Axitinib

Zamkati

• Musanatenge axitinib,
• Axitinib ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:
• Zizindikiro za bongo zingaphatikizepo izi:

Axitinib imagwiritsidwa ntchito payokha pochizira renal cell carcinoma (RCC, mtundu wa khansa womwe umayambira m'maselo a impso) mwa anthu omwe sanalandire chithandizo china ndi mankhwala ena. Axitinib imagwiritsidwa ntchito limodzi ndi avelumab (Bavencio) kapena pembrolizumab (Keytruda) yochizira renal cell carcinoma. Axitinib ali mgulu la mankhwala otchedwa kinase inhibitors. Zimagwira ntchito poletsa proteni yachilendo yomwe imawonetsa kuti ma cell a khansa achulukane. Izi zimathandiza kuchepetsa kapena kuletsa kufalikira kwa maselo a khansa.

Axitinib imabwera ngati piritsi kuti itenge pakamwa. Nthawi zambiri amatengedwa kapena wopanda chakudya kawiri patsiku. Tengani axitinib mozungulira nthawi yofananira tsiku lililonse, pafupifupi maola 12 mutasiyana. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani axitinib ndendende monga momwe adauzira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Kumeza mapiritsi lonse ndi kapu ya madzi; osagawana, kutafuna, kapena kuwaphwanya.

Ngati musanza mutatenga axitinib, musamwe mlingo wina. Pitirizani dongosolo lanu lokhazikika.

Dokotala wanu angakuyambitseni pa mlingo wochepa wa axitinib ndipo pang'onopang'ono muwonjezere mlingo wanu, osati kamodzi pa masabata awiri. Izi zimadalira momwe mankhwalawa amakuthandizirani komanso zovuta zina zomwe mungakumane nazo. Lankhulani ndi dokotala wanu za momwe mukumvera mukamalandira chithandizo. Pitirizani kutenga axitinib ngakhale mutakhala bwino. Osasiya kumwa axitinib osalankhula ndi dokotala.

Funsani wamankhwala kapena dokotala wanu kuti mumupatseko zidziwitso za wopanga kwa wodwalayo.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge axitinib,

• Uzani dokotala ndi wazamankhwala ngati muli ndi vuto la axitinib, mankhwala ena aliwonse, kapena zosakaniza zilizonse m'mapiritsi a axitinib. Funsani wamankhwala wanu kuti awonetse mndandanda wazosakaniza.
• Uzani dokotala wanu komanso wamankhwala mankhwala ena omwe simukupatsidwa, mavitamini, ndi zowonjezera zakudya zomwe mukumwa kapena mukukonzekera. Onetsetsani kuti mwatchulapo izi: bosentan (Tracleer); carbamazepine (Carbatrol, Epitol, Tegretol); clarithromycin (Biaxin, mu Prevpac); itraconazole (Sporanox); ketoconazole (Nizoral); Mankhwala ochizira HIV / AID kuphatikiza atazanavir (Reyataz), efavirenz (Sustiva, ku Atripla), etravirine (Intelence), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir), ndi saquinavir (Invirase); modafinil (Provigil); nafcillin; nefazodone; phenobarbital; phenytoin (Dilantin, Phenytek); rifabutin (Mycobutin); rifampin (Rifamate, Rifater); rifapentine (Priftin); mankhwala a steroid monga dexamethasone (Decadron); telithromycin (Ketek); ndi voriconazole (Vfend). Mankhwala ena ambiri amathanso kulumikizana ndi axitinib, chifukwa chake onetsetsani kuti muwauze adotolo za mankhwala omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• uzani dokotala wanu za mankhwala azitsamba omwe mukumwa, makamaka St John's wort.
• uzani dokotala wanu ngati muli ndi bala lomwe silinachiritsidwe, kapena ngati mwakhalapo ndi vuto lakukha magazi kapena; kuundana kwamagazi; kuthamanga kwa magazi; matenda a mtima; matenda ashuga; kuchuluka kwa mafuta m'thupi; kutuluka magazi m'mimba kapena m'matumbo; khansa ya ubongo; embolism m'mapapo mwanga (magazi a m'mapapu anu); sitiroko kapena ministerroke (TIA); kapena mtima; chiwindi; kapena matenda a chithokomiro.
• uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena ngati mukufuna kukhala ndi mwana. Ngati ndinu wamkazi, muyenera kuyezetsa asanayambe kulandira chithandizo ndikugwiritsa ntchito njira zakulera kuti muchepetse kutenga pakati mukamalandira chithandizo komanso kwa sabata limodzi mutapatsidwa mankhwala omaliza. Ngati ndinu wamwamuna, inu ndi mnzanuyo muyenera kugwiritsa ntchito njira zakulera mukamalandira chithandizo komanso kwa sabata limodzi mutapatsidwa mankhwala omaliza. Lankhulani ndi dokotala wanu za njira zolerera zomwe zingakuthandizeni. Ngati inu kapena mnzanu mumakhala ndi pakati mukatenga axitinib, itanani dokotala wanu. Axitinib ikhoza kuvulaza mwana wosabadwayo.
• Uzani dokotala wanu ngati mukuyamwitsa. Simuyenera kuyamwa mukamamwa mankhwala ndi axitinib komanso kwa masabata awiri mutatha kumwa.
• Muyenera kudziwa kuti mankhwalawa amachepetsa kubereka kwa abambo ndi amai. Lankhulani ndi dokotala wanu za kuopsa kogwiritsa ntchito axitinib.
• ngati mukuchitidwa opaleshoni, kuphatikizapo opaleshoni ya mano, uzani dokotala kapena dokotala kuti mukumwa axitinib. Dokotala wanu angakuuzeni kuti musiye kumwa axitinib osachepera masiku awiri musanachite opareshoni ndipo zitakhala zotheka kuti muyambenso kumwa axitinib mukatha opaleshoni.

