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• Musanatenge venetoclax,
• Venetoclax ingayambitse mavuto. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi kapena zomwe zalembedwa mu gawo la MAWONEKEDWE OTHANDIZA, pitani kuchipatala nthawi yomweyo:

Venetoclax imagwiritsidwa ntchito yokha kapena kuphatikiza obinutuzumab (Gazyva) kapena rituximab (Rituxan) kuchiza mitundu ina ya matenda a khansa ya m'magazi (CLL; mtundu wa khansa womwe umayambira m'maselo oyera a magazi) kapena mitundu ina yaying'ono ya lymphocytic lymphoma (SLL; mtundu wa khansa womwe umayamba makamaka m'ma lymph node). Amagwiritsidwanso ntchito limodzi ndi azacitidine (Vidaza), decitabine (Dacogen), kapena cytarabine ngati mankhwala oyamba a myeloid leukemia (AML; mtundu wa khansa womwe umayamba m'maselo oyera a magazi) mwa anthu azaka 75 kapena okalamba, kapena achikulire omwe ali ndi matenda omwe angawalepheretse kulandira mankhwala ena a chemotherapy. Venetoclax ili mgulu la mankhwala otchedwa B-cell lymphoma-2 (BCL-2) inhibitors. Zimagwira ntchito poletsa zomwe puloteni inayake mthupi imachita kuti maselo a khansa apulumuke. Izi zimathandiza kupha maselo a khansa.

Venetoclax imabwera ngati piritsi kuti itenge pakamwa. Nthawi zambiri amatengedwa ndi chakudya ndi madzi kamodzi patsiku. Tengani venetoclax mozungulira nthawi yomweyo tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani venetoclax ndendende momwe mwalangizira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Kumeza mapiritsi lonse; osagawana, kutafuna, kapena kuwaphwanya.

Ngati musanza mutatenga venetoclax, musabwereze mlingowo. Pitirizani dongosolo lanu lokhazikika.

Dokotala wanu angakuyambitseni pa venetoclax pang'ono pang'onopang'ono ndikuwonjezerani mlingo wanu, osapitilira kamodzi sabata iliyonse kwa milungu isanu yoyambirira ngati mukuchiritsidwa ndi CLL kapena SLL, ndipo kamodzi patsiku masiku atatu kapena 4 oyamba ngati mukuchiritsidwa ndi AML.

Dokotala wanu angafunike kusokoneza kapena kuyimitsa chithandizo chanu mukakumana ndi zovuta zina. Onetsetsani kuti muuze dokotala momwe mukumvera mukamalandira mankhwala a venetoclax. Pazotsatira zina, dokotala angakuuzeni kuti muyambe kumwa venetoclax pamlingo wochepa.

Dokotala wanu kapena wamankhwala adzakupatsani pepala lazidziwitso za wopanga (Medication Guide) mukayamba kulandira mankhwala ndi venetoclax ndipo nthawi iliyonse mukadzaza mankhwala anu. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kuyendera tsamba la Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kapena tsamba laopanga kuti mupeze Medication Guide.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge venetoclax,

• Uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la venetoclax, mankhwala ena aliwonse, kapena zosakaniza zilizonse m'mapiritsi a venetoclax. Funsani wamankhwala wanu kapena onani Chithandizo cha Mankhwala kuti mupeze mndandanda wazosakaniza.
• Uzani dokotala ngati mukumwa clarithromycin, conivaptan (Vaprisol), indinavir (Crixivan), itraconazole (Onmel, Sporanox), ketoconazole, lopinavir (ku Kaletra), posaconazole (Noxafil), ritonavir (Norvir, ku Kaletra, Technivie ), kapena voriconazole (Vfend). Dokotala wanu angakuuzeni kuti musamwe venetoclax ngati mukumwa mankhwala amodzi kapena angapo.
• Uzani dokotala ndi wamankhwala mankhwala ena omwe mumalandira kapena mavitamini omwe mumamwa kapena mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: amiodarone (Nexterone, Pacerone), bosentan (Tracleer), captopril, carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril), carvedilol (Coreg), ciprofloxacin (Cipro), cyclosporine (Gengraf, Neoral, Sandimmune), digoxin (Lanoxin), diltiazem (Cardizem, Cartia XT, Diltzac, Taztia, Tiazac), dronedarone (Multaq), efavirenz (Sustiva, ku Atripla), erythromycin (EES, Eryc, Eryped, Ery-tab, ), etravirine (Intelence), everolimus (Afinitor, Zortress), felodipine, fluconazole (Diflucan), modafinil (Nuvigil, Provigil), nafcillin (Nallpen), phenytoin (Dilantin, Phenytek), quinidine (ku Nuedexta), , rifampin (Rifadin, Rimactane, ku Rifamate, Rifater), sirolimus (Rapamune), ticagrelor (Brilinta), verapamil (Calan, Verelan, ku Tarka), kapena warfarin (Coumadin, Jantoven). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi venetoclax, chifukwa chake onetsetsani kuti muwauze adotolo zamankhwala onse omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• uzani dokotala wanu za mankhwala azitsamba omwe mukumwa, makamaka quercetin kapena wort ya St.
• uzani dokotala wanu ngati mwakhalapo ndi vuto ndi potaziyamu, phosphorous, kapena calcium m'magazi anu; kuchuluka kwa uric acid m'magazi anu; gout (mtundu wa nyamakazi yoyambitsidwa ndimibulu yomwe imayikidwa m'malo olumikizirana mafupa); kapena matenda a impso kapena chiwindi.
• Uzani dokotala wanu ngati muli ndi pakati kapena mukufuna kukhala ndi pakati. Ngati mutha kutenga pakati, muyenera kuyesa mayeso musanakhale ndi venetoclax. Simuyenera kutenga pakati mukamalandira chithandizo komanso masiku 30 mutatha kumwa mankhwala. Lankhulani ndi dokotala wanu za njira zolerera zomwe mungagwiritse ntchito mukamachiza. Mukakhala ndi pakati mukatenga venetoclax, itanani dokotala wanu.
• Uzani dokotala wanu ngati mukuyamwitsa. Musamwe mkaka mukamwa venetoclax komanso kwa sabata limodzi mutangomaliza kumwa mankhwala.
• Muyenera kudziwa kuti mankhwalawa amachepetsa kubereka mwa amuna. Lankhulani ndi dokotala wanu za kuopsa kwakumwa venetoclax.
• mulibe katemera aliyense musanadye, nthawi, kapena mutalandira chithandizo cha venetoclax osalankhula ndi dokotala.
• muyenera kudziwa kuti mutha kukhala ndi chotupa cha lysis (TLS; vuto lomwe limayamba chifukwa cha kuwonongeka kwamaselo a khansa omwe angayambitse impso ndi zovuta zina) mukamalandira venetoclax. Izi ndizotheka kuchitika mukamayamba kulandira chithandizo, ndipo nthawi iliyonse kuchuluka kwanu kumawonjezeka. Pofuna kuchepetsa chiopsezo chokumana ndi TLS muyenera kumwa magalasi osachepera 6 mpaka 8 (ma 48 mpaka 64 aunsi) amadzi tsiku lililonse masiku awiri isanakwane ndi tsiku lomwe mwayamba kumwa mankhwala, ndipo nthawi iliyonse yomwe mlingo wanu ukuwonjezeka. Kuphatikiza apo dokotala wanu adzakupatsani mankhwala oti muzimwa musanayambe komanso mukamalandira chithandizo kuti muteteze izi. Ngati mukukumana ndi zizindikiro zotsatirazi za TLS imbirani dokotala nthawi yomweyo: malungo, kuzizira, nseru, kusanza, kusokonezeka, kupuma movutikira, kukomoka, kugunda kwamtima mosasinthasintha, mkodzo wamdima kapena wamtambo, kutopa kwachilendo, kapena kupweteka kwa minofu kapena kulumikizana.

Musadye zipatso zamphesa, zipatso za nyenyezi, kapena malalanje a Seville (omwe nthawi zina amagwiritsidwa ntchito mu marmalade), kapena kumwa madzi amphesa mukamamwa mankhwalawa.

Ngati mukukumbukira mlingo womwe mwaphonya pasanathe maola 8 kuchokera nthawi yomwe munayenera kumwa, tengani mlingo womwe mwaphonya nthawi yomweyo. Komabe, ngati maola opitilira 8 adutsa kuchokera nthawi yomwe mumakonda kutenga venetoclax, dumpha mlingo womwe umasowa ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Ngati mwaphonya kumwa venetoclax masiku opitilira 7, muyenera kuyimbira dokotala musanamwe mankhwala. Dokotala wanu angafune kuyambiranso mankhwala anu pamlingo wotsika.

Venetoclax ingayambitse mavuto. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kutsegula m'mimba
• kudzimbidwa
• nseru
• kusanza
• kuchepa kudya
• kutopa kwambiri
• kutupa kwa mikono kapena manja anu
• kupweteka kwa msana
• mafupa, minofu, kapena kulumikizana
• kupweteka m'mimba
• kutupa kapena zilonda mkamwa
• kupweteka pakamwa kapena pakhosi
• mutu
• chimfine kapena chotupa m'mphuno, chifuwa
• kupuma movutikira
• chizungulire
• zidzolo
• kuvuta kugona kapena kugona

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi kapena zomwe zalembedwa mu gawo la MAWONEKEDWE OTHANDIZA, pitani kuchipatala nthawi yomweyo:

• malungo okha kapena limodzi ndi zilonda zapakhosi, chifuwa, kuzizira, kutentha, kufiyira, khungu lopweteka kapena lotupa, kuthamanga mwachangu, pafupipafupi, kapena kupweteka, ndi zizindikiro zina za matenda
• kuchepa pokodza
• kutupa kwa miyendo yanu, akakolo, kapena mapazi
• kutuluka mwazi kwachilendo kapena kulemera kapena kuphwanya
• wotumbululuka khungu, kupuma movutikira, chizungulire, kutopa kwambiri, kugunda kwamtima mwachangu

Venetoclax ingayambitse zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Chitani ayi sungani mankhwalawo mu chidebe china. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena a labu musanachitike komanso mukamalandira chithandizo kuti muwone momwe thupi lanu lingayankhire venetoclax.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Venclexta^®