Sofosbuvir ndi Velpatasvir

Zamkati

• Musanatenge sofosbuvir ndi velpatasvir,
• Sofosbuvir ndi velpatasvir zingayambitse zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

Mutha kukhala kuti mwadwala kale matenda a chiwindi a hepatitis B (kachilombo kamene kamayambitsa chiwindi ndipo kakhoza kuwononga chiwindi kwambiri), koma osakhala ndi zisonyezo za matendawa. Poterepa, kutenga kuphatikiza kwa sofosbuvir ndi velpatasvir kumatha kuwonjezera chiopsezo kuti matenda anu akhoza kukhala owopsa kapena owopseza moyo ndipo mudzakhala ndi zizindikiro. Uzani dokotala wanu ngati mwakhalapo ndi kachilombo ka hepatitis B. Dokotala wanu amalamula kuti ayesedwe magazi kuti awone ngati mwadwalapo matenda a hepatitis B. Dokotala wanu adzakuyang'anirani ngati muli ndi matenda a chiwindi cha B mkati ndi miyezi ingapo mutalandira chithandizo. Ngati ndi kotheka, dokotala wanu akhoza kukupatsani mankhwala ochizira matendawa musanachitike komanso mukamamwa mankhwalawa kuphatikiza sofosbuvir ndi velpatasvir. Ngati mukumane ndi zizindikiro izi mukamalandira chithandizo kapena mutalandira chithandizo, itanani dokotala wanu mwachangu: kutopa kwambiri, khungu lachikaso kapena maso, kusowa chilakolako, kunyoza kapena kusanza, mipando yotuwa, kupweteka m'mimba, kapena mkodzo wakuda.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amatha kuyitanitsa mayeso ena asanadye, nthawi, komanso mutalandira chithandizo kuti muwone kuyankha kwa thupi lanu pakuphatikizika kwa sofosbuvir ndi velpatasvir.

Lankhulani ndi dokotala wanu za kuopsa kogwiritsa ntchito sofosbuvir ndi velpatasvir.

Kuphatikiza kwa sofosbuvir ndi velpatasvir imagwiritsidwa ntchito yokha kapena ndi ribavirin (Copegus, Rebetol, Ribasphere) kuchiza matenda a chiwindi a C (matenda opatsirana omwe amawononga chiwindi) mwa akulu ndi ana azaka 6 zakubadwa kapena kupitilira apo kapena omwe amalemera osachepera 37 lbs (makilogalamu 17). Sofosbuvir ali mgulu la mankhwala oletsa tizilombo toyambitsa matenda otchedwa nucleotide hepatitis C virus (HCV) NS5B polymerase inhibitors. Velpatasvir ali mgulu la mankhwala oletsa ma virus omwe amatchedwa HCV NS5A replication complex inhibitors. Kuphatikiza kwa sofosbuvir ndi velpatasvir kumagwira ntchito poletsa kachilombo kamene kamayambitsa matenda a chiwindi a C kufalikira mkati mwa thupi.

Kuphatikiza kwa sofosbuvir ndi velpatasvir kumabwera ngati piritsi kuti mutenge pakamwa. Amamwa nthawi zambiri osadya kamodzi pa tsiku kwa masabata 12. Tengani sofosbuvir ndi velpatasvir mozungulira nthawi yomweyo tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani sofosbuvir ndi velpatasvir ndendende momwe mwalangizira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Pitirizani kumwa sofosbuvir ndi velpatasvir ngakhale mukumva bwino. Osasiya kumwa sofosbuvir ndi velpatasvir osalankhula ndi dokotala.

Funsani wamankhwala kapena dokotala wanu kuti mumupatseko zidziwitso za wopanga kwa wodwalayo.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge sofosbuvir ndi velpatasvir,

• uzani dokotala wanu komanso wamankhwala ngati simukugwirizana ndi sofosbuvir, velpatasvir, mankhwala ena aliwonse, kapena zosakaniza zilizonse m'mapiritsi a sofosbuvir ndi velpatasvir. Funsani wamankhwala wanu kuti awonetse mndandanda wazosakaniza.
• Uzani dokotala wanu komanso wamankhwala mankhwala ndi mankhwala omwe simukulembera, mavitamini, zowonjezera zakudya zomwe mumamwa kapena mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: amiodarone (Nexterone, Pacerone); atorvastatin (Lipitor, mu Caduet); carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril); digoxin (Lanoxin); efavirenz (Sustiva, ku Atripla); oxcarbazepine (Oxtellar, Trileptal); phenobarbital; phenytoin (Dilantin, Phenytek); proton-pump inhibitors monga dexlansoprazole (Dexilant), esomeprazole (Nexium, ku Vimovo), lansoprazole (Prevacid, ku Prevpac), omeprazole (Prilosec, Zegerid), pantoprazole (Protonix), ndi rabeprazole (AcipHex): rifabutin) rifampin (Rifadin, Rimactane, ku Rifamate, Rifater); rifapentine (Priftin); rosuvastatin (Crestor); tenofovir DF (Viread, ku Atripla, Complera, Stribild, Truvada, ena); tipranavir (Aptivus) ikatengedwa ndi ritonavir (Norvir); topotecan (Hycamtin); ndi warfarin (Coumadin, Jantoven). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi sofosbuvir ndi velpatasvir, chifukwa chake onetsetsani kuti muwauze adotolo zamankhwala onse omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• ngati mukumwa maantacid, tengani maola 4 isanakwane kapena maola 4 pambuyo pa sofosbuvir ndi velpatasvir.
• Uzani dokotala ngati mukumwa mankhwala a kudzimbidwa, kutentha pa chifuwa, kapena zilonda (H₂ blockers) monga cimetidine, ranitidine (Zantac), famotidine (Pepcid, in Duexis), kapena nizatidine. Dokotala wanu angakuuzeni kuti mumwe mankhwalawa maola 12 asanakwane kapena maola 12 pambuyo pa sofosbuvir ndi velpatasvir, kapena nthawi yomweyo kuti mutenge sofosbuvir ndi velpatasvir.
• uzani dokotala wanu za mankhwala azitsamba omwe mukumwa, makamaka wort ya St.
• uzani adotolo ngati muli ndi kachilombo ka HIV, kapena mwakhalapo ndi vuto lina lililonse la chiwindi kupatula hepatitis C.
• Uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena mukuyamwitsa. Mukakhala ndi pakati mukatenga sofosbuvir ndi velpatasvir, itanani dokotala wanu.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Tengani mlingo womwe mwaphonya mukangokumbukira. Komabe, ngati ili pafupi nthawi ya mlingo wotsatira, dumpha mlingo womwe umasowa ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Sofosbuvir ndi velpatasvir zingayambitse zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• zidzolo
• kusowa mphamvu
• kumva kupsa mtima
• kumva kukhumudwa

Sofosbuvir ndi velpatasvir zingayambitse zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

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