Musadye zipatso zamphesa kapena kumwa madzi amphesa mukamamwa mankhwalawa.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Ngati mwaphonya mlingo wa axitinib, tulukani mlingowo ndikumwa mlingo wanu wotsatira nthawi yanthawi zonse. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Axitinib ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kutsegula m'mimba
• kuchepa kwa njala kapena kutha kulawa zinthu
• kuonda
• nseru
• kusanza
• kudzimbidwa
• kutopa
• kufooka
• sinthani phokoso lanu
• kufiira, kupweteka, kuchita dzanzi, kumva kulasalasa, kapena kuyabwa kapena khungu la khungu lanu m'manja ndi m'mapazi
• chifuwa
• kulumikizana kapena kupweteka kwa minofu
• zilonda mkamwa
• kupweteka m'mimba
• mtima kutentha
• mutu
• chizungulire
• zidzolo
• kuyabwa
• khungu lowuma
• Kumva kutentha kapena kuzizira
• khungu lotumbululuka
• kuthamanga kwa mtima
• kutayika tsitsi
• kulira m'makutu
• ludzu
• zotupa m'mimba
• bala kapena kudula komwe sikungachiritse

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:

• kupweteka kwambiri m'mimba
• kupuma movutikira
• kutupa m'manja kapena m'miyendo
• kutuluka mwachilendo kapena kuphwanya
• mipando yakuda ndi yodikira
• magazi ofiira m'mipando
• masanzi amagazi
• kusanza komwe kumawoneka ngati malo a khofi
• kupweteka pachifuwa kapena kupanikizika
• kupweteka kwa mikono, kumbuyo, khosi, kapena nsagwada
• kutupa, kukoma, kutentha, kapena kufiyira mwendo
• kufooka mwadzidzidzi kapena kufooka kwa nkhope, mkono, kapena mwendo (makamaka mbali imodzi ya thupi)
• kusokonezeka mwadzidzidzi, kuvuta kuyankhula kapena kumvetsetsa
• vuto ladzidzidzi kuwona m'maso amodzi kapena onse awiri
• kuyenda mwadzidzidzi, chizungulire, kutayika bwino kapena kulumikizana
• kupweteka mutu modzidzimutsa popanda chifukwa chodziwika
• kulanda
• kutaya masomphenya

Axitinib ikhoza kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Zizindikiro za bongo zingaphatikizepo izi:

• chizungulire
• kugwidwa
• kutsokomola magazi

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena a labu kuti muwone kuyankha kwa thupi lanu ku axitinib. Dokotala wanu amawonanso kuthamanga kwa magazi kwanu nthawi zonse mukamamwa mankhwala ndi axitinib.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Inlyta^®