Vemurafenib

Zamkati

• Musanatenge vemurafenib,
• Vemurafenib ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi, itanani dokotala nthawi yomweyo:
• Ngati mukukumana ndi zizindikiro zotsatirazi zosagwirizana ndi khungu kapena khungu lanu, siyani kumwa vemurafenib ndikuyimbira dokotala mwachangu kapena pitani kuchipatala mwadzidzidzi:

Vemurafenib imagwiritsidwa ntchito pochiza mitundu ina ya khansa ya pakhungu (mtundu wa khansa yapakhungu) yomwe singathe kuchiritsidwa ndi opaleshoni kapena yomwe yafalikira mbali zina za thupi. Amagwiritsidwanso ntchito pochiza mtundu wina wa matenda a Erdheim-Chester (ECD; matenda omwe amayambitsa kuchuluka kwa mtundu wamagazi oyera). Vemurafenib ali mgulu la mankhwala otchedwa kinase inhibitors. Zimagwira ntchito poletsa proteni yachilendo yomwe imawonetsa kuti ma cell a khansa achulukane. Izi zimathandiza kuchepetsa kapena kuletsa kufalikira kwa maselo a khansa.

Vemurafenib imabwera ngati piritsi kuti itenge pakamwa. Nthawi zambiri amatengedwa wopanda chakudya kawiri patsiku, m'mawa ndi madzulo, pafupifupi maola 12 atasiyana. Tengani vemurafenib mozungulira nthawi yofananira tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani vemurafenib ndendende monga momwe adauzira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala. Osasiya kumwa vemurafenib osalankhula ndi dokotala.

Kumeza mapiritsi lonse ndi kapu ya madzi; musatafune kapena kuwaphwanya.

Ngati musanza mutatenga vemurafenib, musamwe mankhwala ena nthawi yomweyo. Pitirizani dongosolo lanu lokhazikika.

Dokotala wanu angafunike kuyimitsa chithandizo chanu kwakanthawi kapena kwanthawi zonse kapena kuchepetsa kuchuluka kwa vemurafenib mukamalandira chithandizo. Izi zimadalira momwe mankhwalawa amakuthandizirani komanso zovuta zomwe mumakumana nazo. Onetsetsani kuti muuze dokotala momwe mukumvera mukamalandira chithandizo ndi vemurafenib.

Dokotala wanu kapena wamankhwala adzakupatsani pepala lazidziwitso za wopanga (Medication Guide) mukayamba mankhwala ndi vemurafenib ndipo nthawi iliyonse mukadzaza mankhwala anu. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kuyendera tsamba la Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kapena tsamba laopanga kuti mupeze Medication Guide.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge vemurafenib,

