Avatrombopag

Zamkati

• Musanatenge avatrombopag,
• Avatrombopag itha kuyambitsa zovuta zina. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi, itanani dokotala wanu nthawi yomweyo:
• Zizindikiro za bongo zingaphatikizepo izi:

Avatrombopag imagwiritsidwa ntchito pochiza thrombocytopenia (kuchuluka kwamagazi (mtundu wama cell ofunikira magazi) kwa anthu omwe ali ndi matenda opatsirana a chiwindi (omwe akupitilirabe) omwe akuyenera kukhala ndi njira zamankhwala kapena mano kuti ateteze zovuta zamagazi. Amagwiritsidwanso ntchito pochiza thrombocytopenia mwa anthu omwe ali ndi immune immune thrombocytopenia (ITP; vuto lomwe likupitilira lomwe lingayambitse kuvulaza kapena kutuluka mwazi chifukwa chazitsulo zochepa zamagazi m'magazi) omwe sanathandizidwe ndi mankhwala ena. Avatrombopag ali mgulu la mankhwala otchedwa thrombopoietin (TPO) receptor agonists. Zimagwira ntchito kupangitsa kuti thupi lipange mapaleti ambiri.

Avatrombopag imabwera ngati piritsi kuti itenge pakamwa. Pochiza thrombocytopenia mwa anthu omwe ali ndi matenda a chiwindi omwe amayenera kuchitidwa, nthawi zambiri amatengedwa ndi chakudya kamodzi patsiku kwa masiku 5, kuyambira masiku 10 mpaka 13 njira isanachitike. Pochiza thrombocytopenia mwa anthu omwe ali ndi ITP, nthawi zambiri amatengedwa kamodzi tsiku lililonse ndi chakudya kwa nthawi yayitali. Tengani avatrombopag mozungulira nthawi yomweyo tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani avatrombopag chimodzimodzi monga mwawuzidwa. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Funsani wamankhwala kapena dokotala wanu kuti mumupatseko zidziwitso za wopanga kwa wodwalayo.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge avatrombopag,

• uzani dokotala ndi wamankhwala ngati muli ndi matupi awo sagwirizana ndi avatrombopag, mankhwala aliwonse, kapena zosakaniza zilizonse m'mapiritsi a avatrombopag. Funsani wamankhwala wanu kuti awonetse mndandanda wazosakaniza.
• Uzani dokotala wanu komanso wamankhwala mankhwala ndi mankhwala osapatsirana, mavitamini, zowonjezera zakudya, ndi mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: amiodarone (Nexterone, Pacerone); Aprepitant (Emend); ma antifungal ena monga fluconazole, itraconazole (Onmel, Sporanox), ketoconazole, kapena voriconazole (Vfend); carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril); clarithromycin (Biaxin, mu Prevpac); diltiazem (Cardizem, Cartia, Diltzac, Taztia); enzalutamide (Xtandi); erythromycin (EES, Erythrocin, ena; mankhwala ena ochizira HIV monga efavirenz (Sustiva, ku Atripla), indinavir (Crixivan), nelfinavir (Viracept), kapena nevirapine (Viramune); phenobarbital; phenytoin (Dilantin, Phenytut); Mycobutin); rifampin (Rifadin, Rimactane, ku Rifamate, ku Rifater); ritonavir (Norvir, ku Kaletra, ena), kapena saquinavir (Invirase); nefazodone; ndi verapamil (Calan, Covera, Verelan). Mankhwala ena ambiri amathanso kuthandizana ndi avatrombopag, onetsetsani kuti muwauze adotolo zamankhwala onse omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
• uzani dokotala wanu za mankhwala azitsamba omwe mukumwa, makamaka wort ya St.
• auzeni adotolo ngati mudadwalapo magazi kale, kapena chibadwa chomwe chingayambitse magazi.
• Uzani dokotala wanu ngati muli ndi pakati, kapena konzekerani kutenga pakati. Mukakhala ndi pakati mukatenga avatrombopag, itanani dokotala wanu.
• Uzani dokotala wanu ngati mukuyamwitsa. Dokotala wanu angakuuzeni kuti musamamwe mkaka mukamamwa mankhwala komanso kwa milungu iwiri mutatha kumwa.

Musadye zipatso zamphesa kapena kumwa madzi amphesa mukamamwa mankhwalawa.

Ngati mukumwa avatrombopag kuchiza thrombocytopenia musanachitike, tengani mlingo womwe mwaphonya mukangokumbukira. Ngati ili pafupi nthawi ya mlingo wotsatira, tulukani mlingo womwe mwaphonya ndikupitiliza dongosolo lanu, koma onetsetsani kuti mwatsiriza kumwa mankhwala onse (ngakhale sanatenge masiku 5 motsatira). Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Ngati mukumwa avatrombopag kuchiza matenda a immune thrombocytopenia, tengani mlingo womwe mwaphonya mukangokumbukira. Ngati ili pafupi nthawi ya mlingo wotsatira, tambani mlingo womwe mwaphonya ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Avatrombopag itha kuyambitsa zovuta zina. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kutopa kwambiri
• mutu
• Kutuluka magazi m'mphuno kapena chingamu
• kupweteka pamodzi

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi, itanani dokotala wanu nthawi yomweyo:

• kutupa, kupweteka, kufiyira, kapena mwendo wofewa
• kupuma pang'ono, kutentha thupi, chifuwa, kupweteka pachifuwa, kapena kugunda kwamtima
• kupweteka m'mimba kapena kufatsa
• kutupa kwa manja kapena mapazi

Avatrombopag ikhoza kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Zizindikiro za bongo zingaphatikizepo izi:

• kutupa, kupweteka, mwendo wofiira kapena wofewa
• kupuma pang'ono, kutsokomola, kupweteka pachifuwa, kugunda kwamtima mwachangu
• kupweteka m'mimba kapena kufatsa

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu adzaitanitsa mayesero ena a labu musanayambe kumwa mankhwala kuti musankhe kuchuluka kwa avatrombopag komanso patsiku la njirayi.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Zolemba^®