Apalutamide

Zamkati

• Musanatenge apalutamide,
• Apalutamide angayambitse mavuto. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:

Apalutamide amagwiritsidwa ntchito pochiza mitundu ina ya khansa ya prostate (khansa mwa amuna yomwe imayamba mu prostate [chiberekero chamwamuna)) ndipo yafalikira mbali zina za thupi kapena yomwe sinafalikire mbali zina za thupi koma sinakhalepo kuthandizidwa ndi mankhwala ena. Apalutamide ali mgulu la mankhwala otchedwa androgen receptor inhibitors. Zimagwira ntchito poletsa zotsatira za androgen (mahomoni oberekera amuna) kuti athetse kukula ndi kufalikira kwa maselo a khansa.

Apalutamide amabwera ngati piritsi kuti atenge pakamwa. Nthawi zambiri amatengedwa kapena wopanda chakudya kamodzi patsiku. Tengani apalutamide mozungulira nthawi yomweyo tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani apalutamide ndendende momwe mwalangizira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Kumeza mapiritsi lonse; osagawana, kutafuna, kapena kuwaphwanya. Ngati simungathe kumeza mapiritsi athunthu, ikani mapiritsi athunthu mu 120 mL (ma ouniki 4) a maapulosi potulutsa; komabe, musaphwanye mapiritsi. Yembekezani mphindi 15 ndikusakaniza osakaniza ndi mapiritsi mpaka mutasakanikirana popanda zidutswa zotsalira. Pogwiritsa ntchito supuni, kumeza chisakanizo nthawi yomweyo. Sambani chidebecho ndi madzi okwanira 60 mL (2 ounces) ndipo nthawi yomweyo tengani chisakanizocho. Sambani chidebecho ndi 60 mL (ma ola awiri) amadzi kuti muwonetsetse kuti mulingo wonse watengedwa. Kumeza chisakanizo chonse nthawi yomweyo kapena mkati mwa ola limodzi lokonzekera. Osasunga chisakanizocho kuti mugwiritse ntchito mtsogolo.

Dokotala wanu angakuuzeni kuti musiye kumwa apalutamide kwakanthawi kochepa kapena kuchepetsa mlingo wanu ngati mutakumana ndi zovuta zina mukamalandira chithandizo. Onetsetsani kuti mwalankhula ndi dokotala za momwe mukumvera mukamalandira chithandizo cha apalutamide.

Ngati dokotala wanu wakulemberani mankhwala ena monga goserelin (Zoladex), histrelin (Supprelin LA, Vantas), leuprolide (Eligard, Lupron, ku Lupaneta Pack), kapena triptorelin (Trelstar, Triptodur) yothandizira khansa ya prostate, muyenera kutero pitirizani kulandira mankhwalawa mukamalandira apalutamide.

Pitilizani kumwa apalutamide ngakhale mukumva bwino. Osasiya kumwa apalutamide osalankhula ndi dokotala.

Funsani wamankhwala kapena dokotala wanu kuti mumupatseko zidziwitso za wopanga kwa wodwalayo.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge apalutamide,

• auzeni adotolo komanso asayansi yanu ngati muli ndi vuto la apalutamide, mankhwala ena aliwonse, kapena zosakaniza zilizonse m'mapiritsi a apalutamide. Funsani wamankhwala wanu kuti awonetse mndandanda wazosakaniza.
• Uzani dokotala wanu komanso wamankhwala mankhwala ndi mankhwala osapatsirana, mavitamini, zowonjezera zakudya ndi mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: anticoagulants ('magazi ochepetsa magazi') monga warfarin (Coumadin), fexofenadine (Allegra), gemfibrozil (Lopid), itraconazole (Onmel, Sporanox, Tolsura), ketoconazole (Nizoral), omeprazole ( , ku Yosprala, Zegerid), midazolam (Nayzilam, Seizalam), rifampin (Rifadin, Rimactane, ku Rifamate, ku Rifater), rosuvastatin (Crestor, Ezallor). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi apalutamide, chifukwa chake onetsetsani kuti muwauze adotolo za mankhwala omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• Uzani dokotala ngati mwakhalapo kapena mudakhalapo ndi vuto la mtima monga matenda amtima, angina (kupweteka pachifuwa), kulephera kwa mtima, kapena matenda oopsa kapena sitiroko kapena ministerroke. Komanso, uzani dokotala ngati munagwidwa ndi khunyu, kuvulala muubongo, chotupa muubongo, cholesterol, shuga, kapena kufooka kwa mafupa.
• muyenera kudziwa kuti apalutamide amangogwiritsidwa ntchito mwa amuna. Azimayi sayenera kumwa mankhwalawa, makamaka ngati ali ndi pakati kapena akhoza kutenga pakati kapena akuyamwitsa. Ngati atengedwa ndi amayi apakati, apalutamide atha kuvulaza mwanayo. Ngati mayi wapakati atenga apalutamide, ayenera kuyimbira foni msanga.
• ngati mnzanu ali ndi pakati, muyenera kugwiritsa ntchito kondomu nthawi iliyonse mukamagonana ndi apalutamide komanso kwa miyezi itatu mutalandira mankhwala. Ngati bwenzi lanu silili ndi pakati koma atha kukhala ndi pakati, muyenera kugwiritsa ntchito kondomu ndi njira ina yolerera mukamagonana mukamalandira chithandizo komanso kwa miyezi itatu mutalandira mankhwala. Osapereka umuna kapena umuna pamene mukumwa apalutamide komanso kwa miyezi itatu mutatha kumwa.
• Muyenera kudziwa kuti apalutamide imatha kukomoka. Osayendetsa galimoto kapena kugwiritsa ntchito makina mpaka mutadziwa momwe mankhwalawa amakukhudzirani.
• muyenera kudziwa kuti apalutamide imatha kupangitsa minofu ndi mafupa anu kufooka, zomwe zimakulitsa chiopsezo chanu choduka ndikuthyoka fupa.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Tengani mlingo womwe mwaphonya mukangokumbukira. Komabe, ngati simukumbukira mpaka tsiku lotsatira, dumpha mlingo womwe umasowa ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo woposa umodzi tsiku limodzi ndipo musatenge mlingo wowirikiza kuti mupange omwe mwaphonya.

Apalutamide angayambitse mavuto. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kufooka
• kutopa
• kupweteka pamodzi
• kufooka kwa minofu kapena kuuma
• kutsegula m'mimba
• nseru
• kusowa chilakolako
• kuonda
• kutentha kotentha

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:

• kugwidwa
• kutaya chidziwitso
• kutupa kwa mikono, miyendo, manja, kapena mapazi
• kugwa
• kupweteka pachifuwa
• kupuma movutikira
• dzanzi kapena kufooka kwa nkhope, mkono, kapena mwendo, makamaka mbali imodzi ya thupi; zovuta kulankhula kapena kumvetsetsa; zovuta kuwona m'maso amodzi kapena onse awiri; chizungulire; kutayika bwino kapena kulumikizana; kapena kuyenda movutikira
• zidzolo
• kuphulika kwa khungu, khungu, kapena kufiira kapena kutentha thupi

Apalutamide amatha kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisunge kutentha komanso kutali ndi kuwala, kutentha kwambiri ndi chinyezi (osati kubafa).

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena a labu kuti muwone momwe thupi lanu likuyankhira apalutamide.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

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