Jekeseni wa Axicabtagene Ciloleucel

Zamkati

• Asanalandire jakisoni wa axicabtagene ciloleucel,
• Axicabtagene ciloleucel imatha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa MUCHENJEZO CHENJEZO, itanani dokotala wanu mwachangu:

Jekeseni wa axicabtagene ciloleucel imatha kuyambitsa matenda oopsa kapena owopsa omwe amatchedwa cytokine release syndrome (CRS). Dokotala kapena namwino adzakuyang'anirani mosamala mukamalowetsedwa komanso kwa milungu ingapo pambuyo pake. Uzani dokotala wanu ngati muli ndi vuto lotupa kapena ngati muli kapena mukuganiza kuti mutha kukhala ndi matenda aliwonse pano. Mupatsidwa mankhwala mphindi 60 musanalowetsedwe kuti muthane ndi zomwe axicabtagene ciloleucel imachita. Ngati mukumane ndi zizindikiro zotsatirazi mukamulowetsedwa, uzani dokotala nthawi yomweyo: malungo, kuzizira, kugunda kwamtima kapena kusakhazikika, kugwedeza, kutsegula m'mimba, kutopa, kufooka, kupuma movutikira, kupuma movutikira, kusokonezeka, nseru, kusanza, chizungulire , kapena wamutu wopepuka.

Jekeseni wa axicabtagene ciloleucel imatha kuyambitsa machitidwe owopsa kapena owopsa amoyo. Izi zimatha kuchitika atalandira chithandizo cha axicabtagene ciloleucel. Uzani dokotala wanu ngati mudagwidwa, kudwala sitiroko, kapena kukumbukira kukumbukira. Ngati mukumane ndi izi, uzani dokotala nthawi yomweyo: kupweteka mutu, chizungulire, kuvutika kugona kapena kugona, kusakhazikika, kusokonezeka, nkhawa, kugwedezeka kosalamulirika kwa gawo lina la thupi, kutaya chikumbumtima, kubvutika, kugwidwa, kutaya kusamala, kumvetsetsa zovuta, kapena kuyankhula kovuta.

Jekeseni wa Axicabtagene ciloleucel imapezeka pokhapokha kudzera mu pulogalamu yapadera yogawa yogawa chifukwa cha kuwopsa kwa CRS ndi poizoni wamitsempha. Mutha kulandila mankhwala kuchokera kwa adotolo ndi malo azaumoyo omwe amatenga nawo mbali pulogalamuyi. Funsani dokotala wanu ngati muli ndi mafunso okhudza pulogalamuyi.

Dokotala wanu kapena wamankhwala adzakupatsani pepala lazidziwitso za wopanga (Medication Guide) mukayamba chithandizo ndi axicabtagene ciloleucel. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kuyendera tsamba la Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kapena tsamba laopanga kuti mupeze Medication Guide.

Jekeseni wa Axicabtagene ciloleucel amagwiritsidwa ntchito pochiza mtundu wina wa non-Hodgkin's lymphoma (khansa yomwe imayamba m'maselo oyera am'magazi omwe nthawi zambiri amalimbana ndi matenda) omwe abwerera kapena osamvera mankhwala ena mwa anthu omwe achiritsidwa kale mankhwala ena awiri a chemotherapy. Jekeseni wa Axicabtagene ciloleucel ali mgulu la mankhwala otchedwa autologous cellular immunotherapy, mtundu wa mankhwala omwe amakonzedwa pogwiritsa ntchito maselo am'magazi a wodwalayo. Zimagwira ntchito poyambitsa chitetezo cha mthupi (gulu la maselo, zotupa, ndi ziwalo zomwe zimateteza thupi kuti lisagwidwe ndi mabakiteriya, mavairasi, ma cell a khansa, ndi zinthu zina zomwe zimayambitsa matenda) kulimbana ndi ma cell a khansa.

Jekeseni wa Axicabtagene ciloleucel umabwera ngati kuyimitsidwa (madzi) kuti alowe jakisoni (mumtsempha) ndi dokotala kapena namwino muofesi ya udokotala kapena malo olowerera. Nthawi zambiri amaperekedwa kwa mphindi 30 ngati gawo limodzi. Musanalandire mankhwala anu axicabtagene ciloleucel, dokotala kapena namwino wanu adzakupatsani mankhwala ena a chemotherapy kuti akonzekeretse thupi lanu kulandira axicabtagene ciloleucel.

