Jemtuzumab Ozogamicin jekeseni

Zamkati

• Asanalandire jekeseni wa gemtuzumab ozogamicin,
• Jekeseni wa Gemtuzumab ozogamicin itha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa M'CHENJEZO CHOFUNIKA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:

Jekeseni wa Gemtuzumab ozogamicin ungayambitse chiwindi kapena kuwononga moyo, kuphatikizaponso matenda a hepatic veno-occlusive (VOD; mitsempha yamagazi yotsekedwa mkati mwa chiwindi). Uzani dokotala wanu ngati mwakhalapo ndi matenda a chiwindi kapena mwakhala ndikudyetsedwa kwa hematopoietic stem-cell (HSCT; njira yomwe imalowetsa m'mafupa odwala ndi mafupa athanzi). Ngati mukumane ndi izi, itanani dokotala wanu nthawi yomweyo: kunenepa msanga, kupweteka kapena kutupa kumtunda kwakumimba, chikasu pakhungu kapena maso, nseru, kusanza, mkodzo wamdima wakuda, kapena kutopa kwambiri.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu adzaitanitsa mayeso ena musanadye, nthawi, komanso mutalandira chithandizo kuti muwone momwe thupi lanu limayankhira jakisoni wa gemtuzumab ozogamicin.

Lankhulani ndi dokotala wanu za kuopsa kotenga jekeseni wa gemtuzumab ozogamicin.

Jemtuzumab ozogamicin jekeseni imagwiritsidwa ntchito yokha kapena kuphatikiza mankhwala ena a chemotherapy kuti athetse mtundu wina wa pachimake wa myeloid leukemia (AML; mtundu wa khansa womwe umayambira m'maselo oyera a magazi) mwa akulu ndi ana azaka 1 zakubadwa kapena kupitilira apo omwe anali posachedwa anapeza kuti ali ndi khansara. Amagwiritsidwanso ntchito payekha kuchiza mtundu wina wa AML mwa akulu ndi ana azaka ziwiri kapena kupitilira apo omwe khansa idakulirakulira mukamalandira chithandizo kapena mankhwala ena a chemotherapy. Gemtuzumab ozogamicin jekeseni ali mgulu la mankhwala otchedwa monoclonal antibodies. Zimagwira ntchito pothandiza kupha maselo a khansa.

Jemtuzumab ozogamicin jakisoni amabwera ngati ufa wosakanizidwa ndi madzi ndikupatsidwa kudzera mu singano kapena catheter yoyikidwa mumtsempha. Nthawi zambiri amabayidwa pang'onopang'ono kwa nthawi yayitali ya maola awiri. Dokotala wanu angakuuzeni kangati komwe mungalandire jakisoni wa gemtuzumab ozogamicin. Dongosolo la dosing limadalira ngati mukuchiritsidwa ndi mankhwala ena a chemotherapy, ngati khansa yanu idathandizidwapo kale, komanso momwe thupi lanu limayankhira mankhwalawo.

Jekeseni wa Gemtuzumab ozogamicin itha kubweretsa zovuta kapena zoopsa pangozi ndikulowetsedwa mpaka tsiku limodzi pambuyo pake. Mukalandira mankhwala ena othandiza kupewa zomwe mungachite musanalandire mulingo uliwonse wa gemtuzumab ozogamicin. Dokotala kapena namwino adzakuyang'anirani mosamala mukamakulowetsedwako ndipo posakhalitsa kulowetsedwa kuti awonetsetse kuti simukuyankha bwino mankhwalawo. Uzani dokotala wanu kapena namwino nthawi yomweyo ngati mukukumana ndi zizindikiro izi zomwe zingachitike mkati kapena mkati mwa maola 24 mutalowetsedwa: zidzolo, malungo, kuzizira, kugunda kwamtima, lilime lotupa kapena khosi, kupuma movutikira kapena kupuma movutikira.

