Inotuzumab Ozogamicin jekeseni

Zamkati

• Musanagwiritse ntchito jekeseni wa inotuzumab ozogamicin,
• Inotuzumab ozogamicin jekeseni imatha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa M'CHENJEZO CHOFUNIKA kapena Momwe mungayankhire, itanani dokotala wanu mwachangu kapena mupeze chithandizo chadzidzidzi:

Inotuzumab ozogamicin jekeseni imatha kuwononga chiwindi kapena kuwopsa kwa chiwindi, kuphatikiza matenda a hepatic veno-occlusive matenda (VOD; mitsempha yamagazi yotsekedwa mkati mwa chiwindi). Uzani dokotala wanu ngati mwakhalapo ndi matenda a chiwindi kapena mwakhala mukulowetsedwa ndi hematopoietic stem-cell (HSCT; njira yomwe ma cell amwazi amachotsedwa mthupi ndikubwerera m'thupi). Ngati mukumane ndi izi, itanani dokotala wanu nthawi yomweyo: kunenepa msanga, kupweteka kapena kutupa kumtunda kwakumimba, chikasu pakhungu kapena maso, nseru, kusanza, mkodzo wamdima wakuda, kapena kutopa kwambiri.

Inotuzumab ozogamicin jekeseni imatha kubweretsa chiopsezo chowonjezeka chakufa, osati chifukwa chobwerera kwa leukemia, atalandira HSCT. Ngati mukukumana ndi izi pambuyo pa HSCT mukalandira jekeseni ya inotuzumab ozogamicin, itanani dokotala wanu mwachangu: malungo, chifuwa, zilonda zapakhosi, kuzizira, kapena zizindikilo zina za matenda; kulemera mwachangu, kapena kupweteka kapena kutupa kumtunda chakumanja kwam'mimba.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu adzaitanitsa mayeso ena musanadye, nthawi, komanso mutalandira chithandizo kuti muwone momwe thupi lanu likuyankhira ku inotuzumab ozogamicin.

Inotuzumab ozogamicin jekeseni amagwiritsidwa ntchito pochiza khansa ya m'magazi (YONSE; mtundu wa khansa yomwe imayamba m'maselo oyera a magazi) mwa achikulire omwe sanayankhe kuchipatala cha m'mbuyomu. Inotuzumab ozogamicin jekeseni ali mgulu la mankhwala otchedwa monoclonal antibodies. Zimagwira ntchito poyambitsa chitetezo cha mthupi kuwononga maselo a khansa.

Inotuzumab ozogamicin jekeseni imabwera ngati ufa wosakanikirana ndi madzi kuti alowe jakisoni (mumtsempha) ndi dokotala kapena namwino kuchipatala kapena kuchipatala. Nthawi zambiri amabayidwa masiku 1, 8, ndi 15 pamasabata atatu mpaka 4. Kuzungulira kumatha kubwereza masabata anayi aliwonse malinga ndi zomwe adokotala anu akuuzani. Kutalika kwa chithandizo chanu kumadalira momwe thupi lanu limayankhira ndi mankhwala komanso zovuta zomwe mumakumana nazo.

Dokotala wanu angafunike kusokoneza kapena kuimitsa chithandizo chanu, kuchepetsa mlingo wanu, kapena kukupatsani mankhwala owonjezera, kutengera yankho lanu ku inotuzumab ozogamicin ndi zovuta zilizonse zomwe mungakumane nazo. Mukalandira mankhwala ena othandiza kupewa zomwe mungachite musanalandire mlingo uliwonse wa inotuzumab ozogamicin. Uzani dokotala wanu kapena namwino ngati mukukumana ndi izi mwa ola limodzi kapena kupitilira ola limodzi kulowetsedwa: malungo, kuzizira, kuthamanga, kupuma movutikira, kapena kupuma movutikira. Lankhulani ndi dokotala wanu za momwe mukumvera mukamalandira chithandizo komanso mukamalandira chithandizo.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanagwiritse ntchito jekeseni wa inotuzumab ozogamicin,

• auzeni dokotala ndi wazamankhwala ngati muli ndi vuto la inotuzumab ozogamicin, mankhwala ena aliwonse, kapena zosakaniza zilizonse za inotuzumab ozogamicin jekeseni. Funsani wamankhwala wanu kuti awonetse mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: amiodarone (Pacerone, Nexterone); chloroquine (Aralen); clarithromycin (Biaxin, mu Prevpac); disopyramide (Norpace); erythromycin (EES.S., E-Mycin, PC, ena); haloperidol; methadone (Dolophine, Methadose); nefazodone; pimozide (Orap); kupeza; quinidine (mu Nuedexta); sotalol (Betapace, Betapace AF, Sorine); ndi thioridazine. Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi inotuzumab ozogamicin, chifukwa chake onetsetsani kuti muwauze adotolo za mankhwala omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• auzeni adotolo ngati inu kapena aliyense m'banja mwanu mwakhalapo kapena mwakhalapo ndi nthawi yayitali ya QT (vuto losowa mtima lomwe lingayambitse kugunda kwamtima, kukomoka, kapena kufa mwadzidzidzi). Komanso, uzani dokotala ngati mwakhalapo ndi potaziyamu kapena magnesium wambiri m'magazi anu kapena matenda a impso.
• Uzani dokotala wanu ngati muli ndi pakati kapena mukufuna kukhala ndi pakati. Ngati ndinu wamkazi, simuyenera kutenga pakati mukalandira inotuzumab ozogamicin komanso kwa miyezi yosachepera 8 mutatha kumwa. Lankhulani ndi dokotala wanu za njira zolerera zomwe zingakuthandizeni. Ngati ndinu wamwamuna, inu ndi mnzanuyo muyenera kugwiritsa ntchito njira zakulera mukamalandira chithandizo ndikupitiliza kugwiritsa ntchito njira zolerera kwa miyezi yosachepera 5 mutalandira mankhwala. Ngati inu kapena mnzanu muli ndi pakati mukalandira inotuzumab ozogamicin, itanani dokotala wanu. Inotuzumab ozogamicin itha kuvulaza mwana wosabadwayo.
• Uzani dokotala wanu ngati mukuyamwitsa. Dokotala wanu angakuuzeni kuti musamamwe mkaka mukamamwa mankhwala ndi inotuzumab ozogamicin jekeseni komanso kwa miyezi iwiri mutatha kumwa.
• Muyenera kudziwa kuti mankhwalawa amachepetsa kubereka kwa abambo ndi amai. Lankhulani ndi dokotala wanu za kuopsa kolandira inotuzumab ozogamicin.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Inotuzumab ozogamicin jekeseni imatha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• chizungulire
• wamisala

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa M'CHENJEZO CHOFUNIKA kapena Momwe mungayankhire, itanani dokotala wanu mwachangu kapena mupeze chithandizo chadzidzidzi:

• malungo, kuzizira, chifuwa, kapena zizindikiro zina za matenda
• kutuluka mwachilendo kapena kuphwanya
• mipando yakuda ndi yodikira
• magazi ofiira m'mipando
• khungu lotumbululuka
• kutopa

Inotuzumab ozogamicin jekeseni imatha kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukalandira mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudza inotuzumab ozogamicin jekeseni.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Besponsa^®