Musanaperekedwe jakisoni wa jakisoni wa axicabtagene ciloleucel, maselo anu oyera amwazi adzatengedwa kumalo osungira maselo pogwiritsa ntchito njira yotchedwa leukapheresis (njira yomwe imachotsa maselo oyera amthupi). Chifukwa mankhwalawa amapangidwa kuchokera m'maselo anu, ayenera kuperekedwa kwa inu nokha. Ndikofunika kukhala munthawi yake komanso kuti musaphonye nthawi yomwe mumakonzekera kusonkhanitsidwa kwama cell kapena kulandira mankhwala anu. Muyenera kukonzekera kukhala pafupi ndi komwe mudalandira mankhwala anu axicabtagene ciloleucel kwa milungu yosachepera 4 mutatha kumwa mankhwala. Wothandizira zaumoyo wanu adzawona ngati chithandizo chanu chikugwira ntchito ndikukuyang'anirani zotsatira zoyipa zilizonse. Lankhulani ndi dokotala wanu za momwe mungakonzekerere leukapheresis ndi zomwe muyenera kuyembekezera mukamachita izi.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Asanalandire jakisoni wa axicabtagene ciloleucel,

• uzani dokotala wanu komanso wamankhwala ngati simukugwirizana ndi axicabtagene ciloleucel, gentamicin, mankhwala ena aliwonse, dimethyl sulfoxide (DMSO), kapena zinthu zina zilizonse mu jakisoni wa axicabtagene ciloleucel. Funsani wamankhwala wanu kapena onani Chithandizo cha Mankhwala kuti mupeze mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: ma steroids monga dexamethasone, methylprednisolone (Medrol), prednisolone, ndi prednisone (Rayos). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
• auzeni dokotala ngati mwakhala mukuvutikapo kupuma kapena mapapo, impso, mtima, kapena matenda a chiwindi.
• Uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena mukuyamwitsa. Muyenera kuyezetsa asanayambe kulandira mankhwala axicabtagene ciloleucel. Mukakhala ndi pakati mukalandira jakisoni wa axicabtagene ciloleucel, itanani dokotala wanu mwachangu.
• Muyenera kudziwa kuti jakisoni wa axicabtagene ciloleucel akhoza kukupangitsani kugona ndi kuyambitsa chisokonezo, kufooka, chizungulire, kugwa, komanso mavuto amgwirizano. Musayendetse galimoto kapena kugwiritsa ntchito makina kwa masabata osachepera 8 mutamwa mankhwala axicabtagene ciloleucel.
• musapereke magazi, ziwalo, ziwalo, kapena maselo kuti mumupatse mukalandira jakisoni wa axicabtagene ciloleucel.
• funsani dokotala wanu kuti muwone ngati mukufuna kulandira katemera uliwonse. Musakhale ndi katemera musanalankhule ndi dokotala kwa milungu isanu ndi umodzi musanayambe chemotherapy, mukamamwa mankhwala axicabtagene ciloleucel, mpaka dokotala wanu atakuwuzani kuti chitetezo chamthupi chanu chayamba.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Ngati mwaphonya nthawi yosankhidwa kuti mudzatenge maselo anu, muyenera kuyimbira dokotala wanu ndi malo osonkhanitsira nthawi yomweyo. Ngati mwaphonya nthawi yosankhidwa kuti mulandire mlingo wanu wa axicabtagene ciloleucel, muyenera kuyimbira dokotala nthawi yomweyo.

Axicabtagene ciloleucel imatha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kudzimbidwa
• kupweteka m'mimba
• kupweteka kwa msana
• kulumikizana kapena kupweteka kwa minofu
• pakamwa pouma
• kusowa chilakolako
• kuonda

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa MUCHENJEZO CHENJEZO, itanani dokotala wanu mwachangu:

• magazi mkodzo
• Kutuluka magazi mosavuta kuposa zachilendo
• malungo, zilonda zapakhosi, kuzizira, kapena zizindikiro zina za matenda
• amachepetsa kukodza pafupipafupi kapena kuchuluka
• khungu lotumbululuka
• kutopa
• kutupa kwa maso, nkhope, milomo, lilime, mmero, mikono, manja, mapazi, akakolo, kapena miyendo yakumunsi
• zovuta kumeza
• zidzolo
• ming'oma
• kuyabwa

Jekeseni wa Axicabtagene ciloleucel imatha kukulitsa chiopsezo chokhala ndi khansa. Lankhulani ndi dokotala wanu za kuopsa kolandira mankhwalawa.

Axicabtagene ciloleucel imatha kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukalandira mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani nthawi yonse yokumana ndi dokotala wanu, malo osungira maselo, ndi labotale. Dokotala wanu amatha kuyitanitsa mayeso ena a labu asanadye, nthawi, komanso mutalandira chithandizo kuti muwone momwe thupi lanu likuyankhira jakisoni wa axicabtagene ciloleucel.

Musanapite kukayezetsa labotale, auzeni dokotala ndi ogwira nawo ntchito kuti mukulandira jakisoni wa axicabtagene ciloleucel. Mankhwalawa angakhudze zotsatira za mayeso ena a labotale.

Funsani wamankhwala wanu mafunso aliwonse omwe ali nawo okhudza jekeseni wa axicabtagene ciloleucel.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

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