• uzani dokotala wanu komanso wamankhwala ngati mukugwirizana ndi vemurafenib, mankhwala aliwonse, kapena chilichonse chomwe chili m'mapiritsi a vemurafenib. Funsani wamankhwala wanu kapena onani Chithandizo cha Mankhwala kuti mupeze mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: ma antifungal ena monga itraconazole (Onmel, Sporanox), ketoconazole (Nizoral), ndi voriconazole (Vfend); clarithromycin (Biaxin, mu PrevPac); mankhwala ena a kachirombo ka HIV (HIV) kapena matenda opatsirana m'thupi (AIDS) monga indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, ku Kaletra), ndi saquinavir (Invirase); mankhwala ena ogwidwa monga carbamazepine (Carbatrol, Epitol, Tegretol, ena), phenobarbital, ndi phenytoin (Dilantin, Phenytek); nefazodone; rifampin (Rifadin, Rimactane, ku Rifamate, ku Rifater); tizanidine; ndi warfarin (Coumadin, Jantoven). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi vemurafenib, chifukwa chake onetsetsani kuti muwauze adotolo za mankhwala omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• uzani dokotala wanu ngati mwakhalapo kapena mudakhalapo ndi khansa yapakhungu yamtundu uliwonse; nthawi yayitali ya QT (vuto losowa la mtima lomwe lingayambitse kugunda kwamtima, kukomoka, kapena kufa mwadzidzidzi); mtima kulephera; kashiamu, magnesium, kapena potaziyamu wochepa m'magazi anu; mtima, impso, kapena matenda a chiwindi. Komanso, uzani dokotala ngati mwalandira kapena mukukonzekera kulandira radiation.
• Uzani dokotala wanu ngati muli ndi pakati kapena mukufuna kukhala ndi pakati. Simuyenera kutenga mimba mukamamwa vemurafenib. Muyenera kugwiritsa ntchito njira zakulera kuti muchepetse mimba mukamamwa mankhwala ndi vemurafenib komanso kwa masabata awiri mutatha kumwa. Lankhulani ndi dokotala wanu za njira zolerera zomwe zingakuthandizeni. Mukakhala ndi pakati mukatenga vemurafenib, itanani dokotala wanu. Vemurafenib itha kuvulaza mwana wosabadwayo.
• Uzani dokotala wanu ngati mukuyamwitsa. Simukuyenera kuyamwa mukamamwa vemurafenib komanso kwa masabata awiri mutatha kumwa.
• ngati mukuchitidwa opaleshoni, kuphatikizapo opaleshoni ya mano, uzani dokotala kapena dokotala kuti mukumwa vemurafenib.
• konzani kupewa kupezeka kwa kuwala kwadzuwa kosafunikira kapena kwanthawi yayitali komanso kuvala zovala zodzitetezera, magalasi ofunikira, mankhwala am'milomo ndi zoteteza ku dzuwa (SPF 30 kapena kupitilira apo). Vemurafenib imatha kupangitsa khungu lanu kukhala lowala ndi dzuwa.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Tengani mlingo womwe mwaphonya mukangokumbukira. Komabe, ngati mkati mwa maola 4 a mlingo wanu wotsatira womwe mwakonzedweratu, tulukani mlingo womwe mwaphonya ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Vemurafenib ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kutopa
• kulumikizana, minofu, mkono, mwendo, kapena kupweteka kwa msana
• kufiira kapena kutupa m'manja, mapazi, akakolo, kapena m'munsi mwendo
• sinthani tanthauzo la kukoma
• mutu
• kutayika tsitsi
• khungu louma kapena loyabwa
• kutsegula m'mimba
• kudzimbidwa
• chifuwa

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi, itanani dokotala nthawi yomweyo:

• kusintha kwa khungu
• chida chatsopano
• zilonda pakhungu kapena chifuwa chofiira chomwe chimatuluka magazi kapena sichichira
• kusintha kukula kapena mtundu wa mole
• kutopa kwambiri
• kuvulaza kapena kutuluka mwachilendo
• nseru
• kusanza
• kusowa chilakolako
• kupweteka kumtunda chakumanja kwam'mimba
• chikasu cha khungu kapena maso
• kuzindikira kwa diso kuwala
• kufiira kwa diso kapena kupweteka
• masomphenya amasintha
• kukulitsa kwachilendo kwa kanjedza
• kukhwimitsa kwa zala mkatikati mwa kanjedza
• kukhazikika kwamapazi, komwe kumatha kuwawa

Ngati mukukumana ndi zizindikiro zotsatirazi zosagwirizana ndi khungu kapena khungu lanu, siyani kumwa vemurafenib ndikuyimbira dokotala mwachangu kapena pitani kuchipatala mwadzidzidzi:

• kuvuta kupuma kapena kumeza
• kugunda kwamtima msanga, kosasinthasintha, kapena kwamphamvu
• kukomoka
• zidzolo kapena kufiira thupi lonse
• ming'oma
• khungu losenda kapena lotupa
• malungo

Vemurafenib ikhoza kuonjezera chiopsezo kuti mungakhale ndi khansa zina. Lankhulani ndi dokotala wanu za chiopsezo ichi.

Vemurafenib ikhoza kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu adzaitanitsa mayeso ena a labu kuti awone kuyankha kwa thupi lanu kwa vemurafenib. Dokotala wanu amayang'ana khungu lanu asanayambe kulandira chithandizo, miyezi iwiri iliyonse mukamalandira chithandizo, komanso kwa miyezi 6 mutalandira chithandizo.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Zelboraf^®