Teriflunomide

Zamkati

• Musanatenge teriflunomide,
• Teriflunomide imatha kuyambitsa mavuto. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa M'CHENJEZO CHOFUNIKA, siyani kumwa teriflunomide ndikuyimbira dokotala nthawi yomweyo kapena kupeza chithandizo chamankhwala mwadzidzidzi:

Teriflunomide imatha kuwononga chiwindi choopsa kapena chowopsa, chomwe chingafune kumuika chiwindi. Chiwopsezo cha kuwonongeka kwa chiwindi chitha kuwonjezeka mwa anthu omwe amamwa mankhwala ena omwe amadziwika kuti amawononga chiwindi, komanso mwa anthu omwe ali ndi matenda a chiwindi. Uzani dokotala wanu ngati muli ndi matenda a chiwindi. Dokotala wanu akhoza kukuwuzani kuti musatenge teriflunomide. Uzani dokotala wanu komanso wamankhwala zamankhwala onse omwe mukumwa kuti athe kuwona ngati mankhwala aliwonse angawonjezere chiwopsezo kuti chiwindi chanu chitha kuwonongeka mukamalandira mankhwala a teriflunomide. Ngati mukumane ndi izi, itanani dokotala wanu msanga: nseru, kusanza, kutopa kwambiri, kutuluka mwazi kapena kuvulaza, kusowa mphamvu, kusowa kwa njala, kupweteka kumtunda kwakumimba, chikaso cha khungu kapena maso , mkodzo wakuda, kapena zizindikiro ngati chimfine. Ngati mukukayikira kuwonongeka kwa chiwindi, dokotala wanu akhoza kuyimitsa teriflunomide ndipo angakupatseni chithandizo chomwe chingathandize kuchotsa teriflunomide mwachangu mthupi lanu.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu adzaitanitsa mayeso ena musanayambe kumwa mankhwala komanso nthawi zonse mukamalandira chithandizo kuti muwone momwe thupi lanu likuyankhira ku teriflunomide.

Musatenge teriflunomide ngati muli ndi pakati kapena mukufuna kutenga pakati. Teriflunomide itha kuvulaza mwana wosabadwayo. Simuyenera kuyamba kumwa teriflunomide mpaka mutayezetsa mimba ndi zotsatira zoyipa ndipo dokotala akukuuzani kuti mulibe pakati. Muyenera kugwiritsa ntchito njira yolerera musanayambe kumwa teriflunomide, mukamamwa mankhwala a teriflunomide, komanso kwa zaka ziwiri mutalandira chithandizo, mpaka kuyezetsa magazi kukuwonetsa kuti mulibe teriflunomide m'magazi anu. Ngati kusamba kwanu kwachedwa, mumasowa nthawi, kapena mukuganiza kuti mutha kukhala ndi pakati mukamalandira teriflunomide kapena kwa zaka 2 mutalandira chithandizo, pitani kuchipatala nthawi yomweyo. Ngati muli wamwamuna ndipo mnzanu atha kukhala ndi pakati, inu ndi mnzanuyo muyenera kugwiritsa ntchito njira yolerera yoyenerera mukamalandira chithandizo. Ngati inu kapena mnzanu mukukonzekera kutenga pakati kapena mutha kutenga pakati, lankhulani ndi dokotala wanu za mankhwala omwe angakuthandizeni kuchotsa teriflunomide mwachangu mthupi lanu mutasiya kumwa mankhwalawo.

Dokotala wanu kapena wamankhwala adzakupatsani pepala lazidziwitso za wopanga (Medication Guide) mukayamba chithandizo ndi teriflunomide ndipo nthawi iliyonse mukadzaza mankhwala anu. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kuyendera tsamba la Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kapena tsamba laopanga kuti mupeze Medication Guide.

Lankhulani ndi dokotala wanu za kuopsa kwakumwa teriflunomide.

