeni adotolo ngati mwadwalapo chiwindi kapena impso.
• Uzani dokotala wanu ngati muli ndi pakati kapena mukufuna kukhala ndi pakati. Ngati ndinu mayi amene angathe kutenga pakati, muyenera kuyezetsa asanayambe kulandira chithandizo ndikugwiritsa ntchito njira yolerera panthawi yomwe mukumwa mankhwala komanso kwa miyezi 6 mutatha kumwa. Ngati muli amuna ndi akazi omwe ali ndi pakati kapena atha kukhala ndi pakati, muyenera kugwiritsa ntchito njira yolerera yoyenerera mukamalandira chithandizo komanso kwa miyezi isanu ndi umodzi mutatha kumwa. Lankhulani ndi dokotala wanu za njira zolerera zomwe mungagwiritse ntchito. Ngati inu kapena mnzanu mutakhala ndi pakati mukalandira jakisoni wa brentuximab vedotin, itanani dokotala wanu mwachangu. Jekeseni wa Brentuximab vedotin itha kuvulaza mwana wosabadwayo.
• Uzani dokotala wanu ngati mukuyamwitsa. Simuyenera kuyamwa mukalandira jekeseni wa brentuximab vedotin.
• Muyenera kudziwa kuti mankhwalawa amachepetsa kubereka mwa amuna. Lankhulani ndi dokotala wanu za kuopsa kolandila jakisoni wa brentuximab vedotin.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Jekeseni wa Brentuximab vedotin imatha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kudzimbidwa
• zilonda mkamwa
• kuchepa kudya
• kuonda
• kutopa
• chizungulire
• kufooka
• kuvuta kugona kapena kugona
• nkhawa
• khungu lowuma
• kutayika tsitsi
• thukuta usiku
• olowa, fupa, minofu, msana, mkono, kapena kupweteka kwa mwendo
• kutuluka kwa minofu

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa M'CHENJEZO CHOFUNIKA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:

• kutuluka mwachilendo kapena kuphwanya
• dzanzi, kutentha, kapena kumva kulasalasa m'manja, mikono, mapazi, kapena miyendo
• kufooka kwa minofu
• khungu losenda kapena lotupa
• ming'oma
• zidzolo
• kuyabwa
• nseru
• kusanza
• kutsegula m'mimba
• chifuwa kapena kupuma movutikira
• kuchepa pokodza
• kutupa kwa manja, mapazi, akakolo, kapena miyendo yakumunsi
• kukodza kovuta, kowawa, kapena pafupipafupi
• malungo, kuzizira, chifuwa, kapena zizindikiro zina za matenda
• kupweteka komwe kumayambira m'mimba koma kumafalikira kumbuyo
• khungu lotumbululuka
• chikasu cha khungu kapena maso
• kupweteka kapena kusapeza bwino kumtunda kwam'mimba
• mkodzo wakuda
• matumbo akuda
• kupweteka m'mimba
• kutuluka mwachilendo kapena kuphwanya
• mipando yakuda ndi yodikira
• magazi ofiira m'mipando

Jekeseni wa Brentuximab vedotin imatha kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukalandira mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Zizindikiro za bongo zingaphatikizepo izi:

• malungo, kuzizira, chifuwa, kapena zizindikiro zina za matenda

Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudza jekeseni wa brentuximab vedotin.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

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