Neratinib

Zamkati

• Musanatenge neratinib,
• Neratinib ingayambitse mavuto. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi kapena zomwe zalembedwa mu gawo la MAWONEKEDWE OTHANDIZA, pitani kuchipatala nthawi yomweyo:
• Zizindikiro za bongo zingaphatikizepo izi:

Neratinib imagwiritsidwa ntchito pochiza khansa yam'mawere yamtundu wina (khansa ya m'mawere yomwe imadalira mahomoni monga estrogen kuti ikule) mwa akulu atalandira chithandizo ndi trastuzumab (Herceptin) ndi mankhwala ena. Neratinib imagwiritsidwa ntchito limodzi ndi capecitabine (Xeloda) kuchiza mtundu wina wa khansa ya m'mawere yotulutsa mahomoni yolandila kapena khansa ya m'mawere yomwe yafalikira mbali zina za thupi mutalandira chithandizo ndi mankhwala ena osachepera awiri. Neratinib ali mgulu la mankhwala otchedwa kinase inhibitors. Zimagwira ntchito poletsa proteni yachilendo yomwe imawonetsa kuti ma cell a khansa achulukane. Izi zimathandiza kuchepetsa kapena kuletsa kufalikira kwa maselo a khansa.

Neratinib imabwera ngati piritsi kuti itenge pakamwa. Pamene neratinib imatengedwa yokha kuti ichiritse khansa ya m'mawere, nthawi zambiri imamwedwa ndi chakudya kamodzi tsiku lililonse kwa chaka chimodzi. Pamene neratinib imatengedwa ndi capecitabine kuti ithetse khansa ya m'mawere kapena khansa ya m'mawere yomwe yafalikira mbali zina za thupi, imangotengedwa kamodzi tsiku lililonse ndi chakudya masiku 1 mpaka 21 a masiku 21 mpaka matenda anu atakula kapena kukula zotsatira zoyipa. Tengani neratinib mozungulira nthawi yomweyo tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani neratinib ndendende momwe mwalangizira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Kumeza mapiritsi lonse; osagawana, kutafuna, kapena kuwaphwanya.

Dokotala wanu amachepetsa mlingo wanu kapena amaletsa kwakanthawi mankhwala anu a neratinib mukamalandira chithandizo. Izi zimadalira momwe mankhwalawa amakuthandizirani komanso zovuta zomwe mumakumana nazo. Lankhulani ndi dokotala wanu za momwe mukumvera mukamalandira chithandizo. Pitirizani kumwa neratinib ngakhale mutakhala bwino. Osasiya kumwa neratinib osalankhula ndi dokotala.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge neratinib,

• uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la neratinib, mankhwala ena aliwonse, kapena chilichonse mwazomwe zimaphatikizidwa m'mapiritsi a neratinib. Funsani wamankhwala wanu kapena onani Chithandizo cha Mankhwala kuti mupeze mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: maantibayotiki ena monga ciprofloxacin (Cipro), clarithromycin (Biaxin, ku Prevpac), erythromycin (EES, E-Mycin, Erythrocin), ndi troleandomycin (sikupezeka ku U.S.); ma antifungal ena kuphatikiza clotrimazole (Mycelex), fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), ndi voriconazole (Vfend); Aprepitant (Emend); chifuwa (Tracleer); zotchinga zina za calcium kuphatikiza diltiazem (Cardizem, Tiazac, ena) ndi verapamil (Calan, Verelan, ena); woyendetsa galimoto (Tybost); conivaptan (Vaprisol); crizotinib (Xalkori); cyclosporine (Gengraf, Neoral, Sandimmune); dabigatran (Pradaxa); digoxin (Lanoxin); dronearone (Multaq); enzalutamide (Xtandi); fexofenadine (Allegra); fluvoxamine (Luvox); idelalisib (Zydelig); imatinib (Gleevec); mankhwala ena a hepatitis C kuphatikiza boceprevir (sakupezeka ku U.S., Victrelis), dasabuvir (ku Viekira Pak), ombitasvir (ku Technivie, ku Viekira XR), ndi paritaprevir (ku Technivie, ku Viekira XR); mankhwala ena a kachilombo ka HIV (kachilombo ka HIV) kapena matenda a immunodeficiency (AIDS) kuphatikizapo efavirenz (Sustiva, ku Atripla), elvitegravir (ku Genvoya, ku Stribild), etravirine (Intelence), indinavir (Crixivan), lopinavir (ku Kaletra), nelfinavir (Viracept), ritonavir (Norvir, ku Kaletra), saquinavir (Invirase), ndi tipranavir (Aptivus); mitotane (Lysodren); modafinil (Provigil); nefazodone; proton pump inhibitors monga esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), ndi rabeprazole (AcipHex); rifampin (Rifadin, Rimactane, mu Rifater); ndi mankhwala ena okomoka kuphatikiza carbamazepine (Carbatrol, Epitol, Tegretol) ndi phenytoin (Dilantin, Phenytek). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi neratinib, chifukwa chake onetsetsani kuti muwauze adotolo za mankhwala omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• ngati mukumwa mankhwala opha tizilombo, tengani osachepera maola 3 musanatenge kapena maola atatu mutalandira neratinib.
• ngati mukumwa neratinib ndi mankhwala a kudzimbidwa, kutentha pa chifuwa, kapena zilonda (H₂ blocker) monga cimetidine, famotidine (Pepcid, in Duexis), nizatidine (Axid), kapena ranitidine (Zantac), tengani neratinib osachepera maola 2 kale kapena osachepera maola 10 mutatenga H₂ choyimitsa.
• uzani dokotala wanu za mankhwala azitsamba omwe mukumwa, makamaka wort ya St.
• uzani dokotala wanu ngati mwakhalapo kapena mudakhalapo ndi matenda a chiwindi.
• Uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena ngati mukufuna kukhala ndi mwana. Simuyenera kutenga pakati mukamamwa neratinib. Ngati ndinu wamkazi, muyenera kuyezetsa asanayambe kumwa mankhwala ndipo muyenera kugwiritsa ntchito njira yoletsa kuteteza mimba mukamamwa mankhwala ndi neratinib komanso kwa mwezi umodzi mutalandira mankhwala omaliza. Ngati ndinu wamwamuna, inu ndi mnzanuyo muyenera kugwiritsa ntchito njira zakulera mukamachiza neratinib ndikupitilira miyezi itatu mutatha kumwa. Lankhulani ndi dokotala wanu za njira zolerera zomwe mungagwiritse ntchito mukamachiza. Mukakhala ndi pakati mukatenga neratinib, itanani dokotala wanu mwachangu. Neratinib ikhoza kuvulaza mwana wosabadwayo.
• auzeni dokotala ngati mukuyamwitsa kapena mukufuna kuyamwitsa. Simuyenera kuyamwa mukamamwa neratinib komanso kwa mwezi umodzi mutatha kumwa.
• muyenera kudziwa kuti neratinib nthawi zambiri imayambitsa kutsegula m'mimba, komwe kumatha kukhala koopsa. Dokotala wanu angakuuzeni kuti mutenge loperamide (Imodium AD), mankhwala oletsa kutsegula m'mimba, kuti muchepetse kuchepa kwa madzi m'thupi (kutayika kwa madzi ochulukirapo m'thupi lanu) m'masiku 56 oyamba omwe mumalandira chithandizo cha neratinib. Pambuyo pa chithandizo cha masiku 56, dokotala wanu adzasintha mlingo wanu wa loperamide kuti mukhale ndi matumbo 1 mpaka 2 tsiku lililonse mukamamwa neratinib. Dokotala wanu amathanso kukuuzani kuti muzimwa zakumwa zambiri, musinthe zakudya zanu, kapena mutenge mankhwala ena kuti muchepetse kutsekula m'mimba. Itanani dokotala wanu nthawi yomweyo ngati muli ndi matenda otsekula m'mimba (opitilira 2 matumbo tsiku limodzi kapena kutsekula m'mimba komwe sikutha) kapena kutsekula m'mimba limodzi ndi kufooka, chizungulire, kapena malungo mukamamwa neratinib. Itanani dokotala wanu nthawi yomweyo ngati mukumane ndi izi:

Musadye zipatso zamphesa kapena kumwa madzi amphesa mukamamwa mankhwalawa.

Pitani muyezo womwe mwaphonya ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Neratinib ingayambitse mavuto. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kutsegula m'mimba
• kupweteka m'mimba
• kutentha pa chifuwa
• kuphulika
• Zilonda zam'kamwa
• kusowa chilakolako
• kuonda
• mphuno kutuluka magazi
• msomali mavuto kapena kusintha
• kutuluka kwa minofu

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi kapena zomwe zalembedwa mu gawo la MAWONEKEDWE OTHANDIZA, pitani kuchipatala nthawi yomweyo:

• maso achikaso ndi khungu
• mkodzo wakuda
• kupweteka kapena kusapeza bwino kumtunda kwam'mimba
• kutopa
• nseru
• kusanza
• zidzolo
• malungo, kuvuta kukodza, kupweteka pokodza, ndi zizindikiro zina za matenda

Neratinib ikhoza kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Zizindikiro za bongo zingaphatikizepo izi:

• kutsegula m'mimba
• nseru
• kusanza
• kupweteka m'mimba

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena a labu kuti muwone momwe thupi lanu likuyankhira ku neratinib.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Nerlynx^®