Teriflunomide imagwiritsidwa ntchito pochiza achikulire omwe ali ndi mitundu yosiyanasiyana ya multiple sclerosis (MS; matenda omwe misempha sagwira ntchito moyenera ndipo anthu amatha kufooka, kufooka, kutayika kwa kulumikizana kwa minofu, komanso mavuto a masomphenya, malankhulidwe, ndi chikhodzodzo) kuphatikizapo :

• matenda opatsirana (CIS; zizindikiro za mitsempha zomwe zimakhala pafupifupi maola 24),
• mitundu yobwezeretsanso (matenda omwe matenda amawonekera nthawi ndi nthawi), kapena
• mitundu yachiwiri yopita patsogolo (matenda omwe amabwereranso amapezeka pafupipafupi).

Teriflunomide ali mgulu la mankhwala otchedwa ma immunomodulatory agents. Amaganiziridwa kuti amagwira ntchito pochepetsa kutupa komanso kuchepa kwa maselo amthupi omwe angayambitse mitsempha.

Teriflunomide imabwera ngati piritsi kuti itenge pakamwa. Nthawi zambiri amatengedwa kamodzi patsiku kapena wopanda chakudya. Tengani teriflunomide mozungulira nthawi yomweyo tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani teriflunomide ndendende momwe mwalangizira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Teriflunomide itha kuthandizira kuchepetsa zizindikilo za sclerosis, koma sichichiza. Pitirizani kumwa teriflunomide ngakhale mukumva bwino. Osasiya kumwa teriflunomide osalankhula ndi dokotala.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge teriflunomide,