Dokotala wanu angachedwetse kulowetsedwa kwanu, kuchedwetsa, kapena kuyimitsa chithandizo chanu ndi jakisoni wa gemtuzumab ozogamicin, kapena kukuthandizani ndi mankhwala owonjezera kutengera kuyankha kwanu kwa mankhwala ndi zovuta zilizonse zomwe mumakumana nazo. Lankhulani ndi dokotala wanu za momwe mukumvera mukamalandira chithandizo komanso mukamalandira chithandizo.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Asanalandire jekeseni wa gemtuzumab ozogamicin,

• uzani dokotala ndi wazamankhwala ngati muli ndi vuto la gemtuzumab ozogamicin, mankhwala ena aliwonse, kapena zosakaniza zilizonse mu jekeseni wa gemtuzumab ozogamicin. Funsani wamankhwala wanu kuti awonetse mndandanda wazosakaniza.
• Uzani dokotala wanu komanso wamankhwala mankhwala ndi mankhwala osapatsirana, mavitamini, zowonjezera zakudya, ndi mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: amiodarone (Cordarone, Nexterone, Pacerone), anagrelide (Agrylin), chloroquine, chlorpromazine, cilostazol, citalopram (Celexa), disopyramide (Norpace), dofetilide (Tikosyn), donepezil (Aricept, ku Namzar ), dronedarone (Multaq), escitalopram (Lexapro), flecainide (Tambocor), fluconazole (Diflucan), haloperidol (Haldol), ibutilide (Corvert), methadone (Methadose, Dolophine), ondansetron (Zuplenz, Sofran), pimozide , procainamide, quinidine (mu Nuedexta), sotalol (Betapace, Sorine, Sotylize), ndi thioridazine. Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi jekeseni wa gemtuzumab ozogamicin, chifukwa chake onetsetsani kuti muwauze adotolo zamankhwala onse omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• auzeni adotolo ngati inu kapena wina aliyense m'banja mwanu adakhalapo kapena adakhalapo ndi matenda a QT (zomwe zimawonjezera chiopsezo chokhala ndi kugunda kwamtima kosafunikira komwe kumatha kukomoka kapena kufa mwadzidzidzi), kapena ngati mudakhalapo kapena mwakhalapo kapena kupitilira kapena kutsika kuposa kuchuluka kwa sodium, potaziyamu, calcium, kapena magnesium m'magazi anu.
• Uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena konzekerani kukhala ndi mwana. Simuyenera kutenga pakati pomwe mukulandira jekeseni wa gemtuzumab ozogamicin. Muyenera kukhala ndi mayeso olimbana ndi mimba musanalandire mankhwalawa. Gwiritsani ntchito njira yolerera yoyenerera mukamamwa mankhwala a gemtuzumab ozogamicin komanso kwa miyezi 6 mutalandira mankhwala. Ngati ndinu wamwamuna ndipo mnzanu atha kukhala ndi pakati, muyenera kugwiritsa ntchito njira yolerera yoyenerera mukamalandira chithandizo komanso kwa miyezi itatu mutalandira mankhwala. Ngati inu kapena mnzanu mutakhala ndi pakati mukalandira jekeseni wa gemtuzumab ozogamicin, itanani dokotala wanu.
• Uzani dokotala wanu ngati mukuyamwitsa. Simuyenera kuyamwa mukalandira jekeseni wa gemtuzumab ozogamicin, komanso kwa mwezi umodzi mutatha kumwa mankhwala.
• Muyenera kudziwa kuti mankhwalawa amachepetsa kubereka kwa abambo ndi amai. Lankhulani ndi dokotala wanu za kuopsa kolandila gemtuzumab ozogamicin.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Jekeseni wa Gemtuzumab ozogamicin itha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• zidzolo
• kutsegula m'mimba
• kudzimbidwa
• nseru
• kusanza
• mutu
• kupweteka
• kupweteka, kutupa, kapena zilonda mkamwa kapena pakhosi

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa M'CHENJEZO CHOFUNIKA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:

• kutuluka mwachilendo kapena kwakukulu kapena kuvulala
• chifuwa, kupuma movutikira, kapena kupuma movutikira
• kugunda kwamtima mwachangu
• malungo, kuzizira, zilonda zapakhosi, kapena zizindikiro zina za matenda

Jekeseni wa Gemtuzumab ozogamicin itha kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukalandira mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Mylotarg^®