• Uzani dokotala ndi wazamankhwala ngati muli ndi vuto la teriflunomide (zotupa, ming'oma, kupuma pang'ono, kutupa kwa nkhope, maso, pakamwa, pakhosi, lilime, milomo, manja, mapazi, akakolo, kapena miyendo yakumunsi), leflunomide (Arava) , mankhwala ena aliwonse, kapena chilichonse chosakaniza m'mapiritsi a teriflunomide. Funsani wamankhwala wanu kapena onani Chithandizo cha Mankhwala kuti mupeze mndandanda wazosakaniza.
• Uzani dokotala wanu ngati mukumwa leflunomide (Arava). Dokotala wanu angakuuzeni kuti musamwe teriflunomide ngati mukumwa mankhwalawa.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchula mankhwala omwe adatchulidwa mu gawo LOFUNIKITSA CHENJEZO ndi zina mwa izi: alosetron (Lotronex); maanticoagulants ('oonda magazi') monga warfarin (Coumadin, Jantoven); atorvastatin (Lipitor, mu Caduet); chomera; cimetidine (Tagamet); ciprofloxacin (Cipro); duloxetine (Cymbalta); eltrombopag (Promacta); furosemide (Lasix); gefitinib (Iressa); ketoprofen; mankhwala omwe angayambitse mitsempha monga mankhwala a khansa, HIV, kapena Edzi; Mankhwala ena omwe amapondereza chitetezo cha mthupi monga azathioprine (Azasan, Imuran), cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), ndi tacrolimus (Astagraf, Envarsus XR, Prograf); methotrexate (Otrexup, Rasuvo, Trexall); mitochantrone; mtundu (Starlix); njira zakulera zam'kamwa (mapiritsi olera); paclitaxel (Abraxane, Taxol); penicillin G; pioglitazone (Actos, mu Actoplus Met, mu Duetact); pravastatin (Pravachol); repaglinide (Prandin, ku Prandimet); rifampin (Rifadin, Rimactane, ku Rifamate, ku Rifater); rosiglitazone (Avandia); rosuvastatin (Crestor); simvastatin (Zocor, ku Vytorin); theophylline (Elixophyllin, Theo-24, Uniphyl, ena); tizanidine (Zanaflex); ndi zidovudine (Retrovir, ku Combivir, ku Trizivir). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi teriflunomide, chifukwa chake onetsetsani kuti muwauze adotolo zamankhwala onse omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• auzeni adotolo ngati muli ndi kachilombo tsopano, kuphatikiza matenda omwe akupitilira omwe samatha, kapena ngati mwakhalapo ndi khungu linalake mutalandira mankhwala ena; matenda ashuga; mavuto a kupuma; khansa kapena zina zomwe zimakhudza mafupa kapena chitetezo cha mthupi; kuthamanga kwa magazi; zotumphukira za m'mitsempha (dzanzi, kuwotcha kapena kumva kulira m'manja kapena m'miyendo zomwe zimamveka mosiyana ndi zizindikilo za MS); kapena matenda a impso.
• uzani dokotala wanu ngati mukuyamwitsa. Osamayamwa mukamamwa teriflunomide.
• ngati mnzanu akukonzekera kutenga pakati, muyenera kukambirana ndi adotolo za kuyimitsa teriflunomide ndikupeza chithandizo chothandizira kuchotsa mankhwalawa mthupi lanu mwachangu kwambiri. Ngati mnzanu sakufuna kutenga pakati, inu ndi mnzanuyo muyenera kugwiritsa ntchito njira yolerera panthawi yothandizidwa ndi teriflunomide komanso mpaka zaka ziwiri mutalandira chithandizo, mpaka kuyezetsa magazi kukuwonetsa kuti muli ndi teriflunomide wokwanira magazi.
• ngati mukuchitidwa opaleshoni, kuphatikizapo opaleshoni ya mano, uzani dokotala kapena dokotala kuti mukumwa teriflunomide.
• mutha kukhala kuti mwadwala kale chifuwa chachikulu (TB; matenda akulu am'mapapo) koma mulibe zizindikilo zilizonse za matendawa. Uzani dokotala wanu ngati munakhalapo ndi TB kapena munakhalapo ndi TB, ngati munakhalako kapena munapitako kudziko kumene TB imafala, kapena ngati mwakhalapo ndi munthu amene ali ndi TB. Musanayambe kumwa mankhwala ndi teriflunomide, dokotala wanu adzakuyesani khungu kuti muwone ngati muli ndi TB. Ngati muli ndi TB, dokotala wanu adzachiza matendawa musanayambe kumwa teriflunomide.
• mulibe katemera popanda kulankhula ndi dokotala mukamamwa teriflunomide komanso kwa miyezi 6 mutasiya kumwa.
• Muyenera kudziwa kuti teriflunomide imatha kuyambitsa kuthamanga kwa magazi. Muyenera kuyezetsa magazi anu musanayambe kumwa mankhwala komanso nthawi zonse mukamamwa mankhwalawa.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Tengani mlingo womwe mwaphonya mukangokumbukira. Komabe, ngati ili pafupi nthawi ya mlingo wotsatira, dumpha mlingo womwe umasowa ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Teriflunomide imatha kuyambitsa mavuto. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kutayika tsitsi
• kutsegula m'mimba
• kusawona bwino
• Dzino likundiwawa
• ziphuphu
• kulumikizana kapena kupweteka kwa minofu
• nkhawa
• kuonda

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa M'CHENJEZO CHOFUNIKA, siyani kumwa teriflunomide ndikuyimbira dokotala nthawi yomweyo kapena kupeza chithandizo chamankhwala mwadzidzidzi:

• kuthamanga, kusasinthasintha, kapena kugunda kwapang'onopang'ono
• mutu
• chizungulire
• khungu lotumbululuka
• chisokonezo
• malungo, chifuwa, zilonda zapakhosi, kuzizira, ndi zizindikiro zina za matenda
• dzanzi, kutentha, kapena kumva kulasalasa m'manja, mikono, mapazi, kapena miyendo
• kutayika kwa minofu
• kufooka kapena kulemera kwa miyendo
• ozizira, otuwa khungu
• khungu lofiira, losenda, kapena lotupa
• zidzolo
• ming'oma
• kuyabwa
• zovuta kumeza
• kutupa kwa nkhope, maso, pakamwa, pakhosi, lilime, kapena milomo
• kupuma movutikira
• zotupa zomwe zimatha kuchitika ndi malungo, kutupa kwa gland, kapena kutupa kwa nkhope
• m'mimba, mbali, kapena kupweteka kwa msana

Teriflunomide imatha kubweretsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Aubagio^®